Anti-Infectives Week articles from January 2009

Anti-Infectives Week archives from January 2009

Data from J.K. Klitgaard et al provide new insights into anti-infectives.(Report)
January 5, 2009... "Thioridazine has been shown to reverse oxacillin resistance in methicillin-resistant Staphylococcus aureus (MRSA) in vitro. The aim of this study was to investigate whether thioridazine alone or in combination with oxacillin affects the...

Studies from G. Chillemi and colleagues reveal new findings on cancer.
January 5, 2009... "The role of Thr729 in modulating the enzymatic function of human topoisomerase I has been characterized by molecular dynamics ( MD) simulation. In detail, the structural-dynamical behaviour of the Thr729Lys and the Thr729Pro mutants have been...

Research in the area of depression reported from L.W. Mason and colleagues.
January 5, 2009... According to a study from Sutton Coldfield, the United Kingdom, "Linezolid is the first in a new group of antibiotics called oxazolidinones. As a potent antimicrobial, it has activity against methicillin-resistant Staphylococcus aureus (MRSA),...

Researchers from University of Padua report details of new studies and findings in the area of DNA research.
January 5, 2009... According to a study from Padua, Italy, "Human DNA topoisomerase I (hTop1p) catalyzes the relaxation of supercoiled DNA and constitutes the cellular target of the antitumor drug camptothecin (CPT). The X-ray crystal structure of the enzyme...

Findings in drug resistance reported from University of Minnesota.
January 5, 2009... According to recent research from the United States, "Transformation of mitochondria in mammalian cells is now a technical challenge." "In this report, we demonstrate that the standard drug resistant genes encoding neomycin and hygromycin...

Findings from K. Peleg and co-researchers advance knowledge in burn care research.
January 5, 2009... According to a study from Ramat Gan, Israel, "The use of explosives and suicide bombings has become more frequent since October 2000. This change in the nature of terror attacks has marked a new era in the Israeli-Palestinian conflict." ...

Findings from S. Poulakidas et al in burn care research reported.
January 5, 2009... "Frostbite may result in loss of skin and tissue requiring amputation; it occurs most often on the exposed areas such as extremity, digits, ears, etc. The usual treatment is observation for demarcation of the injury before amputation or...

New burn care research findings from C.F. Chi and co-authors described.(Report)
January 5, 2009... According to a study from Taipei, Taiwan, "The purpose of this study was to examine altered pressure garments requested by burn patients, in Taiwan. Three hundred forty-two pressure garments needing alterations were collected from 127 burn...

New burn care research study findings recently were reported by researchers at University of Alabama.
January 5, 2009... "The hands and forearms are frequent sites of burn injury, and due to the high concentration of superficial tendons, bones, and joints, flaps are frequently needed to cover defects in these areas, We present a patient who suffered remote...

New findings from College of Medicine in the area of burn care research published.(Report)
January 5, 2009... "This study examines the prevalence of risk factors for fires and burns in homebound urban elderly. A home safety assessment was performed on 83 patients enrolled in a physician home visiting program," investigators in the United States report...

New findings from K. Theman and co-authors in the area of burn care research published.(Report)
January 5, 2009... According to a study from Toronto, Canada, "Low voltage electrical injury is associated with minor or no cutaneous burns and its symptoms rarely appear on initial examination. The purpose of this study was to determine the ability to return to...

Reports from University of Western Australia describe recent advances in burn care research.(Report)
January 5, 2009... According to recent research from Perth, Australia, "The Polhemus FastSCAN (R) system offers a noncontact method of quantifying limb edema volume by combining laser scanning with 3D spatial orientation. The aim, of this study was to investigate...

Research data from Technical University of Munich update understanding of burn care research.
January 5, 2009... According to recent research from Munich, Germany, "Amniotic membrane (AM) has been used in burns for nearly 100 years. The purpose of this article is to give a comprehensive review of the English literature published in the last two decades...

Researchers from Dicle University provide details of new studies and findings in the area of burn care research.(Clinical report)
January 5, 2009... According to recent research published in the Journal of Burn Care & Research, "Liquefied petroleum gas (LPG), which is used as a type of fuel, is stored as a liquid under high pressure in tanks. Immediate and sudden explosion of these tanks...

Studies from J.J. Klein and colleagues yield new information about burn care research.
January 5, 2009... According to recent research published in the Journal of Burn Care & Research, "A juvenile fire setter can be classified as any youth setting a fire regardless of the reason. Many communities have programs to deal with this problem, most based...

Studies from Shriners Hospital for Children provide new data on burn care research.(Report)
January 5, 2009... "The use of skin grafts after lower extremity amputation in pediatric patients remains a controversial decision. A skin graft may help to preserve residual limb length and knee joint function; however, the literature suggests that it may make...

Study findings from University of Washington broaden understanding of burn care research.
January 5, 2009... "Accounts of self-inflicted death by fire are numerous and are found from antiquity to present times. We review selected examples of self-immolation from historical record, in mythology and as part of religious and cultural tradition,"...

Studies from L.R. Carpenter et al in the area of infection control described.
January 5, 2009... "Ambulatory care visits for methicillin-resistant Staphylococcus aureus (MRSA) infections are increasing dramatically We investigated a pediatric clinic worker's death caused by MRSA. Among 45 clinic personnel, 16 reported recent skin...

Data on injury infection and critical care published by researchers at Wright State University.
January 5, 2009... "Motor vehicle crashes remain a major cause of morbidity and mortality. Adolescents are disproportionately represented among victims," scientists in the United States report (see also Injury Infection and Critical Care). "Several...

Findings from M. Chavko et al in injury infection and critical care reported.
January 5, 2009... According to a study from the United States, "A critical immediate determinant of survival after exposure to blast overpressure (BOP) is cardiovascular and respiratory impairment related to disruption of the alveolar septa and pulmonary...

Findings in injury infection and critical care reported from University of Texas.
January 5, 2009... "Nationwide reduction of speed limits to 65 miles per hour (mph) has the potential to save 2,985 lives every year. We undertook the current study to measure potential cost savings of implementing this injury prevention strategy," scientists in...

Medical College of Wisconsin, Medical College publishes research in injury infection and critical care.
January 5, 2009... "Beta-blockade decreases mortality and morbidity in selected older patient populations undergoing noncardiac general surgery. We hypothesized that preinjury beta blockade would increase mortality in geriatric trauma patients, given...

Recent studies by Y. Guillodo and co-authors add new data to injury infection and critical care findings.(Clinical report)
January 5, 2009... "Although an early diagnosis is crucial to optimize outcomes after injury to the anterior cruciate ligament (ACL), little is known about the performance of emergency room physicians in diagnosing this injury. We hypothesized that emergency room...

Researchers from Kyungpook National University, Medical Department discuss findings in injury infection and critical care.(Report)
January 5, 2009... According to recent research published in the Journal of Trauma - Injury Infection and Critical Care, "Optimal surgical treatment in elderly patients with type II odontoid fracture is still controversial. The purpose of this study is to...

Scientists at Army publish new data on injury infection and critical care.(Report)
January 5, 2009... According to a study from the United States, "Mechanical ventilation of intubated patients is standard to meet oxygenation and ventilation goals. This can require significant energy and oxygen resources." "In military operations and mass...

Studies from University of Texas describe new findings in injury infection and critical care.
January 5, 2009... "The Institute of Medicine has identified trauma center overcrowding as a crisis. We applied corporate Lean Six Sigma methodology to reduce overcrowding by quantifying patient dwell times in trauma resuscitation units (TRU) and to identify...

Study data from University of Utah update understanding of injury infection and critical care.
January 5, 2009... According to a study from the United States, "Thoracolumbar spine (TLS) fractures are rare in the pediatric population but may result in significant morbidity, necessitating a prompt diagnosis. No formal recommendations have been made for...

New cancer research from University of Pennsylvania, Medical Department outlined.
January 12, 2009... "Hypoxia is a dynamic feature of the tumor microenvironment that contributes to drug resistance and cancer progression. We previously showed that components of the unfolded protein response (UPR), elicited by endoplasmic reticulum (ER) stress,...

New drug resistance study findings have been published by S. Ram and colleagues.(Report)
January 12, 2009... According to a study from Lucknow, India, "To determine the occurrence of Escherichia coli harbouring virulence markers of shiga- or entero-toxins and resistance to antimicrobials in surface waters. Surface water samples were collected at six...

Reports outline drug resistance study findings from M. Westerlund and colleagues.
January 12, 2009... According to a study from Stockholm, Sweden, "The membrane transporter multi-drug resistance 1 (MDR1, P-gp) regulates the bioavailability of endogenous and exogenous compounds and has been implicated in disorders such as Parkinson's disease,...

Research from Bayer Healthcare has provided new data on drug resistance.
January 12, 2009... "The development of resistance has rendered several antibiotics clinically ineffective, and there is an urgent medical need for potent and safe antibacterials with a novel and valid mode of action. To avoid cross-resistance, they should...

Studies from S. Ibrahem et al have provided new data on drug resistance.
January 12, 2009... According to recent research published in the journal Clinical Microbiology and Infection, "In order to study the clonality of clinical methicillin-resistant Staphylococcus epidermidis (MRSE) strains and their staphylococcal cassette chromosome...

New burn care research data have been reported by scientists at University of Alabama.
January 12, 2009... "We outline how a change in the manufacturing of an impregnated gauze dressing product impacts upon wound healing and describe the steps taken by the manufacturer and by the University of Alabama at Birmingham (UAB) in the identification and...

New hospital epidemiology research from H. Gbaguidihaore and co-researchers described.
January 12, 2009... In this recent article published in the journal Infection Control and Hospital Epidemiology, scientists in Besancon, France conducted a study "To assess the impact of isolation precautions on the incidence of patients colonized or infected...

New hospital epidemiology study findings recently were published by E.N. Perencevich and co-researchers.
January 12, 2009... "Recognition of seasonal trends in hospital infections may improve diagnosis, use of empirical therapy, and infection prevention interventions. There are very few data available regarding the seasonal variability of these infections,"...

Reports summarize hospital epidemiology research from P. Kiss and co-authors.
January 12, 2009... According to recent research published in the journal Infection Control and Hospital Epidemiology, "Causes and circumstances related to 162 needlestick injuries in nursing homes were analyzed." "In addition to nurses, geriatrics helpers...

Studies from Vrije University Amsterdam in the area of hospital epidemiology described.
January 12, 2009... In this recent article published in the journal Infection Control and Hospital Epidemiology, scientists in Netherlands conducted a study "To determine the incidence density of highly resistant organisms (HROs) and the relative contribution of...

Data on hospital infection detailed by D. Hansen and co-authors.
January 12, 2009... "Demolition or renovation works adjacent to hospitals pose risks of fungal airborne infections. During November 2005 and March 2006 an old building with three floors was demolished on the area of University Hospital of Essen," scientists in...

New findings from I. Sie and co-researchers in the area of hospital infection described.(Report)
January 12, 2009... According to a study from Oslo, Norway, "Healthcare workers (HCWs) might be important in reducing healthcare-associated infections but infected or colonised HCWs may still spread pathogenic microbes to others. Norwegian policies for infection...

New findings from Medical University of Vienna in the area of hospital infection published.
January 12, 2009... According to a study from Vienna, Austria, "At present, no universal agreement on detailed practice for surgical hand preparation exists. In order to fill this gap, in 2002 a Franco-German recommendation for surgical hand preparation was...

New hospital infection study findings have been reported by G. Livni and co-researchers.
January 12, 2009... According to a study from Israel, "We describe an outbreak of bloodstream infections due to Mycobacterium mucogenicum involving five patients in a paediatric haematology-oncology ward over a six-month period. Specimens from faucets on the floor...

New research on hospital infection from D.S. Thompson and co-authors summarized.
January 12, 2009... According to a study from Gillingham, the United Kingdom, "During a period of 11 years, 77 patients had meticillin-resistant Staphylococcus aureus (MRSA) bacteraemia >= 5 days after admission to the intensive care unit (ICU). Ten had no prior...

Reports outline hospital infection research from J.E.A. Somner and colleagues.(Report)
January 12, 2009... "A growing scientific consensus states that the global climate is changing and that human activity is responsible for these changes. It follows that each of us has a responsibility to took at how our own times impact on the environment,"...

Research results from M.W.D. Wren and co-authors update knowledge of hospital infection.
January 12, 2009... "We compared the ability of ultramicrofibre-woven cloths with conventional cloths moistened with water only, for their ability to remove several types of organisms relevant to hospital-acquired infections from a variety of surfaces in...

Studies from M. Stengele and colleagues reveal new findings on hospital infection.
January 12, 2009... "A 2005 survey showed that there are at least four legal product classifications for hand disinfectants in the European Union: medicinal products, biocidal products, cosmetics and medical devices. An internationally harmonized classification...

Research from S. Rottenberg and co-authors yields new data on breast cancer.
January 19, 2009... "Whereas target-specific drugs are available for treating ERBB2-overexpressing and hormone receptor-positive breast cancers, no tailored therapy exists for hormone receptor- and ERBB2-negative (''triple-negative'') mammary carcinomas....

New cancer research from Bristol-Myers Squibb Company discussed.(Report)
January 19, 2009... " Ixabepilone, a semisynthetic analog of natural epothilone B, was developed for use in cancer treatment. This study extends previous findings regarding the efficacy of ixabepilone and its low susceptibility to tumor resistance mechanisms and...

Research from University of Kentucky in the area of cholestasis published.
January 19, 2009... "The endogenous estradiol metabolite estradiol 17 beta-D-glucuronide (E(2)17G) induces an acute cholestasis in rat liver coincident with retrieval of the canalicular transporters bile salt export pump (Bsep, Abcc11) and multidrug...

Study findings from Beaujon University broaden understanding of colon cancer.(Report)
January 19, 2009... "PEP005 is a novel ingenol angelate that modulates protein kinases C (PKC) functions by activating PKC delta and inhibiting PKC alpha. This study assessed the antiproliferative effects of PEP005 alone and in combination with several other...

Findings in drug resistance reported from University of Texas.
January 19, 2009... "Human AP-endonuclease (APE1/Ref-1), a central enzyme involved in the repair of oxidative base damage and DNA strand breaks, has a second activity as a transcriptional regulator that binds to several trans-acting factors. APE1 overexpression is...

Research from State University of New York in the area of cancer described.
January 26, 2009... "Dysregulation of apoptosis is associated with the development of human cancer and resistance to anticancer therapy. The ultimate goal of cancer treatment is to selectively induce cancer cell death and overcome drug resistance," scientists in...

Findings from L.B. Johnson et al in drug resistance reported.(Clinical report)
January 26, 2009... In this recent report, researchers in the United States conducted a study "To evaluate the prevalence, epidemiologic features, and molecular characteristics of colonization with community-associated methicillin-resistant Staphylococcus aureus...

Investigators at University of Amsterdam release new data on drug resistance.
January 26, 2009... "In lymph node (LN) proliferation centers in chronic lymphocytic leukemia (CLL), the environment protects from apoptotic and cytotoxic triggers. Here, we aimed to define the molecular basis for the increased drug resistance and searched for...

New drug resistance data have been reported by scientists at Montreal General Hospital.
January 26, 2009... According to a study from Montreal, Canada, "The role of plant pleiotropic drug resistance (PDR) type ATP-binding cassette (ABC) transporters remains poorly understood. We characterized the expression of the rice pleiotropic drug resistance...

New drug resistance research from E. Weisberg and colleagues discussed.
January 26, 2009... According to recent research published in the journal Blood, "An attractive target for therapeutic intervention is constitutively activated, mutant FLT3, which is expressed in a subpopulation of patients with acute myelocyic leukemia (AML) and...

University of Washington details research in hospital epidemiology.
January 26, 2009... In this recent report, researchers in the United States conducted a study "To identify healthcare worker (HCW) and work-site characteristics associated with HCWs' reported use of recommended respiratory-infection control practices in primary...

Investigators at University of Texas publish new data on microbial research.
January 26, 2009... According to a study from the United States, "In this study, we examined the tissue specificity of inflammatory and oxidative responses and mitochondrial dysfunction in mice infected by Trypanosoma cruzi. In acute mice, parasite burden and...