Anti-Infectives Week articles from October 2008

Anti-Infectives Week archives from October 2008

Researchers at Ohio State University publish new data on DNA research.(Report)
October 6, 2008... According to a study from the United States, "As a widely used anticancer drug, cis-diamminedichloroplatinum(II) (cisplatin) reacts with adjacent purine bases in DNA to form predominantly cis-[Pt(NH3)(2){d(GpG)-N7(1),-N7(2)}] intrastrand...

Findings from Wayne State University in drug resistance reported.
October 6, 2008... According to recent research published in the Journal of Clinical Microbiology, "To gain a better understanding of epidemiology of resistance in Staphylococcus aureus, we describe the molecular epidemiology of methicillin-resistant...

New drug resistance study findings reported from University of Strasbourg.
October 6, 2008... According to a study from Strasbourg, France, "The development of new aminoglycoside analogues to reduce the emergence of bacterial resistance has become a topic of high interest. We describe here a rapid and facile access to orthogonally...

Research on drug resistance published by scientists at Taipei Medical University.(Report)
October 6, 2008... According to a study from Taipei, Taiwan, "Novel therapies are needed to address the public health problem posed by methicillin-resistant Staphylococcus aureus (MRSA). In this study, we determined the effects of combinations of antibiotics and...

Researchers from University of Bern provide details of new studies and findings in the area of drug resistance.
October 6, 2008... According to recent research published in the Journal of Clinical Microbiology, "PCR tests for the rapid and valid detection of methicillin-resistant Staphylococcus aureus (MRSA) are now available. We evaluated the costs associated with contact...

What can we do for prevention and therapy of anaerobe-associated infections?
October 13, 2008... Anaerobic microorganisms are important constituents of both human and animal intestinal microbiota. Infections caused by anaerobic bacteria are increasingly being recognized as major problem in clinical medicine. The commensal anaerobic...

New anesthesia study findings have been reported by R.W. Loftus and colleagues.
October 13, 2008... "The current prevalence of hospital-acquired infections and evolving amplification of bacterial resistance are major public health concerns. A heightened awareness of intraoperative tramsmission of potentially pathogenic bacterial organisms may...

Reports from University of Lethbridge add new data to research in breast cancer.
October 13, 2008... "Many chemotherapy regiments are successfully used to treat breast cancer; however, often breast cancer cells develop drug resistance that usually leads to a relapse and worsening of prognosis. We have shown recently that epigenetic changes...

Researchers from University of Paris report recent findings in cancer.
October 13, 2008... "Gemcitabine (2',2'-difluorodeoxyribofuranosylcytosine; dFdC) is an anticancer nucleoside analog active against wide variety of solid tumors. However, this compound is rapidly inactivated by enzymatic deamination and can also induce drug...

New colon cancer study results reported from University of Turin.
October 13, 2008... According to recent research from Turin, Italy, "Doxorubicin efficacy in cancer therapy is hampered by the dose-dependent side effects, which may be overcome by reducing the drug's dose and increasing its efficacy. In the present work, we...

New chronic myeloid leukemia study findings reported from University of Bordeaux.
October 20, 2008... According to a study from Bordeaux, France, "Despite the excellent efficacy of imatinib in chronic myeloid leukemia (CML), the response in patients is heterogeneous, which may in part be caused by pharmacogenetic variability. Imatinib has been...

New drug resistance research has been reported by scientists at Suleyman Demirel University.
October 20, 2008... Researchers in Isparta, Turkey conducted a study "To determine grlA and gyrA mutations in ciprofloxacin- methicillin-resistant Staphylococcus aureus isolated and their susceptability to current antimicrobials including a newer fluoroquinolone...

Research from China University reveals new findings on drug resistance.(Report)
October 20, 2008... According to recent research published in the journal Molecular Pharmaceutics, "Multidrug resistance (MDR), a major obstacle to successful cancer chemotherapy, may be induced by amplification of the MDR1 gene and overexpression of the...

Research from R. Kaminsky and colleagues provide new insights into drug resistance.
October 20, 2008... "Anthelmintic resistance has become a global phenomenon in gastro-intestinal nematodes of farm animals, including multi-drug resistance against the three major classes of anthelmintics. There is an urgent need for an anthelmintic with a new...

Research on drug resistance reported by scientists at National Hospital Organization.(Report)
October 20, 2008... According to a study from Nagasaki, Japan, "Primary biliary cirrhosis (PBC) is a multifactorial disease in which genetic factors rather than environmental factors may predominantly contribute to the pathogenesis. In order to identify the...

Research conducted at University of Paris has provided new information about antiretrovirals.
October 27, 2008... "TRIM5 alpha is a restriction factor that interferes with retroviral infections in a species-specific manner in primate cells. Although TRIM5 alpha is constitutively expressed, its expression has been shown to be up-regulated by type I...

Studies from University of Texas yield new data on breast cancer.
October 27, 2008... "Drug resistance is a major concern in cancer therapy. Here, we investigate the clinical potential of the second mitochondria-derived activator of caspase (Smac/DIABLO) in enhancing the apoptosis- inducing potential of commonly used anticancer...

New cancer study results reported from University of Insubria.
October 27, 2008... According to a study from Busto Arsizio, Italy, "Essential oils from various aromatic plants have been reported to exert chemopreventive and/or antitumor effects. In addition, a number of studies have shown the ability of chemopreventive...

Reports from Novartis highlight recent research in cancer.
October 27, 2008... According to recent research published in the journal Cancer Chemotherapy and Pharmacology, " Patupilone is a microtubule stabilizer (MTS) currently in clinical development. Here, we evaluate the anti-cancer activity in vitro and in vivo in...

Research reports from K. Finstad and co-authors provide new insights into cystic fibrosis.
October 27, 2008... "To report a case of neuralgic amyotrophy associated with antibiotic therapy. SUMMARY: A 22-year-old male with cystic fibrosis had been nonadherent to treatment for 4 years; when he returned to the clinic with symptoms, his forced expiratory...

Findings from University of Sydney advance knowledge in burn care research.
October 27, 2008... According to a study from Westmead, Australia, "The Australian and New Zealand Burn Association recommend 20 minutes of cold running tap water as burn first aid. Scientific evidence for the optimal duration of treatment is limited." "Our...

New burn care research from National Taiwan University described.
October 27, 2008... "Although pressure therapy is the mainstay of treatment for hypertrophic scars, its actual mechanism remains unknown. An in vitro study was designed to investigate the effects of positive pressure on the growth of human scar-derived fibroblasts...

New burn care research research has been reported by A.A. Mohammadi et al.(Report)
October 27, 2008... According to recent research from Iran, "Self-inflicted burns are among the most devastating of all burn injuries with serious physical, psychological, and financial effects on the individual, the patient's family, and society. This study was...

New burn care research study findings recently were published by C.Y. Xue and co-researchers.(Report)
October 27, 2008... According to recent research from Shanghai, People's Republic of China, "Trauma patients with high-energy injuries often present with severe tissue damage that extends beyond the immediate zone of injury and require recruitment of vascularized...

Reports summarize burn care research study results from Shriners Hospital for Children.(Report)
October 27, 2008... According to recent research published in the Journal of Burn Care & Research, "The purpose of this study was to examine the incidence, causes, and demographics of burn injuries in Amish children, treated at a pediatric burn center located in...

Research from J.E. Wingo and co-researchers provides new data on burn care research.
October 27, 2008... According to a study from the United States, "Grafted skin has impaired blood flow and sweating responses necessary for heat dissipation. Heat acclimation improves temperature regulation in healthy individuals, but it is unknown whether heat...

Research from University of Washington provide new insights into burn care research.
October 27, 2008... "During the past decades there has been minimal improvement ill prevention and treatment of hypertrophic scarring. Reasons include the lack of a validated animal model, imprecise techniques to dissect scar into the histologic components, and...

Research from Y.F. Hwang and colleagues provide new insights into burn care research.(Report)
October 27, 2008... "Postburn web space scar, if not appropriately treated, can result in the progressive loss of the web space or the increase in angle of the dorsal slant of the web space or both, which will not only lead to cosmetic and hygiene problems, but...

Research results from J. Singerman and co-authors update knowledge of burn care research.(Report)
October 27, 2008... According to recent research from Toronto, Canada, "In North America, electrical injuries result in approximately 20,000 emergency department visits every year. They are the most common form of occupationally related burn injury, and the fifth...

Researchers at USA Scientific release new data on burn care research.
October 27, 2008... According to recent research from the United States, "Functional recovery and outcome from severe burns is oftentimes judged by the time required for a person to return to work (RTW) in civilian life. The equivalent in military terms is return...

Scientists at Loyola University Chicago describe research in burn care research.(Report)
October 27, 2008... "Elevated blood alcohol content (BAC) on admission is associated with poorer outcomes, larger burns and more inhalation injury. This study's purpose was to examine the effects of alcohol through a matched case-controlled study, measuring early...

Scientists at University of Illinois release new data on burn care research.(Clinical report)
October 27, 2008... According to a study from the United States, "Laptop computers are an uncommon source of burns to the thighs and perineum. Burns can result from the prolonged contact of hot surfaces at the base of the computer with the user's lap." "The...

Studies from Loyola University add new findings in the area of burn care research.
October 27, 2008... According to recent research from the United States, "Hydrofluoric acid has a unique mechanism for causing devastating injuries when it contacts human tissue." "Although a great deal of literature exists for cutaneous exposures,...

Study results from McMaster University update understanding of burn care research.
October 27, 2008... According to recent research from Hamilton, Canada, "Acute wound care distress among burn-injured pediatric patients is of major clinical concern. This systematic review, evaluates the benefits of nonpharmacological interventions to reduce this...