Anti-Infectives Week articles from July 2003

Anti-Infectives Week archives from July 2003

Harmless bacteria may contribute to production of deadly toxin.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- The virulent Escherichia coli O157:H7 bacterium could be enlisting the help of formerly harmless intestinal bacteria to cause some lethal side effects, say researchers from the University of Cincinnati...

Carpobrotus edulis extract effective against lymphoma, staphylococcal infection.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- A novel plant extract can sensitize drug-resistant lymphoma cells and induce antistaphylococcal immune responses. "Although alkaloids from the family Aizoaceae have anticancer activity, species of...

Oritavancin effective against cephalosporin-resistant pneumococcal meningitis.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - The novel antimicrobial agent oritavancin (LY333328) is effective against cephalosporin-resistant pneumococcal meningitis, researchers in Spain say. Carmen...

Terbinafine can cause severe hepatitis.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- The antimicrobial agent terbinafine can cause severe hepatitis in some patients. "Terbinafine, an orally and topically active agent licensed for treatment of dermatophytic infection, has gained...

Report says microbial genotyping is an underserved market.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- With public attention focused on outbreaks of severe acute respiratory syndrome (SARS) and monkeypox, along with fears of bioterrorism, microbiologists are increasingly finding themselves in the...

Multiple apoptotic pathways are used by virulent strain of Toxoplasma gondii.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Virulent strains of Toxoplasma gondii appear to induce multiple apoptotic pathways in a wide range of splenic cells. "Toxoplasma gondii is an opportunistic intracellular parasite. Infection with...

IGEN expands biodefense customer base in Europe.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- IGEN International, Inc., (IGEN) announced that the French Ministry of Defense has purchased IGEN's biological agent detection products, adding France to the company's base of European customers using...

INT wins NSF grant biological agents sensor.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- The National Science Foundation awarded Integrated Nano-Technologies (INT) a grant for further development of chemical processes pertaining to its BioDetect system. The device is the first...

Sterilized plastic sheets reduce infection risk during hydrotherapy.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- The use of sterilized plastic sheets reduces the infection risk for burn patients undergoing hydrotherapy. According to published research from Uladag University in Bursa, Turkey, "the shower...

First-ever images of developing virus in cellular host reported.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- High-quality images of a virus still forming in its cellular host shed light on how viruses reproduce, knowledge that could prove important to the development of antiviral drugs. A team including...

Although plant extracts are promising, quality control is still an issue.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Although plant extracts are promising therapeutics, there are still many quality control problems for production. "There is increasing interest in plant extracts as potential therapeutic agents and...

Concern expressed over uncontrolled use of anti-HIV drugs.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Uncontrolled use of antiretroviral drugs in developing countries could accelerate HIV resistance, warn researchers in an article in the British Medical Journal. Most people in developing countries...

H pylori infection should be eradicated early in high-risk groups.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- H pylori infection should be eradicated early in high-risk groups. "Gastric carcinoma is a worldwide disease with widely variable incidence in different geographic areas. In contrast to an overall...

Helicobacter and Chlamydia infections may raise heart disease risk.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Helicobacter pylori and Chlamydia infection may increase the risk of atherosclerosis. In a study from Poland, levels of antibodies to H. pylori, "Chlamydia spp. and Mycobacterium bovis were...

Azithromycin best macrolide against community-acquired pneumonia.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Azithromycin should be the first-line macrolide used to treat community-acquired pneumonia (CAP). "Combination treatment with a beta-lactam plus a macrolide may improve the outcome" for elderly CAP...

Gonococcal ciprofloxacin resistance increasing in United Kingdom.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Neisseria gonorrhoeae resistance to ciprofloxacin is rising in the United Kingdom. "The Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) monitors trends in antimicrobial...

Early and late endosome proteins Rab5 and Rab7 are required for entry, infection.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Influenza virus requires early and late endosome proteins Rab5 and Rab7 for entry and infection of cells. "Enveloped viruses often enter cells via endocytosis; however, specific endocytic...

Monocyte's strong response to Campylobacter jejuni may cause pathology.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Live or killed Campylobacter jejuni are capable of eliciting powerful immune responses from monocytes that may be responsible for the degree of inflammation seen in infected humans. "Campylobacter...

CD4+ and CD8+ T cells produce IL-17 following IL-23 stimulation.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- CD4+ and CD8+ T cells produce IL-17 following IL-23 stimulation as part of the lung response to Klebsiella pneumoniae. "Local production of IL-17 is a significant factor in effective host defense...

Plasmodial heat shock protein 90 may be target.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Plasmodial heat shock protein 90 (Hsp90) may be a target for antimalarial therapy. "Hsp90 is important for normal growth and development in eukaryotes," researchers in India explained. "Together...

CC chemokine ligand 2 concentration can determine nematode's infective ability.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Presence of CC chemokine ligand 2 allows for expulsion of gut nematode Trichuris muris; absence allows infection. According to recent research from England, "Despite a growing understanding of the...

In U.S.A., nosocomial infections of cancer patients are mostly staphylococcal.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- In the United States, nosocomial infections of cancer patients are mostly due to Staphylococci. According to published research from Germany, "A total of 2340 patients with underlying malignancy...

Lack of STD awareness challenges growth of diagnostic market.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Growth of diagnostic markets are directly dependent on an increasing awareness of the symptoms of sexually transmitted diseases (STDs), which in turn spur the demand for routine screening facilities....

S. aureus vancomycin susceptibility affected by mprF gene.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- The vancomycin susceptibility of Staphylococcus aureus is affected by mutations in the mprF gene. In a study from the United States, a chemically generated S. aureus RN4220 mutant, "GC6668, was...

Novel prodrug shows promise against methicillin-resistant S. aureus.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- A novel prodrug shows promise for the treatment of drug-resistant staphylococcal infections. "Crystalline 1 (TAK-599) is a novel N-phosphono prodrug of anti-methicillin-resistant Staphylococcus...

Sortase gene srtA appears to be involved in adhesion to host pharynx.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- The sortase gene srtA of Streptococcus pneumoniae appears to be involved in adhesion to host pharyngeal cells. According to recent research published in the journal Infection and Immunity,...

Novel antimycobacterial agent derived from Apiaceae plant.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- A novel plant-derived agent has demonstrated potent antimycobacterial activity. "Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of...

Pall filter provides barrier from pathogens in hospital water systems.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- In response to the increasing number of outbreaks in U.S. hospitals, Pall Corp. introduced the Pall AquaSafe Water Filter. The point-of-use filter prevents the spread of Legionella and other...

The antimicrobial peptide Ac-RRWWRF-NH2 disrupts bacterial lipid bilayers.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- The antimicrobial peptide Ac-RRWWRF-NH2 disrupts negatively charged bacterial lipid bilayers. According to a study from Canada, "The hexapeptide Ac-RRWWRF-NH2 has earlier been identified as a...

Nano-sized silver particles open way to new breed of antimicrobial materials.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Scientists can now incorporate silver particles into polypropylene to produce an anti-microbial material that could be used in anything from carpets, to napkins, and surgical masks. Silver has...

Infections in France show different degrees of prevalence and resistance.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Gram-positive cocci have variable degrees of prevalence and resistance in France, depending on the area of specialty. According to a study from France, "The contributions of clinical epidemiology...

Growth, resistance, and genotyping of bacteria can help differentiation.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Ochrobactum species can be differentiated by growth and resistance characteristics, but genotyping was not as helpful as was originally expected. According to a study from France, "Two species of...

Interferon alpha and oligoadenylate synthetase isoform mediate resistance.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Interferon alpha and an oligoadenylate synthetase isoform mediate resistance to West Nile virus infection. "Over the past 7 years, West Nile zoonosis has been an emerging concern for public health...

A commercial IgG/IgM Western blot assay works well for early postnatal diagnosis.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- A commercial Western blot assay that compares maternal and infant bands can determine early on if there is congenital toxoplasmosis. "The aim of this study was to evaluate a commercial Western...

Beta 2-microglobulin regulates IFN-gamma, virus-specific IgG; resists disease.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Chronic coxsackievirus myocarditis may develop as a result of beta 2 microglobulin, but not perforin, dysfunction. According to published research from Germany, "To gain insight into the...

Genedata and Novartis expand collaboration in anti-infectives research.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Genedata, AG, a specialist for scientifically validated software systems and solutions for the life-science industry, announced a significant extension of its collaboration with Novartis. Under...

Food Safe expands into sanitization for meat, poultry, and dairy industries.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Food Safe, Inc., announced that the company is expanding its food safe process to include sanitization for the meat, poultry, and dairy industries. Food Safe, which has previously developed food...

Scrub typhus may not suppress infection.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Overall, scrub typhus does not have an inhibitory effect on HIV replication. "While a number of microbial infections induce a transient burst in viral load in individuals infected with human...

Invasin may play key role in Yersinia infection pathogenesis.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- The Yersinia protein invasin may play a key role in the pathogenesis of infection. "The chromosomally encoded inv gene product is an outer membrane protein that is functionally expressed in the...

Highly polymorphic gene region useful for strain identification.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- A highly variable region of the mycobacterial genome is useful for strain identification. "Sequence analysis of a specific region of the mycobacterium rpoB gene in 35 mycobacterial strains...

Fourth patent awarded covering macrolide antibiotics.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Enanta Pharmaceuticals, Inc., announced that the United States Patent and Trademark Office has issued the fourth patent associated with the company's antibacterial research program. This latest...

First pediatric HIV/AIDS center to open in Botswana.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- A unique partnership between a government, a corporation, and an academic institution has led to the opening of the first center in Africa focused exclusively on caring for children with pediatric...

Highmark's flu campaign increased immunization rates among seniors by 14%.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- While the blistery winter left many people feeling drab, few actually came down with the infamous winter illness - the flu - thanks in part to Highmark's successful influenza and pneumococcal...

Agreement entered to accelerate SARS program.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Hemispherx Biopharma, Inc., (HEB) announced that it has entered into a definitive agreement with Business Asia Consultants (BAC), with offices in the U.S. and Hong Kong. BAC assists companies in...

Sendai viral production is temperature-sensitive, does not occur at 41 degrees C.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- At 41 degrees C, Sendai virus doesn't place hemagglutinin-neuraminidase in the membrane, and doesn't begin budding. "In a previous study, it was found that the synthesis of hemagglutinating virus...

Anti-IFN-gamma accelerated fibrin deposition, repair; decreased bacteria.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- In a model of septic peritonitis based on cecal puncture, antibody against IFN-gamma accelerated fibrin deposition and repair of tissue without increasing serum fibrin, and this also decreased...

In situ hybridization suitable for diagnosis.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- In situ hybridization is an effective method for distinguishing smallpox cases from similar infections. "The potential for a bioterrorism-induced smallpox outbreak has been much discussed of...

New test developed to screen donated blood for WNV.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Chiron Corp. (CHIR) announced the availability of the Procleix West Nile Virus Assay to screen donated blood specifically for the West Nile virus (WNV). Blood centers in the United States will...

Fluoroquinolone treatment linked to tendon injury.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Treatment with fluoroquinolone antibiotics is significantly associated with tendon injury. "With the expanded use of fluoroquinolones for the treatment of community-acquired respiratory infections...

Estriol-containing vaginal pessaries not suitable for UTI prevention.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Vaginal pessaries containing estriol are not suitable for infection prophylaxis. Researchers in Israel "compared the efficacy and safety of estriol-containing vaginal pessary use with those of oral...

Dalbavancin highly active against gram-positive bacteria.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- The novel antibiotic dalbavancin may be superior to vancomycin and other agents for the treatment of many bacterial infections. "Dalbavancin is a novel semisynthetic glycopeptide with enhanced...

Low-dose cefaclor effective for UTI prevention in children.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Low-dose cefaclor is safe and effective for preventing urinary tract infections (UTIs) in children with vesicoureteral reflux (VUR). "Sulfamethoxazole/trimethoprim (SMX/TMP) and nitrofurantoin are...

Ertapenem active against resistant pneumococci.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Ertapenem is highly active against drug-resistant, meningitis-causing pneumococcal pathogens. According to published research from Switzerland, "the penetration of ertapenem, a new carbapenem with...

Data shows reduced opportunistic infections in AIDS patients treated with HE2000.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Hollis-Eden Pharmaceuticals, Inc., (HEPH) announced additional data from a phase II clinical trial conducted in South Africa in late-stage HIV patients who have progressed to AIDS (average starting CD4...

FDA okays human trials of ABthrax.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Human Genome Sciences, Inc., (HGSI) announced that it has received clearance from the U.S. Food and Drug Administration (FDA) of its investigational new drug (IND) application to begin human trials of...

Reversible tooth discoloration may occur following linezolid treatment.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Reversible tooth discoloration may occur following linezolid treatment for antibiotic resistant bacteria. According to published research from the United States, "With the increasing frequency of...

Queens, University of Ulster unveil revolutionary therapeutics.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- A new generation of technology will use peptides produced by amphibians to fight multiple-drug-resistant bacteria, the so-called "Doomsday Bugs," and treat cardiovascular diseases and cancer. The...

Hypersensitivity reactions to non-beta-lactam agents are a growing concern.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Hypersensitivity reactions to non-beta-lactam antibiotics and antiviral agents are a growing concern. "As alternatives to beta lactam antibiotics continue to be developed, an increasing number of...

Toxin producing infections may benefit from protein synthesis inhibitors.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Severe microbial infections involving toxins may be best treated by protein synthesis inhibitors; however, comparative clinical studies have not been done. "Morbidity and mortality due to certain...

Pleurisy is found associated with Rickettsia conorii infection.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Pleurisy can be caused by Rickettsia conorii infection, and is treatable with doxycycline. "Rickettsia conorii is endemic in Mediterranean area. We describe an unusual case of R. conorii...

Study suggests Ampligen superior to other antivirals.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Hemispherx Biopharma, Inc., (HEB) announced that the Antiviral Research Group led by Professor Johan Neyts of the Rega Institute, KUL, Leuven, Belgium, has reported a new study that screened several...

DNA viruses like herpes, smallpox, papilloma may be manageable with cidofovir.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Dermatological conditions by DNA viruses including herpes, smallpox, and papilloma may be manageable with topical cidofovir. According to a study from the United States, "Cidofovir is new...

Ivermectin is the best broad spectrum systemic antiparasitic medication.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Ivermectin is the best broad spectrum systemic medication for dermatological parasites including mites. "Ivermectin is the most important systemic antiparasitic medication for dermatologic...

Costs of mass treatment for lymphatic filariasis calculated.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- The costs of mass treatment for lymphatic filariasis using diethylcarbamazine and albendazole in Leogane, Haiti, have been calculated. "In October 2000, 71,187 persons were treated for lymphatic...

Mutations cause resistance to azithromycin in Neisseria gonorrhoeae.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Mutations are causing in vitro resistance to azithromycin in Neisseria gonorrhoeae, according to a report in the International Journal of Antimicrobial Agents. Investigators from the United States...

Viral Tat can kill bystander cells through monocyte TRAIL production.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- The HIV Tat protein can kill healthy cells through the induction of TRAIL secretion by infected monocytes. HIV Tat "has a critical role in viral transcription," explained researchers in the United...

Novel glycosaminoglycans agents have paradoxical effects on viral replication.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- A series of novel glycosaminoglycans agents have paradoxical effects on the replication of different HIV strains. "In the search for new drugs against human immunodeficiency virus type I (HIV-1),"...

Topotecan effective against progressive multifocal leukoencephalopathy.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Topotecan shows promise for the treatment of AIDS-related progressive multifocal leukoencephalopathy (PML). PML "affects about 1 in 20 individuals with the acquired immunodeficiency syndrome...

Therapeutic options for treatment of head lice reviewed.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Therapeutic options for the treatment of head lice (pediculosis capitis) has been reviewed in a recent issue of the journal Clinical Infectious Diseases. "Numerous therapies are available in both...

Novel nucleoside analog active against HBV, HIV.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- A novel agent shows promise for the treatment of both hepatitis B and HIV infection. According to recent research from the United States,...

Caspase-3 causes reactivation of latent herpes simplex virus type 1.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Caspase-3 caused reactivation of latent herpes simplex virus type 1 in sensory neuronal cultures. According to published research from the United States, "Life-long latent herpes simplex virus...

Alpha interferon augments antiviral properties of cidofovir.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Alpha interferon augments the antiproliferative and antiviral activities of cidofovir. According to recent research from the United States, "The antiviral and antiproliferative activities of alpha...

Multidrug-resistant Salmonella enterica found in South Korea.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Multidrug-resistant Salmonella pathogens are present in South Korea. "Six strains of Salmonella enterica serovar Typhi which were resistant to ampicillin, chloramphenicol,...

Role of RovA protein in Yersinia enterocolitica infection elucidated.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- The role of the bacterial RovA protein in Yersinia enterocolitica infection has been elucidated Y. enterocolitica "is an invasive enteric pathogen that causes significant inflammatory disease,"...

Transmission between aquatic birds promotes influenza virus reassortment.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Transmission between aquatic and terrestrial birds likely promotes genetic reassortment of the influenza virus. "A current view of the emergence of pandernic influenza viruses envisages a gene...

Daptomycin effective against resistant staphylococcal, enterococcal pathogens.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - The novel antibiotic daptomycin is highly active against drug-resistant staphylococcal and enterococcal pathogens, researchers in the United States report. ...

Several agents active against vancomycin-resistant Streptococcus pneumoniae.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Several antibiotics are highly active against vancomycin-resistant streptococci. In a study conducted by R. Cha and colleagues at Wayne State University in Detroit, "potential alternatives,...

Polyomavirus infection reduction might improve with early detection, cidifovir.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Renal transplant patients with polyomavirus infection need early detection of virus, reduction of virus, yet avoidance of graft rejection, possibly by treatment with cidofovir. According to a...

NIH grant awarded for novel peptide; phase I study of anti-infective to begin.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Chrysalis BioTechnology, Inc., announced that the company has been awarded a $95,000 SBIR phase I grant from the National Institutes of Health, Division of Microbiology and Infectious Diseases, to fund...

Drosophila model useful for infection study.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- A Drosophila fruit fly model could be useful for study of mycobacterial infections. "Mycobacterium marinum is a pathogenic mycobacterial species that is closely related to Mycobacterium...

Human skin has cathelicidin that acts as a protease inhibitor and antimicrobial.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- The human cathelicidin (HCAP18/LL-37) in skin has dual function of protease inhibition and the cleaved prosequence is a general antimicrobial. "Cathelicidins are a class of small cationic peptide...

Nocardia farcinica was found to be the causative agent in a healthy man.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- A primary psoas abscess was found to have Nocardia farcinica in a non-immunocompromised patient. According to published research from Netherlands, "A 42 yr. old, previously healthy cattle...

Isis and Taiwan company initiate SARS antisense drug discovery effort.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Isis Pharmaceuticals, Inc., (ISIS) and the Industrial and Technology Research Institute (ITRI) of Taiwan (the Republic of China), announced that they will collaborate to identify antisense drug...

T-cell immunophenotyping may aid clinical cytomegalovirus control.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- T-cell immunophenotyping may aid clinical control of cytomegalovirus (CMV) infection after stem cell transplantation. In a study from Spain, "early reconstitution of lymphoid populations was...