Cancer Gene Therapy Week articles from April 2004

Cancer Gene Therapy Week archives from April 2004

Valproic acid impedes angiogenesis in laboratory assays and study models.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Valproic acid impedes angiogenesis in laboratory assays and study models. According to recent research published in the journal Molecular Pharmacology, "valproic acid (VPA) is a widely used...

Bcl-2 small interfering RNA halts human tumor cell growth.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Bcl-2 small interfering RNA halts human tumor cell growth. "A T7 promoter driven siRNA expression vector system (Bcl-2/T7) that targets Bcl-2 mRNA in MCF-7 human cancer cells was designed in the...

Male carriers of germline mutations in BRCA2 are at increased risk for cancer.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Men with BRCA2 mutations are at greater risk for cancer, especially before age 65, researchers report. "Major risks conferred by BRCA1 and BRCA2 in women are for cancers of the breast, ovary,...

CpG oligonucleotides elicit antitumor responses in melanoma models.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- CpG oligonucleotides elicit antitumor responses in melanoma models. "For patients with advanced malignant melanoma, the 5 year survival rate with current treatment modalities is low. There is an...

Epigenetic silencing of adhesion molecule ADAM23 occurs often in breast tumors.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- The adhesion molecule A Desintegrin And Metalloprotease domain 23 gene (ADAM 23) may be downregulated during the progression of breast cancer, researchers say. "Altered cell adhesion is causally...

Patent granted for mammary aspirate specimen cytology test.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Nastech Pharmaceutical Co., Inc., (NSTK) announced the issuance of a second U.S. patent, no. 6,689,073, entitled "Methods and Devices for Collecting, Handling and Processing Mammary Fluid Samples for...

CDH1 and CDH13 methylation is a marker for more aggressive cervical cancer.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Researchers find that cervical cancer patients with unmethylated CDH1/CDH13 had better disease-free survival. "Cervical cancer is the principal cause of death due to cancer in women. Five-year...

Genaera extends alliance IL-9 alliance.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Genaera Corp. (GENR) and the Ludwig Institute for Cancer Research (LICR) announced a 2-year extension of a collaborative agreement on the joint discovery and development of novel genes and proteins as...

Researchers propagate infectious HPV16.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Researchers develop a technique that allows the study of human papillomavirus type 16 (HPV16) and its connection to squamous cell cancer of the cervix, head and neck. "HPV16 infection is a major...

Gefitinib targets tyrosine kinase in non-small cell lung cancer.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Researchers discuss gefitinib (ZD1839, Iressa) as a newly approved drug for treatment of patients with advanced non-small cell lung cancer (NSCLC). "Gefitinib (ZD1839, Iressa), a selective drug...

Simvastatin given with cytotoxic drugs is advantageous in myeloma cell lines.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Researchers report greater antimyeloma activity when simvastatin (Sim) is used in combination with cytotoxic drugs. According to recent research from Israel, "We have evaluated the potential...

Telomerase expression may be a marker for prostate cancer.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Researchers detect telomerase expression in a high number of prostate cancer smears, indicating that it could be a marker for prostate malignancy. According to recent research from Greece, "The aim...

Survivin knockdown reduces the clonogenic survival of sarcoma cells without p53.
April 12, 2004... 2004 APR 12 - (NewsRx.com & NewsRx.net) -- Survivin knockdown reduces the clonogenic survival of sarcoma cells without p53. According to a study from Germany, "survivin, a member of the inhibitors-of-apoptosis gene family, is overexpressed...

Cytokine gene therapy staunches murine melanoma.
April 12, 2004... 2004 APR 12 - (NewsRx.com & NewsRx.net) -- Cytokine gene therapy staunches murine melanoma. "We previously reported that RGD fiber-mutant adenovirus vector (AdRGD) was a very useful vector system for in vivo cytokine gene therapy for...

5-Fluorouracil and interferon gene therapy diminish colon cancer metastasis.
April 12, 2004... 2004 APR 12 - (NewsRx.com & NewsRx.net) -- 5-Fluorouracil and interferon gene therapy diminish colon cancer metastasis. "Preclinical in vitro and in vivo studies have demonstrated synergistic interactions between 5-fluorouracil (5-FU) and...

Chemokine gene modification of dendritic cells improves antitumor activity.
April 12, 2004... 2004 APR 12 - (NewsRx.com & NewsRx.net) -- Chemokine gene modification of dendritic cells improves antitumor activity. "Previous animal studies conducted in our laboratory have shown that tumor antigen-pulsed dendritic cells (TP-DC) can...

Recombinant BCG DNA vaccines and gene immunotherapy treat bladder cancer.
April 12, 2004... 2004 APR 12 - (NewsRx.com & NewsRx.net) -- Recombinant BCG DNA vaccines and gene immunotherapy treat bladder cancer. According to a study from Taiwan, "intravesical immunotherapy with live Mycobacterium bovis bacillus Calmette-Guerin (BCG)...

Breast cancers should be staged at the time of diagnosis.
April 12, 2004... 2004 APR 12 - (NewsRx.com & NewsRx.net) -- Histological changes that occur prior to malignancy can indicate the need for close surveillance or further operative intervention, researchers say. According to recent research published in the...

PTTG mRNA expression in primary breast cancer may indicate tumor aggressiveness.
April 12, 2004... 2004 APR 12 - (NewsRx.com & NewsRx.net) -- The proto-oncogene pituitary tumor-transforming gene (PTTG) overexpression in breast tumor tissue is a potential predictor of tumor aggressiveness. "PTTG is described as abundantly overexpressed in...

Telomere shortening occurs in some normal and malignant breast tissue.
April 12, 2004... 2004 APR 12 - (NewsRx.com & NewsRx.net) -- Telomere shortening occurring in histologically normal terminal duct lobular units may be predictive of malignant transformation. According to a study from the United States, "In the setting of...

MTHFR C677T A1298C polymorphisms may predict risk of colon cancer.
April 12, 2004... 2004 APR 12 - (NewsRx.com & NewsRx.net) -- 5,10-methylenetetrahydrofolate reductase (MTHFR) A1298C polymorphism may be related to the development of colon cancer, researchers say. According to recent research from the United States, "MTHFR...

ARK5 overexpression may signal progression of colorectal cancer.
April 12, 2004... 2004 APR 12 - (NewsRx.com & NewsRx.net) -- Researchers find higher ARK5 expression in tumor samples from more advanced cases. According to recent research published in the American Journal of Pathology, "A novel member of the human AMPK...

Platelet integrin alpha2 marks the efficacy of angiogenesis inhibitor E7820.
April 12, 2004... 2004 APR 12 - (NewsRx.com & NewsRx.net) -- Platelet integrin alpha2 marks the efficacy of angiogenesis inhibitor E7820. "We reported previously that an angiogenesis inhibitor, E7820, inhibits in vitro tube formation of human umbilical vein...

New molecular-based method can assess protein expression in prostate cancer.
April 12, 2004... 2004 APR 12 - (NewsRx.com & NewsRx.net) -- A new system may be able to provide automated screening of prostate tissue biomarkers, researchers say. "Despite years of discovery and attempts at validation, few molecular biomarkers achieve...

Sodium butyrate and tributyrin are effective in vivo in prostate cancer.
April 12, 2004... 2004 APR 12 - (NewsRx.com & NewsRx.net) -- Controlled trials are necessary to test the effect of sodium butyrate and tributyrin in patients at risk for or with prostate cancer, researchers say. "Histone deacetylase inhibitors (HDACs) are...

Stress-responsive promoters leave cells vulnerable to radiation therapy.
April 12, 2004... 2004 APR 12 - (NewsRx.com & NewsRx.net) -- Stress-responsive promoters leave cells vulnerable to radiation therapy. According to recent research from Switzerland, "radiotherapy is one of the principal modalities of cancer treatment, but the...

Molecular targeted therapies for small cell lung cancer are being studied.
April 12, 2004... 2004 APR 12 - (NewsRx.com & NewsRx.net) -- Treatments for small cell lung cancer (SCLC) have only slightly improved survival over the past two decades and research is now investigating molecular targeted therapies, researchers say. "Small...

Silenced clusterin-apolipoprotein J gene causes cancer cells to implode.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Silenced clusterin-apolipoprotein J gene causes cancer cells to implode. According to recent research from Greece, "clusterin/apolipoprotein J (CLU) is a heterodimeric ubiquitously expressed...

Herpes simplex virus thymidine kinase genes diminish nearby neuroblastoma cells.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Herpes simplex virus thymidine kinase genes diminish nearby neuroblastoma cells. "Selective introduction of genes conferring chemosensitivity into proliferating tumor cells may be used to treat...

Altered Rho GTPase signaling pathways potential target for breast cancer therapy.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Altered Rho GTPase signaling pathways are potential targets for breast cancer therapy. "The Rho family of GTPases have emerged as key players in regulating a diverse set of biological activities...

Rho GTPases represent signaling convergence points and relay switches.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Rho GTPases represent signaling convergence points and relay switches. "There is now considerable evidence for the involvement of aberrant Rho GTPase activation in breast cancer development. Like...

Gene therapy shows promise for treating renal diseases.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Gene therapy shows promise for treating renal diseases. "Somatic cell gene therapy has made considerable progress last 5 years and has shown clear success in some clinical trials. In the field of...

EGF gene may be therapy target and prognostic marker for glioblastoma.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Single polymorphism in EGF gene may be useful as a tumor therapy target and prognostic marker for glioblastoma multiforme. "Glioblastoma multiforme, the most aggressive form of primary brain tumor...

Androgen receptor polymorphism alters breast cancer risk in hormone therapy.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Androgen receptor polymorphism may increase breast cancer risk in estrogen progestin therapy users. "There is some evidence that women with a higher number of CAG repeat lengths on the androgen...

Emmprin enhances several malignant properties of cancer cells.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Emmprin enhances several malignant properties of cancer cells. "Emmprin (CD147; basigin) is a plasma membrane glycoprotein, enriched on the surface of many cancer cells, which induces matrix...

Prune cAMP phosphodiesterase binds nm23-H1 and promotes breast cancer metastasis.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Prune cAMP phosphodiesterase binds nm23-H1 and promotes breast cancer metastasis. Identification of "a new enzymatic activity underlying metastasis in breast cancer" and "its susceptibility to...

Expanded roles for checkpoint kinases suggest target modification.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Expanded roles for checkpoint kinases suggest target modification. "An important part of the cellular response to DNA damage is checkpoint activation - checkpoint kinases CHK1 and CHK2...

Urokinase plasminogen activator is increased during colon tumor transformation.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Beta-catenin plays a role in the transactivation of urokinase plasminogen activator (uPA), which is related to the conversion of colon adenomas to malignant tumors. According to recent research...

Triple fusion reporter vectors identify gene expression in living subjects.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Triple fusion reporter vectors identify gene expression in living subjects. "Imaging reporter gene expression in living subjects with various imaging modalities is a rapidly accelerating area of...

Cancer-altered apoptosis leads to tumor progression and therapy resistance.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Cancer-altered apoptosis may lead to tumor progression and resistance to therapy. "Despite the combined action of surgery, radiotherapy and chemotherapy, the leading cause of death in cancer...

MUC1 transforming protein confers resistance to genotoxic anticancer agents.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- The MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents. "The MUC1 transforming protein is overexpressed by most human carcinomas. The present studies demonstrate...

PPAR-delta regulates intestinal adenoma growth in mice.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- PPAR-delta regulates intestinal adenoma growth in mice. Apc(min) mice, which are predisposed to intestinal polyposis, were treated with a selective synthetic agonist of peroxisome...

H. pylori CagA proteins may raise risk of gastric cancer in East Asians.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Researchers report that patients in East Asia with the CagA-positive H. pylori strain are at high risk for greater mortality from gastric cancer. According to a study from Japan, "Recent molecular...

Inducible nitric oxide synthase sensitizes colorectal cancer to radiation.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Inducible nitric oxide synthase sensitizes colorectal cancer to radiation. According to recent research published in the journal Cancer Research, "nitric oxide is a potent radiosensitizer of...

Vectors encoding for angiostatin and endostatin surpass single-encoded vectors.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Vectors encoding for angiostatin and endostatin surpass single-encoded vectors. According to published research from the United States, "angiogenesis is characteristic of solid tumor growth and a...

Genetically altered mice predict toxicity for individual targeted cancer therapy.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Genetically engineered mouse models can be used to predict toxicity in individuals treated with targeted cancer therapies. "Current trends foretell the use of cancer treatments customized to each...

The ceruloplasmin promoter shows an affinity for ovarian tumors.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- The ceruloplasmin promoter shows an affinity for ovarian tumors. "Gene therapy provides a novel treatment approach to cancer patients. Ideally, expression of therapeutic genes driven by...

Cancer drug target Hsp90 susceptible to inhibition by 17AAG with cell activation.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- The cancer drug target Hsp90 is susceptible to inhibition by geldanamycin derivative 17AAG when cancer cells are activated. "The molecular chaperone Hsp90 is an exciting cancer drug target. The...

Specific PP2A subunits suppress tumors.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Specific PP2A subunits suppress tumors. "Reversible phosphorylation of proteins, catalyzed by kinases and phosphatases, is a key regulatory mechanism in the control of multiple cellular signal...

Mathematical approach used to understand cancer initiation and progression.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- A mathematical approach can be used to understand cancer initiation and progression. "Evolutionary concepts such as mutation and selection can be best described when formulated as mathematical...

Mutations in more than 1% of cancer genes may contribute to human cancer.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- A census of cancer genes indicate that mutations in more than 1% of genes contribute to human cancer. "A central aim of cancer research has been to identify the mutated genes that are causally...

Novel targeted expressed gene display analyzes alterations in genes.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Novel targeted expressed gene display analyzes alterations in genes. "To address the challenge of identifying related members of a large family of genes, their variants and their patterns of...

CBP loss mediates lymphomagenesis in synergy with reduction of p27(Kip1).
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- CBP loss mediates lymphomagenesis in synergy with reduction of p27(Kip1). "CBP can function as a tumor suppressor, but the mechanisms that govern oncogenesis in its absence are unknown. Here we...

Paget disease of bone can progress into painful complications.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Researchers report that bisphosphonates are effective in relieving symptoms and reducing disease activity in patients with Paget disease of bone. "Paget's disease of bone is characterized by an...

New nanobacteria patent announced.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Nanobac Pharmaceuticals, Inc., (NNBP) has announced the printing of U.S. patent 6,706,290, "Methods for Eradication of Nanobacteria." This patent, issued to Drs. Kajander and Ciftcioglu of...

DNA content in childhood rhabdomyosarcoma important in predicting prognosis.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- The DNA content in childhood rhabdomyosarcoma is an important variable in predicting prognosis. "The prognostic value of DNA ploidy and proliferative index (PI) are well established in many...

SDHD is the first known tumor suppressor gene encoding a mitochondrial protein.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- SDHD is the first known tumor suppressor gene encoding a mitochondrial protein. "Paragangliomas of the head and neck region are usually benign tumors that develop from chemoreceptors of...

Tumor-suppressors function differently in the nervous system.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Researchers report that tumor suppressor mutations in the nervous system result in unique outcomes as opposed to other organs. According to recent research from the United States, "Tumor...

Specific PP2A complexes transform human cells to form or suppress tumors.
April 19, 2004... 2004 APR 19 - (NewsRx.com & NewsRx.net) -- Specific PP2A complexes can transform human cells to form or suppress tumors. "The SV40 small t antigen (ST) interacts with the serine-threonine protein phosphatase 2A (PP2A). To investigate the...

Partners to develop breast cancer gene expression database.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- In a new attempt towards the identification of novel breast cancer genes, Genomics Collaborative, Inc., (GCI) and Celestar-Lexico Sciences, Inc., announced their partnership to create a large-scale...

Studies: Phenoxodiol produces response and restores chemosensitivity.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- Data presented at the recent American Association for Cancer Research meeting confirms that phenoxodiol is on track in its development as a first-line therapy for early-stage cancers and as a...

CD43 involved in nuclear signaling and cell proliferation via beta-catenin.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- CD43 is involved in nuclear signaling and cell proliferation via beta-catenin. "CD43 is a transmembrane molecule with a highly O-glycosylated extracellular domain of mucin type. It is a normal...

Evidence support mechanistic link between heat shock and oxidative stress.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- Evidence supports a mechanistic link between heat shock and oxidative stress. "In spite of ongoing research efforts, the specific mechanism(s) of heat-induced alterations in the cellular response...

Distinct mechanisms lead to HPRT gene mutations in leukemic cells.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- Distinct mechanisms lead to HPRT gene mutations in leukemic cells. "Leukemias are considered malignant clonal disorders arising from the accumulation of mutations in hematopoietic cells; the...

CBP loss causes T cell lymphomagenesis in synergy with p27(Kip1) insufficiency.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- CBP loss causes T cell lymphomagenesis in synergy with p27(Kip1) insufficiency. "CBP can function as a tumor suppressor, but the mechanisms that govern oncogenesis in its absence are unknown. Here...

Prevention and genetic testing for breast cancer vary geographically.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- A survey conducted in three countries finds differences in the way testing and prophylactic surgery are performed, researchers report. According to recent research from Canada, "The discovery...

Bruceantin is active against tumors in culture and in xenograft models.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- Researchers say that bruceantin is active against some cancers in culture and xenograft models and should be evaluated in clinical trials for its effect in hematological malignancies. According to...

Cancer-causing HDAC isoforms discussed at 2004 AACR meeting.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- MethylGene, Inc., presented a poster describing the key role of histone deacetylase 1 (HDAC1) in oncology at the 2004 American Association for Cancer Research's (AACR) 95th annual meeting in Orlando,...

Data demonstrate IMO compounds inhibit tumor growth.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- Hybridon, Inc., (HBY) announced two presentations of preclinical data showed Hybridon's immunomodulatory oligonucleotide (IMO) compounds inhibited tumor growth in mouse models of cancer. In these...

Data demonstrate vaccine technology's potential to treat/prevent cancer.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- MedImmune, Inc., (MEDI) and Cerus Corp. (CERS) announced preclinical results demonstrating the effectiveness of a therapeutic vaccine technology in suppressing the growth of certain tumors. ...

National Cancer Institute awards discodermolide-related grant.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- Kosan Biosciences, Inc., (KOSN) announced the award of a 2-year, $750,000, phase II small business innovative research (SBIR) grant from the U.S. National Cancer Institute to develop an efficient means...

Cumulative etoposide doses prognostic factor for transplant-related mortality.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- Cumulative etoposide doses are a prognostic factor for transplant-related mortality. "Studies evaluating the effects of previous chemotherapy on stem-cell yield and hematological recovery after...

Novel, small peptide, GA3, has potential as drug delivery ligand.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- A novel, small peptide, GA3, has potential as drug delivery ligand for chemotherapy, radiotherapy, and gene therapy. Investigators in the People's Republic of China explained, "Tie2 is an...

Extracellular signals regulate nucleocytoplasmic shuttling of signal transducers.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- Extracellular signals regulate the nucleocytoplasmic shuttling of signaling transducers. "The nuclear translocation of signal-transduction proteins is an essential step in the control of gene...

Ku86 levels correlate with magnitude of radiation-induced lymphocyte DNA breaks.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- The levels of Ku86 correlate with the magnitude of radiation-induced DNA breaks in human lymphocytes. "The Ku heterodimer, which consists of Ku70 and Ku86 subunits, is a major sensor of DNA...

TRAF3 required for signaling by LMP1 but not CD40 in B cells.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- TRAF3 is required for signaling by LMP1 but not CD40 in B cells. "CD40, a member of the tumor necrosis factor receptor family, and the Epstein-Barr virus-encoded oncoprotein latent membrane protein...

Advexin Clinical Data presented at AACR.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- Introgen Therapeutics (INGN) reported combined safety and efficacy results based on three multicenter, multinational, phase II clinical trials of Advexin p53 gene therapy in 217 patients with recurrent...

Overexpression of COX-2 is associated with radioresistance in oral SSC.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- Overexpression of COX-2 is associated with radioresistance in oral squamous cell carcinoma (SCC). "Cyclooxygenase-2 (COX-2), an inducible isoform of cyclooxygenase, is overexpressed in many types...

E-cadherin is important in prostate cancer cell invasion.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- Study results suggest that E-cadherin plays an important role in regulating the invasive potential of prostate cancer cells through a unique paracrine mechanism, researchers say. "The role(s) of...

NCI collaboration to investigate role of ACE2 in SARS.
April 26, 2004... 2004 APR 26 - (NewsRx.com & NewsRx.net) -- Millennium Pharmaceuticals, Inc., (MLNM) announced that it is collaborating with the National Cancer Institute (NCI) to study the link between the novel enzyme angiotensin-converting enzyme 2 (ACE2)...