Anti-Infectives Week articles from December 2003

Anti-Infectives Week archives from December 2003

Human beta-defensin 3 possesses antibacterial activity against oral bacteria.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Human beta-defensin 3 possessed antibacterial activity against oral bacteria. "The in vitro activities of human beta-defensin 3 (hBD-3) alone or combined with lysozyme, metronidazole, amoxicillin,...

New TB vaccine shows promise in people with AIDS.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- An innovative vaccine against tuberculosis has shown promise in people with HIV, researchers from Dartmouth Medical School and the National Public Health Institute of Finland report. An...

Improved diagnosis of fungal infections no longer requires preventive therapy.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Improved diagnosis of fungal infections no longer requires preventive therapy. According to recent research published in the journal Annals of Hematology, "invasive fungal infections are a primary...

Ravuconazole, voriconazole, and albaconazole are active against Chaetomium.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Antifungals ravuconazole, voriconazole, albaconazole, but not micafungin, are active against Chaetomium. "Chaetomium is an unusual etiological agent of human infections, but the mortality rate...

Oral immunization with Giardia duodenalis protein inhibits shedding of cysts.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Oral immunization of BALB/c mice with Giardia duodenalis recombinant cyst wall protein inhibited the shedding of cysts. "The process of encystation is a key step in the Giardia duodenalis life...

High-dose methadone linked to QT prolongation and Torsades de Pointes in HIV patients.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- High-dose methadone therapy may cause QT prolongation and Torsades de Pointes in HIV patients. According to published research from Spain, "Four patients infected with human immunodeficiency virus...

Growth hormone therapy may kill; monocytes produce IL-1alpha, IL-6, TNFalpha.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Septic shock, uncontrolled infection, and death of adults given growth hormone while ill may be due to its effect on LPS-activated PBMC: It makes them produce increased IL-1alpha, IL-6, TNFalpha. ...

Domestic animals may be bioterrorism targets; broad health, economic damage possible.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Domestic animals may be bioterrorism targets; broad health, economic damage possible. According to a study from France, "after a brief historical introduction, the authors describe a list of...

Peptides effective against Listeria monocytogenes listed.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Researchers have listed the antimicrobial peptides effective against Listeria monocytogenes in a recent issue of FEMS Microbiology Letters. According to published research from Spain, "We assessed...

Smooth muscle cells infected with Chlamydia pneumoniae increase MMP-1, MMP-3.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Smooth muscle cells infected with Chlamydia pneumoniae increase MMP-1, MMP-3; not MMP-2, MMP-9, or TIMPs. According to recent research published in the journal Fems Immunology and Medical...

Nocardia puris characterized as a new species that can produce abscesses.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Nocardia puris is characterized as a new species that can produce abscesses in humans. "A bacterial isolate (IMMIB R-145(T)) from a human abscess was subjected to a polyphasic taxonomic study....

Bordetella pertussis CyaA binds CD11b at different site than catalytic one.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- The CyaA toxin of Bordetella pertussis binds CD11b/CD18 at a site different from the catalytic domain. According to published research from France, "adenylate cyclase toxin (CyaA) is one of the...

BSE test detects youngest case of Mad Cow disease in Japan.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Bio-Rad Laboratories, Inc., (BIO, BIO.B), a multinational manufacturer and distributor of life science research products and clinical diagnostics announced that its bovine spongiform encephalopathy...

Burkholderia cepacia pneumonia can occur in immunocompetent patients.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Prior aspergilloma or Aspergillus infection may influence immunocompetent patients to develop Burkholderia cepacia pneumonia. "A 69 yr old man developed an episode of severe community-acquired...

IDI inks agreements regarding its real-time diagnostic products.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Infectio Diagnostic, Inc., (IDI) and Cepheid have concluded new agreements and have decided to terminate current ARIDIA joint venture. These new agreements will enable IDI and Cepheid to increase...

Pennsylvania partnership announces agreement to build relationship with Roche.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Health Network Laboratories (HNL), a regional provider of medical diagnostics in Pennsylvania and New Jersey, announced a 5-year strategic alliance agreement with Roche Diagnostics. Together the...

Nonresponsive bullous pemphigoid may be bullous scabies.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Nonresponsive bullous pemphigoid may be bullous scabies. "Scabies is an infestation caused by Sarcoptes scabiei, characterized by polymorphous lesions that may include burrows, papules, nodules,...

In organ transplant complications, histology is often needed to assess cause.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- In organ transplant complications, histology is often needed to assess cause. According to recent research published in the journal Springer Seminars in Immunopathology, "immunopathology techniques...

8-Quinolinamines and their pro prodrug conjugates show promise as antimalarials.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- A series of novel 8-quinolinamines and their pro prodrug conjugates show promise as antimalarial agents. Scientists in India reported the "synthesis and antimalarial activities of...

Antitubercular compounds isolated from Caesalpinia pulcherrima root.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Antitubercular compounds have isolated from the root of the "Pride of Barbados". According to published research from Thailand, "Activity-guided fractionation of a root extract of Caesalpinia...

Devil's claw yields potent, selective antimalarial agents.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Potent and selective antimalarial agents have been isolated from the African medicinal plant commonly known as Devil's claw. "The development of drug resistance and resurgence of malaria has...

Borrelia burgdorferi induces inflammatory cytokines during erythema migrans.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Inflammatory cytokines are induced in PBMC of newly infected patients with erythema migrans from Borrelia burgdorferi. According to recent research from the United States, "in a study of cytokine...

E. faecalis gains entry into enterocytes by means of Asc10 functional domain.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Enterocytes internalize Enterococcus faecalis by means of the functional domain of aggregation substance, not the RGD motifs. "Aggregation substance (AS), a surface protein encoded on the...

Severe pneumonitis, cerebral hemorrhage is a risk with Epstein-Barr virus.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Severe pneumonitis, cerebral hemorrhage is a risk with Epstein-Barr virus (EBV), even in apparently healthy individuals. According to a study from Switzerland, "EBV is a ubiquitous human...

Inflammatory diseases drug maker files resale registration statement with SEC.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- AtheroGenics, Inc., (AGIX) announced that it has filed a resale registration statement on Form S-3 with the U.S. Securities and Exchange Commission (SEC) pertaining to its Convertible Notes issued on...

The Bacillus subtilis strain used in biological control can infect cabbages.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Bacillus subtilis strain BB, used in biological control, can infect Brassica vegetables internally. "The ability of Bacillus subtilis, strain BB, to colonize cabbage seedlings endophytically was...

Novel molecular HIV test has single-copy sensitivity for viral RNA.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- A novel molecular HIV test has single-copy sensitivity for viral RNA. According to published research from the United States, "More sensitive assays for human immunodeficiency virus type 1 (HIV-1)...

Elevated cytokine levels in adipose tissue suppress adiponectin output in HALS patients.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Elevated cytokine levels in adipose tissue suppress adiponectin activity in HIV lipodystrophy patients. According to published research from Denmark, "Human immunodeficiency virus (HIV)-associated...

Educational program fails to improve adherence to HIV treatment in minority patients.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- A novel educational intervention does not improve adherence to HIV treatment in minority patients. According to published research from Texas, "A 24-week open-label clinical trial was conducted in...

Expanded HIV care needed for aborigines and women in Canada.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Greater efforts are needed to provide HIV care to aborigines and women in Canada. In a recent study, scientists there "evaluated all human immunodeficiency virus (HIV)-related deaths over the period...

HAART effective for pediatric HIV patients.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Highly active antiretroviral therapy (HAART) is effective for pediatric HIV patients. According to published research from Spain, "An observational study was performed involving 95 children with...

LC/MS/MS assay suitable for measuring atazanavir levels in peripheral blood.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- A novel liquid chromatography-tandem mass spectrometric assay provides accurate and highly sensitive measurements of atazanavir levels in peripheral blood. According to published research from the...

Long-term HAART does not lead to full T-cell recovery.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Long-term HAART regimens do not induce full T-cell recovery in HIV patients. "In most HIV-1-infected patients, highly active antiretroviral therapy (HAART) reduces plasma viral load to variable...

Negative effects of saquinavir hard gel treatment subside over time.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- The negative effects of saquinavir hard gel treatment on the overall outcome of HIV therapy subside over time. "Saquinavir hard gel capsule (hgc), the first human immunodeficiency virus (HIV)...

Hantavirus in Brazilians may be asymptomatic or cause cardiopulmonary syndrome.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Equal amounts of rural and urban population in a Brazilian county are seropositive for hantavirus; prevalence is not associated with disease in most. "Hantaviruses are the causative agents of severe...

Toxigenic and nontoxigenic H. pylori outer membrane vesicles increase IL-8.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Gastric epithelial cells respond to Helicobacter pylori outer membrane vesicles with IL-8 production, proliferation, whether a toxigenic strain or not. "Helicobacter pylori infection, which is...

Glycoproteins B, H of human herpesvirus 7 appear to have few polymorphisms.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Glycoproteins B, H of human herpesvirus 7 appear to be highly conserved; there are only small variations between individuals in Hong Kong. According to published research from Peoples R China,...

Bacterial infection in pregnancy Pap smears signals a risk for complications.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Bacterial infection in pregnancy Pap smears signals a risk for complications. According to a study from Sweden, "previous studies on whether signs of infection in Pap smears imply a risk factor for...

Serum protein carbonyl groups are lower in familiar chronic nail candidiasis.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Serum protein carbonyl groups are lower in familiar chronic nail candidiasis. According to a study from Italy, "familiar chronic nail candidiasis (FCNC) is a rare disorder characterized by early...

Surface metalloprotease gp63 is released by Leishmania species into culture.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- The surface metalloprotease, gp63, is released by Leishmania species into culture. According to published research from Israel, "protease activity was found in spent culture medium collected from...

Combination antimalarial therapy can slow spread of drug resistance.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- The use of multidrug regimens can preserve the efficacy of antimalarial agents in endemic areas. "Combination antimalarial therapy may delay the spread of drug resistance, but clinical data...

Novel beta-diketonate improves synthesis of trioxane antimalarial agents.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- A novel beta-diketonate improves the synthesis of trioxane antimalarial agents. According to a recent study from England, "Bis(2,2;6,6-tetramethyl-3,5-heptanedionato)cobalt(II)...

Oxidative stress underlies antitumor activity of artesunate.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Oxidative stress underlies the antitumor as well as the antimalarial activity of artesunate (ART). ART "is very cytotoxic in tumor cell lines," scientists in Germany explained. "The active moiety...

Human mast cells have Toll-like receptor 4, innate and adaptive immune responses.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Human mast cells have a TLR-4, innate and adaptive immune responses, and induce Th2 reactions. According to a study from Japan, "rodent mast cells (MCs) are reported to play a pivotal role in both...

A quick diagnosis of toxic shock syndrome is critical for avoiding mortality.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- A quick diagnosis of toxic shock syndrome is critical for avoiding mortality. "Toxic-shock-syndrome (TSS) is an acute febrile, exanthematous illness caused by toxins such as...

FDA accepts NDA for ophthalmic anti-inflammatory/antibiotic.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Bausch & Lomb (BOL) and Pharmos Corporation (PHRM) announced that the U.S. Food and Drug Administration (FDA) has accepted for review Bausch & Lomb's New Drug Application for an...

Mycobacterium xenopi treatment is unnecessary for HIV patients on HAART.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Mycobacterium xenopi treatment is unnecessary for HIV patients on HAART. Scientists in England described "treatment decisions and outcomes for 20 patients" with confirmed, symptomatic M. xenopi...

Free-living amoebic pathogen P. acanthamoeba replicates in macrophages.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Free-living amoebic pathogen P. acanthamoeba replicates in macrophages, induces apoptosis. "Parachlamydia acanthamoeba is an obligately intracellular bacterium that naturally infects free-living...

Pharmaceutical company names Charles W. Cramb to board of directors.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Idenix Pharmaceuticals, Inc., announced that Charles W. Cramb will join its board of directors. Cramb is senior vice president, finance and CFO of The Gillette Co., where he has served in financial...

Azithromycin is an effective treatment for pertussis.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Azithromycin is an effective treatment for pertussis. According to a study from the United States, "a prospective, open label, noncomparative trial was conducted to assess the efficacy of a 5-day...

Bifidobacterium DNA induces PBMC IL-10; reduces gut IL-1, increases IL-10.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Probiotic bacterial DNA induces IL-10 in PBMC; probiotic therapy alters gut by reducing IL-1beta, increasing IL-10. "A new therapeutic approach for inflammatory bowel diseases is based on the...

New antibiotic - Cubicin - shipped to U.S. institutions.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Cubist Pharmaceuticals, Inc., (CBST) announced that it has begun shipping its flagship antibiotic product, Cubicin (daptomycin for injection), to U.S. hospitals. Cubist received U.S. Food & Drug...

New staphylococcal enterotoxin SER may be related to SEG; found in 2 plasmids.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- A new staphylococcal enterotoxin, SER, may be related to SEG; it can be found in 2 plasmids. "We identified and characterized a novel staphylococcal enterotoxin-like putative toxin, which is named...

Brain ciliated ependyma appear to sustain damage during bacterial meningitis.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Brain ciliated ependyma appear to sustain damage during Streptococcus pneumoniae meningitis, in animal model. "Streptococcus pneumoniae meningitis remains a disease with poor outcome for the...

Penicillin therapy for S. pneumoniae can create an inflammatory reaction.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Penicillin, but not moxifloxacin or erythromycin, creates TLR-2 mediated inflammation in treatment of Streptococcus pneumoniae infection. According to published research from England, "the...

Streptococcus pyogenes HtsA, upregulated in blood, binds one heme molecule.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Streptococcus pyogenes HtsA is upregulated in blood and binds 1 heme molecule. "Group A streptococci (GAS) can use heme and hemoproteins as sources of iron. However, the machinery for heme...

Chronic exposure to antigen induces IFNgamma-dependent TCR downregulation.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Interferon gamma dependent, T cell antigen receptor zeta chain downregulation occurs in response to chronic inflammation and antigen exposure. "T cell antigen receptor zeta chain downregulation and...

Modified luciferase reporter phages enable rapid detection of TB drug resistance.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- A pair of modified luciferase reporter phages (LRPs) enable rapid detection of mycobacterial drug resistance. LRPs "have proven to be efficient tools for drug susceptibility testing of...

Molecular assay enables rapid, accurate detection of mutant mycobacterial katG.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- A novel real-time polymerase chain reaction (PCR) assay can quickly and accurately identify TB strains carrying katG resistance mutations. "The emergence of drug-resistant strains of Mycobacterium...

Fully automated assay suitable for identifying pyrazinamide-resistant TB.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- A novel automated system is suitable for identifying pyrazinamide-resistant strains of tuberculosis. In a recent study from Greece, "One hundred and fifty clinical isolates of Mycobacterium...

Sodium stibogluconate inhibits authentic hepatitis C virus replication.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Sodium stibogluconate inhibits authentic hepatitis C virus replication. "Using a hepatitis C virus (HCV) subgenomic RNA replicon system, drugs currently being used to treat other human diseases were...

First human trial of West Nile vaccine to begin.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Acambis (ACAM) announced the start of a phase I trial of its investigational vaccine against West Nile virus, ChimeriVax-West Nile. Since it was first identified in New York in 1999, the West Nile...

Some Yersinia enterocolitica biotype 1A appear to have virulence factors.
December 1, 2003... 2003 DEC 1 - (NewsRx.com & NewsRx.net) -- Some Yersinia enterocolitica biotype 1A appear to have virulence factors. According to a study from Australia, "Yersinia enterocolitica strains of biotype 1A lack the known virulence determinants of...

Loss of antibacterial activity used to achieve drug optimization.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Scientists have used a screening assay to measure the loss of antibacterial activity in the presence of proteins to optimize drug structure. "An assay quantifying the loss of antibacterial potency...

Histone H1 antigen protects against cutaneous leishmaniasis in monkeys.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- A recombinant histone H1 antigen provided protection against cutaneous leishmaniasis in outbred vervet monkeys. "Infection with Leishmania major parasites results in the development of cutaneous...

Chronic renal dysfunction linked to oral acyclovir reported.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- A case of chronic renal dysfunction linked to oral acyclovir treatment has been described. "Nephrotoxicity is a well-known side effect of intravenous acyclovir treatment but occurs rarely by oral...

PTP7 is half the size of antibiotic peptide; has antitumor activity.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Gaegurin 6 derivative PTP7 is half the size of the antibiotic peptide and has separate amino terminal antitumor apoptotic activity. "In order to develop peptide agents with reduced length and...

Antimicrobial peptides containing arginine described.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Researchers describe the action of antimicrobial peptides containing arginine in the journal Biochemistry - Moscow. According to recent research from Russia, "Tetradecapeptides...

Cholecystitis with lithiasis can be caused by Campylobacter jejuni.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Cholesystitis with lithiasis can be caused by Campylobacter jejuni. "A 51-year-old man presented with acute cholecystitis and the routine intraoperative culture of the bile grew Campylobacter...

Special marketing strategies could foster teen use of microbicides.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Special marketing strategies could foster teen use of microbicides. "Sexually active teens are at significant risk from sexually transmitted infections and girls and women bear the greatest burden...

Naegleria fowleri common in Arizona kitchens, bathrooms.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Naegleria fowleri is frequently found in domestic water in kitchens, bathroom fixtures in Arizona presenting risk of primary amoebic meningoencephalitis. According to recent research published in...

$9.2 Million grant enables scientists to design antitoxin nanosponges.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- A large, multicenter program project grant has been awarded to a team of scientists at the Scripps Research Institute (TSRI), Harvard Medical School, and the Salk Institute for Biological Studies to...

Membrane localized NADPH oxidases are involved in ROS formation in many cells.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Membrane localized NADPH oxidases are involved in reactive oxygen species formation in phagocytes and nonphagocytic cells. According to a study from the United States, "in addition to their role in...

Pharmaceutical company licenses new antibiotic compound.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Roche and Sankyo announced that Roche has acquired exclusive rights to CS-023, Sankyo's new antibiotic compound entering phase II clinical development. If successful, CS-023, a parenteral carbapenem,...

Clinical isolate fungi are mostly Candida; only amphotericin B acts on all.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Fungal isolates from hospital patients are predominantly Candida; most are susceptibility to amphotericin B, but fewer are to other agents. "The aim of this study was to analyze the type and...

Cathelicidins are natural antimicrobial proteins that protect against infection.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Cathelicidins are natural, broad-spectrum antimicrobial proteins that protect against infection. "Cathelicidins are small cationic peptides that possess broad-spectrum antimicrobial activity. These...

Reaction to unmethylated CpG motifs in bacterial DNA can induce sepsis or cure.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Host reaction to unmethylated CpG motifs in bacterial DNA can induce sepsis or cure. "Unmethylated CpG motifs are prevalent in bacterial, but not vertebrate, genomic DNAs and activate immune cells...

Bacteriophages may serve in transplantation as antibacterial, immune suppressant.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Bacteriophages may serve in transplantation as antibacterial; may even reduce graft rejection risk. According to published research from Poland, "due to the increasing prevalence of drug-resistant...

Enteric toxins modulate gut physiology.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Enteric toxins modulate gut physiology. According to a study from India, "Diarrheal diseases caused by microorganisms and their toxins are a major cause of mortality and morbidity throughout the...

The TRACP enzyme present in osteoclasts and macrophages appears to generate ROS.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- The TRACP enzyme present in osteoclasts and macrophages appears to generate ROS for use in bone resorption and bacterial killing, respectively. "TRACP is an enzyme with unknown biological function....

The zinc-chelating agent disulfiram may have anticancer applications.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- The zinc-chelating agent disulfiram may have anticancer applications. According to published research from Taiwan, "cell invasion and angiogenesis are crucial processes in cancer metastasis that...

Method to distinguish among Candida species developed.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Researchers reported the rapid and unequivocal differentiation of Candida dubliniensis from other Candida species using species-specific DNA probes. "Candida dubliniensis is a recently described...

Lamivudine-resistant patients develop compensatory mutations during therapy.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- Lamivudine-resistant patients develop compensatory mutations during therapy. "Therapy of chronic hepatitis B virus (HBV) infection with the polymerase inhibitor lamivudine frequently is associated...

Antipathogen company moves toward clinical trials, engages GunnAllen Financial.
December 8, 2003... 2003 DEC 8 - (NewsRx.com & NewsRx.net) -- NovaCal Pharmaceuticals announced that it has entered into an agreement under which GunnAllen Financial will provide investment banking services to the company as it moves rapidly into the clinical...