Anti-Infectives Week articles from July 2004

Anti-Infectives Week archives from July 2004

Continuous infusions produce consistent vancomycin levels.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Continuous infusions produce consistent vancomycin levels in serum and the central nervous system. Researchers in the United States conducted a study "to compare the variability of vancomycin...

''Collateral damage'' linked to cephalosporin or quinolone antibiotic therapy.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- ''Collateral damage'' is linked to cephalosporin or quinolone antibiotic therapy. "Collateral damage'' is a term used to refer to ecological adverse effects of antibiotic therapy; namely, the...

Antibiotic resistance emerging in nosocomial urinary tract infections.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Antibiotic resistance is emerging in nosocomially acquired urinary tract infections, which requires prudent use of antibiotic therapy. According to published research from Germany, "Nosocomially...

IDO degraded by the proteasome and NO has an effect on IDO protein stability.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- IDO is degraded by the proteasome and nitric oxide has an effect on IDO protein stability. "Tryptophan depletion resulting from indoleamine 2,3-dioxygenase (IDO) activity within the kynurenine...

Company announces positive trial results for Aminocandin.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Indevus Pharmaceuticals, Inc., (IDEV) announced that aminocandin, under development as a treatment for systemic fungal infections, was well tolerated among healthy volunteers in a phase I clinical trial...

DDR1/DDR2 potential role in obstructive diseases of blood vessels and lungs.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Discoidin domain receptors 1 and 2 have potential roles in obstructive diseases of the blood vessels and lungs. According to a study from the United States, "Obstructive diseases of blood vessels...

Anthrax antibody profiled in medical journal.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Avanir Pharmaceuticals' (AVN) anti-anthrax monoclonal antibodies protected rats from lethal anthrax toxins, according to a study published in the peer-reviewed Journal of Immune Based Therapies and...

Pharmaceutical company receives FDA approval of ciprofloxacin tablets.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Teva Pharmaceutical Industries Ltd. (TEVA) announced that the U.S. Food and Drug Administration has granted final approval for the company's Abbreviated New Drug Application for Ciprofloxacin Tablets...

Antiviral proteins from C. album L leaves inhibit virus infections.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Antiviral proteins from Chenopodium album L leaves inhibit virus infections. According to published research from India, "Antiviral proteins (AVPs) named CAP-I and CAP-II purified from the leaves of...

Implant salvage is possible, but removal and delayed reinsertion is more likely.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Infection and device extrusion can lead to the need for breast implant salvage, although removal and delayed reinsertion is a more likely option, study data indicate. "Among the potential...

Companies ink agreement regarding universal high-titer mammalian cell line hosts.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Morphotek, Inc., announced that it has signed a collaborative research agreement with Tanox, Inc., (TNOX) of Houston, Texas, for the use of Morphotek's proprietary SIP Technology to develop universal...

Therapeutic antibody program acquired from Sunol Molecular.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Caprion Pharmaceuticals announced the acquisition of therapeutic antibodies currently in phase I clinical trials for the treatment of Hemolytic Uremic Syndrome (HUS) resulting from E. coli infection, as...

Method developed to quantify tetracyclines in food using LC.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Scientists have developed a method to quantify tetracyclines in food using liquid chromatography (LC) with electrochemical detection. "Mixed-valent films of ruthenium oxide-ruthenium cyanide were...

Rabbit osteomyelitis effectively treated with biodegradable microspheres.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Antibiotic-loaded microspheres proved highly effective in a rabbit model of osteomyelitis. In a recent study from the United States, "[b]iodegradable microspheres were manufactured from a high...

Different levels of adherence determine specific antiretroviral resistance.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Different levels of adherence determine specific antiretroviral resistance. According to a study from the United States, "Public health debates about providing HIV antiretroviral therapy to...

FDA grants approval for ciprofloxacin in eye conditions.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Bausch & Lomb (BOL) has received U.S. Food and Drug Administration approval of the company's Abbreviated New Drug Application (ANDA) to manufacture and sell ciprofloxacin ophthalmic solution USP, 0.3%....

FDA grants approval of generic Ciprofloxacin tablets.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- IVAX Corp. (IVX) has received final approval from the U.S. Food and Drug Administration for its abbreviated new drug application for Ciprofloxacin tablets in 250 mg, 500 mg, and 750 mg strengths, and...

Early diagnosis and treatment of primary HIV-1 infection may be critical.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Early diagnosis and treatment of primary HIV-1 infection may be critical. According to recent research published in the journal Clinical Infectious Diseases, "Emerging evidence suggests that early...

Fusion inhibitors effective in HIV patients able to maintain virological control.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Fusion inhibitors are effective in HIV patients that are able to maintain virological control. "The number of antiretroviral-experienced HIV patients with multiple resistances against the currently...

Management strategy for anemia in HIV infection elucidated.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- A management strategy for anemia in HIV infection has been elucidated by consensus. According to a study from the United States, "Anemia in human immunodeficiency virus (HIV)-infected patients can...

HAART-PI but not HAART-NNRTI strongly inhibit SAP expression in the oral cavity.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Highly active anti-retroviral therapies with protease inhibitors but not non-nucleoside reverse-transcriptase inhibitors strongly inhibit SAP expression in the oral cavity. "Highly active...

HIV viral load rebounders have limited long-term naive CD4+ cell reconstitution.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- HIV viral load rebound patients have limited long-term naive CD4+ cell reconstitution. According to a study from Greece, "Long-term (3.5 years) immune reconstitution in relation to viral load...

Novel polysulfated galactose-derivatized dendrimers binding antagonists of HIV-1.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Novel polysulfated galactose-derivatized dendrimers are binding antagonists of HIV-1. According to recent research from the United States, "Evidence indicates that galactosyl ceramide (GalCer) and...

Bis-anthracycline antibiotics inhibit HIV-1 transcription.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Bis-anthracycline antibiotics inhibit HIV-1 transcription. According to recent research published in the journal Antimicrobial Agents and Chemotherapy, "The increasing numbers of human...

CCR5 antagonists may be effective as anti-HIV-1 agents.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- CCR5 antagonists may be effective as anti-HIV-1 agents. "We have previously reported the novel lead compound 1a as a CCR5 antagonist for treatment of HIV-1 infection," wrote researchers in Japan....

CD4+ T-cell response increased with sustained virologic control following HAART.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- CD4+ T-cell response is increased in HIV-infected patients with sustained virologic control following HAART. According to recent research published in the Journal of Acquired Immune Deficiency...

Maintenance therapy discontinuation for histoplasmosis safe after HAART response.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Discontinuing maintenance therapy for disseminated histoplasmosis is safe after HIV-infected patients respond to antiretroviral therapy. "We performed a prospective observational study to assess the...

New HIV-1 integrase inhibitors developed.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- New HIV-1 integrase inhibitors have been developed. "Existing AIDS therapies are out of reach for most HIV-infected people in developing countries and, where available, they are limited by their...

Pharmacokinetics of indinavir plus low-dose ritonavir in children similar.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- The pharmacokinetics of indinavir plus low-dose ritonavir in HIV-1-infected children studied. According to a study from Netherlands, "So far, no pediatric doses for indinavir combined with ritonavir...

Piperazine-based CCR5 antagonists effective against HIV-1.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Piperazine-based CCR5 antagonists are effective against HIV-1. According to published research from the United States, "The nature and the size of the benzylic substituent are shown to be the key...

TAMs accumulate at similar rates during ZDV or d4T treatment.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Thymidine analogue resistance mutations accumulate at similar rates during ZDV or d4T treatment. "Zidovudine (ZDV) and stavudine (d4T) select for the same set of thymidine analogue resistance...

Study: Filtration protects patients from pathogens in hospital water.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- As awareness of the dangers of hospital water rise with each new infectious outbreak, Janet Stout, PhD, director of special pathogens laboratory, Veterans Administration (VA) Pittsburgh (Pennsylvania)...

Patient enrollment begins in Doripenem trial for hospital-acquired pneumonia.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Peninsula Pharmaceuticals, Inc., announced that patient enrollment has begun in the fifth pivotal phase III trial of its lead product candidate, doripenem for injection, in patients with...

Octagam is efficacious for treating primary immunodeficiency diseases.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Octagam 5%, an intravenous IgG product, is efficacious and well tolerated in subjects with primary immunodeficiency diseases. According to published research from the United States, "Octagam is an...

Complement has role in pathogenesis of invasive fungal infections.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Complement has a role in the pathogenesis of invasive fungal infections. "New therapeutic approaches enable organ transplantations and guarantee longer survival for AIDS patients or patients with...

Complications with A. niger infection is characterized by a high mortality rate.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Hematological disease complicated by Aspergillus niger infection is characterized by a high mortality rate. According to recent research published in the journal Mycoses, "In this paper we analyzed...

FDA clearance granted for U.S. distribution of bone cement products.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Exactech, Inc., (EXAC) announced that the U.S. Food and Drug Administration (FDA) has cleared for U.S. distribution both the InterSpace Knee Spacer, a pre-formed antibiotic knee spacer, and Cemex Genta,...

Experts call for heightened action to remove pathogens from hospital water.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Thousands of patients in the U.S. become ill and die each year from hospital-acquired (nosocomial) infections. Many of these infections are transmitted on the hands of healthcare workers or from...

Companies will seek European regulatory approval of Cubicin.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Cubist Pharmaceuticals, Inc., (CBST) and Chiron Corporation (CHIR) provided an update on the intended strategy to file for regulatory approval of Cubicin (daptomycin for injection) in Europe. ...

Panixine Disperdose launched for treatment of skin infections.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Ranbaxy Pharmaceuticals Inc. (RPI), a wholly owned subsidiary of Ranbaxy Laboratories Limited (RLL), announced the launch of Panixine DisperDose (Cephalexin Tablets for Oral Suspension) in 250 mg and...

Clostridium tetani sequence offers insights into toxin production.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- The complete genome sequence of Clostridium tetani has provided insights into metabolism and toxin production. According to a study from Germany, "The decryption of prokaryotic genome sequences...

Ampicillin-resistant Haemophilus influenzae type b increasing.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- The prevalence of beta-lactamase-nonproducing, ampicillin-resistant Haemophilus influenzae type b is increasing rapidly in patients with meningitis. According to recent research from Japan, "A...

Antiretroviral treatment more effective when guided by HIV genotype data.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Antiretroviral treatment is more effective when guided by HIV genotype data. "The changes in viral load and CD4+ count at 3 and 6 months in a group of 166 HIV-infected patients was evaluated. The...

Novel DHFR inhibitors active against P. carinii, T. gondii, and M. avium.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Novel dihydrofolate reductase inhibitors are active against P. carinii, T. gondii, and M. avium. According to a study from the United States, "Six previously undescribed...

Initial results reported from analysis of phase III data for Intercept Blood System.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Cerus Corporation (CERS) reported the initial results of an independent review and analysis of data from the previously reported phase III U.S. clinical trial for the Intercept Blood System for...

Essential regions for Henipavirus V proteins are potential therapeutic targets.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Essential regions for Henipavirus V proteins are potential therapeutic targets. According to a study from the United States, "The V proteins of Nipah virus and Hendra virus have been demonstrated...

Recommendations for topical microbicides to prevent HIV updated.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Recommendations for the nonclinical development of topical microbicides for prevention of HIV transmission have been updated. "The development of methods to prevent HIV infection is critical to...

Terbinafine resolves E. jeanselmei infection in heart transplant recipient.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Terbinafine can resolve Exophiala infection in immunosuppressed patients. According to a case report from Minnesota, an "immunosuppressed heart transplant recipient developed Exophiala jeanselmei...

Antibiotic resistance in Streptococcus pneumoniae reviewed.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Scientists review antibiotic resistance in Streptococcus pneumoniae in a recent issue of Clinical Infectious Diseases. According to a study from the United States, "The recent emergence of strains...

In vitro resistance results may not indicate clinical outcomes.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- In vitro resistance results may not correlate with clinical outcomes in pneumococcal pneumonia. "In vitro resistance to antimicrobial agents is escalating among pathogens responsible for the most...

Reduced vancomycin susceptibility has emerged in successful epidemic lineages.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Reduced vancomycin susceptibility has emerged in successful epidemic lineages. According to a study from England, "Methicillin-resistant Staphylococcus aureus (MRSA) with reduced vancomycin...

Risk reduction methods for BSE in U.S. elucidated.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Risk reduction methods for preventing bovine spongiform encephalopathy in the U.S. is elucidated. According to a study from the United States, "Bovine spongiform encephalopathy (BSE) has not been...

New women's condom to be released in Europe.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Intellx, Inc., announced the expansion of its distribution for the VA women's condom throughout Europe this summer, after a year of limited trial distribution in Germany and Spain. The world's...

Infection still associated with poor HIV/AIDS prognosis.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Results of a U.K. study highlight how the treatment of cytomegalovirus infection remains a priority to improve the prognosis for people with HIV-1 infection, including people already receiving...

Dopaminergic system implicated in the etiopathogenesis of HIV dementia.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- The dopaminergic system is implicated in the etiopathogenesis of HIV dementia. According to published research from Germany, "The basal ganglia, structures rich in the neurotransmitter dopamine,...

Lactide/glycolide monomers can improve PLGA gentamicin release.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- The addition of lactide/glycolide monomers can improve gentamicin release from drug-loaded PLGA discs. "In order to develop the desirable drug release patterns such as no lag time and exact...

Liposomal encapsulation of nisin enhances anti-Listeria efficacy.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Liposomal encapsulation of nisin and lysozyme enhances their anti-Listeria efficacy. In a recent study from the United States, the "[e]fficacy and stability against Listeria monocytogenes of nisin...

Synthetic polymers affect migration of monocytes through cervical mucus.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- While studying the use of synthetic polymers in topical microbicides, St. Louis University researchers discovered that two such products alter migration of monocytes through cervical mucus. ...

Mineralization of erythromycin A in aquaculture sediments studied.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Scientists have studied the mineralization of erythromycin A in aquaculture sediments. "Mineralization of erythromycin A was studied using two differently [superscript]14C-labeled erythromycins A,...

Ophthalmics company completes $16.5 million private placement.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- InSite Vision, Inc., (ISV), an ophthalmic therapeutics, diagnostics, and drug-delivery company, has completed a $16.5 million private placement with the receipt of net proceeds from the $14.6 million...

Pharmacy company reports increased revenues for the year.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Immtech International, Inc., (IMM) announced results for its fiscal year ended March 31, 2004. For the year ended March 31, 2004, revenues were $2,416,000, as compared to $1,609,000 for the year...

Company wins FDA approval for ciprofloxacin tablets.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Mylan Laboratories, Inc., (MYL) announced that the U.S. Food and Drug Administration has granted final approval for Mylan Pharmaceuticals, Inc.'s abbreviated new drug application for ciprofloxacin...

Genomic selection strategy likely to define targets relevant for HIV-1 therapy.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- A developed genomic selection strategy is likely to define targets relevant for HIV-1 therapy. According to a study from Denmark, "Defining target sites for antisense oligonucleotides in highly...

Alpha,alpha-trehalose derivatives inhibit HIV-1 Tat-TAR RNA interaction.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Alpha,alpha-trehalose derivatives inhibit HIV-1 Tat-TAR RNA interaction. According to published research from China, "Replication of HIV-1 requires specific interactions of Tat protein with TAR...

Cyclooxygenase inhibitors improve T-cell proliferation in HIV-infected patients.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Cyclooxygenase inhibitors improve T-cell proliferation in HIV-infected patients on HAART. "Prostaglandin E[subscript]2 is synthesized via cyclooxygenases and induces cyclic adenosine 3',...

CRF02_AG is the predominant molecular form of HIV-1 in Kumasi, Ghana.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- CRF02_AG is the predominant molecular form of HIV-1 in Kumasi, Ghana. "Recent studies showed the importance of CRF02_AG in West Africa, although the clinical relevance of these recombinant forms of...

CSF quinolinic acid levels are determined by local HIV infection.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- CSF quinolinic acid levels are determined by local HIV infection. "Quinolinic acid (QUIN) is a product of tryptophan metabolism that can act as an endogenous brain excitotoxin when released by...

CD4-induced T-20 binding to HIV-1 gp120 blocks interaction with CXCR4 coreceptor.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- CD4-induced T-20 binding to HIV-1 gp120 blocks the interaction with the CXCR4 coreceptor. "The synthetic peptide T-20, which corresponds to a sequence within the C-terminal heptad repeat region...

Differentiation-dependent cellular cofactors of RT rate limiting in monocytes.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Differentiation-dependent cellular cofactors of reverse transcriptase are rate limiting in Monocytes. According to research published in theJournal of Virology, "Tissue macrophages are an...

Etavirine and other DAPY analogues adapt to changes in the NNRTI-binding pocket.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Etavirine and other DAPY analogues adapt to changes in the NNRTI-binding pocket. According to a study from the United States, "Anti-AIDS drug candidate and non-nucleoside reverse transcriptase...

HIV viral load of subtype C underestimated in assays optimized for subtype B.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- HIV viral loads from patients with subtype C are underestimated in assays that are optimized for subtype B. According to recent research from Israel, "Quantitation assays of HIV-1 RNA used...

HIV-infected patients have higher antibody levels to Pneumocystis Msg fragments.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- HIV-infected patients have higher antibody levels to Pneumocystis Msg fragments. "Seroepidemiologic studies of Pneumocystis pneumonia (PCP) in humans have been limited by inadequate reagents. We...

Inhibitor-binding site to HIV-1 integrase identified using dual methodology.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- The inhibitor-binding site to HIV-1 integrase was identified using dual methodology. According to published research from the United States, "We report a methodology that combines affinity...

Interaction between NCp7 and cTAR is characterized.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- The interaction between NCp7 and cTAR is characterized. According to a study from France, "The viral nucleic acid chaperone protein NCp7 of HIV-1 assists the two obligatory strand transfers...

Interleukin-18 is elevated in HIV-infected patients with lipodystrophy.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Interleukin-18 is elevated in HIV-infected patients with lipodystrophy. According to published research from Denmark, "The level of interleukin-18 (IL-18) is elevated in patients with HIV infection...

Mutations in Env coreceptor binding site reduces CCR5 binding to various extents.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Mutations in the Env coreceptor binding site reduces CCR5 binding to various extents. "An increasingly large number of antiviral agents that prevent entry of human immunodeficiency virus (HIV) into...

Novel dimeric diketoacid-containing inhibitors of HIV-1 integrase synthesized.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Novel dimeric diketoacid-containing inhibitors of HIV-1 integrase have been synthesized. "Discovery of diketoacid-containing compounds as HIV-1 integrase (IN) inhibitors played a major role in...

Novel stavudine analog improved anti-HIV activity and decreased cytotoxicity.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- A novel stavudine analog has improved anti-HIV activity and decreased cytotoxicity. "The antiviral drug 2',3'-didehydro-3'-deoxythymidine (D4T; also know as stavudine and Zerit), which is used...

Site-directed PEGylation of TCS retains anti-HIV activity with reduced potency.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Site-directed PEGylation of trichosanthin retains anti-HIV activity with reduced potency. "Trichosanthin (TCS) was the first ribosome inactivating protein found to possess anti-HIV-1 activity....

Structural basis for selectivity of novel NNRT inhibitors elucidated.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- The structural basis for selectivity of a group of novel NNRT inhibitors has been elucidated. "We have previously described a novel class of nonnucleoside reverse transcriptase (RT) inhibitors, the...

HIV antibody test false-positive in a dialysis patient.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- An HIV antibody test was false-positive in a dialysis patient. According to recent research published in the journal Pediatric Nephrology, "A patient developed end-stage renal disease secondary to...

Novel oral CCR5 antagonists are highly potent against HIV-1.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Novel oral CCR5 antagonists are highly potent against HIV-1. "The search for orally active CCR5 antagonists was performed by chemical modification of the, 1-benzothiepine 1,1-dioxide 3 and...

Prolonged tenofovir administration results in adverse effects on kidney and bone.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Prolonged tenofovir administration results in adverse effects on kidney and bone. According to a study from the United States, "The reverse transcriptase inhibitor 9-[2-(phosphonomethoxy)propyl]...

Tenofovir's ability to suppress viremia dependent on presence of CD8+ cells.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Tenofovir's ability to suppress viremia is dependent on the presence of CD8+ cells. "The ability of tenofovir to suppress viremia in simian immunodeficiency virus (SM)-infected macaques for years...