Anti-Infectives Week articles from December 2008

Anti-Infectives Week archives from December 2008

New data from Environmental Protection Agency illuminate research in applied pharmacology.
December 1, 2008... "Juvenile Fats have been reported to be more sensitive to the acute neurotoxic effects of the pyrethroid deltamethrin than adults. While toxicokinetic differences between juveniles and adults are documented, toxicodynamic differences have not...

Scientists at University of Helsinki, Medical Department discuss research in campylobacter.
December 1, 2008... "The effects on MIC values and the selection of different base substitutions in the quinolone resistance determining region (QRDR) of gyrA were studied on initially ciprofloxacin-susceptible Campylobacter jejuni strains by challenging them to...

Findings from University of London, Imperial College advance knowledge in drug resistance.
December 1, 2008... According to a study from London, the United Kingdom, "The phosphoinositide-3 kinase (PI3K)/Akt signal pathway plays a key role in the tumorigenesis of many cancers and in the subsequent development of drug resistance. Using the K562 chronic...

New drug resistance findings from D.F. Sahm and co-researchers published.(Report)
December 1, 2008... According to a study from the United States, "Surveillance studies typically fail to provide sufficient information on how susceptibility rates differ among institutions and within patient age groups. Furthermore, antimicrobial resistance in...

New drug resistance findings from Uniformed Services University of the Health Sciences, Medical Department published.
December 1, 2008... According to recent research published in the journal Molecular Microbiology, "The MtrC-MtrD-MtrE efflux pump system confers resistance to macrolide antibiotics and antimicrobial substances of the host innate defence. Clinical isolates with...

Report summarizes hospital epidemiology study findings from J. Li and co-researchers.
December 1, 2008... "Vulvovaginal candidosis (VVC), which is most frequently caused by Candida albicans, is one of the most common vaginal infections and is a common problem worldwide. Despite the fact that extensive epidemiological studies have been performed,...

Researchers at Johns Hopkins University release new data on hospital epidemiology.
December 1, 2008... "Noroviruses, recognized as the leading global cause of viral gastroenteritis and a major contributor to food-borne illness, present a growing challenge in health care and long-term care facilities. The virus spreads easily and by multiple...

Studies from Y.K. Chen et al provide new data on antibiotics.
December 8, 2008... "Silver-containing hydroxyapatite (HA) coatings have been prepared on titanium substrate by vacuum plasma spraying (VPS) method and anti-bacterial properties of the coatings were examined. Three types of bacteria stains, Escherichia coli,...

Research from University of Medicine and Dentistry of New Jersey in breast cancer provides new insights.
December 8, 2008... "The pharmacology, pharmacokinetics, clinical efficacy, safety, dosage, and administration of ixabepilone in patients with metastatic breast cancer are examined. The clinical utility of the three main classes of chemotherapeutic agents used in...

Data from Azabu University, Medical Department provide new insights into drug resistance.
December 8, 2008... According to recent research published in the journal Epidemiology and Infection, "To determine prevalence, serotype diversity and antimicrobial resistance of Salmonella in healthy pigs, faecal samples from 6771 pigs on 73 farms collected...

New drug resistance study findings recently were reported by researchers at University of Maryland.
December 8, 2008... According to recent research published in the Journal of Bacteriology, "The increasing occurrence of multidrug-resistant pathogens of clinical and agricultural importance is a global public health concern. While antimicrobial use in human and...

Reports on drug resistance findings from Seoul National University provide new insights.
December 8, 2008... Researchers in Seoul, South Korea conducted a study "To investigate the underlying mechanism of low bioavailabilities of the water-soluble camptothecin derivatives, belotecan and topotecan. The bioavailability of belotecan and topotecan in rats...

New infection control study findings have been reported by researchers at University of California.(Report)
December 8, 2008... "Staphylococcus epidermidis is the most frequent cause of health care-associated infections, particularly in neonates and patients with indwelling catheters. The pathogenesis of infections caused by this organism is associated with its ability...

Studies from Columbia University describe new findings in infection control.
December 8, 2008... According to recent research from the United States, "State-based laws for reporting of health care-associated infections (HAI) have developed and changed dramatically in recent years. affecting the costs of reporting and impact on infection...

Studies from National Autonomous University have provided new information about infection control.(Report)
December 8, 2008... According to recent research from Mexico, "The quaternary ammonium compound (QUAT) lauryl dimethyl benzyl ammonium bromide (LDBAB) is commercialized in the Caribbean, Central, and South America under label claims to sterilize medical and dental...

Studies from University of Aberdeen have provided new data on infection control.
December 8, 2008... According to a study from Scotland, "This study was designed to assess the knowledge, attitudes, and infection control practices among Nepalese health care workers (HCWs). The study comprised a questionnaire survey of 324 staff from acute care...

Research conducted at C.C. Hong and co-researchers has updated our knowledge about acute myeloid leukemia.
December 15, 2008... "By using a novel profiling analysis of protein tyrosine kinases differentially expressed in the sensitive and refractory leukemia from the same patients we found that AXL was upregulated in drug-resistant leukemia. Furthermore, AXL could be...

Reports summarize breast cancer research from Shandong University.(Report)
December 15, 2008... " Cancer cells with overexpression of heat shock protein 27 (HSP27) are resistant to chemotherapeutic drug doxorubicin (Dox). Paclitaxel (Pacl) was reported to suppress HSP27 expression in ovarian and uterine cancer cells," scientists in Jinan,...

Data from M.Z. David et al provide new insights into drug resistance.(Report)
December 15, 2008... "USA300 is the dominant strain responsible for community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA) infections in most of the United States. We examined isolates from outbreaks of MRSA skin infections in rural...

Data on drug resistance reported by A.I. Hidron and co-researchers.
December 15, 2008... In this recent report, researchers in the United States conducted a study "To describe the frequency of selected antimicrobial resistance patterns among pathogens causing device-associated and procedure-associated healthcare-associated...

Reports outline drug resistance research from University of Miami, Medical Department.
December 15, 2008... "Control of wound infections, especially those associated with methicillin-resistant Staphylococcus aureus, is necessary for the wound healing process. Selection of topical agents should be based not only on their ability to eliminate...

New hospital epidemiology research from P.C. Carling et al outlined.
December 15, 2008... "The prevalence of serious infections caused by multidrug-resistant pathogens transmitted in the hospital setting has reached alarming levels, despite intensified interventions. In the context of mandates that hospitals ensure compliance with...

Recent findings from National Institute for Occupational Safety and Health highlight research in hospital epidemiology.
December 15, 2008... "Upper-room air UV germicidal irradiation (UVGI) is an effective environmental control measure for mitigating the transmission of airborne infections. Many factors influence the efficacy of an upper-room air UVGI system, including the levels...

Data on injury infection and critical care discussed by researchers at USA Scientific.
December 15, 2008... "Traditional vital signs often fail to identify critically injured patients soon enough to permit timely intervention. To improve our ability to forecast the need for prehospital lifesaving interventions (LSIs), we applied heart-rate complexity...

Investigators at Medical University of Vienna publish new data on injury infection and critical care.
December 15, 2008... According to recent research from Vienna, Austria, " Early mortality of patients with multiple injuries has been reduced within the past three decades, and now restoration of functional outcome afterward has become the primary goal. The...

New research on injury infection and critical care from K.M. Lumpkins and co-authors summarized.
December 15, 2008... "Glial fibrillary acidic protein (GFAP) is an intermediate filament protein found in the cytoskeleton of astroglia. Recent work has indicated that GFAP may serve as a serum marker of traumatic brain injury (TBI) that is released after central...

Research from A. Ramasamy and co-authors in the area of injury infection and critical care published.
December 15, 2008... According to recent research from Birmingham, the United Kingdom, "After the invasion of Iraq in April 2003, coalition forces have remained in the country in a bid to maintain stability and support the local security forces. The improvised...

Research from Massachusetts General Hospital has provided new information about injury infection and critical care.
December 15, 2008... According to recent research from the United States, "Prehospital severity scores can be used in routine prehospital care, mass casualty care, and military triage. If computers could reliably calculate clinical scores, new clinical and research...

Research from University of North Carolina, Medical Department has provided new information about injury infection and critical care.
December 15, 2008... "Many high-energy injuries of the pelvic ring involve displacement of both the anterior and posterior bony structures, and displaced fractures of the sacrum are not ail uncommon part of such an injury pattern. Case reports of bowel...

Researchers at Duke University release new data on injury infection and critical care.
December 15, 2008... According to a study from the United States, "A 25-year-old woman sustained numerous gunshot wounds to the abdomen and was taken emergently to the operating theater where she was found to have sustained injuries to the superior mesenteric...

Researchers from University of Vienna, Medical Department detail findings in injury infection and critical care.(Clinical report)
December 15, 2008... "Displaced two-part fractures of the greater tuberosity requiring surgical intervention are rare and the literature gives only few data of functional results after operative treatment. The purpose of this study was to analyze functional and...

Studies from Yonsei University, Medical Department provide new data on injury infection and critical care.(Clinical report)
December 15, 2008... According to recent research from Seoul, South Korea, "Reverse obliquity intertrochanteric fractures have been recognized as having unique anatomic and mechanical characteristics. Even though some clinical reports regarding intramedullary hip...

Study data from University of Sao Paulo provide new insights into injury infection and critical care.
December 15, 2008... "Surgical treatment of lower extremity fractures commonly involves the use of orthopedic table with perineal post for countertraction. However, prolonged application of the perineal post has been associated with significant complications,"...

Research from E.D. Lagadinou and co-authors in the area of acute myeloid leukemia published.
December 22, 2008... According to recent research from Patras, Greece, "Chemotherapy resistance is a major challenge in acute myeloid leukemia (AML). Besides the P-glycoprotein efflux, additional cellular factors may contribute to drug resistance in AML. c-Jun...

Research from A. Furiga and co-authors yields new data on antibiotics.
December 22, 2008... Researchers in Bordeaux, France conducted a study "To investigate the action of different polyphenolic compounds, extracted from red wine, grape marc and pine bark, on oral bacteria. The anti-microbial activity of extracts was examined by...

New breast cancer findings from F. Montemurro and co-researchers published.
December 22, 2008... "Patients with HER2-positive breast cancer whose disease has become resistant to the anti-HER2 monoclonal antibody trastuzumab can benefit from lapatinib, a dual epidermal growth factor receptor/HER2 tyrosine kinase (TK) inhibitor. Before the...

Studies from Virginia Polytechnic Institute in the area of clostridium published.
December 22, 2008... "The predominant organizational state of bacteria in nature is biofilms. Biofilms have been shown to increase bacterial resistance to a variety of stresses," investigators in the United States report (see also Clostridium). "We demonstrate...

Investigators at University of Basel release new data on drug resistance.
December 22, 2008... "The virulence of SCCmec type IV hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates belonging to the major sequence type 8 (ST8 [Lyon clone]) and to a minor upcoming clone, ST5, was compared with that of...

Research from X.M. Chong and colleagues provide new insights into antibiotics.
December 29, 2008... According to recent research from Beijing, People's Republic of China, "beta-Lactam antibiotics are among the most frequently used in clinical therapy. Thirty-three cephalosporin and eleven penicillin antibiotics frequently used in China have...

Research conducted at G. Memmi and co-authors has provided new information about community-acquired.
December 29, 2008... According to a study from the United States, "Recent cases of infections caused by community-acquired methicillin-resistant Staphylococcus aureus (MRSA) (CA-MRSA) strains in healthy individuals have raised concerns worldwide. CA-MRSA strains...

New drug resistance research from University of Texas outlined.
December 29, 2008... According to a study from the United States, "The taccalonolides are a class of structurally and mechanistically distinct microtubule-stabilizing agents isolated from Tacca chantrieri. A crucial feature of the taxane family of microtubule...

Research from University of Heidelberg in the area of drug resistance published.
December 29, 2008... According to recent research from Heidelberg, Germany, "Aspergillus fumigatus is a leading cause of death in immunocompromised patients and a frequent colonizer of the respiratory tracts of asthma and cystic fibrosis (CF) patients. Biofilms...

Research from University of London, Imperial College in the area of drug resistance published.
December 29, 2008... According to recent research from London, the United Kingdom, "FOXO transcription factors are important regulators of cell fate decisions, capable of inducing cell death as well as promoting cell survival and resistance to environmental stress....