Anti-Infectives Week articles from September 2008

Anti-Infectives Week archives from September 2008

New findings in cancer described from University of Naples.
September 1, 2008... According to a study from Naples, Italy, "We investigated the antitumour effect and ability to overcome the resistance to anti-EGFR drugs of enzastaurin, an inhibitor of VEGFR-dependent PKC beta signalling. Enzastaurin was evaluated alone and...

Reports on drug resistance findings from University of California, Medical Department provide new insights.(Report)
September 1, 2008... "Growing evidence suggests that survivin, a member of the inhibitor of apoptosis gene family, is responsible for drug resistance in cancer cells, yet little is known about its role in the endothelial cells of the tumor vasculature. We have...

Reports summarize drug resistance study results from Harvard University.
September 1, 2008... In this recently published article, scientists in the United States conducted a study "To quantify the prevalence, risk factors, and mode of transmission associated with colonization by multidrug-resistant gram-negative bacteria (MDRGN) in the...

Research by D.W. Wareham and colleagues in drug resistance provides new insights.
September 1, 2008... According to recent research from London, the United Kingdom, "Acinetobacter spp. are increasingly reported as important causes of human infection. Many isolates exhibit multi-drug resistance, raising concerns over our ability to treat serious...

Research from A. Vainio and co-authors in the area of drug resistance published.(Report)
September 1, 2008... "In Finland, the incidence of methicillin-resistant Staphylococcus aureus (MRSA) strains has increased ten fold within the last decade. In order to follow the changing epidemiology of MRSA, accurate typing of S. aureus strains is important,"...

Researchers from University of Edinburgh report details of new studies and findings in the area of colon cancer.
September 8, 2008... "ATP-binding cassette transporter P-glycoprotein (ABCB1) is responsible for the multidrug resistance (MDR1) phenotype observed in cancer cells. SJG-136, a new pyrrolobenzodiazepine dimer, is a sequence-dependent DNA crosslinking agent and...

New data from University of California illuminate research in drug resistance.
September 8, 2008... According to recent research from the United States, "Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has emerged as a common cause of skin and soft-tissue infections (SSTIs) in the United States. It is unknown whether...

New drug resistance data have been reported by researchers at Charles University.
September 8, 2008... According to recent research from Czech Republic, "The present study was aimed to evaluate the hepatic zonation of multidrug resistance-associated protein 2 (mrp2), an important drug transporter, and its potential changes during the induction...

Researchers from University of Notre Dame describe findings in drug resistance.
September 8, 2008... According to a study from the United States, "Methicillin-resistant Staphylococcus aureus (MRSA) is a global bacterial scourge that has become resistant to many classes of antibiotics, and treatment options for MRSA infections are limited. The...

Study data from Nara Medical University provide new insights into drug resistance.(Report)
September 8, 2008... According to a study from Nara, Japan, "Endocytic retrieval of multidrug resistance protein 2 (MRP2) is closely associated with cholestasis and may be attributed to the disturbed linking of MRP2 and radixin, a cross-linker between actin...

National Taiwan University publishes research in injury infection and critical care.(Clinical report)
September 8, 2008... According to recent research published in the Journal of Trauma - Injury Infection and Critical Care, "Humeral shaft fractures can be effectively treated by either antegrade or retrograde locked intramedullary nailing, but these two methods...

New injury infection and critical care data have been reported by scientists at University of Michigan.
September 8, 2008... According to a study from the United States, "Trauma centers are an ideal site to conduct screening and intervention programs that target risk taking behaviors. We hypothesized that a parent/child-centered intervention is a feasible method of...

New injury infection and critical care findings from Liverpool Hospital, Emergency Department described.
September 8, 2008... "Cooling of recently amputated digits is recommended to preserve tissue pending reimplantation. Although many methods are describe for cooling digits, it is unknown which method is optimal," scientists writing in the Journal of Trauma - Injury...

New injury infection and critical care research reported from University of Michigan.
September 8, 2008... "Tight glycemic control in a mixed surgical intensive care unit patient population has been associated with improved survival. We postulated targeted therapy to achieve glucose levels "Adult trauma patients admitted to our American College...

New injury infection and critical care study findings recently were published by N.K. Garg and co-researchers.
September 8, 2008... According to recent research from Liverpool, the United Kingdom, "The majority of the pediatric diaphyseal forearm fractures are treated with closed reduction and the application of an above elbow cast for a varying period, depending on the age...

Reports outline injury infection and critical care study findings from University of Bern.(Report)
September 8, 2008... "intermittent (IT) and continuous (CT) thermodilution and esophageal Doppler (ED), are all used for hemodynamic monitoring. The aim of this study was to test the agreement between these methods during endotoxin (ET) and dobutamine infusion,"...

Research from University of Pennsylvania yields new data on injury infection and critical care.
September 8, 2008... "Most case series involving routine serial computed tomography (CT) scans of the head in patients with mild traumatic brain injury (TBI) have suggested that they only occasionally provide useful information and imply that the practice is...

Scientists at Simon Fraser University target injury infection and critical care.
September 8, 2008... "Timely access to definitive trauma care has been shown to improve survival rates after severe injury. Unfortunately, despite development of sophisticated trauma systems, prompt, definitive trauma care remains unavailable to over 50 million...

Studies from F.J. Kim et al in the area of injury infection and critical care described.
September 8, 2008... According to a study from the United States, "Since Parra reported the first case of laparoscopic repair of bladder rupture caused by nonlaparoscopic injury to the bladder in 1994, several case reports have demonstrated the feasibility of this...

Studies from H. Kuendig et al in the area of injury infection and critical care described.
September 8, 2008... According to a study from Lausanne, Switzerland, "Acute alcohol consumption has been reported to be an important risk factor for injury, but clear scientific evidence on issues such as injury type is not available. The present study aims to...

Studies from Rush University yield new data on injury infection and critical care.(Report)
September 8, 2008... "The null hypothesis to be tested in this study is that the compression forces generated with a novel compressible intramedullary nail are not different from compression plating techniques. A custom sensor was used to measure the compressive...

Studies from University of Barcelona in the area of injury infection and critical care described.
September 8, 2008... "High vascular flow aggravates lung damage in animal models of ventilator-induced lung injury. Positive end-expiratory pressure (PEEP) can attenuate ventilator-induced lung injury, but its continued effectiveness in the setting of antecedent...

Studies from University of Texas have provided new information about injury infection and critical care.
September 8, 2008... "Shrimp winch injuries range from phalangeal injuries to life-threatening limb amputations. The injuries often result in significant morbidity, significant cost, and lengthy hospitalizations," scientists in the United States report (see also...

Study results from University of Heidelberg in the area of injury infection and critical care published.
September 8, 2008... "Interhospital transportation of critically ill and mechanically ventilated patients represents a common, yet difficult problem. Three different methods to determine PCO2 during transport are available: arterial blood gas analysis (PaCO2),...

Research from University of Heidelberg provides new data on breast cancer.
September 15, 2008... "Intestinal ATP binding cassette (ABC) transporters may affect the bioavailability and effectiveness of orally administered drugs. Available studies on regional expression of intestinal efflux transporters were done with selected intestinal...

Researchers from Hamamatsu University, Medical Department detail findings in breast cancer.
September 15, 2008... According to recent research from Hamamatsu, Japan, "The possibility of interactions between natural products/supplements and conventional prescription medicines is one of the most important issues in pharmacotherapeutic safety. Recently, we...

New drug resistance findings from C. Skazik and co-authors described.
September 15, 2008... According to a study from Aachen, Germany, "Human macrophages (M Phi) express cytochrome P450 enzymes verifying their capacity to metabolize a variety of endogenous and exogenous substances. Here we analysed the mRNA and protein expression of...

New drug resistance findings from University of Groningen described.(Report)
September 15, 2008... "Hepatic stellate cells (HSCs) survive and proliferate in the chronically injured liver. ATP-binding cassette (ABC) transporters play a crucial role in cell viability by transporting toxic metabolites or xenobiotics out of the cell," scientists...

Reports summarize drug resistance research from University of Thessaly, Medical Department.(Report)
September 15, 2008... According to a study from Larisa, Greece, "Coagulase-negative staphylococci (CoNS) are frequently encountered pathogens in hospital environment. Dialysis patients, often carrying central venous catheters, are prone to CoNS infections." ...

Researchers at Columbia University publish new data on antibiotics.
September 22, 2008... In this recent study, researchers in the United States conducted a study "To evaluate the antimicrobial efficacy of and risk of organisms developing resistance to 2 novel hand soaps: (1) a soap containing triclosan, polyhexamethylene biguanide,...

Data on drug resistance discussed by J.P. Bankstahl and colleagues.
September 22, 2008... According to a study from Seibersdorf, Austria, "The multidrug efflux transporter P-glycoprotein (P-gp) is expressed in high concentrations at the blood-brain barrier (131313) and is believed to be implicated in resistance to central nervous...

Findings from Y.M. Abouzeed and co-authors provide new insights into drug resistance.
September 22, 2008... "In the sequenced genome of Salmonella enterica serovar Typhimurium strain LT2, an open reading frame (STM0580) coding for a putative regulatory protein of the TetR family is found upstream of the ramA gene. Overexpression of ramA results in...

New drug resistance findings from A.F. Shorr and co-authors described.
September 22, 2008... "Methicillin-resistant Staphylococcus aureus causes significant morbidity and mortality. Initially inappropriate antibiotic therapy for methicillin-resistant S. aureus increases the risk for mortality," investigators in the United States report...

New drug resistance study findings reported from University of Bern.
September 22, 2008... According to a study from Bern, Switzerland, "We evaluated a double screening strategy for carriage of methicillin-resistant Staphylococcus aureus (MRSA) in patients exposed to a newly detected MRSA carrier." "If the first screening of the...

New hospital epidemiology data have been reported by scientists at Rhode Island Hospital.
September 22, 2008... According to a study from the United States, "We studied uninsured patients admitted to Rhode Island Hospital from January 1 through June 30, 2005, and from January 1 through June 30, 2006." "The mean total hospital charge for an uninsured...

Research from Simmons College in the area of infection control published.
September 22, 2008... According to recent research from the United States, "The major sources of Staphylococcus aureus. including methicillin-resistant S aureus (MRSA), in the home are colonized or infected individuals and pets, such as cats and dogs; however, the...

Researchers from Hacettepe University, Medical Department describe findings in infection control.
September 22, 2008... According to a study from Ankara, Turkey, "Three clusters of Chryseobacterium meningosepticum infections in a tertiary health center in July 2006 and January 2007 involving 8 newborns and 5 older children were investigated. The index patient...

Researchers from University of California, Medical Department publish new studies and findings in the area of infection control.
September 22, 2008... "Physicians. nurses, and others are at risk of needlesticks, yet little national information is available regarding incidence across demographic and occupational categories. Analysis was conducted on national data on occupational injuries for...

Studies conducted at Mahidol University, Medical Department on infection control recently published.
September 22, 2008... "Performance monitoring and feedback of infection control process measures is an important tool for improving guideline adherence. Different feedback strategies may lead to distinctive outcomes," investigators in Bangkok, Thailand report (see...

Scientists at University of Piemonte Orientale report research in antibiotics.
September 29, 2008... According to recent research from Novara, Italy, "Marijuana (Cannabis sativa) has long been known to contain antibacterial cannabinoids, whose potential to address antibiotic resistance has not yet been investigated. All five major cannabinoids...

Data on breast cancer reported by researchers at King Abdul-Aziz University.(Report)
September 29, 2008... According to recent research from Jeddah, Saudi Arabia, "Purpose 2-Methoxyestradiol (2ME), an endogenous estradiol metabolite, was developed as a novel agent based on its antitumor activity and lack of toxicity. This study was designed to...

Recent studies by C.J. Lord and co-authors add new data to breast cancer findings.
September 29, 2008... According to recent research published in the journal Cell Cycle, "Drugs that target the reliance of tumor cells upon estrogen signalling have revolutionised the treatment of breast cancer." "Despite this, resistance to these endocrine...

Research on breast cancer reported by scientists at East Carolina University, Medical Department.
September 29, 2008... "Ectopic expression of mutant forms of phosphatase and tensin homologue deleted on chromosome 10 ( PTEN) lacking lipid ( G129E) or lipid and protein ( C124S) phosphatase activity decreased sensitivity of MCF-7 breast cancer cells, which have...

Studies from University of Bordeaux provide new data on chronic myeloid leukemia.
September 29, 2008... According to recent research from Bordeaux, France, "Understanding the molecular basis of resistance to imatinib, a tyrosine kinase inhibitor used as front-line therapy in chronic myeloid leukemia, remains a challenge for successful treatment....

Data on injury infection and critical care detailed by L.M. Napolitano and co-authors.
September 29, 2008... " A randomized, double-blind, placebo-controlled, multicenter trial (EPO-2, N = 1,302) in anemic critically ill patients demonstrated a 29-day survival benefit in the trauma subgroup receiving epoetin alfa (mortality 8.9% vs. 4.1%). A second...

Findings from T.T. Huynh and co-authors provide new insights into injury infection and critical care.
September 29, 2008... "Increasing patient volume and residents' work hour restrictions have increased the workload at trauma centers. Further, comprehensive tertiary surveys after initial stabilization and appropriate follow-up plans for incidental findings are time...

New injury infection and critical care data have been reported by scientists at University of Delaware.(Clinical report)
September 29, 2008... According to recent research from the United States, "Few studies have examined alcohol use in the older trauma population. The purpose of the present study was to examine blood alcohol level testing and results among older trauma patients."...

New injury infection and critical care findings from National Defense Medical College, Medical College described.
September 29, 2008... "Although parenteral nutrition (PN) prevents progressive malnutrition, lack of enteral nutrition (EN) during PN leads to gut associated lymphoid tissue (GALT) atrophy and dysfunction. Administering a small amount of EN with PN reportedly...

Research from M.A. Demoya and co-authors yields new data on injury infection and critical care.(Report)
September 29, 2008... According to recent research from the United States, "The purpose of this study is to prospectively examine the use of Human Acellular Dermal Matrix (HADM) in trauma patients with large open abdominal wounds and assess the long-term outcome....

Researchers at University of Mississippi Medical Center target injury infection and critical care.
September 29, 2008... "The predictors of amputation for patients with lower extremity vascular trauma are well described in the literature, but the predictors of amputation in the upper extremity are not so well defined. We hypothesize that the predictors of...

Researchers from University of Pennsylvania report on findings in injury infection and critical care.(Report)
September 29, 2008... "Many series have found that certain associated injuries occur with greater frequency in patients with scapula fractures than in patients without scapula fractures. However, several of the published series were limited by lack of a control...

Scientists at James Whitcomb Riley Hospital for Children report research in injury infection and critical care.(Report)
September 29, 2008... According to recent research published in the Journal of Trauma - Injury Infection and Critical Care, "It was the purpose of this study to review equestrian-related injuries using a large nation wide database and analyze predictors of...

Studies from Duke University reveal new findings on injury infection and critical care.
September 29, 2008... "Severe pulmonary contusions are a common cause of acute respiratory distress syndrome (ARDS) and are associated with significant morbidity. High frequency oscillatory ventilation (HFOV) is a ventilatory mode that employs a lung protective...