Cancer Gene Therapy Week articles from August 2003

Cancer Gene Therapy Week archives from August 2003

The antisense therapy GTI-2040 is a potent combatant against cancer.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- The antisense agent GTI-2040 is a potent combatant against cancer. According to published research from Canada, "GTI-2040 is a 20-mer oligonucleotide that is complementary to a coding region in the...

Cyclooxygenase-2 promoter enables gene therapy to select for melanoma.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Cyclooxygenase-2 promoter enables gene therapy to select for melanoma. "Novel therapeutic strategies are warranted for the treatment of metastatic melanoma as conventional therapies are inefficient....

Targeting Ki-67 mRNA is an effective strategy for preventing tumor growth.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Targeting Ki-67 mRNA is an effective strategy for preventing tumor growth. "The Ki-67 protein is tightly regulated and depends on the proliferative status of a cell. It is present in the nuclei of...

Wild-type p16 gene shows promise as therapy against colorectal cancer.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Wild-type p16 gene shows promise as therapy against colorectal cancer. According to recent research from South Korea, "human gastric cancer SNU 484 cells express mutant p16, which migrates slower...

The p73 gene activates apoptosis in pancreatic cancer cells lacking p53.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- The p73 gene activates apoptosis in pancreatic cancer cells lacking p53. "Novel therapies such as gene therapy are needed for the treatment of pancreatic carcinomas. Here we show that...

Fusogenic genes potentiate the effects of oncolytic virus in tumors.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Fusogenic genes potentiate the effects of oncolytic virus in tumors. "Oncolytic viruses have shown considerable promise in the treatment of solid tumors, but their potency must be improved if their...

Hot spots in Tcf4 for the interaction with beta-catenin studied.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Hot spots in Tcf4 for the interaction with beta-catenin studied. According to recent research published in the Journal of Biological Chemistry, "The interaction of beta-catenin with T-cell factor...

Oral glutamine did not protect against cisplatin-induced nephrotoxicity in rats.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Oral glutamine did not protect against cisplatin-induced nephrotoxicity in rats. "The antioxidant activity of the amino acid glutamine was investigated to obtain protection against peroxidative...

The magnitude of hedgehog signaling activity defines skin tumor phenotype.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- The magnitude of hedgehog signaling activity defines skin tumor phenotype. According to a study from the United States, "Gain-of-function mutations in SMO have been implicated in constitutive...

A small fraction of giant cells potentially clonogenic.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- A small fraction of giant cells might be potentially clonogenic. "This study was designed to examine the viability and proliferation of uninucleated and multinucleated giant cells formed after 6 Gy...

BRCA1 and BRCA2 mutations may contribute to early-onset breast cancer in Germany.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- BRCA1 and BRCA2 mutations may contribute to early-onset breast cancer in Germany. "This study was undertaken to investigate the prevalence of BRCA1 and BRCA2 germline mutations in 91 German patients...

Multiple suppressor genes may exist on the short arm of chromosome 8.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Multiple suppressor genes may exist on the short arm of chromosome 8. According to a study from Australia, "Loss of heterozygosity (LOH) of the short arm of chromosome 8 occurs frequently in breast...

Haplotype II is over-represented among chromosomes harboring mutations in BRCA1.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Haplotype II is over-represented among chromosomes harboring mutations in BRCA1. According to a study from Spain, "The BRCA1 gene is included in a 200-400 kb region that is subjected to a...

Bronchioloalveolar carcinoma improved by tyrosine kinase inhibitor ZD1839.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Bronchioloalveolar carcinoma can be improved by tyrosine kinase inhibitor ZD1839. "Bronchioloalveolar carcinoma (BAC), a form of pulmonary adenocarcinoma, presents unique clinical features, such as...

Some HOX genes may be involved in transformation of normal cervical cells.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Some HOX genes may be involved in transformation of normal cervical cells. According to published research from Taiwan, "An association between deregulation of homeobox (HOX) gene expression and...

B-CLL drug resistance may occur due to p53 mutation caused by chemotherapy.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- B-CLL drug resistance may occur following p53 mutation caused by prior DNA damaging chemotherapy. According to a study from Germany, "Inactivation of p53 has been shown to correlate with poor...

Integrin-linked kinase signalling is dysregulated early in human colon cancer.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Integrin-linked kinase signalling is dysregulated early in human colon cancer. "The putative oncogene, integrin-linked kinase (ILK), is a protein serine/threonine kinase that has been reported to...

Absence of cyclin D2 expression is associated with promoter hypermethylation.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Absence of cyclin D2 expression is associated with promoter hypermethylation. According to recent research published in the British Journal of Cancer, "Expression of cyclin D2 is absent in 30%-70% of...

Helicase-like transcription factor is inactivated by promoter hypermethylation.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Helicase-like transcription factor is inactivated by promoter hypermethylation. "Helicase-like transcription factor (HLTF), a member of the SWI/SNF (mating type switching/sucrose nonfermenting)...

p16 Promoter hypermethylation in serum may be a marker for tumor DNA.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- p16 Promoter hypermethylation in serum may be a marker for tumor DNA. "For the early detection of tumor-related aberrant DNA in the serum of patients, we examined promoter hypermethylation of the...

Sequence-based cancer genomics presents progress, lessons and opportunities.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Sequence-based cancer genomics presents progress, lessons and opportunities. According to a study from the United States, "Technologies that provide a genome-wide view offer an unprecedented...

Gonadoblastoma occurs in a patient with del(9)(P22) and sex reversal.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Gonadoblastoma occurs in a patient with del(9)(P22) and sex reversal. "Studies of distinct clinical prototypes have significantly contributed to our understanding of evolutionary abnormalities and...

Gene transfection downregulates VEGF expression in endometrial cancer cells.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Gene transfection downregulates VEGF expression in endometrial cancer cells. "It has been reported that tumor suppressor gene p53 regulates vascular endothelial growth factor (VEGF) expression, but...

BCR/ABL blast amplification may have role in blast transformation.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- BCR/ABL blast amplification may have role in blast transformation. According to published research from Argentina, "Although the chronic phase of chronic myelocytic leukemia (CML) is characterized...

Mutations in PTPN11 associated with JMML caused a gain of function.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Mutations in PTPN11 associated with JMML caused a gain of function. "We report here that individuals with Noonan syndrome and juvenile myelomonocytic leukemia (JMML) have germline mutations in...

Real-time reverse transcriptase-PCR measures SIL-TAL1 fusion gene transcripts.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Real-time reverse transcriptase-PCR measures SIL-TAL1 fusion gene transcripts. "TAL1 disruption at 1p32 [del(1p)] is a common rearrangement in the development of T-cell acute lymphocytic leukemia...

The leukemic protein MLL-ELL can functionally inactivate p 53.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- The leukemic protein MLL-ELL can functionally inactivate p 53. "The Eleven Lysine-rich Leukemia (ELL) gene undergoes translocation and fuses in frame to the Multiple Lineage Leukemia (MLL) gene in...

EBV + T-cell Asian lymphoma may have prognostic correlations.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- EBV + T-cell Asian lymphoma may have prognostic correlations. According to recent research from the United States, "Evidence of Epstein-Barr virus (EBV) infection in patients continues to be...

Lymphoma development in Bax transgenic mice is inhibited by Bcl-2.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Lymphoma development in Bax transgenic mice is inhibited by Bcl-2. According to published research from the United States, "Bax is a Bcl-2 family member that promotes apoptosis but has paradoxical...

Monitoring of the TNF-alpha levels may be a useful prognostic marker.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Monitoring of the TNF-alpha levels may be a useful prognostic marker. According to recent research from Japan, "We have attempted to find any relationships between circulating tumor necrosis factor...

Murine models are useful for studying human lymphoid neoplasias.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Murine models are useful for studying human lymphoid neoplasias. According to recent research published in the journal Leukemia Research, "Using an animal model for the study of murine thymic...

Nodal marginal zone B-cell lymphoma found with novel t(X;5)(Q28;q22) abnormality.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Nodal marginal zone B-cell lymphoma has been found with a novel t(X;5)(Q28;q22) abnormality. "Cytogenetic studies provide important information for the diagnosis and classification of malignant...

Antiangiogenic therapy produces liver injury in treated animals.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Recent studies of a therapy designed to suppress tumor angiogenesis show it causes liver injury in research animals. According to medical investigators at...

The CXCL9 gene generates angiogenesis-independent antitumor effects.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- The CXCL9 gene generates angiogenesis-independent antitumor effects. "We examined whether expression of monokine induced by IFN-gamma (Mig, CXCL9) in tumors could produce antitumor effects. Murine...

Combination gene therapy overrides ovarian cancer growth.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Combination gene therapy overrides ovarian cancer growth. "Increased survivin expression is a negative prognostic marker in many tumors, including ovarian cancer. We show here that ovarian...

Comparative genomic hybridization detected genomic alterations in all 18 cases.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- According to a study from England, "Ovarian clear cell carcinoma (OCCC) accounts for a small but significant proportion of all ovarian cancers and is a distinct clinical and pathological entity. ...

Docetaxel and angiostatin gene therapy can combine to inhibit prostate tumors.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Docetaxel and angiostatin gene therapy can combine to inhibit prostate tumors. According to recent research published in the journal Molecular Therapy, "the antitumor effects of adenovirus-delivered...

A new transmembrane collagen is identified in rat metastatic tumor cells.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- A new transmembrane collagen is identified in rat metastatic tumor cells. "We have identified a transmembrane collagen, collagen XXIII, in rat prostate carcinoma cells. Differential display of mRNA...

Alpha1-ARs play a role in promoting hPCE cell proliferation via TRP channels.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Alpha1-ARs play a role in promoting hPCE cell proliferation via TRP channels. "The prostate gland is a rich source of alpha1-adrenergic receptors (alpha1-ARs). Alpha1-AR antagonists are commonly...

Novel IL-10 signaling mechanism regulates TIMP-1 expression in tumor cells.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Novel IL-10 signaling mechanism regulates TIMP-1 expression in tumor cells. According to a study from the United States, "We have previously reported that interleukin 10 (IL-10) signaling stimulated...

Translation inhibitors sensitize prostate cancer cells to apoptosis.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Translation inhibitors sensitize prostate cancer cells to apoptosis. According to a study from the United States, "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis...

Chk2 tumor suppressor is not required for p53 responses in human cancer cells.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Chk2 tumor suppressor is not required for p53 responses in human cancer cells. "Ionizing radiation damages chromosomal DNA and activates p53-dependent transcription in mammalian cells. The Chk2...

TRAIL and gamma-radiation apoptosis is impaired by deficient caspase-9 cleavage.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- TRAIL and gamma-radiation apoptosis is impaired by deficient caspase-9 cleavage. According to recent research from Germany, "TNF-related apoptosis-inducing ligand (RAIL APO-2L) is a member of the...

TRAIL signaling pathway circumvents caspase-8 activation.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- TRAIL signaling pathway circumvents caspase-8 activation in rhabdomyosarcoma. According to recent research from the United States, "Tumor necrosis factor-related apoptosis inducing ligand (TRAIL)...

Novel therapies for patients with granulocytic sarcoma are required.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Novel therapies for patients with granulocytic sarcoma are required. According to recent research from the United States, "Granulocytic sarcoma (GS) is an extramedullary tumor composed of immature...

Molecular analysis of esopharyngeal brush samples could detect head, neck cancer.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Molecular analysis of esopharyngeal brush samples could detect head, neck cancer. "Esopharyngeal brush (OPB) sampling with cytological analysis can yield exfoliated cells from asymptomatic tumors of...

Hematopoietic stem cells ferry exogenous genes directly to tumor vessels.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Hematopoietic stem cells ferry exogenous genes directly to tumor vessels. According to published research from Italy, "angiogenic tumor vessels are promising targets for the activity and the...

Tumor cells evolve in vivo after generation of double-strand DNA breaks.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Tumor cells evolve in vivo after generation of double-strand DNA breaks. "In vitro, the ratio of single- to double-strand DNA breaks (DSB) and their absolute values determine the cell death pathway....

Chk1 and Chk2 are unlikely to be regulators of p53 in some human tumor cells.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Chk1 and Chk2 are unlikely to be regulators of p53 in some human tumor cells. According to a study from the United States, "Cdc25C and p53 have been reported to be physiological targets of...

Zinc inhibits Bax and Bak activation and cytochrome c release.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Zinc inhibits Bax and Bak activation and cytochrome c release. "Zinc has been known for many years to inhibit apoptosis but the mechanism remains unclear. Originally thought to inhibit an apoptotic...

FHIT loss is associated with cancer progression and reduced survival.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- FHIT loss is associated with cancer progression and reduced survival. According to recent research from the United States, "The FHIT gene encompassing the most active common human chromosomal...

Deficiency of Mbd2 suppresses intestinal tumorigenesis in the mouse.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Deficiency of Mbd2 suppresses intestinal tumorigenesis in the mouse. "Gene silencing through de novo methylation of CpG island promoters contributes to cancer," wrote O.J. Sansom and colleagues,...

Mutation CDP may allow tumor growth.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Mutation CDP may allow tumor growth. According to published research from Australia, "Leiomyomas are the most common gynecologic tumors in women, but very little is known about their molecular...

The TERT promoter guides adenovirus-driven oncolysis.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - New research shows a distinctive characteristic of tumor cells can be co-opted by conditionally replicative adenovirus to produce the death of those same cells....

Keratin 19 enhancer-promoter sequences enhance suicide gene therapy.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Keratin 19 enhancer-promoter sequences enhance suicide gene therapy. "To achieve the specific expression of a transfected suicide gene in malignant mesothelioma cells, we applied the...

Escherichia coli genes can be incorporated into colorectal cancer therapy.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Escherichia coli genes can be incorporated into colorectal cancer therapy. According to recent research published in the journal Anticancer Research, "5-Fluorouracil (5-FU) is one of the most...

Gene transduction improves the use of radiation against multiple myeloma.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Gene therapy makes multiple myeloma cells more sensitive to radiotherapy, researchers at the Mayo clinic say. "Multiple myeloma is a disseminated neoplasm...

The survivin pathway can be pinpointed for angiogenesis suppression in tumors.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Medical researchers believe survivin may be an important target for suppressing tumor-related angiogenesis. New research from the University of...

Retinoic Acid stimulates radioiodine uptake in gene-transformed cancer cells.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Retinoic acid enhances the efficacy of radioiodine in prostate cancer cells also treated with gene therapy. According to Christine Spitzweg of...

Effective gene delivery to tumors depends on a variety of factors.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Effective gene delivery to tumors depends on a variety of factors. "Systemic application of surface-shielded transferrin-polyethylenimine/DNA complexes leads to predominant DNA uptake and gene...

Adenoviral E1A deactivates cancer growth mechanisms by inducing p21.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Adenoviral E1A deactivates cancer growth mechanisms by inducing p21. According to a study from the United States, "the adenovirus-5 E1A gene encodes two main proteins of 289 and 243 amino acid...

Apoptosis triggered redistribution of caspase-9 from cytoplasm to mitochondria.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Apoptosis triggered redistribution of caspase-9 from cytoplasm to mitochondria. According to recent research from Slovenia, "Caspase-9 is an apoptosis initiator protease activated as a response to...

Putative tumor suppressor gene KLF6 is mutated in astrocytic gliomas.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas. "Gliomas are the most common tumors of the central nervous system and have a grave prognosis. Deletion of chromosome 10p15...

JNK/SAPK pathway activation may be a therapeutic intervention in breast cancer.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- JNK/SAPK pathway activation may be a therapeutic intervention in breast cancer. "Pharmacologic induction of cancer cell differentiation has potential in the treatment of breast cancer," scientists...

Mutant p53 and aberrant cytosine methylation silence gene expression.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Mutant p53 and aberrant cytosine methylation silence gene expression. According to published research from the United States, "p53 is an important transcriptional regulator that is frequently...

No association in polymorphisms in ERbeta gene and risk of breast cancer.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- No association in polymorphisms in ERbeta gene and risk of breast cancer. "Polymorphisms in the estrogen receptor beta (ERbeta) gene may influence the cellular growth regulating effects of...

Inhibition of signaling pathways may represent promising therapeutic strategies.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Inhibition of signaling pathways may represent promising therapeutic strategies. According to recent research published in the journal Anticancer Research, "The role of growth factors in tumor...

Spontaneous and full recovery from advanced cancers is found in mouse model.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Spontaneous and full recovery from advanced cancers is possible; there is a mouse strain with this immune capacity. According to a study from the United States, "We have established and studied a...

Specific connexins tend to control beta-cell functioning.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Specific connexins tend to control beta-cell functioning. "We have generated novel lentiviral vectors to integrate various connexin cDNAs into primary, non-dividing cells. We have used these...

Insertional translocation caused Wilms tumor and bilateral retinoblastoma.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Insertional translocation caused Wilms tumor and bilateral retinoblastoma. "Retinoblastoma and Wilms' tumor are rare childhood embryonic tumors associated with loss or inactivation of tumor...

Cyclin D1 overexpression in normal cells may cause oncogenic transformation.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Cyclin D1 overexpression in normal cells may cause oncogenic transformation. According to a study from Israel, "cyclin D1 plays an important role in the multi-step process of gastrointestinal...

Genetic changes alter pancreatic cancer's sensitivity to IFN gamma.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Genetic changes alter pancreatic cancer's sensitivity to IFN gamma. "Combined injections into experimental tumor nodules of adenovirus encoding IL-12 and certain chemokines are capable of inducing...

COX-2 inhibition may offer a new approach for HCC chemoprevention.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- COX-2 inhibition may offer a new approach for HCC chemoprevention. According to a study from the Peoples Republic of China, "Cyclooxygenase (COX-2) has been recently suggested to play a role in...

Colon cancer cells that express interleukin-23 generate systemic immunity.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- "Interleukin-23 (IL-23), a novel cytokine composed of a newly identified p19 molecule and the p40 subunit of IL-12, can stimulate the proliferation in vitro of memory T cells. We examined whether Colon...

Gene modified cytotoxic T lymphocytes present anticancer possibilities.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Gene modified cytotoxic T lymphocytes present anticancer possibilities. According to a study from Japan, "genes encoding 2C T cell receptor (TCR) alpha, beta chains from H-2(b)-restricted...

Insertion of MLL sequences is a rare abnormality associated with infant leukemia.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Insertion of MLL sequences is a rare abnormality associated with infant leukemia. According to recent research published in the journal Genes Chromosomes & Cancer, "MLL gene rearrangements leading...

Inhibition of the paternal gene PEG10 might abate hepatocellular carcinogenesis.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Inhibition of the paternal gene PEG10 might abate hepatocellular carcinogenesis. According to recent research published in the journal Cancer Research, "through a genome-wide cDNA microarray, we...

Researchers pinpoint genes involved in cancer growth.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- In a study made possible by the sequencing of the human genome, scientists at the University of Illinois at Chicago have identified 57 genes involved in the growth of human tumor cells. Some of...

A new cytokine cocktail reduces melanoma growth in mice.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- "The vascular endothelial growth factor (VEGF) and its interaction with the vascular endothelial growth factor receptor 2 [VEGFR2/murine fetal liver kinase 1 (Flk-1) human kinase domain receptor] are...

Fibroblast growth factor-2 fosters melanocyte progression to melanoma.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Fibroblast growth factor-2 fosters melanocyte progression to melanoma. According to a study from Germany, "a variety of melanoma-associated antigens have been identified that mediate adhesion,...

Balance of pathways may determine the effect of IL-6 on AR transactivation.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Balance of pathways may determine the effect of IL-6 on AR transactivation. According to recent research from the United States, "The effects of IL-6 on prostate cancer cells are well documented...

Human epithelial cell immortalization is a step in carcinogenesis.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Human epithelial cell immortalization is a step in carcinogenesis. "Human epithelial cells encounter two senescence barriers that enforce a limited proliferative potential. A first barrier is...

Analysis of the ATP7B gene and/or protein will help in choosing chemotherapy.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Analysis of the ATP7B gene and/or protein will help in choosing chemotherapy. According to a study from Japan, "A major obstacle in the treatment of human solid carcinomas is the intrinsic/acquired...

Galectin-3 is involved in the malignant transformation of thyroid cells.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Galectin-3 is involved in the malignant transformation of thyroid cells. "Galectin-3, a beta-galactoside binding lectin, is highly expressed in thyroid carcinomas of follicular cell origin, whereas...