Cancer Gene Therapy Week articles from April 2003

Cancer Gene Therapy Week archives from April 2003

E1A sensitizes cells to TNF alpha by downregulating c-FLIP gene.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- A new study indicates E1A sensitizes cells to tumor necrosis factor alpha by downregulating the c-FLIP gene. "Tumor necrosis factor alpha (TNF-alpha) activates both apoptosis and...

An adenovirus encoding for rat protein suppresses human thyroid carcinoma.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- An adenovirus encoding for rat protein suppresses human thyroid carcinoma. "We demonstrated previously that rat tyrosine phosphatase r-PTPeta expression was suppressed in rat and human thyroid...

Interleukin-12 gene therapy is a viable alternative for treating thyroid cancer.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Based on its low toxicity and ability to retard tumor growth, interleukin (IL)-12 gene therapy may offer a viable alternative for treating follicular thyroid...

CHD5 is a nervous system chromodomain protein found absent in the cancer.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- CHD5 is a nervous system chromodomain protein found absent in the cancer. "Chromatin remodeling is one of the mechanisms by which gene expression is regulated developmentally. Chromatin structure...

Manganese superoxide dismutase causes cells to resist doxorubicin therapy.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Manganese superoxide dismutase causes cells to resist doxorubicin therapy. According to a study from the United States, "overexpression of manganese superoxide dismutase (MnSOD) has been postulated...

Some CDKN2A gene polymorphisms in the population lower cancer survival.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Some CDKN2A gene polymorphisms in the population lower cancer survival. "Point mutations and single nucleotide polymorphisms (SNPs) in the CDKN2A gene in bladder cancer patients have been resolved...

Primitive neuroectodermal may represent an unknown paraneoplastic syndrome.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Primitive neuroectodermal may represent an unknown paraneoplastic syndrome. According to recent research from the United States, "Primitive neuroectodermal tumors (PNETs) account for one-fifth of...

Chromosomal imbalances are rare in craniopharyngiomas.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Chromosomal imbalances are rare in craniopharyngiomas. According to a study from Germany, "Craniopharyngiomas are among the most common pediatric tumors and are thought to arise from embryonic...

Molecular screening discovers thousands of new genes, including BASE.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Molecular screening discovers thousands of new genes, including BASE. According to a study from the United States, "To identify unknown membrane proteins that could be used as targets for breast and...

Serum antibodies to lipophilin B are correlated to disease stage.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Serum antibodies to lipophilin B are correlated to disease stage. According to recent research from the United States, "Lipophilin B mRNA is overexpressed in approximately 70% of breast tumors and...

Researchers study multiple mutations and cancer.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Researchers study multiple mutations and cancer. According to recent research from the United States, "Most human tumors are highly heterogenous. We have hypothesized that this heterogeneity...

Large-cell medulloblastoma may have arrestin-like protein expression.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Large-cell medulloblastoma may have arrestin-like protein expression. A study from France "reports a case of a cerebellar large-cell medulloblastoma in a 12 yr old patient. Despite a gross total...

The E2/E6 gene ratio in papillomavirus-16 cancer can help diagnose stage.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- The E2/E6 gene ratio in papillomavirus-16 cancer can help diagnose stage. According to a study from Poland, "Integration of human papillomavirus (HPV) DNA into host genome occurs early in cancer...

Cisplatin resistance could be defeated with gene targeting.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Cisplatin resistance could be defeated with gene targeting. According to recent research from the United States, "the current chemotherapeutic modalities for advanced colorectal cancer are limited....

The human DNA methyltransferase gene DNMT1 is a target for cancer therapy.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- The human DNA methyltransferase gene DNMT1 is a target for cancer therapy. According to recent research from Canada, "epigenomic changes in DNA methylation patterns are evident in a variety of...

Two expressed enzyme levels can predict the efficacy of chemotherapy.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Two expressed enzyme levels can predict the efficacy of chemotherapy. "Dihydropyrimidine dehydrogenase (DPD) and thymidylate synthase (TS) gene expressions in metastatic colorectal cancer have been...

Researchers synthesize CC-1065 analogues.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Researchers synthesize CC-1065 analogues. According to a study from the United States, "CC-1065 analogues bearing different DNA-binding subunits were synthesized. A terminal C5-NO2 and -F moiety...

Several experiments prove principle of genetically engineered mouse models.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Several experiments prove principle of genetically engineered mouse models. "Engineering cancer-associated mutations into the mouse germline is an important tool for biological studies of growth...

RU486 inhibits growth of cells by involving the NF-kappa B signaling pathway.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- RU486 inhibits growth of cells by involving the NF-kappa B signaling pathway. According to recent research from the United States, "Previous studies indicated that the antiprogestin RU486 could...

The new human cell line EN has a TP53 mutation and a 1-day doubling time.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- The new human cell line EN has a TP53 mutation and a 1-day doubling time. According to a study from Japan, they created "a new cell line, EN, established from an invasive endometrioid adenocarcinoma...

Telomeres have allelic length variation and can shorten slowly or quickly.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Telomeres have allelic length variation and can shorten slowly or quickly. "By imposing a limit on the proliferative lifespan of most somatic cells, telomere erosion represents an innate mechanism...

Advances led to prospects for targeted therapy in hematological malignancies.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Advances led to prospects for targeted therapy in hematological malignancies. According to a study from the United States, "The high remission rates observed in patients with chronic myelogenous...

A rare leukemia type has certain genetic mutation and symptom characteristics.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- A rare type, minimally differentiated acute myeloblastic leukemia, has certain genetic mutation and symptom characteristics. According to recent research from France, "Mutations of the AML1 gene...

An aqueous extract of Phyllanthus urinaria has cancer specific cytotoxicity.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- An aqueous extract of Phyllanthus urinaria has cancer specific cytotoxicity. According to recent research from Taiwan, "Phyllanthus urinaria (P. urinaria), a widely used herb medicine, was tested...

Two colliding cancers - adenosquamous and neuroendocrine origin - found.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Two colliding cancers are found, of adenosquamous and neuroendocrine origin. A study from Japan reports on "an extremely rare case of primary lung cancer showing various histological elements...

INI1 expression after adenovirus delivery induces cell cycle arrest.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- INI1 expression after adenovirus delivery induces cell cycle arrest. "The INI1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is...

Comparative genomic hybridization can help classify ambiguous lesions.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Comparative genomic hybridization can help classify ambiguous lesions. "The differential diagnosis between benign Spitz nevus and malignant melanoma may present considerable difficulties in some...

The heparanase promoter can be transactivated by ETS transcription factors.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- The heparanase promoter can be transactivated by ETS transcription factors. According to recent research from Taiwan, "The remodeling of extracellular matrix (ECM) is an important process required...

E2F proteins regulate MYCN expression in neuroblastomas.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- E2F proteins regulate MYCN expression in neuroblastomas. According to a study from Germany, "Amplification of the MYCN gene, resulting in overexpression of MYCN, distinguishes a subset of...

C-myc has many molecular interactions with cell cycle and growth arrest genes.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- C-myc has many molecular interactions with cell cycle and growth arrest genes. "Constitutive expression of the proto-oncogene c-myc results in oncogenic activation and contributes to progression of...

Apoptosis and senescence counteract oncogenic transformation.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Apoptosis and senescence counteract oncogenic transformation. According to a study from Germany, "Apoptosis and premature senescence, an acutely inducible terminal cell-cycle arrest, are known to...

Modified coxsackie-adenovirus receptor increases adenoviral transgene expression.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Modified coxsackie-adenovirus receptor increases adenoviral transgene expression. According to a study from Finland, "an important determinant of gene transfer efficacy with adenoviral vectors is...

Molecular markers, Ki-67 and p27, may distinguish carcinoma from adenoma.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Molecular markers, Ki-67 and p27, may distinguish carcinoma from adenoma. According to a study from the United States, "We studied 45 patients with typical and eight with atypical parathyroid...

Promising approaches are being tested in pediatric cancer.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Promising approaches are being tested in pediatric cancer. "There is reason to believe that the unfolding revolution in molecular biology and translational research will allow selective targeting...

C-myc oncoprotein is a prognostic marker for intermediate-thickness melanoma.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- C-myc oncoprotein is a prognostic marker for intermediate-thickness melanoma. According to recent research from England, "For 25 years, the Breslow depth of primary tumors has remained the most...

Magnolol has antiproliferative and antiapoptotic effects in a cell line.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Magnolol has antiproliferative and antiapoptotic effects in a cell line. According to a study from Taiwan, "Magnolol, an active component isolated from the root and stein bark of Magnolia...

Downregulation of Smad3 leads to resistance to TGF-beta-induced growth arrest.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Downregulation of Smad3 leads to resistance to TGF-beta-induced growth arrest. "In normal epithelial cells, transforming growth factor-beta (TGF-beta) typically causes growth arrest in the G(1)...

Tumor histological subtypes have different Ret chimeric transcripts.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Tumor histological subtypes have different Ret chimeric transcripts. According to recent research from Ireland, "Ret rearrangements are common in papillary thyroid carcinoma (PTC), with ret/PTC-3...

Insulin-like growth factor-II is a target for cancer gene therapy.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Insulin-like growth factor-II is a target for cancer gene therapy. According to a study from the United States, "towards understanding the insulin-like growth factor (IGF) system during cancer...

Gene replacement therapies might help children with xeroderma pigmentosum.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Gene replacement therapies might help children with xeroderma pigmentosum. According to a study from Germany, "xeroderma pigmentosum is a rare disorder transmitted in an autosomal recessive manner....

Study finds secondary chromosomal abnormalities in acute lymphoblastic leukemia.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Study finds secondary chromosomal abnormalities in acute lymphoblastic leukemia. "Secondary chromosomal abnormalities (both numerical and structural) were studied in 55 Acute lymphoblastic leukemia...

Ara-C treated leukemia cells produce high molecular weight DNA fragments.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Ara-C treated leukemia cells produce uniform, high molecular weight DNA fragments. According to recent research from Japan, "The necessity of internucleosomal DNA fragmentation for the complete...

A combination treatment strategy could be key to combating liver cancer.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Treatment strategies that combine oncolytic viral therapy and local immune stimulation may make a difference for staunching the recurrence of primary liver...

Lymphoid enhancer factor 1 makes cells resistant to transforming growth factor.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Lymphoid enhancer factor 1 makes cells resistant to transforming growth factor. "The activation of lymphoid enhancer factor (LEF)/T-cell factor (TCF)-mediated transcription by sustained expression...

Researchers detect the PSA-RP2 variant in prostate tissue.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Researchers detect the PSA-RP2 variant in prostate tissue. "PSA (prostate-specific antigen), the most useful serum marker for prostate cancer, is encoded by the hKLK3 gene and is present in the...

Interferon-beta gene therapy has an antitumor effect against kidney cancer.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Medical researchers in Japan have announced that interferon-beta gene therapy is able to suppress renal cell carcinomas by encouraging apoptosis, or programmed...

Smac protein could be a payload for gene therapies.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Smac protein could be a payload for gene therapies According to a study from Canada, "Smac/DIABLO is a mitochondrial protein that is proteolytically processed and released during apoptosis along...

A kinase-inactive type II TGF beta receptor impairs BMP signaling.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- A kinase-inactive type II TGF beta receptor impairs BMP signaling in breast cancer. According to a study from the United States, "Dominant negative receptor mutants are often utilized in order to...

Researchers describe novel cell culture models for preventing breast cancer.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Researchers describe novel cell culture models for preventing breast cancer. According to recent research from the United States, "Human breast cancer is a multifactorial, multistep disease wherein...

Researchers propose analyzing cancers based on genetic chaos and antichaos.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Researchers propose analyzing cancer based on genetic chaos and antichaos. According to recent research from the United States, "Cancer is considered the genetic disease with the most complex...

The protein, PRH, is a tissue-specific inhibitor of elF4E in myeloid cells.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- The protein, PRH, is a tissue-specific inhibitor of elF4E in myeloid cells. According to recent research from the United States, "The translation initiation factor eIF4E is involved in the...

A coculture model is useful for studying tumor-host interactions in vitro.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- A coculture model is useful for studying tumor-host interactions in vitro. According to a study from Germany, "The production of abundant connective tissue within malignant tumors, the so-called...

Viral vectors encoding for E2F-1 sensitize cancer cells to camptothecin.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Adenoviral vectors encoding for the transcription factor E2F-1 can sensitize colorectal cancer to camptothecin chemotherapy. Camptothecin is a...

A cystatin-like molecule, CLM, is found in human bone marrow and other cells.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- A cystatin-like molecule, CLM, is found in human bone marrow and other cells. According to recent research from the People's Republic of China, "The cystatins are physiological cysteine proteinase...

ETS2 overexpression is linked to p53 dependent apoptosis.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Chromosome 21 abnormality involved in Down syndrome, creates overexpression of ETS2 which induces p53 dependent apoptosis; this may be involved in the formation of syndrome symptoms and pathology. ...

Black tea extract preferentially induces apoptosis over growth arrest.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Black tea extract promotes a p53 and Bax related apoptotic pathway to occur instead of growth arrest in a mouse model using Ehrlich ascites carcinoma. "Next to water, tea is the most ancient and...

Locked nucleic acid antisense oligonucleotides can target specific tumor genes.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Locked nucleic acid antisense oligonucleotides can target specific tumor genes. According to recent research from Netherlands, "locked nucleic acids (LNA) are novel high-affinity DNA analogs that...

Nontoxic TAT peptide-liposome-DNA complexes are viable tools for gene delivery.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Nontoxic TAT peptide-liposome-DNA complexes are viable tools for gene delivery. "Liposomes modified with TAT peptide (TATp-liposomes) showed fast and efficient translocation into the cell cytoplasm...

Some doubt cast on the role of platelet-activating factor in leukemia.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Some doubt is cast on the role of platelet-activating factor in leukemia. "Platelet-activating factor (PAF), a phospholipid mediator with a wide range of actions on mature leukocytes, acts directly...

A DNA methylation database (MethDB) now available on the web.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- A DNA methylation database (MethDB) is now available on the web. According to recent research from France, "Cytosine methylation is a characteristic property of prokaryotic and eukaryotic genomes....

E-cadherin promoter is subjected to epigenetic control.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- In laryngeal carcinoma, E-cadherin promoter is subjected to epigenetic control. According to recent research from Germany, "Intercellular adhesion is promoted by many-fold structures formed by...

Leukemic cells might undergo secondary transformation.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Leukemic cells might undergo secondary transformation in T-prolymphocytic leukemia. "An unusual course was observed in a patient with indolent T-prolymphocytic leukemia (T-PLL) who subsequently...

Mutation of the RB2/p130 gene may be involved in adult T-cell leukemia/lymphoma.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Mutation of the RB2/p130 gene may be involved in adult T-cell leukemia/lymphoma. According to recent research from Japan, "The retinoblastoma (Rb) family consists of the tumor suppressor Rb/p105...

R-PTP-kappa deletions at 6q22-23 are common; may identify a new tumor suppressor.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- A deletion in a possible tumor suppressor at 6q22-23 (human R-PTP-kappa gene) is identified as common in primary central nervous system lymphomas. According to a study from Japan, "Deletions on the...

Coexposure to heavy metals cadmium, cobalt, and lead create dangerous DNA damage.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Occupational exposure to multiple heavy metals rearranges the level of genotoxicity that can occur in mononuclear cells. According to recent research from Germany, "Coexposure to cadmium, cobalt,...

Mdm2 and HPV protein E6 have independent mechanisms for disabling the protein.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Mdm2 and papillomavirus protein E6 have different methods and locations for the ubiquitination of p53, which leads to cancer. "The human papillomavirus (HPV) protein E6 can promote the...

PPAR gamma activation could be therapeutic as it leads to PI3K deactivation.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- PPAR gamma activation could be therapeutic as it increases the PTEN tumor suppressor levels and inhibiting PI3K activity. "The PI3K pathway contributes to the invasive properties and apoptosis...

Anti-cancer DNA vaccination is less effective in older mice than younger.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Study results showed that DNA vaccination to induce immunity against cancerous tumors was less effective in older mice than younger animals. The researchers conducting the work suggest this would...

Selective inhibition of the Ets2 gene shows the potential for stopping cancer.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Selective inhibition of the Ets2 gene shows the potential for stopping cancer. "The transcription factor Ets2 has a role in cancer development and represents an attractive therapeutic target. In...

BRCA1 E3 ubiquitin ligase activity is enhanced by the BARD1 protein.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- BRCA1 and BARD1 proteins can heterodimerize and addition of BARD1 can enhance the ubiquitination function of BRCA1. According to recent research from the United States, "The breast and ovarian...

The effects of activation/suppression must be utilized in therapeutic design.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Telomerase activity may be enhanced after radiation treatment (thereby prolonging cell or tumor life), and thus must be studied in order to design new therapeutic approaches. "Telomerase is a...

A MALT lymphoma developed in the absence of any apparent immune dysfunction.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- A MALT lymphoma at the tongue base developed in the absence of any apparent immune dysfunction. "We report a very rare case of a mucosa associated lymphoid tissue (MALT) lymphoma of the base of...

Chromatin stereochemistry alters transcriptional ability of estrogen receptors.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Intranuclear estrogen receptors behave differently when faced with chromatin showing that chromatin conformation directly affects the abilities of transcriptional activator proteins. "The...

Inhibiting the p53-MDM2 interaction is an important target for cancer therapy.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Inhibiting the p53-MDM2 interaction is an important target for cancer therapy. According to a study from Switzerland, "p53 is an attractive therapeutic target in oncology because its...

Researchers discuss novel insights into cadherin processing.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Researchers discuss novel insights into cadherin processing. "Proprotein convertases (PCs) are known to activate many important molecules and their overexpression plays a significant role in tumor...

Cisplatin and oxaliplatin promote an efficient p53-independent tumor response.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Cisplatin and oxaliplatin promote an efficient p53-independent tumor response in a murine model. "A transgenic mouse tumor model was used to investigate the role of p53 in tumor response to two...

Drinking hot water increases tumors in rats.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Drinking hot water increases tumors in rats. "This study is to determine the effects of hot water on N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis model," researchers in...

B cell tumors can be targeted by CD80/IL-15 stimulated T lymphocytes.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Human B cell tumors can be eradicated with targeted T lymphocytes co-stimulated with CD80 and IL-15. "The genetic transfer of antigen receptors provides a means to rapidly generate autologous...

Gene therapy boosts immume system against cancer.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Transfusions of genetically engineered blood cells could give bowel cancer patients a powerful boost against their disease, scientists from Cancer Research UK report. In a laboratory-based pilot...

Transgenic expression of decorin results in cancer cell apoptosis.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Adenovirus-mediated transfer and expression of human decorin cDNA induced in vivo apoptosis of xenograft tumor cells in nude mice, a new study reports. "Decorin is a well-known, ubiquitous...

Germline BACH1 mutations do not appear linked to breast and ovarian cancer.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Mutation in BACH1, a helicase, suggested to be a marker for breast and ovarian cancer, was not found to be prevalent in Finnish patients. According to a study from Finland, "Recently, BACH1, a...

HSA genetic coupling increases activity of circulating angiogenic inhibitors.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- An adenovirus (AdK3-HSA) that carries a chimeric gene encoding a fusion protein between angiostatin K1-3 and human serum albumin (HSA) increases the antitumoral activity of circulating angiogenic...

Microsatellite instability and hMLH1 promoter hypermethylation are associated.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Richter syndrome, the transformation of lymphocytic leukemia to large B cell lymphoma, is associated with microsatellite instability and hypermethylation of hMLH1 gene. According to a study from...

Profiling B cell transcriptional germinal center aids malignancy studies.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- The normal sequence of gene transcription from naive to memory B cells is complex and disrupted in B cell malignancy. According to a study from the United States, "The germinal center (GC)...