Anti-Infectives Week articles from April 2009

Anti-Infectives Week archives from April 2009

Reports outline breast cancer study findings from Middle East Technical University.(Clinical report)
April 6, 2009... According to a study from Ankara, Turkey, "Multidrug resistance (MDR) is a serious handicap towards the effective treatment of breast cancer patients. One of the most prevalent MDR mechanisms is through the overexpression of genes coding the...

Studies from University of North Carolina yield new data on breast cancer.
April 6, 2009... "BCRP transports numerous drugs/derived metabolites and toxins, and exhibits overlapping substrate specificity with P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (MRP2). Assessing the contribution of BCRP to...

New findings from National Institutes of Health in the area of cancer described.
April 6, 2009... "ABCG2 is a half-transporter initially described in multidrug-resistant cancer cells and lately identified as an important factor in the pharmacokinetics of its substrates. Q141K is by far the most intensively studied single nucleotide...

Study data from Nagoya University provide new insights into carcinoma.
April 6, 2009... According to a study from Nagoya, Japan, "To investigate the choleretic effects of inchinkoto (ICKT) on livers of patients with biliary obstruction due to bile duct carcinoma. Twenty-seven patients with bile duct carcinoma who were due to...

Investigators at University of Lausanne target drug resistance.
April 6, 2009... According to recent research from Geneva, Switzerland, "P-glycoprotein (Pgp/ABCB1) both accounts for multidrug resistance (MDR) in chemotherapy and contributes to reduce oral bioavailability and brain distribution of drugs. Flavonoids, reported...

Studies from Pfizer Inc. provide new data on antibiotics.
April 13, 2009... "As the need for novel antibiotic classes to combat bacterial drug resistance increases, the paucity of leads resulting from target-based antibacterial screening of pharmaceutical compound libraries is of major concern. One explanation for this...

Studies from University of Nebraska provide new data on cancer.
April 13, 2009... According to a study from the United States, "Previous studies have indicated that the ERK1/2 MAP kinase signaling pathway plays an important role not only in cell growth, cell cycle regulation, and differentiation, but also in determining the...

Researchers from Yale University provide details of new studies and findings in the area of cholestasis.(Report)
April 13, 2009... According to a study from the United States, "Progressive familial intrahepatic cholestasis 1 (PFIC1) results from mutations in ATP8B1, a putative aminophospholipid flippase. Conflicting hypotheses have been proposed for the pathogenesis of...

Data from E.O. Fallon et al provide new insights into drug resistance.
April 13, 2009... According to a study from the United States, "Infections caused by antimicrobial-resistant bacteria are associated with substantial morbidity and mortality. Residents of long-term care facilities (LTCF) are among the main reservoirs of...

New research on drug resistance from Princess Alexandra Hospital summarized.(Report)
April 13, 2009... "Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are emerging in southeast Queensland, Australia, but the incidence of carriage of CA-MRSA strains is unknown. The aim of this study was to assess the nasal...

Reports summarize burn care research study results from B. Allen and co-researchers.
April 13, 2009... "Fluoroscopic radiation burns are being reported with increasing frequency because of the rise in number and duration of procedures performed under fluoroscopic guidance," investigators in the United States report (see also Burn Care Research)....

Research by C. Weinand and colleagues in burn care research provides new insights.
April 13, 2009... According to recent research published in the Journal of Burn Care & Research, "The vacuum-assisted closure (VAC) device has a wide range of clinical applications, including treatment of infected surgical wounds, traumatic wounds, pressure...

Research from A.J. Singer and co-researchers provides new data on burn care research.(Report)
April 13, 2009... According to a study from the United States, "Scar formation after thermal injury is common and results in significant aesthetic and functional impairment. Transforming growth factor beta (TGF-beta) plays a significant role in scar formation."...

Research from M. Adam et al broadens understanding of burn care research.(Report)
April 13, 2009... According to recent research from Adana, Turkey, "The abbreviated Burn-Specific Health Scale (BSHS) is an instrument that measures physical, mental, social, and general health in burn survivors. This scale is composed of 80 items." "The...

Research from University of Queensland broadens understanding of burn care research.(Report)
April 13, 2009... "Silver dressings have been widely used to successfully prevent burn wound infection and sepsis. However, a few case studies have reported the functional abnormality and failure of vital organs, possibly caused by silver deposits,"...

Research reports from Hallym University provide new insights into burn care research.(Report)
April 13, 2009... According to a study from Seoul, South Korea, "Pruritis (itching) constitutes a source of severe distress for burn patients. The authors administered naltrexone to burn patients suffering from itching that was refractory to treatment with...

Studies in the area of burn care research reported from P.M. Glat and co-researchers.(Clinical report)
April 13, 2009... "This prospective, randomized study assessed the clinical, microbiological, and patient comfort characteristics of two silver-based topical agents in the management of partial-thickness burn wounds. Pediatric patients were randomly assigned to...

Research findings from K.L. Wallis et al update understanding of burn science.
April 13, 2009... "Coding inpatient episodes plays an important role in determining the financial remuneration of a clinical service. Insufficient or incomplete data may have very significant consequences on its viability," scientists in Stockport, the United...

Reports summarize bipolar disorder study results from Pamukkale University.
April 20, 2009... "P-glycoprotein (P-gp), an efflux transporter protein, is an ABC transporter encoded by the multidrug resistance 1 gene (MDR1, ABCB1). The common synonymous C3435T polymorphism in exon 26 is reported to associate with lower P-gp functional...

New cancer study results reported from Royal North Shore Hospital.
April 20, 2009... " The H69CIS200 and H69OX400 cell lines are novel models of low-level platinum-drug resistance. Resistance was not associated with increased cellular glutathione or decreased accumulation of platinum, rather the resistant cell lines have a cell...

Studies from C. Morales et al in the area of cancer described.
April 20, 2009... According to recent research published in the journal Molecular Cancer Therapeutics, "Gene amplification is one of the most frequent manifestations of genomic instability in human tumors and plays an important role in tumor progression and...

Investigators at University of Liverpool have published new data on cytokines.
April 20, 2009... "The function of transporters in peripheral blood mononuclear cells (PBMC) has been characterized, but less is known about cytochrome P450 (CYP) enzyme function in these cells. Given that cytokines are dysregulated in many diseases, the purpose...

New dentistry study findings have been reported from University of Medicine and Dentistry of New Jersey.
April 20, 2009... According to a study from the United States, "Microtubule-stabilizing and microtubule-destabilizing agents are commonly used as anticancer agents. Although highly effective, success with these agents has been limited due to their relative...

Research from University of Sao Paulo has provided new information about microbial research.
April 20, 2009... "Trypanosoma cruzi trypomastigotes continuously shed into the medium plasma membrane fragments sealed as vesicles enriched in glycoproteins of the gp85 and trans-sialidase (TS) superfamily and alpha-galactosyl-containing glycoconjugates....

Research from V.J. Avramis et al broadens understanding of acute lymphoblastic leukemia.
April 27, 2009... "Therapeutic uses of asparaginases (ASNase) have been shown to elicit immune responses resulting in the development of potentially life-threatening human anti-bacterial antibodies (Ab). A robust screening enzyme-linked immunosorbent assay...

Reports from Vrije University Amsterdam describe recent advances in breast cancer.
April 27, 2009... In this recently published article, scientists in Netherlands conducted a study "To determine whether multidrug-resistance efflux transporters are expressed on immune effector cells in synovial tissue from patients with rheumatoid arthritis...

New cancer study findings have been reported by A. Younus and co-researchers.
April 27, 2009... "Cancer patients undergoing chemotherapy are highly prone to infections because of suppression of their immune system. In the present study, the activity of fluoroquinolones, cephalosporins, glycopeptides and oxazolidinones was evaluated in...

Data from T. Okamura and colleagues advance knowledge in drug resistance.
April 27, 2009... According to recent research published in the Journal of Cerebral Blood Flow and Metabolism, "Multidrug resistance-associated protein 1 (MRP1) acts as a defense mechanism by pumping xenobiotics and endogenous metabolites out of the brain. The...

Data on drug resistance detailed by A. Dejong and co-authors.
April 27, 2009... "The aim of the study was to study antimicrobial susceptibility in Escherichia coli, Salmonella, Campylobacter and Enterococcus recovered from chickens, pigs and cattle using uniform methodology. Intestinal samples were taken at slaughter in...