Anti-Infectives Week articles from November 2003

Anti-Infectives Week archives from November 2003

Phase I trial yields positive results for the prevention of serious infections.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Ipsat Therapies presented positive Phase I clinical trial data for its lead product, P1A, at the BioPartnering Europe Conference in London. This product fulfils many of the criteria for fast-track...

Novel thymidine analogues show promise as anti-TB agents.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Novel thymidine derivatives show potential as antituberculosis agents. In a recent study from Belgium, "The affinity of a series of 2', 3'- and 5-modified thymidine analogues for Mycobacterium...

Aggregated antibiograms useful for monitoring drug-resistant Streptococcus.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Aggregated antibiograms are useful for the monitoring of drug-resistant Streptococcus pneumoniae. "Community-specific antimicrobial susceptibility data may help monitor trends among drug-resistant...

Mechanism of metronidazole-resistance by Enterococcus proposed.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Researchers propose a mechanism for metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract. ...

Hydrogen peroxide safely inhibits C. parvum in fruit juice.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Low-level H[subscript]2O[subscript]2 treatment safely inhibits "Cryptosporidium parvum in fruit juice. C. parvum "has historically been associated with waterborne outbreaks of diarrheal illness,"...

Mutant toxic shock syndrome toxin 1 prevents Staphylococcus infection.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Vaccination with nontoxic mutant toxic shock syndrome toxin 1 protects against Staphylococcus aureus infection. "To investigate whether vaccination with nontoxic mutant toxic shock syndrome toxin 1...

FDA grants anti-CD4 drug fast-track status for the treatment of HIV-1.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Tanox, Inc., (TNOX) announced that the U.S. Food and Drug Administration (FDA) has granted fast-track status to TNX-355 for the treatment of patients with human-immunodeficiency virus 1 (HIV-1)...

No association found between serum hepcidin and markers of anemia.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- No significant association exists between serum hepcidin and other markers of iron status or anemia. "The hepatic antimicrobial protein, hepcidin, is implicated in duodenal iron absorption and...

The C-terminal domain of human CAP18 was used to develop more active analogues.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The C-terminal domain of human antibacterial protein CAP18 was used as a base to develop 2 proteins with stronger antibacterial effect. "This paper reports the effect of the synthesized 27-amino...

Pacidamycin derivatives active against drug-resistant bacterial pathogens.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A series of pacidamycin derivatives have demonstrated activity against drug-resistant bacterial pathogens, including E. coli and M. tuberculosis. According to a recent study from California,...

Innate antimicrobials are important, despite some bacterial immune evasion.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Antimicrobial peptides are involved in innate immune defense against bacteria, and bacteria have evolved some ways to evade these molecules. According to recent research published in the journal...

Interferons alpha and beta act on p53; do have antitumor, antiviral activities.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Interferons alpha and beta collaborate with p53, effecting tumor suppression and antiviral effects; new types of interferon or better targeted delivery may be clinically effective. "In the recent...

Plasmid-driven siRNAs useful for controlling viral pathogen gene expression.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Plasmid-driven siRNAs offer extensive control over the gene expression of viral pathogens. In a recent study from St. Louis, "Short interfering double-stranded RNAs (siRNAs) expressed under the...

Dendritic cells battle meningococcal, listerial meningitis two separate ways.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Dendritic cells function by two different pathways to combat bacterial meningitis from Listeria monocytogenes and Neisseria meningitides. "Few bacteria are capable of causing infections of the...

Overproduction of inactive variants of murein synthase lyses E. coli.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Overproduction of inactive variants of the murein synthase PBP1B causes lysis in Escherichia coli. "Penicillin-binding protein 1B (PBP1B) of Escherichia coli is a bifunctional murein synthase...

Brucellosis patient sera reacts to aminopeptidase N purified from Brucella.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Acute and chronic brucellosis patient sera reacts to an aminopeptidase N purified from Brucella. According to a study from Mexico, "An immunogenic aminopeptidase was purified from Brucella...

Bisphosphonates inhibit Trypanosoma cruzi farnesyl pyrophosphate synthase.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. "Studies on the mode of action of a series of bisphosphonates derived from fatty...

ICOS to manufacture clinical antibody candidate, M200.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- ICOS Corp. (ICOS) announced that it has entered into a manufacturing agreement with Protein Design Labs (PDL), Inc., (PDLI), a biopharmaceutical company based in Fremont, California. Under the...

Alliance will focus on infectious, parasitic disease research.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Invest U.K., the British government's worldwide inward investment agency, announced that the U.S. Centers for Disease Control and Prevention (CDC) has signed a formal memorandum of understanding with...

Glycolytic enzyme plays key role in L-nucleoside analog efficacy.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- An enzyme crucial for the efficacy of L-nucleoside analogs has been identified. These drugs represent "a new class of clinically active antiviral and anticancer agents," scientists in the United...

Yingzhaosu A analogues show promise for malaria treatment.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Novel yingzhaosu A analogues show promise as antimalarial agents. According to a recent study from Japan, "Co(II)-catalyzed peroxidation of dienes including (S)-limonene in the presence of...

Lactoferrin appears to have serine protease activity against bacterial proteins.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Lactoferrin, found in human milk, can degrade enteropathogenic E. coli proteins involved in attachment and pore formation; this antibacterial action can work on other bacteria that use the same system....

Pharmaceutical company developing products to fight E. coli contamination.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Nymox Pharmaceutical Corporation (NYMX) is taking two approaches to address the serious public health problem posed by the contamination of meat and other food and drink products by potentially deadly...

Chlorine dioxide gas treatment safely inactivates E. coli in apples.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Chlorine dioxide (ClO[subscript]2) gas treatment safely inactivates pathogenic E. coli in apples. In a recent study from Indiana, the efficacy of ClO[subscript]2 gas "in inactivating a mixture of...

Persistent pediatric gastroenteritis may be due to astrovirus serotype-3.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Persistent pediatric gastroenteritis may be due to astrovirus serotype-3. "The relationship between cases of persistent diarrhea and the levels and type of human astrovirus was investigated,"...

Substantial increase in survival seen after introduction of HAART.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- New research highlights the substantial increased survival for people with HIV-1 since the introduction of highly active antiretroviral therapy (HAART) in 1997. However the study also shows a shift...

Dimeric derivatives of peptide HIV integrase inhibitors show improved efficacy.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Dimeric derivatives of peptide HIV integrase inhibitors show improved efficacy over their parent agents. In a recent study from the United States, "Dimers of known HIV-1 integrase inhibitory...

Modified HIV PIs active against drug-resistant virus, but lack bioavailability.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A series of modified HIV PIs are highly active against PI-resistant strains, but have limited bioavailability. According to published research from Merck Research Laboratories, "Transposition of...

Plasma-derived HIV should be used for drug resistance genotyping.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Plasma-derived HIV should be used for viral genotyping to determine drug resistance. "HIV-1 genotype assays using plasma viruses have been widely applied for detection of resistant viruses in...

Genetic therapy options for HIV patients reviewed.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Gene therapy options for HIV patients have been reviewed. "Despite the tremendous success of highly active antiretroviral treatment (HAART) introduced nearly eight years ago for the treatment of...

Mathematical model predicts effects of microbicide-based HIV prevention efforts.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A novel statistical technique can be used to predict the effects of microbicide-based HIV prevention efforts. In a recent study, scientists in the United States developed "a simple mathematical...

Antiretroviral treatment can impair antimalarial immune activity.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Antiretroviral treatment can impair antimalarial immune activity. "In response to the HIV/AIDS pandemic, antiretroviral treatment is currently being implemented in sub-Saharan Africa, where malaria...

Efavirenz analog binding to K103N HIV mutants determined.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The factors that determine efavirenz analog binding to mutant HIV RT have been identified. In a recent study from the United States, "Monte Carlo-extended linear response (MC/ELR) calculations"...

Effect of blood-brain barrier on hydroxyurea elucidated.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The effect of the blood-brain barrier on hydroxyurea pharmacokinetics has been elucidated. "Hydroxyurea is used in the treatment of HIV infection in combination with nucleoside analogues,...

Female HIV patients have higher risk of antiretroviral-induced ATAs.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Female HIV patients have higher risk of antiretroviral-induced adipose tissue alterations (ATAs) compared to their male counterparts. In a recent study from Italy, ATAs "were clinically assessed in...

Improved method for aryl beta-diketo acids developed.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A novel oxalylation technique may lead to increased production of anti-HIV beta-diketo acids. According to published study results from China, "An improved and efficient oxalylation of aryl methyl...

Indinavir suppresses transendothelial migration of immature dendritic cells.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The anti-HIV agent indinavir (IDV) suppresses the transendothelial migration of some immature immune cells. IDV "is a protease inhibitor that successfully suppresses HIV-1 replication as part of...

Not approvable letter issued for Helicide.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Axcan Pharma, Inc., has announced that the U.S. Food and Drug Administration (FDA) has determined that the New Drug Application (NDA) that Axcan re-submitted for Helicide for the eradication of...

Real-time PCR best choice for CMV monitoring in ATL patients.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Real-time polymerase chain reaction (PCR) assays are the best choice for CMV monitoring in ATL patients. In a recent study, scientists in Japan "analyzed the efficiency of the quantitative...

Herpes simplex virus induces the chemokine RANTES/CCL5.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Herpes simplex virus infection induces the chemokine RANTES/CCL5; IRF-3, NF-kappaB are involved. According to published research from Denmark, "Chemokines regulate migration of leukocytes to sites...

Following infection, tissue homeostasis depends on adenosine A(2A) receptors.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Tissue homeostasis following infectious disease depends of adenosine A(2A) receptors; dysfunction in sepsis may cause immunoparalysis. "Adenosine can be described as a retaliatory metabolite, the...

Inhibitex awarded FDA grant for the clinical development of Veronate.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Inhibitex, Inc., has been awarded a grant, funded by the U.S. Food and Drug Administration (FDA) Office of Orphan Products Development, for the premarket development of Veronate, an investigational drug...

Healthcare professionals updated on new CDC hand hygiene guidelines.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- 3M Health Care has sponsored a new video to make it easier for healthcare professionals to update their procedures in light of the new hand hygiene guidelines issued recently by the U.S. Centers for...

Novel phage-based assay improves S. enterica Heidelberg typing.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A phage-based assay offers a simple and accurate method for "Salmonella enterica serovar Heidelberg typing. S. enterica serovar Heidelberg "is perhaps the second most frequent Salmonella serovar...

Amphotericin B lipid complex safe, effective for HIV visceral leishmaniasis treatment.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A lipid formulation of amphotericin B is safe and effective for the treatment of VL in HIV patients. "Optimal treatment for HIV-related visceral leishmaniasis (VL) has still to be established,"...

Structure of P. vivax DHFR determined.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Recent study results have shed new light on a key plasmodial enzyme. According to published research from Italy, "The structure of Plasmodium vivax dihydrofolate reductase (PvDHFR), a potentially...

Amodiaquine resolves hyperparasitemia during uncomplicated falciparum malaria.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Amodiaquine can resolve hyperparasitemia in patients with falciparum malaria. This agent "is one of the possible alternative therapeutic options to treat chloroquine-resistant Plasmodium falciparum...

Chloroquine with primaquine effective against malaria in Azerbaijan.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Chloroquine followed by primaquine remains effective against malaria in Azerbaijan. In a recent study from Switzerland, the efficacy of this regimen was "monitored in 153 patients in seven...

Over-the-counter drugs can reduce malarial drug resistance.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A number of agents contained in over-the-counter drugs can be used to reduce malarial drug resistance. "Ferriprotoporphyrin IX (FP) is released inside the food vacuole of the malaria parasite...

Agency assigned to handle StaphVAX and WinRho SDF.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Integrity Healthcare Communications, the newest agency in the HealthSTAR Communications network, has been assigned several projects by Nabi Biopharmaceuticals (NABI). Nabi Biopharmaceuticals, which...

Compartmentalization of melanogenesis in melanomas may provide a target.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Specific compartmentalization of melanogenesis in melanomas may yield a way to target the cancer. "Melanins are the principal surface pigments in vertebrates and, in humans, play a major role in...

ITN use can delay pediatric malaria immunity in endemic areas.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The use of insecticide-treated materials (ITM) can delay the development of malaria immunity in children living in endemic areas. ITM "are considered a useful malaria control measure for endemic...

Protease inhibitors used for treating HIV also block Kaposi sarcoma.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Protease inhibitors used for treating HIV also block Kaposi sarcoma. According to recent research from Italy, "HIV protease inhibitors are antiretroviral drugs that block the enzyme required for...

Valacyclovir inhibits EBV replication in HIV-associated HLP.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Valacyclovir can suppress EBV activity in patients with HIV-related HLP. In a recent study from the United States, "Nineteen cases of human immunodeficiency virus (HIV)-associated oral hairy...

Leishmania binds red blood cells after antibody, complement.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Leishmania promastigotes become antibody-bound and activate the complement system, but also adhere to erythrocytes. According to a study from Spain, "In human blood, promastigotes bind natural...

Ohio company wins NIH contract to manufacture Parvovirus vaccine.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Meridian Bioscience, Inc., (VIVO) of Cincinnati, Ohio, has been awarded a contract to manufacture clinical-grade recombinant-protein Parvovirus-B19 vaccine for the U.S. National Institutes of Health....

Enterocolitis of pseudomembranous or neutropenic origin must be identified early.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Pediatric cancer patients with pseudomembranous or neutropenic enterocolitis must be distinguished early on for best therapy and results. According to published research from Netherlands,...

Ibis program receives $6 million grant from the CDC.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Isis Pharmaceuticals, Inc., (ISIS) confirmed that its Ibis program received a 3-year grant for up to $6 million from the U.S. Centers for Disease Control and Prevention (CDC) to develop and apply its...

Citrus oils inhibit growth of salmonellae.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Citrus oils inhibit the growth of salmonellae. According to a study from the United States, "The manufacture of orange juice sometimes involves the use of flavor fractions recovered from oranges....

Skin infection treatment undergoes phase III clinical trial.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Vicuron Pharmaceuticals, Inc., (MICU) announced the initiation of a phase III clinical trial to evaluate the safety and efficacy of the company's semi-synthetic glycopeptide antibiotic, dalbavancin,...

Low-dose short-course ganciclovir effective as post-SCT CMV prophylaxis.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Limited ganciclovir regimens are safe and effective for CMV prophylaxis in stem cell graft recipients. According to scientists in St. Louis, "In contrast to allogeneic bone marrow transplantation...

Grant to confirm efficacy of pathogen-inactivation technology on plasma.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The National Heart Lung and Blood Institute of the U.S. National Institutes of Health (NIH), in conjunction with the Small Business Administration, has provided a $750,000 small business innovation...

Phthalocyanine tetrasulfonate effective treatment for scrapie.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Phthalocyanine tetrasulfonate was effective at preventing and treating scrapie in mice. "The transmissible spongiform encephalopathy (TSE) diseases are rare, neurodegenerative diseases that include...

Modified thiazolidinones disrupt mycobacterial rhamnose pathway.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A series of modified thiazolidinones can disrupt mycobacterial rhamnose biosynthesis, and thus show promise as antituberculosis agents. "The emergence of multi-drug resistant tuberculosis, coupled...

Snake venom-derived peptides active against drug-resistant TB.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A series of snake venom-derived peptides have demonstrated activity against drug-resistant tuberculosis strains. "The recent re-emergence of tuberculosis, especially the multidrug-resistant cases,...

Statistical model facilitates TB drug data comparisons.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A novel statistical technique facilitates comparisons of antituberculosis medications. According to published research from England, "A model for evaluating the potency of a new antituberculosis...

Novel assay highly effective for identifying drug-resistant TB.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A novel molecular test is highly effective at identifying drug-resistant strains of Mycobacterium tuberculosis. "The INNO-LiPA Rif.TB assay is designed for the detection of rpoB gene mutations...

RNI effects on M. tuberculosis gene expression clarified.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The effects of RNI treatment on M. tuberculosis gene expression have been elucidated. "Nitric oxide (NO) and related reactive nitrogen intermediates (RNI) are effective anti-mycobacterial agents and...

First patients enrolled in pivotal trial of iseganan for prevention of VAP.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- IntraBiotics Pharmaceuticals, Inc., (IBPI) announced that it has enrolled the first patients in a pivotal clinical trial of its lead product, iseganan, in patients receiving mechanical ventilation to...

New antiviral agents from marine-derived fungus reported.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Researchers report the discovery of new antiviral agents from a marine-derived fungus of the genus Scytalidium. "Marine micro-organisms represent an underexplored resource for the discovery of...

Curcumin shows promise as intravaginal spermicide and anti-HIV agent.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Curcumin shows promise as an intravaginal spermicide and anti-HIV agent. According to published research from the United States, "The purpose of this investigation was to evaluate the...

Mechanism of antibiotic efflux in Gram-negative bacteria reviewed.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Scientists have reviewed the mechanism of antibiotic efflux in Gram-negative bacteria in a recent issue of the journal Frontiers in Bioscience. "Active efflux of antibiotics mediated by multidrug...

Assay for diagnosis of disseminated candidiasis developed.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Researchers have developed a competitive binding inhibition enzyme-linked immunosorbent assay that uses the secreted aspartyl proteinase of Candida albicans as an antigenic marker for diagnosis of...

Peginterferion alfa-2a improves health-related quality of life.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Peginterferion alfa-2a improves health-related quality of life. According to a study from Austria, "compared with conventional interferon alfa, peginterferon alfa-2a (40KD) has improved...

Prion protein in the endoplasmic reticulum disrupts cell viability.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Post-translational import of the prion protein into the endoplasmic reticulum interferes with cell viability. "Aberrant folding of the mammalian prion protein (PrP) is linked to prion diseases in...

Drugmaker cuts costs on HIV/AIDS medications.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- GlaxoSmithKline (GSK) has reduced the not-for-profit prices of its HIV/AIDS medicines for qualifying countries and organizations. It has also extended the voluntary license granted to Aspen...

Hong Kong hospitals get new tool for the fight against SARS.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- IQAir North America announced that the Hong Kong Hospital Authority (HKHA) has selected IQAir's advanced air-filtration systems as a new tool for combating the severe acute respiratory syndrome (SARS)...

SBIR grant from NIAID awarded to expand development of antibodies.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Avanir Pharmaceuticals (AVN) announced the award of a $100,000 grant through the Small Business Innovative Research (SBIR) program of the National Institute of Allergy and Infectious Diseases (NIAID)...

Reduced use of antibiotics could save U.S. hospitals more than $1B annually.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- U.S. hospitals could save more than $1 billion annually by reducing unnecessary use of antibiotics, while also reducing complications for patients, according to research presented at the Infectious...

NOXAFIL demonstrates activity against coccidioidomycosis.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Schering-Plough Corp. (SGP) reported results from a case series evaluating the efficacy and safety of NOXAFIL (posaconazole oral suspension) for the treatment of coccidioidomycosis, a potentially...

Multidrug-exporting secondary transporters reviewed.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Researchers describe aspects of multidrug-exporting secondary transporters in a recent issue of Current Opinion in Structural Biology. "The major cause of intrinsic drug resistance in Gram-negative...

Antibiotic management program causes pseudo-outbreak of nosocomial infections.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Introduction of an antibiotic management program led to a pseudo-outbreak of nosocomial infections. According to recent research published in the Journal of Hospital Infection, "An abrupt and...

Adaptive mutation is common in E. coli.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- The quickening of genetic mutation rates in bacteria may not only happen when the microorganisms find themselves in strange and stressful circumstances. A new report in Molecular Microbiology by...

High rate of surgical-site infections found at Tanzanian medical center.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- A high rate of surgical-site infections was found at a Tanzanian medical center. "A 5-month prospective survey of surgical-site infections (SSI) was conducted in the department of general surgery...