Anti-Infectives Week articles from December 2004

Anti-Infectives Week archives from December 2004

Enterobacteriaceae isolated from powdered infant milk formulas.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Enterobacteriaceae has been isolated from powdered infant milk formulas. "The presence of Enterobacter sakazakii and other Enterobacteriaceae was surveyed in 82 powdered infant formula milk (IFM)...

Evaluate C. pneumoniae IgG antibodies in cases of coronary artery disease.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Researchers have investigated the relationship between dyslipidemia, C-reactive protein and serological evidence of Chlamydia pneumoniae in Turkish patients with coronary artery diseases. ...

Methicillin resistance did not affect mortality of patients with VAP.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Researchers have investigated the impact of methicillin resistance on the outcome of Staphylococcus aureus ventilator-associated pneumonia. Scientists in France report, "The impact of methicillin...

High-dose antibiotic-loaded cement spacers safe.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- High-dose antibiotic-loaded cement spacers are safe for use in infected knee prostheses. Researchers in Minnesota conducted a study "to assess the systemic safety and potential adverse effects of...

Cutaneous gene therapy provides wound coverage and blocks microbial growth.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Cutaneous gene therapy provides wound coverage and blocks microbial growth. "Infection represents a major associated problem in severely burned patients, as it causes skin graft failure and...

Nuclear localization of adenovirus E4orf4 protein correlates with cell death.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Nuclear localization of adenovirus E4orf4 protein correlates with cell death. "The adenovirus E4orf4 protein induces p53-independent death of human cancer cells by a mechanism requiring interactions...

Study patients clear African sleeping sickness parasite in DB289 phase IIb trial.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Immtech International, Inc., (IMM) announced that all 30 patients participating in the concluded phase IIb extended dose regimen arm of its clinical trial of DB289 for treating African sleeping sickness...

New technology promises to cut time in discovery of antibody drugs.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Affitech AS, the human antibody discovery and development company, launched a technology at BioEurope 2004 that promises to dramatically cut the time needed to discover new antibody drugs and their...

C-terminal heptapeptide has key role in maintaining GGN4 pore-forming activity.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- C-terminal heptapeptide has a key role in maintaining GGN4 high pore-forming activity, but it does not participate in forming GGN4-induced pore structure. According to a study from South Korea,...

Fluid diagnostics company receives award.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- OraSure Technologies announced that its OraQuick Advance Rapid HIV-1/2 Antibody Test has been awarded a 2004 "Best of What's New" award by Popular Science magazine in the Personal Health category. ...

Enrollment complete for Cubicin's phase III endocarditis/bacteremia trial.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Cubist Pharmaceuticals, Inc., (CBST), following consultation with the U.S. Food and Drug Administration (FDA), announced that it has completed enrollment of patients in its international phase III...

Anti-infective technologies company receives NASDAQ noncompliance notification.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- V.I. Technologies, Inc. (VITX), a biotechnology company developing anti-infective technologies, reported that the NASDAQ Stock Market, Inc. had notified the company that it does not comply with the...

Glycerol plus polyvinylpyrrolidone optimally preserves frozen bone marrow cells.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Glycerol plus polyvinylpyrrolidone optimally preserves frozen bone marrow cells. According to a study from the Netherlands, "Quantitative studies are presented of the effect of different storage...

Company reports third quarter results, Chrysalin product activities.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- OrthoLogic Corp. announced results for the third quarter ended Sept. 30, 2004. It also updated its product development activities related to its Chrysalin Product Platform. OrthoLogic reported a...

Agreement signed to codevelop Tandabs.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Affimed Therapeutics AG, a Heidelberg, Germany-based drug development company, has signed a partnership agreement with the biopharmaceutical unit of Syngenta AG of Basel, Switzerland, to codevelop one...

Dyax announces antibody discovery collaboration.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Dyax Corp. (DYAX) announced a research collaboration to provide Biogen Idec (BIIB) with access to Dyax's fully human antibody libraries for the purpose of identification and characterization of...

Cryptococcus neoformans outbreak at Vancouver Hospital between 1997-2002.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A Cryptococcus neoformans outbreak at Vancouver Hospital between 1997-2002 was note retrospectively. According to a study from Canada, "An outbreak of infections due to a rare subspecies of...

CMV UL84 insertion mutant is defective for viral DNA synthesis and growth.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The human cytomegalovirus UL84 insertion mutant is defective for viral DNA synthesis and growth. According to a study from the United States, "Human cytomegalovirus (HCMV) UL84 is required for...

Cytomegalovirus inhibits cytokine-induced macrophage differentiation.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Cytomegalovirus inhibits cytokine-induced macrophage differentiation. According to a study from Sweden, "Human cytomegalovirus (HCMV) infection in immunocompromised patients is associated with...

Diagnostics products company announces reagent for common respiratory viruses.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Nanogen, Inc., (NASDAQ:NGEN) announced that it is developing new analyte specific reagents (ASRs) for clinical reference laboratories to develop and validate a single test to detect six of the most...

Novel chemiluminescent immunosensor assay detects serum CA19-9 levels.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A novel chemiluminescent immunosensor assay detects serum CA19-9 levels. "A novel chemiluminescent immunosensor for carbohydrate antigen 19-9 (CA19-9) based on the immobilization of CA19-9 on the...

Respiratory epithelial cells internalize Corynebacterium diphtheriae.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Cultured human respiratory epithelial cells internalize non-toxigenic Corynebacterium diphtheriae. "Although infection by Corynebacterium diphtheriae is a model of extracellular mucosal...

African leaders, health activists push for money to fight disease.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Four African presidents appealed November 17, 2004, for new grants from a fund set up to combat three of the world's deadliest diseases, while the United States has called for restraint in spending...

Communicable disease treatment exempt from Proposition 200.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Health workers will still be able to treat illegal immigrants with communicable diseases after the passage of Proposition 200, a spokesman for the Arizona Department of Health Services said November 16,...

Pharmaceutical company announces distribution agreement in Korea.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- LAM Pharmaceutical, a biomedical company that develops wound healing and transdermal drug delivery systems, announced that it has entered into an agreement with Medi-Health USA and Jeil Medix...

New study reaffirms progress toward eliminating blinding trachoma.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The New England Journal of Medicine has published a study entitled "Mass Treatment with Single-Dose Azithromycin for Trachoma." The study, conducted among villagers suffering from blinding trachoma...

Family home AIDS care in rural sub-Saharan Africa is a minimal burden.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Family home AIDS care in rural sub-Saharan Africa is a minimal burden. According to recent research from the United States, "In rural sub-Saharan Africa, most care for patients with AIDS is provided...

Level of HIV/AIDS patient care better if health facility funded by CARE Act.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The level of HIV/AIDS patient care is better if the health facility is funded by the Ryan White CARE Act. "The Ryan White Comprehensive AIDS Resources Emergency Act 1990 (CARE Act) is one of the...

HIV-infected patients with CNS HSV coinfection have varied presentations.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- HIV-infected patients with a CNS HSV coinfection have varied presentations. According to recent research published in the International Journal of STD & AIDS, "We report clinical, radiological and...

Household costs attributable to AIDS in Chad are devastating.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Household costs attributable to AIDS in Chad are devastating. "This paper assesses the economic costs of AIDS at the household level in Chad, one of the poorest countries in the world. "One...

HAART adherence shifts during HIV infection course for women caring for children.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- HAART adherence shifts during the course of HIV infection for women caring for children. "Few studies have directly focused on adherence to highly active antiretroviral medication (HAART) in HIV...

HIV drug resistance not a problem if immune response maintains above threshold.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- HIV drug resistance is not a problem if immune response is maintained above threshold. "The treatment of viral infections using antiviral drugs has had a significant public health benefit in the...

Most recent common ancestor of HIV subtype C appeared in mid to late 1960s.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The most recent common ancestor of HIV subtype C appeared in the mid- to late 1960s. "Human immunodeficiency virus type 1 (HIV-1) subtype C is responsible for more than 55% of HIV-1 infections...

Reduction in new HIV infections in Southeast Spain.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- There is a reduction in new HIV infections in Southeast Spain. "We analyze the characteristics of patients diagnosed with HIV infection in the highly active antiretroviral therapy era in the...

HIV/AIDS patients in Malawi seek hospital healthcare as a last resort.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- HIV/AIDS patients in Malawi seek hospital healthcare as a last resort. According to a study from the United States, "Health-seeking practices in Malawi are not well understood and it is not clear...

HIV-1 DNA burden stable in monocytes and CD4 cells after ART resumption.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- HIV-1 DNA burden is stable in monocytes and CD4 cells after the resumption of antiretroviral therapy. "Replication-competent HIV, as well as HIV-1 DNA, has been detected in CD4 T cells and in...

Complement mediates HIV binding to erythrocytes.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Complement mediates HIV binding to erythrocytes. According to a study from Switzerland, "A fraction of HIV is associated with erythrocytes even when the virus becomes undetectable in plasma under...

Distinct mechanisms of HIV-1 Nef action in different populations of target cells.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- There are distinct mechanisms of HIV-1 Nef action in different populations of target cells. According to a study from Canada, "HIV-1 Nef is a critical determinant of pathogenicity in humans and...

Entry/transcription key determinants of CD4 T-cell permissiveness to HIV-1.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Entry and transcription are the key determinants of CD4 T-cell permissiveness to HIV-1 infection. According to recent research from Switzerland, "Isolated primary human cells from different donors...

Fluorescent-labeled HIV-1 developed to investigate interaction with live cells.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A fluorescent-labeled HIV-1 was developed in order to investigate its interaction with live cells. According to recent research published in the Journal of Virology, "The introduction of a label...

Novel method targeting HIV-1-Ag-SCs identifies latently HIV-1-infected CD4 cells.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A novel method targeting HIV-1-antigen-secreting cells identifies latently HIV-1-infected CD4 cells. "In resting CD4+ T lymphocytes harboring human immunodeficiency virus type 1 (HIV-1),...

Prostratin antagonizes HIV latency by NF-kappa B activation.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Prostratin antagonizes HIV latency by NF-kappa B activation. According to recent research from the United States, "A subset of quiescent memory CD4 T cells harboring integrated but...

Prostratin inhibits infection/reactivates latent HIV in PBLs/lymphoid tissue.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Prostratin inhibits infection and reactivates latent HIV in peripheral blood lymphocytes and lymphoid tissue. "To design strategies to purge latent reservoirs of human immunodeficiency virus type 1...

Raft-promotion of virion-associated cholesterol determines HIV-1 infectivity.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Raft-promotion of virion-associated cholesterol determines HIV-1 infectivity. According to a study from Australia, "Lipid rafts are enriched in cholesterol and sphingomyelin and are isolated on the...

Riboswitch regulates RNA dimerization and packaging in HIV-1 virions.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A riboswitch regulates RNA dimerization and packaging in HIV-1 virions. According to investigators in the Netherlands, "The genome of retroviruses, including human immunodeficiency virus type I...

Vpr nuclear localization crucial for efficient HIV-1 replication in CD4 cells.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Vpr nuclear localization is crucial for efficient HIV-1 replication in CD4 cells. According to recent research published in the journal Virology, "The human immunodeficiency virus type 1 (HIV-1)...

High-risk sexual behavior prevalent among drug users in Pakistan.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- High-risk sexual behavior is prevalent among drug users in Pakistan. According to recent research from the United States, "Our objective was to describe HIV/STD risk behaviors and awareness among a...

Measuring validity of self-reported symptoms among people with HIV.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Symptoms are important indicators of health and treatment for people with HIV. Symptoms are measured by patient self-report, but there has been...

Antiretroviral use differs by sociodemographic differences.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The use of antiretroviral drugs vary by sociodemographic differences. According to published research from Canada, "The objective of this study was to examine the level of antiretroviral use and...

Data involving Combivir presented at recent meeting.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A significant number of abstracts that include Combivir (lamivudine 150 mg and zidovudine 300 mg) Tablets were presented at the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy in...

HIV CCR5 antagonist GW-873140 shows potent activity against primary isolates.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The HIV CCR5 antagonist GW-873140 shows potent activity against primary isolates. According to a study from Spain, "The human immunodeficiency virus (HIV) is a highly mutative virus, representing a...

Novel HIV-1 mutation associated with resistance to nevirapine.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A novel HIV-1 mutation is associated with resistance to nevirapine. "Several reports have recently shown that drug-resistant human immunodeficiency virus type 1 (HIV-1) is often isolated from...

Racivir phase II HIV study initiated.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Pharmasset, Inc., has initiated a phase II clinical study to assess the safety, tolerability, and antiviral effect of substituting Racivir (RCV) for Epivir (lamivudine, 3TC) in treatment-experienced...

Discreet species of gp41 high-MW aggregates present in HIV-related dementia.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Discreet species of gp41 high-molecular weight aggregates are present in HIV-related dementia. According to investigators in the United States, "Accumulation of the HIV envelope protein gp41 is...

Novel SNP in human perforin gene associated with outcome of HTLV-1 infection.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A novel SNP in the human perforin gene is associated with the outcome of HTLV-1 infection. According to recent research published in the journal Human Immunology, "Human T lymphotropic virus I...

Neugene antisense drugs reported to suppress influenza A virus.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- AVI BioPharma, Inc., (AVII) announced that Qing Ge, PhD, of the Massachusetts Institute of Technology (MIT) Center for Cancer Research, presented data characterizing the effect of AVI's Neugene drugs...

Flu season starts in Oregon.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A 28-year-old man has Oregon's first confirmed case of the flu this season. The case was reported by Providence Portland Medical Center, Oregon health officials said. The flu typically kills...

Alabama nursing homes still waiting for flu shots.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Alabama nursing home residents are still waiting to get their flu shots after a second wave of vaccine was administered November 17, 2004, in county health departments. Over 100,000 doses of flu...

Chiron asks British regulators to inspect flu vaccine facility.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Chiron Corp. has asked British regulators to inspect its facility producing an experimental bird flu vaccine to make sure it doesn't run into the same contamination problems that forced the closing of...

Hawaii opens flu shot clinics for chronically ill.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The Hawaii Department of Health on November 15, 2004, held the first of many flu vaccine clinics for people who are chronically ill. Health officials expect to deliver about 10,000 flu shots to...

Ineffective vaccine given to about 300 in Arkansas, health official says.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The state's top health official says some central Arkansas residents think they're protected from the flu, when they're not. Fay Boozman, MD, director of the state Health Department, said about 300...

Senator says money for new flu vaccine research probably on the.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A senator suggested November 16, 2004, that money federal health officials were seeking to upgrade flu vaccine production is on the way, in an effort to avoid another year like this one, when the United...

Utah lifting flu shot restrictions.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Additional shipments of vaccine are allowing the Utah Department of Health to lift all restrictions for receiving the flu vaccine, the department announced November 17, 2004. Now, anyone over the...

Vermont to hold 17 flu shot clinics.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Statewide in Vermont, 17 clinics will administer 12,000 flu vaccines to people at highest risk from the flu. Vermont Health Commissioner Paul Jarris, MD, isn't sure what kind of turnout to expect...

Herpesvirus saimiri ORF73 modulates tumor suppressor proteins p53 and pRb.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Herpesvirus saimiri ORF73 modulates the tumor suppressor proteins p53 and pRb. "All known DNA tumor viruses are known to target and inactivate two main cell cycle regulatory proteins, retinoblastoma...

KSHV LANA up-regulates hTERT promoter transcription through Sp1 interaction.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- KSHV latency-associated nuclear antigen up-regulates human telomerase reverse transcriptase promoter transcription through interaction with Sp1. "Telomerase is required for the maintenance of...

Cell-free systems compare capsid assembly of genetically diverse lentiviruses.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Cell-free systems were developed to compare capsid assembly of genetically diverse lentiviruses. "We recently demonstrated that capsids from three main primate lentiviral lineages appear to form...

Lentivirus clone SIVmac239 does not complete capsid assembly in cell-free system.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A lentivirus clone, SIVmac239, does not complete capsid assembly in a cell-free system. According to published research from the United States, "We have previously described a cell-free system that...

Self-inactivating lentiviral vectors resist proviral methylation.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Self-inactivating lentiviral vectors resist proviral methylation. "Oncoretroviral expression is transcriptionally silenced in embryonic and hematopoietic stem cells (HSCs). This is associated with...

Biotechnology holding company signs agreement to acquire Portage Biomed.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Nutra Pharma Corp., (NPHC) a biotechnology holding company, has signed an agreement to acquire 100% of Portage BioMed, LLC. The acquisition will be made through a restricted stock transaction and...

Macrophage IL-1 beta production inhibits caspase-1 after nitrite inhalation.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Macrophage IL-1 beta production inhibits caspase-1 after nitrite inhalation. "Epidemiological studies have identified abuse of nitrite inhalants as an independent co-factor in HIV infection and in...

HLA alleles regulate disease severity in recurrent respiratory papillomatosis.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- HLA alleles regulate disease severity in recurrent respiratory papillomatosis. "Recurrent respiratory papillomatosis (RRP) remains an immunologic enigma. Human papillomavirus (HPV) types 6 and 11...

Pediatric nutrition company lists steps to keep families well during flu season.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Due to the flu vaccine shortage, parents are searching for answers on how to keep their children healthy during this flu season, according to information from Abbott's Ross Products Division. While...

Biotech oral health company names new business development leader.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Oragenics, Inc., has named James W. Sharpe as vice president of business development. Chuck Soponis, Oragenics CEO, said, "James Sharpe joins Oragenics with over 25 years experience managing growing...

Martin Kaplan, U.N. scientist and former head of Pugwash, dies at 89.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Martin M. Kaplan, a health researcher and former secretary-general of the Nobel Peace Prize-winning Pugwash conferences on disarmament, has died. He was 89. Kaplan, a veterinarian, published more...

Closing schools can't contain whooping cough outbreak.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Iowa health officials say closing schools in an attempt to contain an outbreak of whooping cough has had little effect. "When we close school, coughing kids go to the mall or their friends' house,"...

IND submitted for aerosolized antibiotic.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Aerogen, Inc., (AEGN) announced that it has submitted an Investigational New Drug Application (INDA) to the U.S. Food and Drug Administration to begin a second phase II study of its aerosolized...

Avoidance of negative factors linked to mammalian cell culture technology.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Research and Markets announced the addition of Choosing The Proper Long-Term Manufacturing Strategy - System Comparison to their offering. All antibodies currently on the market are manufactured by...

Respiratory syncytial virus associated with lipid-raft Hep2 cells in infection.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Respiratory syncytial virus is intimately associated with lipid-raft Hep2 cells during infection. According to recent research in Scotland, "The assembly of respiratory syncytial virus (RSV) in...

Novel SARS-CoV entry inhibitor may be a viable candidate therapy for SARS.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A novel SARS coronavirus entry inhibitor may be a viable candidate therapy for SARS. "Infection of receptor-bearing cells by coronaviruses is mediated by their spike (S) proteins. The coronavirus...

FLICE-like inhibitory protein protects cells from bacterial endotoxin.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- FLICE-like inhibitory protein protects cells from bacterial endotoxin. "Bacterial lipopolysaccharide (LPS) via its activation of Toll-like receptor-4 contributes to much of the vascular...

CD3/MHC-I/MHC-II/Ii surface expression modulation insufficient for SIV virulence.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- CD3/MHC-I/MHC-II/Ii surface expression modulation alone is insufficient for SIV virulence. "A variety of simian immunodeficiency virus (SIVmac) nef mutants have been investigated to clarify which in...

Real-time PCR independently samples single SIV genomes from range of viral loads.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A real-time PCR assay independently samples single SIV genomes from macaques with a range of viral loads. According to a study from the United States, "The generation of a diverse population of...

SIV-induced blood-brain barrier activation requires cell-associated virus.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- SIV-induced blood-brain barrier activation requires cell-associated virus. According to a study from the United States, "It has never been determined if activation of the blood-brain barrier (BBB)...