Anti-Infectives Week articles from February 2004

Anti-Infectives Week archives from February 2004

ABC multidrug efflux pump identified in Enterococcus faecalis.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- An ABC multidrug efflux pump, EfrAB, has been identified in Enterococcus faecalis. According to recent research published in the journal Antimicrobial Agents and Chemotherapy, "A DNA fragment...

Atazanavir is novel azapeptide inhibitor of HIV-1 protease.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Atazanavir is a novel azapeptide inhibitor of the HIV-1 protease. "Atazanavir is a novel azapeptide protease inhibitor (PI) that has been approved by Food and Drug Administration (FDA) for use in...

Reversible anosmia reported after amikacin therapy.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Reversible anosmia is possible after amikacin therapy. "Olfactory disorders are among the rare adverse effects of antibiotic therapy," scientists in Switzerland explained. "To date, olfactory...

CsA derivatives show promise as antiretroviral agents.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- A series of novel CsA-derived agents strongly inhibit HIV activity with limited immunomodulatory effects. In a study conducted by M. Evers and colleagues at Aventis Pharma S.A. in Vitry-sur-Seine,...

Quinupristin/dalfopristin may be effective against Gram-positive infections.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Quinupristin/dalfopristin may be effective in hematology or oncology patients with multidrug-resistant Gram-positive infections, researchers say. "Gram-positive pathogens, primarily Staphylococcus...

Subcontract given to develop anthrax vaccines using nanotechnology.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- BioSante Pharmaceuticals, Inc., (BPA) announced that it has been awarded a subcontract valued at $658,207 for the development of anthrax vaccines for delivery via alternative routes of administration....

TetL tetracycline efflux protein from Bacillus subtilis is dimer in membrane.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- The TetL tetracycline efflux protein from Bacillus subtilis is a dimer in the membrane and in detergent solution. According to recent research published in the journal Biochemistry, "The TetL...

Genome Therapeutics retains certain rights to bone diseases' research program.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Genome Therapeutics Corp. (GENE) and Amgen, Inc., have concluded their research collaboration focused on discovering and developing therapeutics for bone diseases. Announced in January of 2003, the...

New antibiotic effective for diabetic foot infections.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- A clinical trial involving 371 patients in eight countries shows that linezolid, a new antibiotic, is at least as effective as two older therapies for treating diabetic foot infections. The drug...

Federal government report illustrates current diphtheria risks.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- According to the January 9 issue of the U.S. Centers for Disease Control and Prevention's (CDC) Morbidity & Mortality Weekly Report (MMWR), a recent case of fatal diphtheria was diagnosed in a U.S....

Aminoglycoside-arginine conjugates show promise as antiretroviral agents.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- A series of novel compounds show great promise as antiretroviral agents. In a recent study, scientists in Israel "designed and synthesized aminoglycoside-arginine conjugates (AACs) as potential...

Fullerene C[subscript]60 derivatives have antiretroviral activity.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Novel [60]fullerene derivatives have demonstrated potent antiretroviral activity. According to recent research from Italy, "A new series of bis-functionalized fullerene C[subscript]60 derivatives...

Glycosylated beta-amino hydroxamates show promise as antimalarials.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- A series of novel beta-amino hydroxamates show promise as antimalarial agents. According to research from India, "Glycosylated beta-amino acids (3-18, 38, 39), obtained by hydrolysis of glycosylated...

L-chicoric acid analogues strongly inhibit HIV integrase.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- A series of novel L-chicoric acid derivatives provide improved inhibition of HIV integrase compared with their parent drugs. "HIV integrase catalyzes the integration of HIV DNA copy into the host...

Lysine sulfonamides inhibit HIV protease.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Novel sulfonamides show promise as HIV protease inhibitors. In a recent study from Canada, "A series of Nalpha-isobutyl-Nalpha-arylsulfonamido-(Nepsilon acyl) lysine and lysinol derivatives were...

Novel 1beta-methylcarbapenems have potent antimicrobial activity.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- A series of novel carbapenems have demonstrated potent antimicrobial activity. Scientists in South Korea described the "synthesis and antibacterial activity of novel 1beta-methylcarbapenems 1a-f...

Novel nucleoside analogues fail to show anti-HIV activity.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- A series of novel nucleoside analogues have failed to demonstrate anti-HIV activity. D. Egron and colleagues working at the University of Montpellier II described the results of their "detailed...

Food safety company reports record quarter; net income increases 10%.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Neogen Corp. (NEOG) announced second quarter net income increased 10% to $1,543,000 from $1,401,000 in the prior year. Adjusted for the December 5-for-4 stock split, net income per share was $0.19...

MacAndrews & Forbes and TransTech Pharma complete $10,000,000 investment.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- SIGA Technologies, Inc., (SIGA), a biopharmaceuticals company developing products for the prevention and treatment of serious infectious diseases, including products for use against biological warfare...

Detergent rinses have limited efficacy for produce decontamination.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Detergent rinses have limited efficacy in removing pathogens from produce. "Fresh produce has been implicated in several foodborne disease outbreaks," researchers in the United States noted....

Company to transfer S. pneumoniae patent portfolio to Aventis.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Genome Therapeutics Corp. (GENE) and Aventis (AVE) have agreed to the sale of Genome Therapeutics' pending patent applications relating to the organism Streptococcus pneumoniae (S. pneumoniae) to...

PTSD has some beneficial effects in HIV patients.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Surprisingly, PTSD appears to have some beneficial effects in HIV patients. "Previous research has reported rates of posttraumatic stress disorder (PTSD) following diagnosis with a life-threatening...

M. tuberculosis co-infection possible in HIV CAP patients.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- M. tuberculosis co-infection should be tested for in HIV patients with refractory CAP. According to physicians in South Africa, "Pulmonary infections with more than one organism are common in human...

Novel regimen may improve disseminated aspergillosis survival.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- A novel treatment regimen may improve survival in disseminated aspergillosis patients. Researchers in Israel conducted a study "to assess the efficacy of amphotericin B (AMB), AMB-intralipid...

Viral fitness determines viral rebound during treatment interruptions.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- HIV fitness determines viral rebound during planned therapy interruptions. According to recent research from Switzerland, "Human immunodeficiency virus type 1 (HIV-1) isolates from 20 chronically...

Lymph node TB characterized in HIV+ and HIV- patients.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- The features of lymph node tuberculosis have been characterized in HIV and other patients. "Lymph node tuberculosis is the most frequent form of extrapulmonary tuberculosis especially in...

Specialist clinic service for HIV+ mineworkers helps prevent TB.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- A novel clinic helps prevent tuberculosis and other infections in HIV+ mineworkers. "Occupational settings offer an ideal opportunity to provide preventive health services for HIV-infected workers,"...

IgG antibodies confer sterilizing protection to SHIV-infected macaques.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Transfer of neutralizing IgG antibodies to macaques 6 hours (but not 24 hours) after SHIV infection conferred sterilizing protection. According to a study from the United States, "Passive transfer...

Antibiotics may help stop stomach cancer.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Antibiotics can help prevent stomach cancer in people who carry a common strain of bacteria known to cause ulcers, a study found. The Chinese study added to the already strong evidence that...

H. pylori CagA mimicry may underlie cITP.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Molecular mimicry by the Helicobacter pylori CagA protein may underlie cITP associated with infection. H. pylori eradication "often leads to platelet recovery in patients with chronic idiopathic...

Chloroquine-resistant Plasmodium vivax present in Peru.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Chloroquine-resistant P. vivax is present in some areas of Peru. According to a study from Peru, "Reports from several sites in South America suggest the presence of isolated cases of...

Halofantrine effective in Vietnam.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Halofantrine remains effective against malaria in Vietnamese patients. "Drug-resistant Plasmodium falciparum is present in Vietnam," scientists there noted. In a recent study, D.H. Nhan and...

Advances reported in antimicrobial drug discovery through assay development.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- A team of scientists from Genedata and Bayer HealthCare published in the January issue of Genome Research a novel technology that is expected to significantly accelerate the hunt for novel antimicrobial...

M. smegmatis GPLs inhibit macrophage phagocytosis.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- A group of M. smegmatis GPLs prevents macrophage phagocytosis of several mycobacterial species. "Phagocytosis by macrophages represents the early step of mycobacterial infection. It is governed...

Acinetobacter baumannii is hospital opportunist.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Acinetobacter baumannii is an opportunistic pathogen operating in hospitals creating serious infections such as pneumonia. It principally affects patients who have weakened health. The mortality...

Hemorrhoid banding system maker assigned Japanese patent application number.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Medsurge Medical Products Corp. (MSR) was notified and assigned a patent application number establishing priority for Japan. The application was filed by Medsurge. Establishing a priority date and...

Milne joins board of directors at antibiotics drug development company.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Rib-X Pharmaceuticals, Inc., a privately held biotechnology company developing the next generation of antibiotics, announced that George M. Milne, Jr., PhD, a former executive VP for global research and...

Palivizumab used for prophylaxis against respiratory syncytial virus.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Palivizumab is recommended for use as prophylaxis against respiratory syncytial virus in infants with congenital cardiac disease. "New data are emerging on the use of palivizumab as prophylaxis...

High-dose pulse corticosteroid treatment more effective than low-dose therapy.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- High-dose pulse corticosteroid treatment for SARS is superior to low-dose therapy. According to a study from China, "The treatment of atypical pneumonia, subsequently termed severe acute respiratory...

Inhibition of SARS coronavirus with Neugene antisense drugs reported.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- AVI BioPharma, Inc., (AVII) presented confirmatory positive results on the inhibition of the SARS coronavirus using its Neugene antisense drugs. Michael Buchmeier, PhD, of The Scripps Research...

Topical application of DEET effective schistosome repellant.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Topical application of DEET is reported to be an effective schistosome repellant. "N,N-diethyl-m-toluamide (also known as DEET) is a broad-spectrum insect repellent that is used extensively against...

Crystal structure of S. pneumoniae chorismate synthase solved.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- The structure of streptococcal CS has been characterized, providing information that could lead to novel antimicrobial agents. In a recent study from Scotland, "The crystal structure of chorismate...

Structure of mycobacterial EPSP synthase elucidated.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- The molecular structure of mycobacterial EPSP synthase has been elucidated. "The shikimate pathway is an attractive target for herbicides and antimicrobial agent development because it is essential...

Fluconazole Injection issued tentative ANDA approval.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Sicor Inc. (SCRI) announced that the U.S. Food and Drug Administration has issued a tentative approval of an Abbreviated New Drug Application (ANDA) submitted by its wholly owned subsidiary, Sicor...

Clinical management of Mycobacterium fortuitum skin infection outlined.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Researchers describe the clinical management and outcome of nail salon-acquired Mycobacterium fortuitum skin infection in a recent issue of Clinical Infectious Diseases. "Nontuberculous...

Salmonella enterica isolated from humans and food animals characterized.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Researchers have characterized Salmonella enterica serotype Newport isolated from humans and food animals. "Salmonella enterica serotype Newport isolates resistant to at least nine antimicrobials...

Accuracy of six systems for Vibrionaceae identification compared.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Scientists have compared the accuracy of six commercially available systems for identification of members of the family Vibrionaceae. According to recent research published in the Journal of...

Antimicrobial agents isolated from Turkish Pimpinella plants.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- A series of novel antimicrobial agents have been isolated from Turkish Pimpinella plants. In a recent study from Turkey, "A new, 4-(2-propenyl)-phenyl angelate (1) and four known phenylpropanoids...

STAT1 blockade shows promise for clearance of latent HIV reservoirs.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- STAT1 blockade shows promise for the clearance of HIV reservoirs in patients with latent infection. "Current highly active antiretroviral therapy (HAART) cannot eliminate HIV-1 from infected...

Pharmaceutical company begins phase I clinical trial of inhaled doripenem.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Peninsula Pharmaceuticals, Inc., announced that patient enrollment has begun in a phase I trial of an inhaled formulation of its lead product candidate, doripenem, a broad-spectrum carbapenem...

Bacteriophage genomics method to antimicrobial drug discovery published.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Identifying the targets that bacterial viruses, or phages, use to halt bacterial growth and then screening against those targets for small molecule inhibitors that attack the same targets provides a...

Once-weekly Dalbavancin shows superiority for bloodstream infections in study.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Vicuron Pharmaceuticals Inc. announced results of a phase II clinical trial demonstrating that dalbavancin showed superior efficacy to vancomycin, the current standard of care for the treatment of...

CRADA inked for pancreatic, ovarian, and lung cancer antibody development.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Morphotek, Inc., announced it has signed a cooperative research and development agreement (CRADA) with the National Cancer Institute (NCI) for the development of therapeutic antibodies to a...

Alliance with Baxter to discover anti-MIF antibody.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Dyax Corp. (DYAX) announced a research collaboration with Baxter Healthcare Corporation (BAX) to utilize Dyax's proprietary phage display technology to discover antibodies that block macrophage...

FDA clears phototherapy technology developed in Israel.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- A new technology developed by Israeli dermatologists for psoriasis, vitiligo, atopic dermatitis, and leukoderma has been cleared by the U.S. Food and Drug Administration to be marketed in the U.S. ...

Lavendamycin analogues show promise as antiretroviral agents.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- A series of lavendamycin analogues show promise as antiretroviral agents. In a recent study from Indiana, "Novel lavendamycins including two water soluble derivatives were synthesized via short and...

Liminoids strongly inhibit HIV protease activity.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- A pair of novel liminoids act as potent HIV protease inhibitors. "In the last years several plant-derived natural compounds have been screened for their anti-HIV activity in order to find lead...

New advance to combat antibiotic-resistant pneumonia and malaria.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- New biochemical studies may hold clues to more powerful malaria and pneumonia treatments that could save more than 2 million lives worldwide. Using baker's yeast as a surrogate disease model,...

Glycopeptide-resistant Enterococcus faecium found in ICU.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Researchers report the detection of enterococcal surface protein gene (Esp) and the typing of glycopeptide-resistant Enterococcus faecium during its emergence in a Greek intensive care unit. "The...

Expression of N-formylated proteins in E. coli described.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Scientists describe the expression of N-formylated proteins in Escherichia coli in a recent issue of Protein Expression and Purification. According to a study from the United States, "In bacteria,...

Pharmaceutical company secures $12M under new management.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Enanta Pharmaceuticals announced new senior management and additional funding of $12 million to advance the company's lead macrolide antibiotic program into the clinic for the treatment of community...

Veronate maker completes $20 million private placement.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Inhibitex, Inc., has raised $20 million through a private placement of series E convertible preferred stock to existing investors, including New Enterprise Associates (NEA), William Blair Capital...

Main bacteria contributing to histamine formation in seafood identified.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Investigators have identified the main bacteria contributing to histamine formation in seafood. According to recent research published in the journal Food Science and Biotechnology, "Histamine is...

New drug class may enable body's immune system to halt HIV infection.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Trillium Group and the University of Rochester Medical Center (URMC) announced that the University Technology Seed Fund will invest in the formation of OyaGen, Inc., a start-up company at work on a new...

Oral CMV therapy cost effective.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Oral therapy for cytomegalovirus (CMV) infection is cost-effective. "The overall costs usually are lower for the oral route of administration than for the intravenous route, although the cost to the...

Viral AAC resistance mutations identified.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Viral mutations associated with resistance to aminoglycoside-arginine conjugates (AACs) have been identified. These agents "inhibit HIV-1 replication and act as Tat antagonists," scientists in...

Risk factors for malaria in U.K. travelers identified.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Risk factors for malaria in U.K. travelers have been identified, and include the use of chloroquine and proguanil as chemoprohylaxis. "After observing an apparent increase in severe falciparum...

Effects of PKC on artemisinin-induced leukemia cell differentiation clarified.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- The involvement of PKC in artemisinin-induced leukemia cell differentiation has been elucidated. According to a study from South Korea, "Artemisinin, a sesquiterpene lactone endoperoxide that...

Patient trials to begin with middle ear infection treatment.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- OctoPlus and the Leiden University Medical Center (LUMC) have joined forces to put an innovative drug against chronic middle ear infection into patient trials shortly in Leiden, The Netherlands. ...

Company acquires technology from Fraunhofer Center.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Integrated BioPharma (INB) has acquired intellectual property developed by the Center for Molecular Biotechnology (CMB) of Fraunhofer USA, Inc. The agreement covers exclusive rights to proprietary...

Use of recombinant bacteria for mosquito control reviewed.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- The use of recombinant bacteria for mosquito control has been reviewed. "Bacterial insecticides have been used for the control of nuisance and vector mosquitoes for more than two decades,"...

IFN-gamma autoantibodies can increase susceptibility to mycobacterial infection.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- IFN-gamma autoantibodies can cause susceptibility to drug-resistant disseminated mycobacterial infection. Physicians in England "evaluated a patient with disseminated Mycobacterium tuberculosis and...

New system rapidly identifies patients with nasal colonization of S. aureus.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Interventions to prevent nosocomial infection in patients who undergo cardiac surgery may improve outcomes and decrease costs. "Nosocomial and surgical-site infections are significant burdens to...

Crystal structure of M. tuberculosis PPAT characterized.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- The crystal structure of mycobacterial PPAT has been elucidated. "The penultimate step of prokaryotic coenzyme A (CoA) biosynthesis is directed by the essential enzyme phosphopantetheine...

Isoniazid toxicity characterized.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- The toxic effects of INH on different cell types have been characterized. Scientists in Austria conducted a study "to investigate in vitro the mechanism of toxicity of isoniazid (=INH), the drug...

PCR assay for enhanced detection of Francisella tularensis developed.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Scientists have developed a multitarget real-time TaqMan PCR assay for the enhanced detection of Francisella tularensis in complex specimens. According to recent research from the United States,...

Sponge sterol reverses Candida fluconazole resistance.
February 16, 2004... 2004 FEB 16 - (NewsRx.com & NewsRx.net) -- A compound derived from the sponge Dysidea arenaria reverses candidal drug resistance. According to published research from the United States, "The sponge sterol...

Protein with antimicrobial activity from frog skin identified as histone H2B.
February 16, 2004... 2004 FEB 16 - (NewsRx.com & NewsRx.net) -- Scientists have identified a protein with antimicrobial activity in the skin of Schlegel's green tree frog Rhacophorus schlegelii (Rhacophoridae) as histone H2B. "An extract of the skin of...

Analysis of antibiotics by capillary electrophoresis reviewed.
February 16, 2004... 2004 FEB 16 - (NewsRx.com & NewsRx.net) -- A researcher has reviewed the analysis of antibiotics by capillary electrophoresis in a recent issue of the journal Electrophoresis. According to recent research from the United States, "Recent...

Mutagenesis of SugE, a small multidrug resistance protein, investigated.
February 16, 2004... 2004 FEB 16 - (NewsRx.com & NewsRx.net) -- Researchers have investigated the mutagenesis of SugE, a small multidrug resistance protein. "The small multidrug resistance protein family has two subclasses. In this study we used a mutation...

Antibiotic prophylaxis is most effective systemically and in the bone cement.
February 16, 2004... 2004 FEB 16 - (NewsRx.com & NewsRx.net) -- Researchers have learned that the outcome of total hip arthroplasty is positively affected when antibiotic prophylaxis is given both systemically and in the bone cement. According to published...

XMP.629 peptide acne treatment advances into phase II clinical trial.
February 16, 2004... 2004 FEB 16 - (NewsRx.com & NewsRx.net) -- Xoma Ltd. (XOMA) announced the initiation of a phase II clinical trial with its XMP.629 peptide, which is being developed as a topical treatment for acne. In several preclinical studies, XMP.629...

FDA approves Zithromax as treatment for acute bacterial sinusitis.
February 16, 2004... 2004 FEB 16 - (NewsRx.com & NewsRx.net) -- Pfizer Inc reported that the U.S. Food and Drug Administration (FDA) has approved Zithromax (azithromycin) as a once-daily, 3-day treatment for acute bacterial sinusitis (ABS). Zithromax is the...

Use of fermentation route to make beta-lactams could offer huge cost savings.
February 16, 2004... 2004 FEB 16 - (NewsRx.com & NewsRx.net) -- Recombinant beta-lactam synthetase can be used to prepare substituted beta-lactams from non-natural substrates. Many of the currently used antibiotics from the cephalosporin and penicillin family...