Anti-Infectives Week articles from March 2004

Anti-Infectives Week archives from March 2004

Genetic element linked to streptococcal macrolide resistance characterized.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- A chimeric genetic element linked to streptococcal macrolide resistance has been characterized. According to recent research from the United States, "The resistance of group A Streptococcus (GAS)...

National nosocomial infections surveillance program reduces infection rate.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- The Centers for Disease Control and Prevention's National Nosocomial Infections Surveillance (NNIS) system has reduced the incidence of urinary tract infections, bloodstream infections, and pneumonia in...

Antimicrobial diflunisal hydrazide-hydrazones synthesized.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- A series of novel diflunisal hydrazide-hydrazone have demonstrated significant antimicrobial activity. According to recent research from Turkey, "Several diflunisal hydrazide-hydrazone derivatives...

Antiretroviral mechanisms of DSB identified.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- The antiretroviral mechanisms of the novel agent DSB have been characterized. According to published research from Tennessee, "Despite the effectiveness of currently available human immunodeficiency...

Crt and Mdr1 orthologues not involved in P. chabaudi chloroquine resistance.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Crt and Mdr1 orthologues do not play a major role in P. chabaudi chloroquine resistance. In a recent study, parasitologists in Scotland "identified in the rodent malaria parasite Plasmodium...

Anti-infective technology licensed to GMP.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- The Procter & Gamble Co. (PG) and GMP Cos., Inc. announced that P&G has licensed to GMP its newly developed, topical anti-infective technology for exclusive worldwide use in medical settings and...

Marketing agreement signed for promotion of aspergillus test.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Bio-Rad Laboratories, Inc., (BIO; BIOb), a multinational manufacturer and distributor of life science research products and clinical diagnostics, announced that it has entered into a marketing agreement...

Partnership to develop new treatment for tropical disease.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Roche and AEterna Laboratories, Inc., (AEL; AELA) announced a partnership for the marketing in Brazil of Impavido (Miltefosine), the breakthrough oral therapy of leishmaniasis. The agreement was...

Ivory Coast medicinal plants demonstrate antiparasite activity.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- A number of medicinal plants used in the Ivory Coast have potent antiparasitic activity. According to published research from France, "During an ethnopharmacological survey of antiparasitic...

Antiviral and DNA-cleaving activities of fullerene derivatives reviewed.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- The antiviral and DNA-cleaving activities of fullere derivatives have been reviewed. "The fullerene family, and especially C-60, has very appealing photo-, electro-chemical and physical properties,...

Inhibition of HIV integrase by styrylquinoline derivatives characterized.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- The inhibition of HIV IN by styrylquinoline derivatives (SQ) has been characterized. SQ "efficiently inhibit the 3'-processing activity of integrase (IN) with IC50 values of between 0.5 and 5...

Kenyan medicinal plants may yield antimalarial agents.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Extracts from several Kenyan medical plants show promise as antimalarial agents. In a recent study from Kenya, "The organic extracts of leaves and roots of five plants used for treating malaria in...

Primaquine analogue lacks methemoglobin toxicity.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- A novel primaquine analogue has potent antimalarial activity without MetHb toxicity. In a recent study from India, "To eliminate an unwarranted metabolic pathway of the quinoline ring, a set of two...

Trimethoprim derivatives active against drug-resistant malaria parasites.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Novel TMP derivatives show promise for the treatment of drug-resistant malaria. "The resistance to pyrimethamine (PYR) of Plasmodium falciparum arising from mutation at position 108 of dihydrofolate...

Vancomycin-resistant Staphylococcus aureus isolate found in Pennsylvania.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- "A vancomycin-resistant Staphylococcus aureus (VRSA) isolate was obtained from a patient in Pennsylvania in September 2002. "Species identification was confirmed by standard biochemical tests and...

Novel gp41-derived peptides inhibit HIV cell entry.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Novel gp42-derived peptides inhibit strongly inhibit HIV-cell membrane fusion. According to a study from Germany, "As the limitations of antiretroviral drug therapy, such as toxicity and resistance,...

Prevalence and effects of P. jirovecii DHPS mutations determined.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- The frequency and clinical significance of P. jirovecii DHPS polymorphisms have been elucidated. According to published research from France, "Dihydropteroate synthase gene (DHPS) mutations at...

Effects of indinavir on sterol, fatty acid homeostasis clarified.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- The effects of indinavir on sterol and fatty acid homeostasis have been characterized. "Human immunodeficiency virus protease inhibitors induce hyperlipidemia in many patients treated with these...

Injection drug use attenuates HAART benefits.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Injection drug use attenuates the benefits of HAART. "There is evidence that HIV-positive injecting drug users benefit less than other risk groups from highly active antiretroviral therapy that has...

Lipid membranes likely involved in enfuvirtide activity.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Lipid membranes are likely involved in the antiretroviral activity of enfuvirtide. According to recent research from Portugal, "Partition of the intrinsically fluorescent HIV fusion inhibitor...

Methamphetamines augment HIV replication in humans.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Meth use augments HIV replication in humans. "Abuse of methamphetamine (METH) is a frequent comorbidity among individuals infected with human immunodeficiency virus (HIV) type 1," scientists in the...

T-20 cross-reactive gp41 antibody does not reduce T-20 efficacy.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Enfuvirtide cross-reactive gp41 antibody has no significant effect on the outcome of enfuvirtide treatment. In a recent study, scientists in Canada "investigated the effect of enfuvirtide...

HBV treatment can lead to recovery of virus-specific T-cell responses.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- HBV treatment can lead to the recovery of HBV-specific T-cell responses in HIV patients. "Liver-related mortality is an increasing problem in human immunodeficiency virus (HIV)/hepatitis B virus...

Varicella infections in pregnant women require expeditious management.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Varicella infections in pregnant women require expeditious management. According to recent research from France, "varicella during pregnancy is a rare occurrence because of a high rate of...

Scientists link Candida glabrata to fertility treatments and vaginal fluid.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Scientists link Candida glabrata to fertility treatments and vaginal fluid. "Presented here are two cases of systemic Candida glabrata infection diagnosed in two expectant mothers and their fetuses...

Late CMV PRP reported after stem-cell transplantation.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- An incidence of late CMV PRP has been reported in a stem-cell transplant recipient. In a case described by physicians in Germany, a "55-year-old man with acute myeloid leukemia in second relapse...

Mosquito nets treated with multiple insecticides show promise.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Mosquito nets treated with multiple insecticides may improve malaria prevention efforts in endemic regions. "Only pyrethroid insecticides have so far been recommended for the treatment of mosquito...

High-dose artemisinin has D[subscript]2 receptor-mediated sedative effect.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- At high doses, artemisinin has a sedative effect mediated by dopamine receptors. "Artemisinin or qinghaosu is the active principle of quinghao (Artemisia annua L.) developed from Chinese traditional...

Shareholders approve Genome Therapeutics merger.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- At separate special meetings, shareholders of Genome Therapeutics Corp. (GENE) and Genesoft Pharmaceuticals approved each of the proposals relating to the pending merger of the two companies. The...

FDA clears U.S. distribution of cement hip spacer containing antibiotics.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Exactech, Inc., (EXAC) announced that it has received clearance from the U.S. Food and Drug Administration (FDA) for distribution of the only pre-formed cement hip spacer containing antibiotic available...

HAART induces abnormal bone metabolism, reduces BMD in children.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- HAART causes abnormal bone metabolism and reduces BMD in children. According to recent research from Italy, "Highly active antiretroviral therapy (HAART) may be a contributory factor for a...

Production of drug-sensitive HIV continues in children during successful HAART.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- HIV production continues in HAART-treated children with undetectable viremia, although the evolution of drug resistance is halted in these patients. "Highly active antiretroviral therapy (HAART) can...

Drug discovery company announces new vice president.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Cetek Corporation announced that Vincent Gullo, PhD, has joined the company as vice president, drug discovery. Dr. Gullo comes to Cetek from Schering-Plough Research Institute where as Senior...

Pre-pregnancy antibiotics do not prevent preterm birth, study shows.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- A randomized clinical trial has found that antibiotic treatment before pregnancy did not prevent preterm birth among women who had had a previous premature baby. "Interconceptional Antibiotics to...

Biopharmaceutical research company reduces debt.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- The management team at Medical Discoveries, Inc., (MLSC) announced that as a result of their restructuring efforts, the company has written off $610,828 in liabilities from its balance sheet. MDI...

Meropenem prophylaxis reduces febrile episodes in stem cell transplant patients.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Meropenem prophylaxis reduces febrile episodes in stem cell transplant patients. According to recent research published in the journal Bone Marrow Transplantation, "in the present study, we analyze...

Crystal structure of M. tuberculosis MshB determined.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- The crystal structure of M. tuberculosis MshB has been characterized. "All living species require protection against the damaging effects of the reactive oxygen species that are a natural by-product...

Structural features of M. tuberculosis AKmt identified.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- The structure of M. tuberculosis AKmt has been determined. "Tuberculosis is the leading cause of death worldwide from a single infectious disease. Search of new therapeutic tools requires the...

Rifampicin reduces focal ischemia-induced brain damage.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Treatment with rifampicin may help prevent ischemic brain damage. "Rifampicin is an antibacterial agent that is widely used in tuberculosis and leprosy therapy," neurologists in Switzerland...

Negative-pressure wound dressings promote healing of diabetic foot wounds.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Negative-pressure wound dressings promote healing of diabetic foot wounds. According to published research from the United States, "Optimal treatment for large diabetic foot wounds is ill defined....

Community-acquired pyelonephritis is linked to drug-resistant E. coli.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Community-acquired pyelonephritis is linked to drug-resistant E. coli. According to a study from the United States, "from October 1999 through January 2000, an Escherichia coli clonal group...

New antibiotic improves treatment of parasitic infection.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- A team of researchers from the Universitat Autonoma de Barcelona, led by Professor Jordi Alberola, has demonstrated the efficacy and safety of a new type of antibiotic, belonging to the family called...

Galactopyranosyl amino alcohols show promise as antimicrobial agents.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- A series of novel amino alcohols show promise as antimicrobial agents. In a study from India, the "galactopyranosyl amino alcohols (3-16) were synthesised by regioselective oxirane ring opening of...

Antibiotic prophylaxis in aseptic orthopedic surgery is evaluated.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- The use of local antibiotics in bone cement has not proven useful as a prophylactic measure. According to recent research from Germany, "Disagreement exists on the topic of antibiotic prophylaxis...

IS6110 augments phoP transcription in MDR TB.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- IS6110 augments phoP transcription in an outbreak strain of drug-resistant tuberculosis. "Drug resistance in Mycobacterium tuberculosis complex strains is solely due to chromosomal mutations that...

Data presented on potential new class of antiretroviral therapy.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Bristol-Myers Squibb Company (BMY) presented data from study AI430-003 on BMS-488043, one of the compounds from its series of experimental HIV-1 attachment inhibitors - a potential new class of...

Artemisinin alkylates human hemoglobin A[subscript]0.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Artemisinin alkylates human hemoglobin A[subscript]0. According to published research from France, "In vitro, the heme cofactor of human iron(II) hemoglobin was efficiently and quickly alkylated at...

Solid-phase synthesis of cyclic decapeptide antibiotic streptocidins reported.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Scientists report the facile solid-phase synthesis of cyclic decapeptide antibiotic streptocidins A-D in a recent issue of Tetrahedron Letters. "Total synthesis of decapeptide antibiotics...

Infection-control company launches fight against avian flu.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- JohnsonDiversey, Inc., is partnering with its customers across the globe to launch an offensive against the spread of avian flu. The effort includes offering products that are registered by the...

U.S. Food and Drug Administration approves clinical trial for MethLock.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- The U.S. Food and Drug Administration has approved a clinical trial for MethLock, a catheter lock solution developed by Ash Access Technology, Inc., a Lafayette, Indiana, company focused on vascular...

Emory, partner, identify topical microbicides for drug development.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- FemmePharma, Inc., a prescription pharmaceutical company dedicated to developing drugs for diseases and disorders disproportionately affecting women, has initiated a collaboration with Emory University...

Bacillus thuringiensis crystal proteins protect against malaria in mice.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Bacillus thuringiensis crystal proteins have potent antimalarial activity in mice. In a recent study from China, eight B. thuringiensis strains "were used to test their activity against Plasmodium...

Amino acid-conjugated quinolinamines are potent antimalarials.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Novel amino acid-conjugated quinolinamines have potent antimalarial activity. In a recent study from India, "Alanine, lysine, ornithine and valine conjugated to primaquine and other 8-quinolinamine...

Bicyclam-GalCer agents have disappointing antiretroviral activity.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Novel bicyclam-GalCer conjugates have surprisingly weak antiretroviral activity. According to published research from France, the "synthesis of bipharmacophore anti-HIV compounds which, in a single...

Cyclohexane derivatives strongly inhibit HIV integrase activity.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- A series of novel cyclohexane derivatives strongly inhibit HIV integrase activity. According to published research from Italy, "A number of 2,6-bisbenzylidenecyclohexane-1-one derivatives have been...

Novel method improves bremazocine enantiomer synthesis.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- A novel method facilitates the synthesis of bremazocine enantiomers. "In order to provide ready access to multigram quantities of the optically pure bremazocines [(-)- and...

Novel trioxane derivatives have improved antimalarial activity.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Novel trioxane derivatives have demonstrated improved antimalarial activity. According to published research from India, "Using readily available trioxanes 6a-b, a new series of amino functionalized...

Water-soluble dipeptide HIV PI prodrugs synthesized.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- A series of novel water-soluble HIV protease inhibitor prodrugs has been developed. "To improve the low water-solubility of HIV protease inhibitors," scientists in Japan "synthesized water-soluble...

New test could help reduce unnecessary antibiotic use.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- A blood test could help doctors determine whether antibiotics are needed for common respiratory infections and may reduce the over-prescribing that creates drug-resistant germs, new research suggests....

Pharmaceutical company reports loss of $0.29 per share.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Advancis Pharmaceutical Corporation (AVNC) announced results for the quarter and fiscal year ended December 31, 2003. Advancis reported fourth quarter 2003 revenue of $3.3 million, resulting mainly...

Genotypic resistance after abacavir, efavirenz salvage treatment characterized.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- The rate of HIV resistance mutations has been determined in patients undergoing abacavir- and efavirenz-based salvage therapy. "Once highly active antiretroviral therapy (HAART) fails to suppress...

Conformation of HIV gp41 during cell entry determined.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- The conformation of HIV gp41 during cell entry has been determined, providing information that may facilitate the design of novel antiretroviral agents. "Triggered by receptor binding of gp120, the...

Cytotoxic T-cell CD38 expression predicts viral control in HAART-treated children.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Expression of CD38 by cytotoxic T cells can be used to predict the efficacy of HIV treatment in children. In a recent study from Spain, an "observational study of children vertically infected with...

Adiponectin attenuates protease inhibitor-induced dyslipidemia.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Adiponectin may be useful for the treatment of protease inhibitor-induced dyslipidemia in HIV patients. "Although the clinical application of HIV protease inhibitors (PIs) has markedly reduced...

Adiponectin levels linked to lipodystrophy, stavudine treatment.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Low adiponectin levels are associated with lipodystrophy in HIV patients, and are especially common after stavudine treatment. In a recent study, immunologists in Denmark "tested the hypothesis...

CTP biosynthesis inhibitors augment 3TC efficacy.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Inhibitors of cytidine-5'-triphosphate (CTP) biosynthesis augment the antiretroviral effects of lamivudine. According to N. Dereuddre-Bosquet and colleagues at the University of Paris-South,...

Efavirenz-induced sleep abnormalities evaluated.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Efavirenz-induced sleep abnormalities have been evaluated. In a recent study from Spain, "Ambulatory electroencephalogram monitoring was performed for 18 HIV-infected subjects treated with...

No GPG-NH[subscript]2 resistance mutations seen in vitro.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Cultured HIV isolates failed to develop resistance mutations after exposure to GPG-NH[subscript]2. According to published research from Sweden, the "chemically modified tripeptide...

Once-daily lopinavir/ritonavir pill evaluated.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- A once-daily lopinavir/ritonavir pill has efficacy comparable to that of twice-daily regimens. In a recent study from the United States, the "safety, pharmacokinetics, and antiviral activity of...

Sarcoidosis rate and severity reduced in HAART era.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- The advent of HAART has reduced the rate and severity of sarcoidosis in HIV patients. "To analyze the impact of highly active antiretroviral therapy (HAART) on the characteristics and outcome of...

Significance of residual lymphoid HIV RNA determined.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- The significance of residual lymphoid HIV RNA has been determined. According to scientists in Switzerland, HIV RNA that "persists in the lymphoid tissue of patients despite treatment with highly...

Rifampin strongly reduces indinavir levels.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Indinavir treatment for HIV can be rendered ineffective by rifampin co-administration. "Rifampin is an important drug in the treatment of tuberculosis, but administration of rifampin in combination...

FDA grants orphan drug designation for Altastaph.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Nabi Biopharmaceuticals (NABI) announced that the U.S. Food and Drug Administration (FDA) has granted orphan drug designation to Nabi's investigational product, Altastaph [Staphylococcus aureus Immune...

SCT with voriconazole treatment feasible for AML with pulmonary aspergillosis.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Stem-cell transplantation with extended voriconazole therapy is safe and effective for acute myeloid leukemia (AML) patients with pulmonary aspergillosis. According to recent research published from...

Molecular basis of P. jirovecii atovaquone resistance clarified.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- The molecular mechanics of P. jirovecii atovaquone resistance have been characterized. "Atovaquone is a substituted hydroxynaphthoquinone that is widely used to prevent and clear Plasmodium...

Genome Therapeutics merger complete; merged company focused on anti-infectives.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Genome Therapeutics Corp. (GENE) has completed its merger with Genesoft Pharmaceuticals and its related common stock offering. The company's product portfolio now includes the U.S. Food and Drug...

Harvard inks letter of intent to acquire assets of antibody development company.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Harvard Group, Inc., announced the signing of a letter of intent to acquire the assets of NexTherapeutics, Inc. (NEXT). NEXT is a private antibody development company focused on the clinical...

FDA approves Neomycin, Polymyxin B Sulfates, Bacitracin Zinc ophthalmic ointment.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Akorn, Inc., (AKRN) announced that it has received approval from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Neomycin and Polymyxin B Sulfates, and...

Discovery could lead to better treatment for cryptosporidum infections.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- In 1993, a water-borne parasite in Milwaukee was responsible for an estimated 403,000 cases of acute gastrointestinal disease, and the outbreak revealed that patients with AIDS are at an especially...

Docs aim to reduce blood infection deaths.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- An international group of doctors is pushing for aggressive treatment to prevent half a million deaths worldwide from a common bloodstream infection. Sepsis kills more than 200,000 people annually...

Nitric oxide blockade's role in treating septic shock unclear.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- While initial clinical studies of the nitric oxide synthase inhibitor NG-methyl-L-arginine (L-NMMA) in patients with septic shock showed promising results and reasonably could have been expected to...

Celiac disease can impair TB therapy.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Celiac disease can reduce the efficacy of antituberculosis treatment. Scientists in England described "two cases of pulmonary tuberculosis, which did not respond to adequate therapy." "Both...

Isoniazid more cost-effective than rifampin-pyrazinamide for latent TB treatment.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Isoniazid is more-effective than RZ regimens for the treatment of latent tuberculosis. According to published research from California, "2 months of treatment with rifampin-pyrazinamide (RZ) and 9...

SMD technology plus lab card device to provide diagnosis of organisms.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Centrex, Inc., (CNEX) announced that Micronics, Inc., has advanced the development of an assay that contains Centrex's single molecule nucleic acid detection (SMD) technology for application in a...