Anti-Infectives Week articles from March 2009

Anti-Infectives Week archives from March 2009

Findings from University of Mississippi advance knowledge in anti-infectives.
March 2, 2009... "A new potent antiinfective and antiparasitic 2,3-dihydro-1H-indolizinium chloride (1) was isolated from Prosopis glandulosa var. glandulosa. Three additional new (2-4) and one known (5) indolizidines were also isolated, and the dihydrochloride...

Research from Y. Wang and co-authors provides new data about apoptosis.
March 2, 2009... According to recent research from the United States, "Antiapoptotic Bcl-2 family proteins are overexpressed in many types of tumors and are believed to be associated with tumor formation, tumor growth and drug resistance. ABT-263 is a...

Reports outline bladder cancer study results from University of British Columbia.
March 2, 2009... According to a study from Vancouver, Canada, "To characterize changes in clusterin (sCLU-2) expression in bladder cancer cells after continuous treatment with gemcitabine and to determine whether knockdown of sCLU-2 can re-introduce sensitivity...

Research conducted at M. Ostergaard and co-researchers has updated our knowledge about breast cancer.
March 2, 2009... According to recent research from Viborg, Denmark, "Crohn's disease (CD) and ulcerative colitis (UC) are characterized by an impaired mucosal defence to normal constituents of the intestinal flora and a dysregulated inflammatory response. The...

Data on cancer detailed by researchers at Kyoto University.
March 2, 2009... "The pharmacokinetics of vancomycin was retrospectively examined based on trough concentrations obtained during routine therapeutic drug monitoring to examine possible pharmacokinetic differences between adult Japanese cancer and non-cancer...

Data on hospital epidemiology detailed by researchers at Cincinnati Children's Hospital.
March 2, 2009... In this recent article published in the journal Infection Control and Hospital Epidemiology, scientists in the United States conducted a study "To identify risk factors associated with surgical site infection (SSI) after pediatric posterior...

Study findings on hospital epidemiology are outlined in reports from University of Gottingen.
March 2, 2009... According to recent research from Germany, "The sterility assurance level of 10(-6) is an established standard that defines the quality of sterile products. The aim of the present study was to develop a method that correlated the results from...

Data on injury infection and critical care detailed by researchers at University of Toronto.(Report)
March 2, 2009... "Background., We have previously demonstrated improved medical student performance using standardized live patient models in the Trauma Evaluation and Management (TEAM) program. The trauma manikin has also been offered as an option for teaching...

New injury infection and critical care research from S.L. Duffy and co-researchers described.
March 2, 2009... According to recent research from the United States, "Postburn insulin dysfunction is a significant contributor to morbidity and mortality. A satisfactory mechanism for explaining this phenomenon remains elusive; however, resistin has been...

New injury infection and critical care study findings recently were published by L.T. Rael and co-researchers.
March 2, 2009... According to recent research from the United States, "Transfusion-related acute lung injury (TRALI) is a life-threatening condition characterized by oxidative stress. Longer storage times of packed red blood cells (PRBC) and other blood...

Research from Chang-Gung University yields new data on injury infection and critical care.
March 2, 2009... According to recent research from Taiwan, "No surgical procedure has clearly proven superior in treating femoral supracondylar nonunions after plating. All traditional devices have limitations." "A technique for improving the approach of...

Research on injury infection and critical care reported by S.D. Nichols et al.(Report)
March 2, 2009... "Cervical near-hangings are not rare, but have received little attention in the trauma literature. Increasing numbers of patients received from our local jail and detention centers prompted this study," scientists in the United States report...

Scientists at University Hospital publish new data on injury infection and critical care.(Report)
March 2, 2009... According to recent research from Geneva, Switzerland, "Iliac wing fractures have received little attention in the literature. Commonly occurring after a direct blow, they are rotationally and vertically stable." "However, one must be...

Studies from University of Toronto in the area of injury infection and critical care published.
March 2, 2009... "Background., Traumatic brain injury (TBI) is a leading cause of death and disability in developed countries. We document trends in TBI-related hospitalizations in Ontario, Canada, between April 1992 and March 2002, focusing on relationships...

Study data from University of Washington provide new insights into injury infection and critical care.
March 2, 2009... "An arterial CO2 (Paco(2)) of 30 mm Hg to 39 mm Fig has been shown to be the ideal target range for early ventilation in trauma patients; however, this requires serial arterial blood gases. The use of end-tidal capnography (Etco(2)) has been...

Study results from Y. Kosashvili and colleagues update understanding of injury infection and critical care.
March 2, 2009... "Backboards are routinely used to protect the spine of trauma patients during transportation. Nevertheless, little is known about the biomechanical properties of this type of immobilization," investigators in Toronto, Canada report (see also...

New findings from University of Ghent in the area of drug resistance described.(Report)
March 9, 2009... "The purpose of this study was to assess the in vitro susceptibility of 64 Vietnamese isolates of Edwardsiella ictaluri, the causal agent of the infectious disease Bacillus Necrosis Pangasius in Pangasianodon hypophthalmus, using the agar...

Research in the area of drug resistance reported from University of Chile.
March 9, 2009... According to recent research from Santiago, Chile, "The aim of this research was to identify the presence of integrons among Escherichia coli strains isolated from poultry and swine and to characterize the topological association of these...

Research on drug resistance published by scientists at University of Porto.
March 9, 2009... "Under field conditions, three commercial antimicrobials were sequentially prescribed to 16,000 broiler chickens during their rearing period, via drinking water using subtherapeutic levels for 3 days. A control group of 16,000 broilers was...

Studies from P.L. Lu and co-authors have provided new information about drug resistance.(Report)
March 9, 2009... According to recent research from Taiwan, "In this study, a rapid and simple one-tube multiplex PCR (M-PCR) method was developed for Staphylococcal Cassette Chromosome mec (SCCmec), primary screening. One hundred and eight methicillin-resistant...

Research from Technical University of Dresden in glioblastoma provides new insights.
March 9, 2009... "Some patients with glioblastoma multiform do not respond to temozolomide even though they have aberrant promoter methylation of the DNA repair enzyme O-6-methylguanine methyltransferase (MGMT). This suggests that additional factors hamper...

Why does aspirin increase the susceptibility of Helicobacter pylori to antimicrobials?(Report)
March 16, 2009... Resent studies reported that aspirin inhibited the growth of H. pylori in a dose-dependent manner and significantly affected the activity of virulence factors of H. pylori. In addition, aspirin increased the susceptibility of H. pylori to...

Recent studies from University of Keele add new data to breast cancer.
March 16, 2009... According to recent research published in the journal Oncogene, "Effective control of both cell survival and cell proliferation is critical to the prevention of oncogenesis and to successful cancer therapy. Using functional expression cloning,...

New findings from Technion describe advances in drug resistance.
March 16, 2009... "The present study aimed to elucidate the contribution of the intracellular binding of drugs to multidrug resistance. For this purpose, uptake of rhodamines was studied in cells whose mitochondria had been uncoupled with carbonyl cyanide...

Research from University of Bologna has provided new data on drug resistance.
March 16, 2009... "The reversal of multidrug resistance by 22 molecules [8-aryl-8-hydroxy-5-R'-8H-[1,4]thiazino[3,4-c]-[ 1,2,4]oxadiazol-3-ones (1a-i) and 8-aryl-8-alkoxy-5-methyl-8H-[1,4]thiazino[3,4-c] [1,2,4]oxadiazol-3-ones (2a-m)] related to...

Research reports from M. Bounthavong and co-authors provide new insights into drug resistance.
March 16, 2009... According to recent research from the United States, "To evaluate the cost-effectiveness of vancomycin vs. linezolid in complicated skin and soft tissue infections (cSSTIs) with methicillin-resistant Staphylococcus aureus (MRSA) using a...

New anti-infectives study findings have been reported from Gunma University, Medical Department.
March 23, 2009... "Eighteen identical VanB-type Enterococcus faecalis isolates that were obtained from different hospitalized patients were examined for their drug resistance and plasmid DNAs. Of the 18 strains, 12 strains exhibited resistance to erythromycin (...

Research from National Institutes of Health has provided new information about neuropharmacology.
March 23, 2009... "Cue-induced drug-seeking in rodents progressively increases after withdrawal from cocaine, suggesting that cue-induced cocaine craving incubates over time. Here, we explored the role of the medial prefrontal cortex (mPFC, a brain area...

Recent studies from University of Porto add new data to cardiology.
March 23, 2009... "Isolated heart cells are highly susceptible to the toxicity of catecholamine oxidation products, namely, to catecholamine-glutathione adducts. Although cellular uptake and/or efflux of these products may constitute a crucial step, the...

Researchers at Tel-Aviv University have published new data on colon cancer.(Report)
March 23, 2009... According to recent research from Tel Aviv, Israel, "Pre-clinical Studies Of multidrug resistance (MDR) usually address severe resistance, yet moderate MDR is already clinically-impeding. The purpose of this study was to characterize moderate...

Findings in drug resistance reported from National Institutes of Health.
March 23, 2009... According to recent research from the United States, "Sunitinib malate (Sutent, SU11248) is a small-molecule receptor tyrosine kinase inhibitor that inhibits cellular signaling of multiple targets such as the platelet-derived growth factor...

Research from University of Bologna yields new findings on chronic myeloid leukemia.
March 30, 2009... "Docking simulations were used to predict the most favorable interaction between the T315I mutated form of Abl (invariably associated with resistance to the tyrosine kinase inhibitor imatinib mesylate, IM) and C6-unsubstituted and substituted...

Investigators at Pamukkale University target clinical trial research.(Report)
March 30, 2009... According to a study from Denizli, Turkey, "We aimed to investigate the therapeutic efficacy of linezolid in an experimental mediastinitis model and to compare it with vancomycin, which is commonly used. The objective of this study was also to...

New drug resistance study findings reported from Medical University of South Carolina.
March 30, 2009... "Interactions of hyaluronan with CD44 in tumor cells play important cooperative roles in various aspects of malignancy and drug resistance. Emmprin (CD147; basigin) is a cell surface glycoprotein of the immunoglobulin superfamily that is highly...

Recent findings in drug resistance described by L.B. Rosengren and colleagues.(Report)
March 30, 2009... "Escherichia coli often carries linked antimicrobial resistance genes on transmissible genetic elements. Through coselection, antimicrobial use may select for unrelated but linked resistance or virulence genes," scientists in Canada report (see...

Research data from University of Barcelona update understanding of drug resistance.(Clinical report)
March 30, 2009... According to recent research from Barcelona, Spain, "To assess the role of antipseudomonal agents on Pseudomonas aeruginosa colonization and acquisition of resistance. Prospective cohort study. Two medical intensive care units. 346 patients...

Findings from Aristotle University provide new insights into hospital infection.
March 30, 2009... "Prions are proteinaceous infectious agents postulated to be the causative agents of a group of fatal neurodegenerative diseases known as transmissible spongiform encephalopathies (TSEs). A known iatrogenic transmission route of TSEs to humans...

New hospital infection data have been reported by F. Eftekhar and co-authors.
March 30, 2009... According to recent research from Iran, "Correlation of biofilm formation and presence of the icaADBC genes was studied in 161 clinical isolates of S. epidermidis from persistent and non-persistent neonatal infections. Biofilm formation was...

New hospital infection research from L.K. Bergen and colleagues discussed.(Report)
March 30, 2009... According to a study from Copenhagen, Denmark, "The impact of environmental contamination on nosocomial cross-transmission is mostly unresolved and in Danish hospitals assessment of cleaning is based on visible criteria only. The use of...

Reports by R. Bou and co-researchers describe recent advances in hospital infection.
March 30, 2009... "A total of 67 patients involved in an outbreak of Pseudomonas aeruginosa in the intensive care unit (ICU) were retrospectively followed to determine whether case patients experienced differences in cost, length of stay and survival rates when...

Data from Medical College of Wisconsin, Medical College provide new insights into injury infection and critical care.(Report)
March 30, 2009... "Although studies have been conducted to analyze brain injuries from motor vehicle crashes, the association of head contact has not been fully established. This study examined ciation in occupants sustaining diffuse axonal injuries (DAIs),"...

Data on injury infection and critical care detailed by R. Hashem and co-authors.
March 30, 2009... "Cervical spine (c-spine) injuries (CSI) in trauma patients are common and potentially catastrophic. Numerous guidelines involving clinical and radiologic criteria have been devised to diagnose such injuries," researchers in Hamilton, Canada...

New injury infection and critical care study findings have been reported by O. Tasaki and co-researchers.
March 30, 2009... According to a study from Osaka, Japan, "Although sonic predictive models for patient outcomes after severe traumatic brain injury have been proposed, a mathematical model with high predictive value has not been established. The purpose of the...

Recent findings from P.C. Dischinger and co-authors highlight research in injury infection and critical care.(Clinical report)
March 30, 2009... According to a study from the United States, "The purpose of this analysis was to determine which of the initial symptoms after mild traumatic brain injury (MTBI) can best predict the development of persistent postconcussive syndrome (PCS). One...

Recent findings in injury infection and critical care described by P. Ciriaco and colleagues.
March 30, 2009... According to recent research from Milan, Italy, "We reviewed our experience of the surgical management and follow-up of patients admitted with an isolated traumatic sternal fracture (TSF) to a Thoracic Surgical Unit through the Emergency...

Reports from University of Queensland highlight recent research in injury infection and critical care.
March 30, 2009... "The discipline of economics supplies principles that may contribute to the discourse about investments in trauma registries and the role of the public sector, as well as the optimal use of the datasets those investments create. Methods.'...

Reports outline injury infection and critical care research from J.T. Hausmann and colleagues.
March 30, 2009... According to a study from Vienna, Austria, "The role of the forearm interosseous membrane (IOM) in trauma remains not fully understood. Information from experimental models simulating sudden axial loading of the IOM is limited." "The...

Reports summarize injury infection and critical care study results from University of California.
March 30, 2009... "A large portion of the injuries treated at urban trauma centers are preventable with alcohol and substance use presenting as common antecedent risk factors. Alcohol and drug use characteristics of vulnerable adults treated for intentional...

Research by P. Hadjizacharia and colleagues in injury infection and critical care provides new insights.
March 30, 2009... "It has been reported that cocaine is associated with trauma patients at epidemic proportions. However, the injury patterns, complications, and mortality in cocaine test-positive trauma patients are not well known," researchers in the United...

Research from G.E. Ryb et al has provided new information about injury infection and critical care.
March 30, 2009... In this recent article published in the Journal of Trauma - Injury Infection and Critical Care, scientists in the United States conducted a study "To compare injury patterns and outcomes of near- and far-side collisions. Near- and far-side...

Research from S.L. Evans and colleagues provide new insights into injury infection and critical care.
March 30, 2009... According to a study from the United States, "Passenger compartment intrusion, loss of integrity of the vehicle occupant compartment due to a motor vehicle crash, has frequently been used as a triage criterion. Data to support intrusion as a...

Research from University of Athens, Medical Department provide new insights into injury infection and critical care.
March 30, 2009... According to recent research published in the Journal of Trauma - Injury Infection and Critical Care, "Unintentional injury remains the leading cause of death among individuals "ICD-10 coded unintentional injury mortality data were...

Studies from J.A. Johannigman and co-authors have provided new information about injury infection and critical care.
March 30, 2009... "Transport of mechanically ventilated patients in a combat zone presents challenges including conservation of resources. In the battlefield setting, the provision of adequate oxygen supplies remains a significant issue," scientists writing in...

Studies from M.H.K. Motamedi and colleagues yield new information about injury infection and critical care.(Report)
March 30, 2009... According to recent research published in the Journal of Trauma - Injury Infection and Critical Care, "Trauma is a major cause of hospitalization in both civilians and military personnel (MP). It constitutes one of the most common causes of...

Studies from University of California in the area of injury infection and critical care described.
March 30, 2009... "The clinical effects of methamphetamines (MA) may complicate medical management, potentially increasing resource utilization and hospital costs out of proportion to the patient's severity of injury. We hypothesize that minimally injured (MI)...

Study results from University of Alabama, Medical Department provide new insights into injury infection and critical care.
March 30, 2009... "The temporal distribution of trauma-related deaths his been described as tri-modal with immediate, early, and late peaks. With the development of trauma centers and systems, it has been suggested that this distribution might be altered,"...