AIDS Vaccine Week articles from September 2003

AIDS Vaccine Week archives from September 2003

Tat-expressing Sendai viral vector-booster does not increase protection.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- No significant enhancement of protection by Tat-expressing Sendai viral vector-booster occurred in a macaque AIDS model. According to a study from Japan, "We previously developed a...

HIV-1-infected children have impaired immunological memory.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- HIV-infected children who were immunized with "Haemophilus influenzae vaccine exhibited impaired immunological memory. According to a study from Greece, "Haemophilus influenzae type b (Hib)...

Novel HIV-based cDNA cloning system may aid genetic research.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- A novel HIV-based cDNA cloning system may aid genetic research. "Expression cloning of cDNAs is a powerful tool with which to identify genes based on their specific functional properties,"...

Small interfering RNAs protect stem cells from HIV infection.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Hematopoietic stem cells transduced with antiviral RNA become resistant to HIV infection. "The phenomenon of RNA interference mediated by small interfering RNAs (siRNAs) is a potent gene-silencing...

FDA license granted for new HIV test kit.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Bio-Rad Laboratories, Inc., (BIO, BIO.B) has received a license from the U.S. Food and Drug Administration for its HIV-1/HIV-2 PLUS O EIA test kit used for diagnostic testing and the screening of blood...

Kappa-opioid, prostanoid EP3 receptors mediate HIV gp120-induced allodynia.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Kappa-opioid and prostanoid EP3 receptors mediate pain caused by the HIV coat protein. "HIV-1 glycoprotein gp120 administered intrathecally induces tactile pain (allodynia) in animals," scientists...

Novel SHIV chimera may improve simian HIV models.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- A novel SHIV strain may improve simian model of HIV infection. In a recent study from Japan, "a new simian/human immunodeficiency virus (SHIV) chimera with the reverse transcriptase (RT)-encoding...

Novel less-sensitive EIA may improve HIV infection tracking.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- A novel immunoassay may improve epidemiological tracking of HIV infection. "The sensitive/less-sensitive (S/LS) enzyme immunoassay (EIA) testing strategy for discriminating 'early' from...

Resistance mutation patterns different in subtype B and E HIV strains.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- The pattern of drug resistance mutations varies by HIV subtype. "An increasing number of HIV-1-infected patients living in developing countries now have access to antiretroviral drugs," scientists...

Anti-gp41 antibody and interleukin-16 have synergistic anti-HIV effects.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- The cytokine interleukin (IL)-16 and an antibody targeting the HIV gp41 protein have synergistic antiviral effects. "HIV-1 replication is inhibited in T cells transfected with an anti-gp41 single...

Neuronal heat shock defenses not activated by HIV gp120.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- The HIV coat glycoprotein gp120 does not activate neuronal heat shock defenses. HIV gp120 "can damage CNS neurons," scientists in California noted. "This appears to mostly involve an indirect...

HIV p24 levels linked to CD4 count change in successfully treated patients.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- HIV p24 levels are linked to changes in CD4+ T-cell counts in successfully treated patients. According to published research from Switzerland, "an HIV-1 p24 antigen test involving signal...

Novel HEPT analogs show improved antiretroviral activity.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- A series of HEPT derivatives have improved antiretroviral activity compared to their parent compounds. In a recent study from China, "1-Alkoxymethyl-5-alkyl-6-naphthylmethyl uracils, which are...

Novel stavudine derivatives synthesized.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- A series of novel stavudine derivatives has been developed and tested for anti-HIV activity "The synthesis and biological evaluation of a bicyclo[3.1.0]hexene nucleoside designed as a...

Proflavine disrupts HIV Rev protein activity.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- The novel antiretroviral agent proflavine efficiently disrupts the activity of the HIV Rev protein. "Rev is an essential regulatory HIV-1 protein that binds the Rev responsive element (RRE) within...

BlockAide trial to begin in fourth quarter; scientific advisory board formed.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Adventrx Pharmaceuticals, Inc., (AVRX) announced the formation of its new scientific advisory board, consisting of three well-known academic experts in the areas of anticancer and antiviral development....

Activists oppose state proposal to report names of HIV patients.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- A state proposal to collect the names of all those who test positive for the HIV virus has drawn fire from AIDS and gay rights activists, who say patients may be afraid to seek testing and treatment if...

UAB awarded $16 million grant to develop new HIV vaccine.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- The University of Alabama at Birmingham (UAB) has been awarded a 4 1/2 year, $16 million grant from the U.S. National Institutes of Allergy and Infectious Diseases (NIAID) to lead a multicenter study to...

NIH awards HIV vaccine development grant.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- As part of a multi-institutional $16 million grant from the National Institute of Allergy and Infectious Diseases (NIAID), scientists in the Department of Microbiology and Immunology at Emory University...

Infection of macaques with SIV induces species-specific antibody response.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Infection of macaques with simian immunodeficiency virus induces a species-specific antibody response to major histocompatibility complex class I and class II molecules. According to a study from...

Field evaluation of mobility assay for subtyping of HIV-1 described.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Field evaluation of the gag-based heteroduplex mobility assay for genetic subtyping of circulating recombinant forms of human immunodeficiency virus type 1 described in the Ivory Coast. According...

Standardized editing guidelines needed for HIV genotyping.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Standardized editing guidelines are needed for scientists performing HIV genotyping. "Sequencing-based human immunodeficiency virus type 1 (HIV-1) genotyping assays require subjective interpretation...

gp120 Thai E and SF2 vaccines elicits immune response in healthy Thai adults.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- A combination of the gp120 Thai E and SF2 vaccines elicited a strong immune response in healthy Thai adults and should be considered for phase 3 clinical testing. According to recent research from...

WHO promotes 100% condom use among sex workers in Asia.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- In an effort to slow the spread of AIDS in Asia, the World Health Organization (WHO) recently met in Laos to promote its policy of 100% condom use among sex workers. The 4-day meeting was held in...

Ethics of Botswana AIDS vaccine trials not assured, group says.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- A Botswana human rights organization has criticized the government for not passing legislation protecting people participating in HIV/AIDS vaccine trials. Alice Mogwe, director of the Botswana...

Indirect IMGU measures not reliable in diabetic HIV patients.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Indirect IMGU measures can be unreliable in diabetic HIV patients. "Various indirect indices have been used in human immunodeficiency virus (HIV)-infected individuals to assess insulin resistance,...

Clinical trial expenses and terminated merger affect vaccine maker's Q2 results.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Epimmune, Inc., (EPMN) announced its financial results for the second quarter ended June 30, 2003. During the quarter, cash and cash equivalents declined $1.7 million to an ending balance of $5.9...

Company puts focus on acquiring new technologies, initiating R&D.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- CytRx Corp. (CYTR), a biopharmaceutical company, announced financial results for the 3-month and 6-month periods ended June 30, 2003. For the second quarter of 2003, the company reported a net loss...

Natural mutation in HIV Tat enhances viral genome expression.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- A mutation in HIV Tat has been found to enhance viral genome expression. "A natural amino acid substitution in the human immunodeficiency virus type 1 (HIV-1) transcriptional activator Tat...

CD28 and ligands involved in AIDS- and EBV-associated lymphoma development.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- The CD28 molecule appears to play a key role in the development of AIDS- and EBV-associated lymphoma. According to recent research from the United States, "CD28, which is expressed on most T cells,...

Versant HCV RNA 3.0v assay valuable for measuring HCV RNA levels in HIV patients.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- A novel Versant HCV RNA assay is valuable for measuring HCV RNA levels in coinfected HIV patients. In a recent study from Italy, "the new generation assay Versant HCV RNA 3.0v (Bayer Diagnostics)...

HIV M184V mutation linked to viroimmunologic discordant response to HAART.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- The M184V mutation in HIV reverse transcriptase is linked to a viroimmunologically discordant response to treatment. "Whether highly active antiretroviral therapy (HAART) should be modified in...

With the help of P-TEFb, HIV Tat can activate latent viral reservoirs.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- With the help of P-TEFb, the HIV Tat protein can activate latent viral reservoirs. "The persistence of human immunodeficiency virus (HIV) in optimally treated infected individuals poses a major...

Cholesterol depletion of lipid rafts inactivates HIV virions.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Cholesterol depletion of lipid rafts can inactivate HIV virions. "Recent evidence suggests that human immunodeficiency virus type 1 (HIV-1) particles assemble and bud selectively through areas in...

HIV transframe protein helps maintain dimerization in mutant protease.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- The HIV transframe protein helps maintain dimerization activity in mutant protease (PR). HIV PR "is essential for viral replication: this aspartyl protease, active only as a dimer, is responsible...

DIS stem loop not needed for HIV replication in PBMCs.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Contrary to conventional wisdom, the HIV DIS stem loop is not needed for viral replication in some cell types. "Human immunodeficiency virus type 1 (HIV-1) contains two copies of genomic RNA that...

Antiretroviral treatment-associated vitiligo case reported.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- A case of skin pigmentation loss linked to antiretroviral therapy has been reported. "Autoimmune disorders such as vitiligo have been previously reported in patients with human immunodeficiency...

Murine CEM15 strongly inhibits wild-type HIV replication.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- The murine version of a human protein strongly inhibits HIV replication. "The HIV-1 accessory protein Vif (virion infectivity factor) is required for the production of infectious virions by CD4+...

Novel HIV protease inhibitor highly active against PI-resistant viruses.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- A novel HIV protease inhibitor is highly active against drug-resistant viral strains. "A biaryl pyridylfuran P-3 substituent on the hydroxyethylene isostere scaffold affords HIV protease inhibitors...

Unusual inflammatory PML seen in HIV patient on antiretroviral treatment.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- An unusual case of inflammatory PML has been observed in an HIV patients undergoing antiretroviral therapy. In a recent study from Germany, "a case of biopsy verified progressive multifocal...

AMPLICOR, Quantiplex HIV assays suitable for use in Portugal.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- AMPLICOR and Quantiplex HIV assays are suitable for use with children in Portugal. In a recent study, "the viral load assays AMPLICOR HIV-1 Monitor Test 1.5, Nuclisens HIV-1 QT, and Quantiplex HIV...

Collaborative effort focuses on AIDS in Africa.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Amid the human catastrophe that is AIDS in Africa, the absence of health care systems and practices that are taken for granted in other parts of the world routinely hampers efforts to care for patients...

HRSA awards $600,000 "twinning" grant to fight HIV/AIDS in the Caribbean.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- The Health Resources and Services Administration (HRSA) has announced a $600,000 Caribbean "twinning" program grant to Lutheran Medical Center in Brooklyn, New York, to improve the delivery and quality...

Scientists: Cloak of human proteins gets HIV into cells.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Three Johns Hopkins researchers propose, for the first time, that HIV and other retroviruses can use a Trojan horse style of infection, taking advantage of a cloak of human proteins to sneak into...

Pneumococcal vaccine modestly effective in HIV patients on HAART.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- The 23-valent pneumococcal polysaccharide vaccine is only modestly effective in HIV-infected patients receiving highly active antiretroviral therapy (HAART). "Whether HAART impacts responses to...

Structure-based phenotyping predicts HIV-1 protease inhibitor resistance.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Structure-based phenotyping can predict HIV-1 protease inhibitor resistance. "Mutations in HIV-1 drug targets lead to resistance and consequent therapeutic failure of antiretroviral drugs....

Tyrosine sulfation enhances efficacy of antibodies against HIV gp120.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Tyrosine sulfation enhances the efficacy of antibodies targeting the HIV coat protein gp120. "Sulfated tyrosines at the amino terminus of the principal HIV-1 coreceptor CCR5 play a critical role...

Cambodia hails U.S. plan to give $22.6 million for AIDS prevention.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Health officials hailed an announcement by the United States that it will provide US$22.6 million to help combat the spread of AIDS in Cambodia. The U.S. Embassy said in a statement that the funds...

Vical grants options for cancer targets.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Vical, Inc., (VICL) announced that Merck & Co., Inc., (MRK) and Vical have amended their existing license agreement. Under the amended agreement, Merck has obtained an option license for rights to...

Importin 7 mediates nuclear import of HIV intracellular reverse transcription complexes.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Importin 7 mediates the nuclear import of intracellular HIV RTC, and may represent a target for future antiretroviral agents. "Human immunodeficiency virus type 1 (HIV-1), like other lentiviruses,...

Whole-blood agglutination assay allows on-site detection of HIV infection.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Whole-blood agglutination assay allows on-site detection of human immunodeficiency virus infection. According to recent research from India, "Simple and rapid diagnostic tests are needed to...

CD4+ natural killer cells may play key role in HIV pathogenesis.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- NK cells expressing CD4 may play a key role in the pathogenesis of HIV infection. Scientists in the United States had previously discovered "the presence of a CD4+ subpopulation of natural killer...

CCR5 genotype affects Langerhans cell susceptibility to HIV infection.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- CCR5 genotype affects Langerhans cell susceptibility to HIV infection. "Langerhans cells (LCs) are suspected to be initial targets for HIV after sexual exposure (by becoming infected or by...

HIV Nef transports cholesterol to lipid rafts and virions.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- The HIV Nef protein transports cholesterol to lipid rafts and virions. "HIV buds from lipid rafts and requires cholesterol for its egress from and entry into cells," scientists in the United States...

Human topoisomerase I may account for HIV species-specificity.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Human topoisomerase I may underlie the species-specificity of HIV. "Although HIV type 1 (HIV-1) cannot efficiently replicate in simian cells, the mechanism(s) involved in the restriction of virus...

SDF-1 mutations not linked to syncytia risk in HIV patients.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- SDF-1 mutations do not affect the risk of HIV-induced syncytia induction. SDF-1 "is the principal ligand for CXCR4, a co-receptor with CD4 for T lymphocyte cell line-tropic human immunodeficiency...

Anti-nerve growth factor antibody shows promise for HIV control.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- An anti-NGF antibody shows great promise for the control of HIV infection. "Infection by HIV-1 causes persistent, long-term high virus production in macrophages," scientists in Italy explained....

OPTIMA trial to compare antiretroviral treatment efficacy.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- The OPTIMA trial will provide a comprehensive comparison of antiretroviral treatment regimens. "OPTIMA (OPTions In Management with Antiretrovirals) is a clinical trial with a factorial...

RNA-based gene therapy techniques show promise for HIV control.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- RNA-based gene therapy techniques may provide control of HIV infection. "Gene therapy strategies for HIV infection require gene transduction of hematopoietic stem cells with effective therapeutic...

GenVec completes merger.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- GenVec, Inc., (GNVC) announced that it has completed the merger of Diacrin, Inc., of Charlestown, Massachusetts, with and into GenVec. The transaction closed following approval of the merger by...

Paul Volberding joins scientific advisory board of AIDS vaccine company.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- The Immune Response Corp. (IMNR) announced the appointment of Paul Volberding, MD, to its scientific advisory board Volberding, an expert on HIV/AIDS, is professor and vice chair of the department...

HIV coreceptor structure and function reviewed.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- The role of HIV coreceptor structure, posttranslational modifications, and internalization in viral-cell fusion and as targets for entry inhibitors has been reviewed in a recent issue of Biochimica Et...

Experimental molecular design of combined vaccines reported.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Researchers have published a report on the experimental molecular design of combined vaccines in the journal Molecular Biology. According to published research from Russia, "A method was...

Retroviral reverse transcription primer selection is coordinated with tRNA biogenesis.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Selection of retroviral reverse transcription primers is coordinated with tRNA biogenesis. "Initiation of retrovirus reverse transcription requires the selection of a tRNA primer from the...

CD4 count and HIV RNA predictive of HIV therapy success.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- CD4 count and HIV RNA during the first 6 months on highly active antiretroviral therapy are predictive of outcome in chronic human immunodeficiency virus infection. According to a study from...

Innovations in oligonucleotide drug delivery reported.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Researchers have reported innovations in oligonucleotide drug delivery in a recent issue of the Journal of Pharmaceutical Sciences. According to a study from the United States, "Oligonucleotides...

HIV env gene plays key role in viral fitness.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- The gene coding for the HIV Env protein plays a key role in determining viral fitness. "A human host offers a variety of microenvironments to the infecting human immunodeficiency virus type I...

Cyanovirin-N highly active against influenza viruses.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Cyanovirin-N (CV-N) is highly active against influenza viruses. CV-N "was initially discovered based on its potent activity against the human immunodeficiency virus (HIV)," researchers in the...

Lactate levels can be used to measure antiretroviral drug adherence in children.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Lactate levels can be used to measure antiretroviral drug adherence in pediatric HIV patients. In a recent study from New York, "a total of 251 venous lactate levels were obtained from 127...

Lamivudine has CD4-cell dependent effect on HBV activity.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Lamivudine can reduce HBV activity in HIV patients with relatively high CD4 cell counts. In a recent study, scientists in the Netherlands "retrospectively analyzed the effect of lamivudine on...

Novel assay may improve HIV fitness measures in treated patients.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- A novel assay may improve measurements of HIV viral fitness in treated patients. "Despite numerous studies on human immunodeficiency virus type 1 (HIV-1) fitness, many key conceptual and technical...

Zidovudine/lamivudine regimens to prevent vertical transmission studied.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Zidovudine/lamivudine regimens used to prevent vertical HIV transmission do not cause viral resistance mutations. According to published research from Italy, "two zidovudine/lamivudine regimens...

Vaccine maker reports financial performance, provides clinical update.
September 22, 2003... 2003 SEP 22 - (NewsRx.com & NewsRx.net) -- Bavarian Nordic A/S announced its interim results for the 6-month period ending June 30, 2003, and provided an update on its AIDS and smallpox vaccine development. Commenting on Bavarian Nordic's...

N- and C-terminal zinc fingers in HIV NC protein have different roles.
September 29, 2003... 2003 SEP 29 - (NewsRx.com & NewsRx.net) -- The N- and C-terminal zinc fingers in the HIV NC protein have distinct functional roles during viral replication. "The replication process of human immunodeficiency virus requires a number of...

The HIV group O frameshift stimulatory signal is a pseudoknot.
September 29, 2003... 2003 SEP 29 - (NewsRx.com & NewsRx.net) -- The shape of the HIV group O frameshift stimulatory signal has been identified. "Human immunodeficiency virus type 1 (HIV-1) requires a programmed -1 ribosomal frameshift to produce Gag-Pol, the...

Intestinal cell cycle dysregulation occurs during SIV infection.
September 29, 2003... 2003 SEP 29 - (NewsRx.com & NewsRx.net) -- High-throughput gene expression profiling indicates dysregulation of intestinal cell cycle mediators and growth factors during primary simian immunodeficiency virus infection. According to a study...

Update provided on HIV, cancer vaccines, workforce reduction.
September 29, 2003... 2003 SEP 29 - (NewsRx.com & NewsRx.net) -- Epimmune, Inc., (EPMN) provided an update of its three ongoing clinical trials in HIV, lung cancer, and colorectal cancer, and the company announced a workforce reduction aimed at focusing its...

Bacteria may show promise in AIDS fight.
September 29, 2003... 2003 SEP 29 - (NewsRx.com & NewsRx.net) -- A modified form of bacteria normally present in the vagina may one day be used to protect women from AIDS, according to new research. The engineered bacteria showed promise in laboratory testing,...

Dawson James Securities initiates coverage of HIV vaccine developer.
September 29, 2003... 2003 SEP 29 - (NewsRx.com & NewsRx.net) -- Robert Wasserman, director of Research for Dawson James Securities, a division of ViewTrade Financial, has initiated coverage on Immune Response Corporation (IMNR) with a buy rating and a 12-month...

Phase I trial of autologous VRX496 modified T cells deemed safe.
September 29, 2003... 2003 SEP 29 - (NewsRx.com & NewsRx.net) -- VIRxSYS Corporation, a private biotechnology company focused on the development of genetic medicines for the treatment of serious diseases such as HIV/AIDS, announced that an independent Data Safety...

Mechanisms underlying hypertriglyceridemia in HIV patients elucidated.
September 29, 2003... 2003 SEP 29 - (NewsRx.com & NewsRx.net) -- The mechanisms underlying elevated triglyceride levels in HIV patients have been elucidated. "Hypertriglyceridemia is common in individuals with human immunodeficiency (HIV) infection, but the...

HIV infection impairs astrocyte glutamate transport.
September 29, 2003... 2003 SEP 29 - (NewsRx.com & NewsRx.net) -- The HIV coat protein downregulates glutamate transporter expression by infected astrocytes. "L-Glutamate is the major excitatory neurotransmitter in the brain," researchers in New York explained....

Vav prevents HIV Nef-induced GM1 downregulation and NF-AT inhibition.
September 29, 2003... 2003 SEP 29 - (NewsRx.com & NewsRx.net) -- The exchange factor Vav prevents HIV Nef-induced GM1 downregulation by T cells, preserving their ability to be activated by the transcription factor NF-AT. "Several findings support the importance...

Tat acetylation needed for CyclinT1-independent HIV transactivation.
September 29, 2003... 2003 SEP 29 - (NewsRx.com & NewsRx.net) -- Acetylation of the HIV Tat protein is needed for CyclinT1-independent transactivation. "The HIV transcriptional activator Tat is acetylated by p300 at a single lysine residue in the TAR RNA binding...