Cancer Gene Therapy Week articles from April 2009

Cancer Gene Therapy Week archives from April 2009

Automatic slicing system: Ex-vivo culture normal and cancerous pancreatic tissue.(Clinical report)
April 6, 2009... Pancreatic cancer is a devastating disease with a very poor prognosis. This warrants the development of novel therapies including gene therapy. Several of these treatments were found to be effective in pre-clinical (animal) models. However, in...

Studies from Polytechnic University have provided new information about cancer gene therapy.(Report)
April 6, 2009... "CD147 plays a critical role in the invasive and metastatic activity of hepatocellular carcinoma (HCC) cells by stimulating the surrounding fibroblasts to express matrix metalloproteinases (MMPs). Tumor cells adhesion to extracellular matrix...

Studies from Sichuan University have provided new data on chemotherapy.
April 6, 2009... "Interferon-gamma-inducible protein 10 (IP-10) is a potent inhibitor of tumor angiogenesis. It has been reported that the antiangiogenic therapy combined with chemotherapy has synergistic effects," investigators in Chengdu, People's Republic of...

Scientists at Lanzhou University, Institute of Urology release new data on cancer gene therapy.
April 6, 2009... A report, 'Construction of urothelium-specific recombinant adenovirus and its inhibition in bladder cancer cell,' is newly published data in Urologia Internationalis. In this recent report, researchers in Lanzhou, People's Republic of China...

Data on cancer gene therapy detailed by researchers at University of Kuopio.
April 13, 2009... According to a study from Kuopio, Finland, "We studied antiangiogenic and antilymphangiogenic effects of sVEGFR-1 (sFlt-1), sVEGFR-2 (sFlk-1/KDR), and sVEGFR-3 (sFlt-4) gene transfers and their combinations in intraperitoneal ovarian cancer...

Iowa State University describes research in cancer gene therapy.(Report)
April 13, 2009... Fresh data on cancer gene therapy are presented in the report 'Novel pentablock copolymers for selective gene delivery to cancer cells.' According to recent research from the United States, "In this study, the novel...

Scientists at University of South Florida, Department of Chemistry target cancer gene therapy.(Report)
April 13, 2009... Data detailed in 'Role of protein kinase C-iota in transformed non-malignant RWPE-1 cells and androgen-independent prostate carcinoma DU-145 cells' have been presented. "Prostate cancer is one of the leading causes of death among men in the...

University of Chicago, Brain Tumor Center details research in glioma gene therapy.(Report)
April 13, 2009... Current study results from the report, 'Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo,' have been published. "Conditionally replicative...

Evanston Northwestern Hospital, Department of Pathology publishes research in cancer gene therapy.(Report)
April 20, 2009... Research findings, 'MicroRNA-based therapeutics for cancer,' are discussed in a new report. According to a study from the United States, "MicroRNAs (miRNAs) are non-protein-coding small RNA molecules that negatively regulate target messenger...

National University of Ireland describes research in cancer gene therapy.(Report)
April 20, 2009... Fresh data on cancer gene therapy are presented in the report 'Combined IFN-gamma-endostatin gene therapy and radiotherapy attenuates primary breast tumor growth and lung metastases via enhanced CTL and NK cell activation and attenuated tumor...

Report summarizes cancer gene therapy study findings from S. Rodriguez-Nieto and co-researchers.
April 20, 2009... Fresh data on cancer gene therapy are presented in the report 'BRG1 and LKB1: tales of two tumor suppressor genes on chromosome 19p and lung cancer.' According to a study from Barcelona, Spain, "Losses of heterozygosity (LOH) of the short arm...

Research from University of Cologne in cancer gene therapy provides new insights.
April 20, 2009... Fresh data on cancer gene therapy are presented in the report 'Death-associated protein kinase (DAPK) promoter methylation and response to neoadjuvant radiochemotherapy in esophageal cancer.' According to recent research from Cologne, Germany,...

Research from University of Georgia, Research Center has provided new information about cancer gene therapy.
April 20, 2009... Scientists discuss in 'Knockdown of GnT-Va expression inhibits ligand-induced downregulation of the epidermal growth factor receptor and intracellular signaling by inhibiting receptor endocytosis' new findings in cancer gene therapy. "Changes...

Researchers from University of California discuss findings in cancer gene therapy.
April 20, 2009... New investigation results, 'BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer,' are detailed in a study published in Carcinogenesis. "BTG3/ANA/APRO4 has been reported to...

Researchers from University of Kentucky, Department of Physiology report on findings in cancer gene therapy.
April 20, 2009... Researchers detail in 'Gene therapy for pancreatitis pain,' new data in cancer gene therapy. "Pancreatic cancer and chronic pancreatitis are clinical syndromes associated with severe pain that is difficult to manage. Thus, seeking additional...

Study data from Fox Chase Cancer Center, Department of Medical Oncology update knowledge of cancer gene therapy.
April 20, 2009... Scientists discuss in 'The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis' new findings in cancer gene therapy. "Birt-Hogg-Dubé (BHD) syndrome is a tumor-suppressor gene disorder characterized by skin...

Recent findings from A. Bauer and co-authors highlight research in gene therapy.
April 20, 2009... New investigation results, 'Identification of malignancy factors by analyzing cystic tumors of the pancreas,' are detailed in a study published in Pancreatology. According to a study from Heidelberg, Germany, "The diversity in the...

Researchers from Mount Sinai School of Medicine, Department of Medicine detail findings in gene therapy.
April 20, 2009... A new study, 'AAV for pain: steps towards clinical translation,' is now available. According to a study from the United States, "Recombinant adeno-associated virus (rAAV) vectors consisting of self-complementary genomes and packaged in certain...

New research on leukemia gene therapy from University Hospital summarized.
April 20, 2009... New investigation results, 'Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D,' are detailed in a study published in Gene Therapy. According to recent research from Hamburg, Germany,...

New research on leukemia gene therapy from University of Ulm, Department of Internal Medicine III summarized.(Report)
April 20, 2009... New research, 'Chronic lymphocytic leukemia and 13q14: miRs and more,' is the subject of a report. According to a study from Ulm, Germany, "Loss of a critical region in 13q14.3 [del(13q)] is the most common genomic aberration in chronic...

Scientists at University of Cologne target leukemia gene therapy.
April 20, 2009... Scientists discuss in 'Overexpression of the Fas-inhibitory molecule TOSO: a novel antiapoptotic factor in chronic lymphocytic leukemia' new findings in leukemia gene. According to a study from Cologne, Germany, "Chronic lymphocytic leukemia...

Data on cancer gene therapy described by investigators at Kyushu University, Research Institute for Diseases of the Chest.
April 27, 2009... Investigators publish new data in the report 'Tetracycline-inducible promoter-based conditionally replicative adenoviruses for the control of viral replication.' "The use of conditionally replicative adenoviruses (CRAds) as a promising...

Researchers from Boston University detail findings in cancer gene therapy.(Clinical report)
April 27, 2009... A new study, 'Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer,' is now available. According to a study from the United States, "Preclinical and clinical studies of CYP gene-directed enzyme prodrug...

Researchers from Cell Genesys, Inc. discuss findings in cancer gene therapy.
April 27, 2009... New investigation results, 'Combination therapy with radiation or cisplatin enhances the potency of Ad5/35 chimeric oncolytic adenovirus in a preclinical model of head and neck cancer,' are detailed in a study published in Cancer Gene Therapy....

Researchers from Pusan National University publish findings in cancer gene therapy.
April 27, 2009... Scientists discuss in 'Expression of HBX, an oncoprotein of hepatitis B virus, blocks reoviral oncolysis of hepatocellular carcinoma cells' new findings in cancer gene therapy. According to recent research from Korea, "Although reovirus has...

Researchers from University of Saskatchewan report on findings in cancer gene therapy.
April 27, 2009... Researchers detail in 'Transgene expression of alpha tumor necrosis factor with mutations D142N and A144R under control of human telomerase reverse transcriptase promoter eradicates well-established tumors and induces long-term antitumor...

Researchers from University of Toronto, Department of Medical Biophysics describe findings in cancer gene therapy.
April 27, 2009... Current study results from the report, 'Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells,' have been published. "Adoptively transferred T cells possess anticancer activities...

Study findings from University of Rome, Institute of Molecular Biology and Pathology broaden understanding of cancer gene therapy.
April 27, 2009... Scientists discuss in 'RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner' new findings in cancer gene therapy. "Mitotic microtubule (MT)-targeting drugs are widely used to treat cancer. The GTPase Ran...

Data on cancer gene therapy animal studies published by researchers at University of Texas, Division of Pharmaceutics.
April 27, 2009... Data detailed in 'Drug-virus interaction: effect of administration of recombinant adenoviruses on the pharmacokinetics of docetaxel in a rat model' have been presented. According to recent research published in the journal Cancer Gene Therapy,...

Data on cancer gene therapy vaccines reported by S. Dharmapuri and co-researchers.(Report)
April 27, 2009... Research findings, 'An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models,' are discussed in a new report. According to a study from Pomezia, Italy, "In vivo electroporation of plasmid DNA (DNA-EP) is an...

Researchers from INSERM publish findings in gene therapy.
April 27, 2009... Current study results from the report, 'Recurrent genomic aberrations combined with deletions of various tumour suppressor genes may deregulate the G1/S transition in CD4+CD56+ haematodermic neoplasms and contribute to the aggressiveness of the...

Gene therapy for muscular dystrophy shows promise beyond safety.
April 27, 2009... Researchers have cleared a safety hurdle in efforts to develop a gene therapy for a form of muscular dystrophy that disables patients by gradually weakening muscles near the hips and shoulders (see also Gene Therapy). Described as the...