Anti-Infectives Week articles from January 2004

Anti-Infectives Week archives from January 2004

Amphotericin B lipid complex used to treat invasive fungal infections.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Amphotericin B lipid complex is useful in the treatment of invasive fungal infections. "Amphotericin B lipid complex (ABLC; Abelcet), Enzon Pharmaceuticals) has become the dominant marketed lipid...

The antifungal ketoconazole may cause liver injury.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- The antifungal ketoconazole may cause liver injury. "We describe a previously healthy woman who developed liver cirrhosis as a sequela of acute hepatic injury that was induced by ketoconazole...

Varying antimicrobial activity in follicular fluids may be due to lysosyme.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Human follicular fluids (HFF) have varying antimicrobial activities that may be due to lysosyme. "The aim of this study was to explore the antimicrobial activity of HFF, to test the hypothesis that...

Lactoferrin-derived peptides have antimicrobial activity beyond iron depletion.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Lactoferrin-derived peptides have antimicrobial activity beyond simple iron sequestration. "Lactoferrin is a member of the transferrin family of iron-binding proteins. Numerous functions have been...

Antisense peptide nucleic acid offers strain selection without antibiotics.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Antisense peptide nucleic acid offers strain selection without antibiotics. According to recent research from Denmark, "antibiotics are widely useful in medicine, agriculture, and industrial...

Company issues statement on antiretroviral treatment study.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- GlaxoSmithKline issued the following statement: We welcome the publication in the December 11 [2003] issue of New England Journal of Medicine of the results of ACTG384, a study comparing anti-HIV...

Age-related disease susceptibility may depend on complement regulatory proteins.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Healthy babies, children, and adults have different levels of complement regulatory proteins that may play a role in age-related disease susceptibility and morbidity. According to recent research...

Inhaled endotoxin increases lung surfactant protein A, lowers it in lavage fluid.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Surfactant protein A (SP-A) is expressed more in lung, but presence lowered in lung lavage fluid, following repeat exposure to inhaled endotoxin. "Chronically inhaled endotoxin, which is ubiquitous...

Therapy of intestinal protozoa outlined.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- A researcher has outlined the treatment of intestinal protozoa in a recent issue of Trends in Parasitology. According to published research from the United States, "Protozoa that parasitize the...

Doxycycline inhibits T cell cytokine reaction to staphylococcal exotoxin.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Doxycycline inhibits T-cell proliferation, cytokine reaction to staphylococcal exotoxins (SE); thus may lower toxic effects. According to a study from the United States, "proinflammatory cytokines...

V. cholerae's resistance genes can leave host, integrate into new one.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Medication may actually stimulate the spread of antibiotic resistance, according to a new report. Vibrio cholerae's antibiotic resistance genes are located on a mobile genetic element, called SXT, which...

Daptomyclin effective for treating resistant Gram-positive infections.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Daptomyclin is a novel lipopeptide antibiotic for the treatment of resistant Gram-positive infections. According to recent research from the United States, "The continuing rise of resistance rates...

Generic amoxicillin with clavulanate potassium launched.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- IVAX Corp. (IVX) announced that its wholly owned subsidiary, IVAX Pharmaceuticals, Inc., is distributing amoxicillin with clavulanate potassium, supplied and licensed by GlaxoSmithKline (GSK). ...

Penicillium chrysogenum can inhibit some aspergilli with PAF protein.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Penicillium chrysogenum produces an antifungal protein, PAF, that is internalized and works on some aspergilli. "The Penicillium chrysogenum antifungal protein PAF inhibits the growth of various...

Gastric epithelial cells produce beta-defensins after H. pylori infection.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Gastric epithelial cells produce beta-defensins following Helicobacter pylori infection. "The beta-defensin peptides are known to be potent antibacterials with a wide spectrum of activity. They,...

Adenovirus proteinase is inhibited by NO from NONOates; viral infection lowered.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Adenovirus proteinase is inhibited by NO from NONOates; viral infectivity lowered. "Nitric oxide (NO) is an antiviral effector of the innate immune system, but few of the viral targets of NO have...

Escherichia coli adheres to bladder epithelium with fimbriae, sialic acid.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Escherichia coli adheres to bladder epithelium with fimbriae, and nonspecifically with sialic acid. "The first step in the bacterial colonization and infection of uropathogenic Escherichia coli is...

Anti-idiotypic antibody fragment effective against candidiasis.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- An engineered synthetic killer anti-idiotypic antibody fragment was effective against experimental mucosal and systemic candidiasis. "Peptides derived from the sequence of a single-chain,...

Pediatric measles-like rash may be separate or coinciding HHV-6, HHV-7 infection.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Pediatric measles-like rash may be separate or coinciding human herpesvirus-6 and/or 7 (HHV-6 and/or HHV-7) primary infection. According to a study from Brazil, "we investigated primary HHV-6,...

Biodegradable particles mimic white blood cells, target inflamed tissue.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Scientists have developed biodegradable polymers that can mimic the ability of white blood cells to target inflamed blood vessel walls, according to a new study led by Ohio University researchers. ...

Antiviral pronucleotides improved through cycloSal system.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- The cycloSal system can be used to improve the efficacy of antiviral pronucleotide agents. "Pronucleotides represent a promising alternative to improve the biological activity of nucleoside analogs...

HIV RNase H activity characterization leads to novel anti-HIV agents.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- The activity of HIV RNase H has been elucidated, and this information has been used to develop novel anti-HIV agents "Human immunodeficiency virus (HIV) RNase H activity is essential for the...

Markovian model can aid anti-HIV drug design.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- A novel Markovian model may aid the design of antiretroviral agents. "The design of novel anti-HIV compounds has now become a crucial area for scientists working in numerous interrelated fields of...

Oxygenated xanthones show antimalarial activity in vivo.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- A group of novel xanthone agents has demonstrated antimalarial activity in animals. In a recent study from Cameroon,"A series of oxygenated xanthones was prepared so that the antimalarial activity...

Suramin analogues block P. falciparum MSP1 secondary processing.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- A group of suramin analogues disrupt plasmodial MSP1 secondary processing, a key process in malaria infection. According to a study from England, "Malarial merozoites invade erythrocytes; and as an...

Advanced and refractory human alveolar echinococcosis responds to amphotericin B.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Advanced and refractory human alveolar echinococcosis responds to amphotericin B; parasite growth is controlled. According to recent research from Germany, "most patients with alveolar...

Exam gloves now available with anatomically correct fitting.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Aloetouch, the only glove coated on the inside with natural aloe vera gel, is now available in an anatomically correct fitting version to provide optimum comfort while helping to reduce hand muscle...

Posaconazole is most effective against the zygomycete Rhizopus microsporus.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Zygomycete responses differ to amphotericin B, itraconazole, and posaconazole; posaconazole is most effective against Rhizopus microsporus. According to a study from France, "Three isolates of...

Intravenous immunoglobulin may resolve acquired factor V inhibitor complications.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Intravenous immunoglobulin may resolve acquired factor V (FV)inhibitor complications; antibiotics could be one cause. "We report two patients who developed acquired... FV inhibitors not related to...

Spatial technology company launches food safety system.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Global Technology Resources (GTR) has introduced a new system designed to detect, track, and manage food safety threats across the supply chain. Combining web-based global positioning system...

Exposure to UV irradiation kills off harmful bacteria in food.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- The presence of Escherichia coli bacteria, found in foods such as egg white and apple juice, is a major public health concern. The bacteria have, in the past, been inactivated by heat pasteurization -...

Surgery still the best option for allergic fungal sinusitis in atopic patients.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Surgery remains the best option for allergic fungal sinusitis (AFS) in atopic patients. "Since the early 1980s, AFS has been an increasingly recognized and diagnosed chronic health disorder....

Agreement signed with NIH to develop Theralux device.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Celmed BioSciences, a subsidiary of Theratechnologies (TH), announced that it has signed a collaboration agreement with the National Heart, Lung and Blood Institute (NHLBI) and the U.S. National...

Growth hormone treatment can improve NK-cell function.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Growth hormone therapy can improve NK-cell function in HIV patients. "Previous studies have shown that human natural killer (NK) cells are lost from the periphery and are functionally suppressed...

Mediators of protease inhibitor-induced bone resorption identified.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- The molecular mediators of HIV protease inhibitor-induced bone damage have been identified. "Accelerated bone resorption leading to osteopenia and osteoporosis has been noted in human...

Modified p24 antigen assay useful for disease monitoring in HIV patients.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- A modified p24 antigen assay may simplify disease monitoring in HIV patients. "HIV-1 RNA has become the standard for monitoring antiretroviral therapies," immunologists in Switzerland explained....

Prophylactic antiretroviral treatment reduces T-cell apoptosis.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Prophylactic antiretroviral treatment significantly reduces T-cell apoptosis. "It has been proposed that antiretroviral therapies (ART) possess both antiviral and immunomodulatory activities when...

HIV-1 viral load influences risk of mother-to-child HIV transmission.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Researchers list risk factors for mother-to-child transmission of HIV-1 in a breast-feeding population in a recent issue of the Journal of Acquired Immune Deficiency Syndromes. "Short-course...

IL-4 reduces Helicobacter gastritis, increases somatostatin, lowers gastrin.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Interleukin 4 therapy reduces Helicobacter gastritis by way of somatostatin increases, which reduce gastrin. According to recent research from the United States, "Fifty percent of the world's...

Reinfection with new H. pylori strains is common after antibiotic therapy.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- In Peruvian adults, reinfection with new H. pylori strains is common in the years following antibiotic therapy. According to recent research published in the Journal of Infectious Diseases, "to...

Data support safety, efficacy of Advate.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Study results on Baxter Healthcare Corporation's Advate Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method (rAHF-PFM), presented at the 45th Annual Meeting and Exposition of the American...

New or old Pap smears can be destained and used to test for HSV-2 viral DNA.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- New or old Pap smears can be destained and used to test for herpes simplex 2 viral DNA. "Papanicolaou-stained cervicovaginal smears from six patients with herpes simplex virus (HSV) infection were...

Human enterovirus 71 contains a type I IRES element similar to other enterovirus.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Human enterovirus 71 (EV71) contains a noncoding region with a type I IRES element similar to other enterovirus genomes. According to a study from the United States, "human EV71 is a member of the...

Virological responders to hepatitis C virus therapy have more CD8+ cells.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Virological responders to hepatitis C virus therapy have more CD8+ cells. According to researchers in the Netherlands, "we analyzed the relationship between virological response and baseline immune...

FDA grants approval for Piperacillin injection.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- American Pharmaceutical Partners, Inc., (APPX), announced that it has received approval from the U.S. Food and Drug Administration (FDA) to launch Piperacillin for injection, USP, the generic equivalent...

New flu test for physician offices launched.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Meridian Bioscience, Inc., (VIVO) announced it has begun marketing a new physician's office influenza A&B test. According to Meridian, this rapid test is simple enough to be performed in...

FDA clearance granted for Lyme test kit.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Boston Biomedica, Inc., (BBII) announced that it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for its BBI Borrelia burgdorferi IgM and IgG Western Blot Test Kit. ...

Lyme borreliosis is a risk to zoo visitors; there are infected animals and ticks.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Lyme borreliosis is a risk to zoo visitors; there are infected animals and ticks present on vegetation. According to a study from Germany, "we conducted the first seroepidemiological study to...

DB289 demonstrates potent antimalarial results in human clinical trial.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Immtech International, Inc., (IMM) announced that the company's oral drug candidate, DB289, demonstrated potent antimalarial activity in the human clinical trial conducted in Bangkok, Thailand. The...

Amodiaquine treatment effective for children in chloroquine-resistance area.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Amodiaquine treatment is effective against pediatric malaria in regions with chloroquine-resistant parasites. In a recent study from Nigeria, "The efficacy of amodiaquine against Plasmodium...

Emerging viral diseases present opportunities for niche diagnostics.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- A host of emerging viral infections is providing a market for niche manufacturers of new diagnostic tests, according to a new study released from Kalorama Information. In both human and animal...

PCR can diagnose and type antibiotic-treated invasive meningococcal disease.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Antibiotic-treated invasive meningococcal disease (IMD) can be diagnosed and typed by polymerase chain reaction (PCR). According to recent research published in the journal FEMS Immunology and...

Scientists discover new pathway critical to pathogen survival.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Tuberculosis, the age-old scourge of mankind, is particularly deadly because the bacteria can linger in the body for years or even decades, popping up at any time to cause the life-threatening lung...

Staphylococcus lugdunensis may be the cause of some vertebral osteomyelitis.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Staphylococcus lugdunensis may be the cause of some vertebral osteomyelitis. "We report a case of vertebral osteomyelitis due to the coagulase-negative staphylococcus, Staphylococcus lugdunensis....

FDA approves marketing of Dispermox.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Ranbaxy Pharmaceuticals Inc. (RPI), a wholly owned subsidiary of Ranbaxy Laboratories Limited (RLL), announced that RLL had received approval from the U.S. Food and Drug Administration to market...

Additional patent granted on cartridge technology for DNA analysis.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Cepheid (CPHD) announced that it has been issued U.S. Patent No. 6,660,228, "Apparatus for performing heat-exchanging, chemical reactions." This patent covers the design of the reaction chambers...

Patent granted for method of tissue oxygenation.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Hydron Technologies, Inc., (HTEC) announced the company has been issued patent number 6,649,145, from the United States Patent and Trademark Office, for its new tissue oxygenation technology. This...

David Arkowitz becomes CFO.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Idenix Pharmaceuticals, Inc., announced the appointment of David Arkowitz to the position of CFO. Arkowitz has more than 13 years of experience in financial leadership positions at Merck & Co,...

Following total knee arthroplasty, IL-6 levels are related to a febrile state.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Endogenous pyearogen IL-6 is responsible for postoperative fever in patients with total knee arthroplasty, most likely as a result of surgical inflammation. According to a study from the United...

Resistant rhinosinusitis may indicate another underlying condition.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Resistant rhinosinusitis may mean misdiagnosis of another underlying condition. According to a study from the United States, "there are some patients with rhinosinusitis in whom the condition never...

Compound for influenza tests positive in preliminary in vitro SARS study.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- The Quigley Corporation (QGLY) announced that an independent in vitro study conducted by Retroscreen Virology Limited found that a Quigley test compound previously tested on the influenza virus showed...

LPS-binding domain of cathelicidin linked to IgG is protective against sepsis.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- A cathelicidin fragment with the lipopolysaccharide- (LPS) binding domain linked to IgG is protective against sepsis and death experimentally; while the domain alone is not. According to published...

Survey shows antibiotics initially ineffective in some sinusitis patients.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Almost 40% of acute bacterial sinusitis sufferers report the antibiotic they were initially prescribed did not work the first time, according to a national survey conducted by Wirthlin Worldwide. ...

Pharmaceutical and USAMRIID collaborate on molecule-screening program.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Kemin Pharma announced the formation of a collaborative molecule-screening program with the U.S. Army Medical Research Institute for Infectious Diseases (USAMRIID). Under the terms of the...

Company provides update on StaphVAX development program.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Nabi Biopharmaceuticals (NABI) has continued to advance the development of StaphVAX (Staphylococcus aureus polysaccharide conjugate vaccine) and announced updates to its manufacturing and clinical trial...

High-level vancomycin-resistant Staphylococcus aureus isolated.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Investigators have isolated a high-level vancomycin-resistant strain of Staphylococcus aureus. According to published research from the United States, "Vancomycin is usually reserved for treatment...

Amotosalen-treated T cells prevent CMV infection without inducing GVHD.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- T cells treated with amotosalen prevent CMV infection in murine stem-cell transplant recipients, without triggering graft-versus-host reactions "Infusion of donor antiviral T cells can provide...

Available rapid streptococcal-A-antigen assays still need backup culture.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Available rapid streptococcal-A-antigen assays still need backup culture. "Rapid streptococcal-A-antigen detection assays have good specificity (over 90%) but moderate sensitivity (80-90%), when the...

Immune-mediated inner ear disease has recurrences like some autoimmune diseases.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Immune-mediated inner ear disease (IMIED) behaves recurrently like some autoimmune diseases. "Since the McCabe report, growing indirect evidence has accumulated to indicate the implication of immune...

Molecular assay can aid detection of M. tuberculosis isoniazid resistance.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- A novel molecular assay can help identify INH-resistant strains of mycobacteria. In a study from Italy, "A real-time PCR genotypic assay was developed for the detection of isoniazid (INH) resistance...

Doripenem meets primary endpoints in phase II clinical trial.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Peninsula Pharmaceuticals, Inc., has completed a preliminary analysis of results from its first international phase II clinical trial of doripenem (also known as S-4661), a broad-spectrum carbapenem...

Companies sign agreement to humanize vascular targeting agent antibody.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Peregrine Pharmaceuticals, Inc., (PPHM) has signed an agreement with Aeres Biomedical, Ltd. (London, UK) to humanize one of its vascular targeting agent (VTA) antibodies. Peregrine will provide the...

Company announces extension of Wound Gel shelf life.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- LAM Pharmaceutical Corp. (LAM), a biomedical company focused on the development and commercialization of wound healing and transdermal drug-delivery systems, announced that the shelf life of its IPM...

Antifungals affect gene expression in pathways of Candida albicans.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Fluconazole plus lovastatin had antifungal activity and affected gene expression in the ergosterol and prenylation pathways of Candida albicans. According to published research from the United...

Early antiretroviral treatment is neuroprotective in vertically infected children.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Early antiretroviral treatment has a neuroprotective effect in children vertically infected with HIV. S. Sanchez-Ramon and colleagues at the University of Madrid "performed a retrospective study...

Intranasal RANTES/CCL5 chimera plus truncated exotoxin may prevent fungal asthma.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Intranasal RANTES/CCL5 chimera plus truncated Pseudomonas exotoxin A may prevent early fungal-induced asthma, accelerate clearance. "Regulated upon activation in normal T cells, expressed, and...

Activated gamma delta T cells go to lymph nodes; increase antibody production.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- TCR-triggered gamma delta T cells migrate to lymph nodes; produce costimulatory molecules that enhance B cell antibody production. "Gammadelta T cells are inadequately defined both in terms of...

Linezolid does not raise thrombocytopenia risk in nosocomial pneumonia patients.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Linezolid treatment does not increase the thrombocytopenia risk in nosocomial pneumonia patients. According to recent research from Boston, "Reports from uncontrolled studies suggest that...

Company advances MBI-2401 for bacterial infections.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Micrologix Biotech, Inc., (MGIXF), a developer of anti-infective drugs, has advanced MBI-2401 as the lead development candidate from its lipopeptide program. The compound selected is intended to be...

Pseudomonas aeruginosa has two quorum sensing systems that could be targeted.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Pseudomonas aeruginosa has two quorum sensing systems that could be targeted. "Both of these systems have been shown to be important for Pseudomonas virulence in multiple models of infection,"...

Oral ulceration may indicate Behcet disease, inflammatory bowel syndrome.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Oral ulceration may indicate Behcet disease, inflammatory bowel syndrome, or other systemic disease. "Oral ulceration is a common complaint of patients attending outpatient clinics. The aim of...

Study: Noxafil demonstrates significantly better outcome.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Schering-Plough Corp. (SGP) reported results from an oral presentation on the activity of Noxafil (posaconazole oral suspension) in patients with invasive aspergillosis, a life-threatening fungal...

Application filed with FDA for approval of chlamydia test.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Digene Corporation (DIGE) announced that it has submitted a 510(k) with the U.S. Food and Drug Administration for approval to use the Cytyc PreservCyt vial (used for the ThinPrep Pap Test) as a...

Company achieves phase III patient enrollment goal for Xibrom.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- ISTA Pharmaceuticals, Inc., (ISTA) announced that it had reached its goal for patient enrollment in the company's phase III study of Xibrom (0.1% bromfenac sodium ophthalmic solution). A topical,...