Anti-Infectives Week articles from October 2003

Anti-Infectives Week archives from October 2003

Novel MKC-442 analogues show potent antiretroviral activity.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A series of novel MKC-442 analogues have potent activity against both wild-type and MKC-442-resistant strains of HIV. According to a recent study from Denmark, "bis(alken-1-yloxy)methanes (2) were...

Anti-tuberculous efficacy of fluoroquinolones compared.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The anti-tuberculous efficacy of several fluoroquinolone antibiotics has been compared, with no clear victor emergent. "Mycobacterium tuberculosis (MTB) is capable of invading not only macrophages...

Study will test antiviral drug tenofovir to prevent HIV infection.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- University of California San Francisco (UCSF) researchers have been funded by the U.S. National Institutes of Health to study the antiretroviral drug tenofovir as a potential pre-exposure prophylaxis in...

Effects of mutant Neisseria penA on encoded penicillin-binding protein clarified.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The effects of mutations in the penA gene on the penicillin-binding protein it encodes in Neisseria have been clarified. "Reduced susceptibility to penicillin G in Neisseria meningitidis is...

First VEB-1-producing Acinetobacter baumannii strain found in French hospital.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The first known Acinetobacter strain to produce the beta-lactamase VEB-1 has been found in a French hospital. According to published research from France, "twelve clonally related and...

Antibiotics that bind to S. aureus 30S ribosomal subunit also block subunit assembly.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Antibiotics that bind to the S. aureus 30S ribosomal subunit also block the assembly of that subunit. "A number of different antibiotics that prevent translation by binding to the 50S ribosomal...

Incyte enters licensing agreement for a phase II HIV drug.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Incyte Corp. (INCY) and Pharmasset, Ltd., announced that they have entered into a collaborative licensing agreement to develop and commercialize the antiretroviral drug Reverset, also known as RVT,...

Study: Patients can benefit from simplified antiretroviral treatments.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A large study shows that simplified antiretroviral treatment regimens containing Viramune (nevirapine) or efavirenz offer comparable efficacy and safety in patients who switched from a protease...

Some Acanthamoeba strains are different enough to need reclassification.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Two Acanthoamoeba polyphaga strains are different enough to need reclassification, and they may even have different pathogenicity. "The genus Acanthamoeba includes more than 20 morphological...

FDA clears BLU-U Blue Light Photodynamic Therapy Illuminator.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- DUSA Pharmaceuticals, Inc., (DUSA) reported that on September 9, 2003, it received 510(k) marketing clearance from the U.S. Food and Drug Administration (FDA) for the BLU-U Blue Light Photodynamic...

Vaginal natamycin treatment during pregnancy does not harm the fetus.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Vaginal natamycin treatment during pregnancy does not harm the fetus. "The aim of this study was to investigate the teratogenicity of vaginal natamycin treatment during pregnancy, because the data...

Innovative Medical enters partnership to develop, market Axenohl-based products.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Innovative Medical Services (PURE) has signed an agreement with Therapeutics, Inc., a drug development company based in La Jolla, California, for the development and commercialization of U.S. Food and...

HHS, public health partners unveil campaign to promote proper antibiotic use.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The U.S. Department of Health and Human Services (HHS) and a consortium of national health organizations have urged consumers to be cautious about their use of antibiotics as the cold and flu season...

Initiative achieves significant antibiotic prescription cost savings.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The Health Action Council of Northeast Ohio and Caremark, Inc., have demonstrated that prescription drug expenses, one of the fastest growing components of healthcare costs, can be reduced while...

Actinonin might be useful in increasing neutrophil response against bacteria.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Actinonin might be useful in increasing production of unique bacterial proteins that neutrophils respond to. According to recent research from Sweden, "Bacterial protein synthesis starts with a...

Costs of antibacterial resistance outlined.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The costs of antibacterial resistance have been outlined. "Despite increasing bacterial resistance to existing drugs, investment in antibacterial discovery and development efforts appears to be...

Minocycline therapy for acne can induce cutaneous polyarteritis nodosa.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Minocycline therapy for acne can induce antineutrophil cytoplasmic antibodies and cutaneous polyarteritis nodosa. According to a study from France, "Minocycline is an antibiotic widely used in the...

Company updates stent technology developments.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Global Precision Medical, Inc., (GBPMF) has provided an update on corporate developments pertaining to its stent technologies and, specifically, the commercialization of its first application, the...

The mold Exophiala dermatitidis can infect patient via dialysis catheters.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Exophiala dermatitidis can be a cause of peritonitis due to environmental infection in peritoneal dialysis catheters; aggressive Amphotericin B can resolve it. "Exophiala (Wangiella) dermatitidis...

CaCo-2 cells have concentration-dependent responses to CPE enterotoxin.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Increasing doses of Clostridium perfringens enterotoxin induce different mitochondrial apoptosis and oncosis pathways in vitro, and thus either may occur in the intestine. "Clostridium perfringens...

Trial shows Probactrix is effective for treating diarrhea caused by antibiotics.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The BioBalance Corp., a wholly owned subsidiary of New York Health Care (BBAL), released the results of a randomized clinical study in which a formulation containing its proprietary biotherapeutic...

Mexican distributor granted exclusive rights for Microcyn 60.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Oculus Technologies of Mexico, S.A., de C.V., a subsidiary of Oculus Innovative Sciences, announced the finalization of an exclusive agreement with Quimica Pasteur, S. De RL., for distribution of...

First ESBL-producing Shigella sonnei strain found in Turkey.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The first ESBL-producing Shigella pathogen has been identified in Turkey. "A Shigella sonnei strain resistant to cefotaxime and aztreonam (but not ceftazidime) was isolated from the stool sample of...

VIM-1 metallo-beta-lactamase-producing K. pneumoniae found in Greek hospitals.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Klebsiella strains producing the VIM-1 metallo-beta-lactamase have been identified in Greek hospitals According to published research from Greece, in 2002, "seventeen Klebsiella pneumoniae clinical...

Chickpea-derived peptide has potent and durable antifungal activity.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A novel peptide derived from chickpeas shows promise as an antifungal agent. "A peptide designated cicerarin, with an N-terminal amino acid sequence VKSTGRADDDLAVKTKYLPP dissimilar from known...

Antimicrobial peptides in our bodies have evolutionarily conserved functions.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Many of the hundreds of antimicrobial peptides found in our bodies have conserved functions with those in invertebrates. "Production of antimicrobial peptides and proteins is an important means of...

DNA immunization enhances immune response to fowlpox-based SIVmac vaccine.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Prior DNA immunization enhances immune response to dominant and subdominant viral epitopes induced by a fowlpox-based SIVmac vaccine in long-term slow-progressor macaques infected with SIVmac251. ...

Baseline serum IL-7 levels do not predict immunologic HAART outcome.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Serum levels of the cytokine interleukin (IL)-7 have little prognostic value in HIV patients undergoing antiretroviral therapy. Baseline IL-7 level "has been proposed as a predictor of immunologic...

High-performance LC assay improves measurement of plasma tenofovir levels.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A novel assay may help physicians monitor circulating levels of the antiretroviral agent tenofovir in HIV patients. According to published research from France, a "high-performance liquid...

Metal chelation underlies anti-HIV integrase activity of beta-diketo acids.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Metal chelation underlies the ability of beta-diketo acids (DKAs) to inhibit HIV integrase activity. DKAs "represent a major advance for anti-HIV-1 integrase drug development," scientists in the...

Prophylactic single-dose nevirapine linked to low rate of HIV V106M mutations.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A low rate of HIV V106M mutations - usually associated with efavirenz treatment - has been observed in women treated with single-dose nevirapine as vertical transmission prophylaxis. "Nevirapine...

Some antiretroviral drugs induce PBMC P-glycoprotein expression.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Some anti-HIV agents can trigger the expression of drug efflux pumps by peripheral blood cells. "Several antiretroviral compounds have been shown to be substrates for the efflux protein...

T-cell apoptosis overwhelms proliferation during structured HIV treatment interruptions.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- T-cell apoptosis is much more extensive than T-cell proliferation during structured HIV treatment holidays. "Multiple failures of antiretroviral treatments, as a result of multidrug-resistant...

Hepatitis vaccine approved for sale in Argentina.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Corixa Corporation (CRXA) announced the Argentinean approval of Supervax, Berna Biotech's prophylactic vaccine containing Corixa's synthetic RC-529 adjuvant, for the prevention of Hepatitis B infection....

Leukocyte calprotectin has antimicrobial activity vs. Borrelia burgdorferi.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The protein calprotectin in leukocytes has antimicrobial activity against Borrelia burgdorferi. According to recent research published in the journal Infection and Immunity, "We previously showed...

Many species of Lactobacillus can cause bacteremia.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Many species of Lactobacillus can cause bacteremia in the immunocompromised. "Six cases of bacteremia in hospitalized patients, five with a depressed immune status, were caused by lactobacilli,"...

Hydroxychloroquine should not be used to treat chloroquine-resistant malaria.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Hydroxychloroquine should not be used to treat chloroquine-resistant malaria. "The 4-aminoquinoline drug hydroxychloroquine (HCQ) is reported to be as active as chloroquine (CQ) against falciparum...

Novel culture augments Artemisia annua artemisinin production.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A novel culture technique augments artemisinin production. "Artemisinin, an anti-malarial drug isolated from the annual wormwood Artemisia annua L, has a marked activity against...

Polyamine analogues active against resistant P. falciparum.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A series of novel polyamine analogues have demonstrated promising activity against drug-resistant malaria parasites. "Polyamine biosynthesis and function has been shown to be a good drug target in...

Quinacrine binds to cellular prion protein's C-terminal helix.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The anti-malarial agent quinacrine binds to the C-terminal helix of the cellular prion protein. "Using NMR [nuclear magnetic resonance] spectroscopy," M. Vogtherr and colleagues at the Swiss...

Acquisition offers company methods to fight bioterrorism.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Nutra Pharma Corp. (NPHC) has signed a letter of intent to acquire 100% of the capital stock of Infectech Inc. (IFEC) in a cash and stock transaction, providing Nutra Pharma with patented technologies...

Nanogen teams to develop infectious disease diagnostics.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Nanogen, Inc., (NGEN) and Prodesse, Inc., announced the signing of a collaboration agreement to develop automated, highly sensitive microarray-based products to detect a number of infectious disease...

High-dose steroids, CPAP, strict quarantine helped control Chinese SARS outbreak.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Treatment with high-dose steroids and CPAP ventilation - as well as strict quarantine procedures - helped control a SARS outbreak in China. SARS, "now known to be caused by a coronavirus, probably...

Levin named to scientific advisory board at infectious disease firm.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Aethlon Medical, Inc., (AEMD) announced that Nathan W. Levin, MD, has been appointed to the company's science advisory board. Levin is the medical and research director of the Renal Research...

Product approved to treat primary humoral immune deficiency disease.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Results from the largest clinical study on licensure of immune globulin intravenous (IGIV) in primary humoral immune deficiency disease (PI) demonstrate the excellent efficacy, safety, and tolerability...

Lack of funding threatens to derail WHO's Roll Back Malaria program.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A lack of funding from donor countries may derail the World Health Organization's ambitious anti-malaria program. "The WHO announced the Roll Back Malaria (RBM) movement in 1998, with the goal of...

Gastricsin processes hCAP-18 in semen to antimicrobial ALL-38, at vaginal pH.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Seminal plasma hCAP-18 is processed by a prostate protease, gastricsin, to the antimicrobial ALL-38 at vaginal pH. According to recent research published in the Journal of Biological Chemistry,...

Routine gonorrhea, Chlamydia screening at HIV clinics may slow HIV spread.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Routine gonorrhea and Chlamydia screening at HIV clinics may help slow the spread of all three infections. "Because bacterial sexually transmitted diseases (STDs) facilitate HIV transmission,...

Sexually transmitted diseases treatment guidelines explained.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Two researchers explain the sexually transmitted diseases treatment guidelines released in 2002. "Sexually transmitted diseases (STDs) are a major health problem for adolescents. Health care...

New antibiotic compound has activity against drug-resistant bacteria.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Ecopia BioSciences, Inc., (EIA) announced the discovery of its first antibacterial compound, named ECO-00501. The structure of this compound defines an entirely new class of antibacterial agents....

Phase I study of Aurexis finished.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Inhibitex, Inc., announced the completion of a phase I clinical trial of Aurexis. Inhibitex is developing Aurexis to treat serious Staphylococcus aureus infections in hospitalized patients. The...

Expanded distribution and promotion for Strep A test.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Quidel Corporation (QDEL), a provider of rapid point-of-care (POC) diagnostic tests, announced that Physician Sales and Service, Inc. (PSS), a PSS/World Medical Company (PSSI), commenced promoting and...

T. brucei has interrelated editosome proteins.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Trypanosoma brucei has interrelated editosome proteins, many with ribonuclease or RNA binding sites. "The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates...

Isoniazid effective for latent tuberculosis infection.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Isoniazid is an effective treatment for a latent tuberculosis infection. "Isoniazid is an efficacious treatment for latent tuberculosis. Concerns remain, however, regarding hepatotoxicity...

Enterocolitis diarrheal symptom may result from expression of chemokine GROalpha.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Animal models of typhoid fever may vary in diarhheal symptoms due to variation in different species of GROalpha chemokine transcript activity. "Infection of bovine ligated loops with the Salmonella...

Listeria monocytogenes has a virulence-related gene homologous to AgrA.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Listeria monocytogenes has a virulence-related gene homologous to Staphylococcus aureus AgrA. "Listeria monocytogenes is a Gram-positive facultative intracellular foodborne pathogen that can cause...

Crotalus durissus terrificus venom inhibits measles virus growth.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- The venom from the rattlesnake Crotalus durissus terrificus inhibited measles virus growth. "This paper presents the antiviral activity found in a snake with Crotalus durissus terrificus venom...

New potential target for anti-parasite drugs reported.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Scientists have described a new potential target for anti-parasite drugs in a recent issue of the journal Nucleic Acids Research. According to published research from Spain, "We identified a type...

Subfractions of human milk lactoferrin have five different enzymatic properties.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Subfractions of human milk lactoferrin have five different enzymatic properties that may be involved in antimicrobial, antiviral defense. "Lactoferrin (LF) is a Fe[superscript]3+-binding...

Jatrorrhizine shows promise as antifungal therapy.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Jatrorrhizine shows promise as an antifungal therapy. In a recent study from Slovakia, "The crude extract of Mahonia aquifolium (Berberidaceae) stem bark and its components berberine, palmatine...

Salmonella uses molecular "staples" to change structure of infected cells.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Salmonella, a well-known food-borne bacterium, uses protein "staples" to restructure the shape of the gut cells it invades, forcing these cells to flow around the bacteria and engulf them, researchers...

Anti-infective drugs highlighted at 43rd ICAAC.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Cubist Pharmaceuticals, Inc., (CBST) provided details of key data presentations at this year's Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Chicago, Illinois. More...

TB toxin blocking phagosome maturation blocks Ca2+/calmodulin-P13K hVPS34 cascade.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Tuberculosis toxin blocking phagosome maturation blocks a Ca2+/calmodulin-P13K hVPS34 cascade, a key step in the establishment of latent TB infection. "The capacity of Mycobacterium tuberculosis to...

Research: FUZEON-based regimens provide significant durable response.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Eighty percent of patients receiving a FUZEON (enfuvirtide)-based anti-HIV drug regimen who achieved undetectable levels of the virus at 24 weeks maintained this response at 48 weeks, according to new...

Study: Kaletra regimen shows viral suppression for patients new to therapy.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Study data showed the majority of patients initiating therapy with Abbott Laboratories' protease inhibitor (PI), Kaletra (lopinavir/ritonavir), as part of their treatment regimen achieved and...

Model predicts optimal antibiotic prophylaxis duration during anthrax outbreak.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- A novel model predicts the optimal duration of antibiotic prophylaxis during an anthrax outbreak. "A critical consideration in effective and measured public health responses to an outbreak of...

Anti-infective tablet for oral suspension receives FDA approval.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Ranbaxy Pharmaceuticals Inc. (RPI) announced that Ranbaxy Laboratories Limited (RLL) has received approval from the U.S. Food and Drug Administration (FDA) to market Panixine DisperDose (cephalexin...

Bioadhesive gel ensures that drug sticks to the problem.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- A new type of drug delivery formulation could improve treatment of a variety of conditions, according to research presented at the British Pharmaceutical Conference. Scientists at Queen's...

Company releases data on two novel antibiotic classes at ICAAC.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- GeneSoft Pharmaceuticals, Inc., presented new data on its portfolio of novel mode-of-action antibiotics at the 43rd annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). ...

Molecule compounds identified that kill growth of disease-causing bacteria.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- By discovering and exploiting the targets that bacteriophages, or bacterial viruses, attack to inhibit microbial growth, scientists at PhageTech Inc. have identified novel small molecule compounds that...

Colorectal cancer may be treatable with 9-cis-RA, tamoxifen plus ciprofloxacin.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Colorectal cancer cell lines respond very well, with high rates of apoptosis and inhibition of proliferation with combinations of 9-cis-retinoic acid or tamoxifen with ciprofloxacin. "The...

Terbinafine safe, effective in children.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Terbinafine is safe and effective in children "Terbinafine is an allylamine antifungal agent that has been effective and safe in the treatment of superficial and some deep mycotic infections in...

Burkholderia cepacia is an increasing problem in CF, immunodeficient patients.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Burkholderia cepacia, a naturally antimicrobial resistant pathogen, is increasingly a problem in cystic fibrosis and immunodeficient patients. "Although sporadic human infection due to Bulkholderia...

Plant compounds from Stylogne cauliflora block hepatitis C virus protease.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Plant compounds from Stylogne cauliflora block hepatitis C virus protease. According to a study from the United States, "the 70% aqueous ruethanolic extract of the Peruvian plant Stylogne...

G-CSF given before or with ceftazidime provides no added benefit against melioidosis.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- G-CSF given before or during ceftazidime gave no added benefit in an animal model of melioidosis. "Burkholderia pseudomallei, the causative agent of melioidosis, is an important pathogen in...

Canadian company gets patents protecting cancer and infectious disease programs.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- MethylGene, Inc., has received two patents from the United States Patent and Trademark office. "Acyl Phosphonate Inhibitors of beta-Lactamases" and "beta-Lactamase and DD-Peptidase Inhibitors"...

LifeValve Platinum, company's newest central venous catheter, launched.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Horizon Medical Products, Inc., (HMP) announced the launch of the LifeValve Platinum, their newest central venous catheter. These catheters are used for the infusion of antibiotics, chemotherapy,...

Study shows positive clinical results for AECB patients on Avelox.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Study results presented at the 43rd annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) showed that patients with acute exacerbations of chronic bronchitis (AECB) who took a...

New class II cytokines, receptors have antiviral and anti-inflammatory potential.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- New class II cytokines and receptors have antiviral and anti-inflammatory therapeutic potential. According to published research from Belgium, "Class II cytokine receptors were originally defined...

Molecular diagnostic test manufacturer earns ISO 9001:2000 certification.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Primagen Holding B.V., a provider of molecular diagnostic tests for infectious diseases, AIDS, and cancer, has earned full ISO (International Organization for Standardization) 9001:2000 certification....

EnvirOx launches Critical Care containing Axenohl technology.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Innovative Medical Services (PURE) announced that EnvirOx, LLC, of Danville, Illinois, has launched Critical Care, a new commercial disinfectant-fungicide-virucide, featuring Axen-30 as the active...

Anti-HIV mechanisms of SPMG clarified.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- The antiretroviral mechanisms of SPMG have been clarified. In a recent study from China, "The potential targets of marine sulfated polymannuroguluronate (SPMG) involved in inhibition of HIV-1...

CCR5 antagonists derived from fungus.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- A pair of novel CCR5 antagonists have been derived from a common fungus. According to published research from Singapore, "Two new compounds, 10-methoxydihydrofuscin (1) and fuscinarin (2), and one...

Caffeoyl naphthalenesulfonamide derivatives inhibit HIV integrase activity.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- A group of novel caffeoyl naphthalenesulfonamides inhibit HIV integrase (IN) activity. HIV-1 IN "is an essential enzyme for retroviral replication and a rational target for the design of anti-AIDS...