AIDS Vaccine Week articles from October 2003

AIDS Vaccine Week archives from October 2003

AIDS vaccine protects against infection in a macaque AIDS model.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A single DNA priming followed by a single booster with a recombinant replication-defective Sendai virus vector was protective in a macaque AIDS model. According to a study from Japan, "We previously...

Scientists invent search-and-destroy method to flush HIV out of hiding places.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- University of California Los Angeles AIDS Institute scientists have devised a new technique to switch on and drive hibernating HIV from its hiding places in the body. Reported in Immunity, the...

DNA immunization enhances immune response to fowlpox-based SIVmac vaccine.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Prior DNA immunization enhances immune response to dominant and subdominant viral epitopes induced by a fowlpox-based SIVmac vaccine in long-term slow-progressor macaques infected with SIVmac251. ...

Cytidine deaminase with potent but Vif-abolished antiretroviral activity identified.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A novel endogenous enzyme has the potential to profoundly disrupt HIV replication. "A human gene with potent antiretroviral activity has recently been found to encode a new member of the family of...

To recruit cytoplasmic Tsg101, HIV Gag mimics human Hrs protein.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The HIV Gag protein emulates the human Hrs protein in order to draw a key cytoplasmic factor to the endosomal membrane, where it can aid viral replication. HIV Gag "recruits the cellular factor...

Smallpox vaccines may protect against HIV.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Smallpox vaccinations may also provide protection against the virus that causes AIDS, according to researchers at George Mason University. The findings are only preliminary and based on a very small...

Study: Patients can benefit from simplified antiretroviral treatments.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A large study shows that simplified antiretroviral treatment regimens containing Viramune (nevirapine) or efavirenz offer comparable efficacy and safety in patients who switched from a protease...

HIV-based vectors do not require rev gene.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The rev gene does not need to be included in HIV-based gene therapy vectors. "HIV-1-based vectors are promising tools for gene therapy because of their ability to integrate into nondividing cells,"...

Genetically enhanced bacteria may prevent HIV infections in women.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers at the Stanford University School of Medicine have found in laboratory experiments that bacteria that naturally live in the body can be genetically enhanced for potent antiviral activity,...

Rapid HIV immunoassay effective.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A rapid HIV immunoassay is suitable for clinical use. In a recent study, scientists in the Netherlands "evaluated the reliability of a rapid human immunodeficiency virus type I test for quick...

Lentiviral vectors can protect transduced cells from HIV infection.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- With the proper load, lentiviral vectors can protect transduced cells from HIV infection. "A primary advantage of lentiviral vectors is their ability to pass through the nuclear envelope into the...

Novel assay detects replication-competent lentiviral vectors.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A novel assay can detect very low levels of lentiviral vector contamination with replication-competent pathogens. "Lentiviral vectors have demonstrated great potential as gene therapy vectors,...

Yeast-based HIV cloning system useful for research.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A novel yeast-based viral cloning system may aid research on uncommon HIV subtypes and strains. According to recent research from the United States, "A recent shift from studies on a few subtype B...

Antioxidant treatment may do more harm than good.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Antioxidant treatment may do more harm than good for patients with HIV-associated lipodystrophy. In a recent study from the United States, "ten HIV-infected nucleoside reverse transcriptase...

Leptin replacement can ameliorate protease inhibitor-induced lipid abnormalities.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Leptin replacement therapy can ameliorate the lipid dysfunction triggered by some anti-HIV drugs. "A major complication associated with the use of protease inhibitors (PIs) in treatment of...

Caveolae used for HIV Tat fusion protein internalization.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Caveolae are used for cellular internalization of HIV Tat fusion proteins. "The Tat protein from HIV-1, when fused with heterologous proteins or peptides, can traverse cell membranes," scientists in...

Role of Tsg101 in HIV Gag trafficking and release clarified.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The role of the Tsg101 protein in the trafficking and release of HIV Gag from infected cells has been clarified. "The structural precursor polyprotein of human immunodeficiency virus type 1,...

Through ESCRT recruitment, Hrs helps regulate endosomal multivesicular body formation.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The Hrs protein helps regulate endosomal multivesicular body formation through ESCRT recruitment. "Hrs and the endosomal sorting complexes required for transport, ESCRT-I, -II, and -III, are...

Virus assembly takes place in late endosomes in HIV-infected primary macrophages.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Virus assembly takes place in late endosomes in HIV-infected primary macrophages. "Although human immunodeficiency virus type 1 (HIV-1) is generally thought to assemble at the plasma membrane of...

Metal chelation underlies anti-HIV integrase activity of beta-diketo acids.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Metal chelation underlies the ability of beta-diketo acids (DKAs) to inhibit HIV integrase activity. DKAs "represent a major advance for anti-HIV-1 integrase drug development," scientists in the...

Novel MKC-442 analogues show potent antiretroviral activity.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A series of novel MKC-442 analogues have potent activity against both wild-type and MKC-442-resistant strains of HIV. According to a recent study from Denmark, "bis(alken-1-yloxy)methanes (2) were...

Nuclear protein phosphatase-1 helps mediate HIV transcription.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Nuclear protein phosphatase-1 (PP1) appears to play a key role in the process of HIV transcription. Scientists in Washington, DC, previously demonstrated that PP1 "dephosphorylates RNA polymerase...

Prophylactic single-dose nevirapine linked to low rate of HIV V106M mutations.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A low rate of HIV V106M mutations - usually associated with efavirenz treatment - has been observed in women treated with single-dose nevirapine as vertical transmission prophylaxis. "Nevirapine...

T-cell apoptosis overwhelms proliferation during structured HIV treatment interruptions.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- T-cell apoptosis is much more extensive than T-cell proliferation during structured HIV treatment holidays. "Multiple failures of antiretroviral treatments, as a result of multidrug-resistant...

Vitamin A deficiency common in HIV, tuberculosis patients in Africa.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- In African patients, HIV and/or tuberculosis infections are associated with vitamin A deficiency. In a recent study from Tanzania, "serum vitamin A was determined" and compared in "100 HIV-positive...

KSHV transcription factor K-bZIP prolongs cell cycle transition in infected cells.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The KSHV transcription factor K-bZIP prolongs cell cycle transition in infected cells. "In order to cope with hostile host environments, many viruses have developed strategies to perturb the...

Corixa Corp. signs research, development, and license agreement.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- InNexus Biotechnology, Inc., (IXS), a monoclonal antibody-development company, and Corixa Corp. (CRXA), a developer of immunotherapeutic products, announced that the companies have entered into an...

Role of HIV nucleocapsid protein zinc fingers in reverse transcription clarified.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The role played by zinc fingers in the HIV nucleocapsid protein during reverse transcription has been clarified. "In the minus-strand transfer step of HIV-1 reverse transcription, the nucleocapsid...

Ubiquitin plays non-proteolytic role in HIV Tat-mediated viral transactivation.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Ubiquitin plays a non-proteolytic role in HIV Tat-mediated viral transactivation. "The human immunodeficiency virus type 1 (HIV-1) encodes a potent transactivator, Tat, which functions through...

Researchers continue AIDS vaccine research with $15 million grant.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A team of medical researchers from three Seattle research facilities recently received a grant of more than $15 million from the National Institute of Allergy and Infectious Diseases (NIAID) to continue...

First report of combined spinal subdural tuberculous empyema and intramedullary tuberculoma.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- For the first time, a patient with combined spinal subdural tuberculous empyema and intramedullary tuberculoma has been reported. "Tuberculous involvement of the spinal subdural and intramedullary...

Phthalocyanines may prevent sexually transmitted HIV infection.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Phthalocyanines may prevent sexually transmitted HIV infection According to published research from the United States, "The ability of selected phthalocyanines and metallophthalocyanines to block...

Protein grafting used to create anti-HIV epitope.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- An HIV-inhibiting epitope has been developed through the use of protein grafting. "Protein grafting, the transfer of a binding epitope of one ligand onto the surface of another protein, is a...

HIV vaccine candidate trial begins in 18 cities around the world.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- The HIV Vaccine Trials Network (HVTN) and Merck & Co., Inc., announced that they have begun the first global clinical trial of Merck's HIV vaccine candidate in 18 cities around the world. The...

Dendritic cells respond to antigens through heat shock protein receptor.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptor. According to recent research published in the journal Blood, "The most...

HIV-1 peptide protects mice against virus expressing HIV-1 antigen.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- An epitope-enhanced conserved HIV-1 peptide protected HLA-A2-transgenic mice against virus expressing HIV-1 antigen. "HIV epitopes may have developed to be poor immunogens. As a counterapproach...

Despite increased attention, Africa's AIDS fight remains only half funded.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Although an increasing number of leaders of African and donor nations are demonstrating a greater willingness to address HIV/AIDS in Africa, recent analyses show that the total funding anticipated is...

WHO vows to renew commitment to treating 3 million AIDS patients by 2005.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- In an effort to salvage at least one of the international community's goals to fight HIV/AIDS, the World Health Organization renewed its commitment to treat 3 million patients in poor countries by...

The MHC-II may bind antigen first, then protein is unfolded and trimmed.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Antigens to be used by MHC-II appear to be bound before unfolding, not after, and then trimmed to size. "Ever since the emergence of models for the processing and presentation of antigenic...

p73 in neuroblastoma may have oncosupressor, oncogenic properties.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- p73 in neuroblastoma may have oncosupressor, oncogenic properties. "The p73 gene is a p53 homologue localized at 1p36.3, a chromosomal region frequently deleted in neuroblastoma. p73 was...

Anti-HIV mechanisms of SPMG clarified.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- The antiretroviral mechanisms of SPMG have been clarified. In a recent study from China, "The potential targets of marine sulfated polymannuroguluronate (SPMG) involved in inhibition of HIV-1...

CCR5 antagonists derived from fungus.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- A pair of novel CCR5 antagonists have been derived from a common fungus. According to published research from Singapore, "Two new compounds, 10-methoxydihydrofuscin (1) and fuscinarin (2), and one...

Caffeoyl naphthalenesulfonamide derivatives inhibit HIV integrase activity.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- A group of novel caffeoyl naphthalenesulfonamides inhibit HIV integrase (IN) activity. HIV-1 IN "is an essential enzyme for retroviral replication and a rational target for the design of anti-AIDS...

NIH grant to fund Texas center for immunology and biodefense.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Baylor Research Institute (BRI) announced that it has received a $14.6 million grant from the National Institute of Allergy and Infectious Disease (NIAID), one of the U.S. National Institutes of...

Aberrant somatic hypermutation linked to AIDS-associated NHL development.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Aberrant somatic hypermutation may play a key role in the development of AIDS-associated NHL. "The pathogenesis of AIDS-related non-Hodgkin lymphomas (AIDS-NHLs) is associated with chromosomal...

Non-parametric methods can predict HIV drug susceptibility from genotype.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Non-parametric methods have been devised to predict HIV drug susceptibility from the viral genotype "Medical management of HIV infection requires an understanding of the relationship between viral...

MAPK signaling needed for beta-chemokine production by CD40L-stimulated macrophages.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- MAPK signaling is needed for beta-chemokine production by CD40L-stimulated macrophages. "CD40 ligand is a cell surface molecule on CD4+ T cells that interacts with its receptor, CD40, on antigen...

Virological suppression in HIV patients linked to improved psychomotor speed.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Virological suppression is linked to improved psychomotor speed in HIV patients. In a recent study, scientists in the United States "evaluated the association of a virologic response to highly...

CCR5 and CXCR4 have distinct mechanisms of agonist-induced endocytosis.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- CCR5 and CXCR4 have distinct mechanisms of agonist-induced endocytosis. "Desensitization of the chemokine receptors, a large class of G protein-coupled receptors, is mediated in part by...

High IL-7 levels linked to CD4 cell recovery in pediatric HIV patients.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Elevated levels of the cytokine IL-7 are linked to CD4 cell recovery in pediatric HIV patients. According to published research from Spain, "To asses the role of interleukin 7 (IL-7) in the thymic...

LEDGF/p75 needed for nuclear and chromosomal targeting of HIV-1 integrase.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- LEDGF/p75 is needed for nuclear and chromosomal targeting of HIV-1 integrase in human cells. Previous research by scientists in Belgium revealed that HIV-1 IN "forms a specific nuclear complex with...

Antiretroviral drug interaction with lamivudine can affect its transport.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Interactions with other antiretroviral drugs can alter lamivudine transport through the blood-brain barrier. "To treat human immunodeficiency virus (HIV) within the central nervous system (CNS),...

Mutations in HIV gp41 linked to C-34 resistance.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Mutations in the HIV glycoprotein gp41 linked to C-34 resistance have been identified. "The gp41 subunit of HIV-1 has been recently recognized as a target for antiviral therapy," scientists in...

Switch maintenance may prevent lipodystrophy in NNRTI-treated HIV patients.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Switch maintenance may prevent lipodystrophy in NNRTI-treated HIV patients. According to recent research from France, "Forty patients participating in the TRIZAL study were treated with a...

Cultural changes in Namibia may hasten spread of HIV infection.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Cultural changes in Namibia may hasten the spread of HIV infection there. Researchers at the University of Namibia conducted a study "to see how changes in patterns of sexual life may affect HIV...

Early antiretroviral treatment helps prevent vertical HIV transmission.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Early antiretroviral treatment helps prevent vertical HIV transmission. In a recent study from Brazil, "A cohort of 297 HIV-infected pregnant women was followed from January 1996 to December 2001."...

Human trials begin of investigational HIV prime-boost vaccine candidates.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Aventis and Merck & Co., Inc., announced human trials have begun to test the safety and immune responses generated by using a combination of two anti-HIV-1 vaccine candidates in a complementary way....

IL-2 prevents MCMV retinitis by increasing intraocular perforin mRNA levels.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- IL-2 prevents CMV retinitis in mice by increasing intraocular levels of perforin mRNA. "Mice with a retrovirus-induced immunosuppression (MAIDS) are susceptible to experimental murine...

Increased antimicrobial use by HIV patients may heighten MRSA risk.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Increased antimicrobial use by HIV patients may heighten their risk of drug-resistant staphylococcal infections. "HIV-infected individuals, especially those with a history of injecting drug use,...

Oral lesions may mark HIV infection in Thai, Cambodian populations.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Oral lesions may be a sign of HIV infection in Thai and Cambodian populations. According to published research from Germany, "Oral manifestations were studied in 87 HIV-positive Thai adults (study...

E. coli RNA aptamers used inhibit HIV reverse transcriptase.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- RNA aptamers have been used to inhibit HIV RT function in transgenic E. coli. "A better understanding of aptamer function in bacteria would help to establish simple model systems for screening...

Lymphocyte HSP70 expression altered during HIV infection.
October 20, 2003... 2003 OCT 20 - (NewsRx.com & NewsRx.net) -- Lymphocyte expression of heat shock protein (HSP) 70 is altered during HIV infection. In a recent study from Australia, HSP expression "in lymphocytes isolated from 20 patients with HIV disease...

Cellular internalization of HIV Tat fusion proteins characterized.
October 20, 2003... 2003 OCT 20 - (NewsRx.com & NewsRx.net) -- The mechanisms by which HIV Tat fusion protein are internalized into cells have been determined. "The transactivator protein of human immunodeficiency virus type 1 Tat has the unique property of...

Virus entry is potential target for anti-HIV intervention.
October 20, 2003... 2003 OCT 20 - (NewsRx.com & NewsRx.net) -- Virus entry is a potential target for anti-HIV intervention. "The replicative cycle of the human immunodeficiency virus (HIV) can be interrupted at several stages. Until recently only the viral...

U.S. awards $81 million for HIV vaccine development.
October 20, 2003... 2003 OCT 20 - (NewsRx.com & NewsRx.net) -- The National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health (NIH), has announced four new contracts to support development of candidate HIV...

Anti-HIV CXCR4 antagonists may also inhibit breast cancer.
October 20, 2003... 2003 OCT 20 - (NewsRx.com & NewsRx.net) -- An anti-HIV agent shows promise for the treatment of breast cancer. "A chemokine receptor, CXCR4, and its endogenous ligand, stromal cell-derived factor-1 (SDF-1), have been recognized to be...

Biotechnology company receives grants from NIAID, NIAAA.
October 20, 2003... 2003 OCT 20 - (NewsRx.com & NewsRx.net) -- Large Scale Biology Corp. (LSBC) has been awarded a 2-year research grant by the National Institute of Allergy and Infectious Diseases (NIAID) to investigate the potential of LSBC's proprietary plant...

Apelin-13 interactions with APJ receptor characterized.
October 20, 2003... 2003 OCT 20 - (NewsRx.com & NewsRx.net) -- The interaction between apelin-13 and the APJ receptor have beeen characterized, providing information that may aid the development of anti-HIV agents. "The APJ receptor is widely expressed in the...

Cyclophilin A modulates HIV sensitivity to host restriction factors.
October 20, 2003... 2003 OCT 20 - (NewsRx.com & NewsRx.net) -- Cyclophilin A modulates HIV sensitivity to host restriction factors. "Many mammalian species express restriction factors that confer host resistance to retroviral infection," scientists in New...

Antiretroviral DOT improves outcome for drug-abusing HIV+ women.
October 20, 2003... 2003 OCT 20 - (NewsRx.com & NewsRx.net) -- Antiretroviral DOT is effective for drug-abusing women infected with HIV. In a recent study from the United States, "Six women with substance abuse and poor adherence histories received daily...

Definition of virologic failure in HIV drug trials questioned.
October 20, 2003... 2003 OCT 20 - (NewsRx.com & NewsRx.net) -- The standards for determining virologic failure in HIV drug trials have been challenged. "Definition of the time of loss of virological response is important when designing a viral load endpoint...

HAART effective for HIV control in developing areas.
October 20, 2003... 2003 OCT 20 - (NewsRx.com & NewsRx.net) -- Antiretroviral treatments are as effective in developing countries as they are in more affluent regions. In a recent study, scientists in France evaluated "the short-term results of highly active...

HIV protease inhibitors may lower vitamin B-12 serum levels.
October 20, 2003... 2003 OCT 20 - (NewsRx.com & NewsRx.net) -- PI-based therapy may reduce vitamin B-12 levels in HIV patients. "The dietary intake of micronutrients and serum micronutrient status have been topics of concern in relation to human...

HIV treatment interruptions linked to thrombocytopenia.
October 20, 2003... 2003 OCT 20 - (NewsRx.com & NewsRx.net) -- Structured HIV treatment holidays may increase patients' risk of thrombocytopenia. According to published research from Thailand, "In a structured treatment interruption (STI) trial, 3 of 23...

SHIV 89.6 proviral DNA and live virus elicit similar immune responses.
October 27, 2003... 2003 OCT 27 - (NewsRx.com & NewsRx.net) -- SHIV 89.6 proviral DNA and live virus elicited similar immune responses in vaccinated rhesus macaques. "Inoculation of cats, goats, and monkeys with plasmids encoding full-length proviral genomes...

SIV virus-like particles conjugated to cholera toxin elicit immune responses.
October 27, 2003... 2003 OCT 27 - (NewsRx.com & NewsRx.net) -- Mucosal immunization with virus-like particles of simian immunodeficiency virus conjugated with cholera toxin subunit B elicited humoral and cellular immune responses. According to a study from...

Adenoviral vector HIV vaccine stimulates enhanced mucosal IgA response.
October 27, 2003... 2003 OCT 27 - (NewsRx.com & NewsRx.net) -- An intranasal adenoviral vector human immunodeficiency virus vaccine stimulated an enhanced mucosal immunoglobulin A response. According to recent research published in the Journal of Virology,...

Cytotoxic-T-lymphocyte responses elicited by multiepitope DNA vaccination.
October 27, 2003... 2003 OCT 27 - (NewsRx.com & NewsRx.net) -- Cytotoxic-T-lymphocyte responses were elicited by a multiepitope DNA vaccine in rhesus monkeys. According to published research from the United States, "In an effort to develop an AIDS vaccine...

A fifth of South Africa's military infected with HIV.
October 27, 2003... 2003 OCT 27 - (NewsRx.com & NewsRx.net) -- At least one-fifth of South Africa's military is infected with the virus that causes AIDS, the defense minister says. But he sought to dismiss concerns about the effects of the disease on the armed...

AIDS vaccines still elusive, but trials now include humans.
October 27, 2003... 2003 OCT 27 - (NewsRx.com & NewsRx.net) -- The patient's inoculation was as routine as any Dr. Robert Johnston had seen. Roll up the sleeve, a cotton swab of alcohol on the upper arm and a "this shouldn't hurt much." What was in the...

Two NIH biodefense grants to be used for vaccine development.
October 27, 2003... 2003 OCT 27 - (NewsRx.com & NewsRx.net) -- AlphaVax, Inc., has been awarded two U.S. National Institutes of Health (NIH) biodefense grants to develop new vaccines, using the company's proprietary technology, against two groups of...

Drug discovery company receives $300K in grants.
October 27, 2003... 2003 OCT 27 - (NewsRx.com & NewsRx.net) -- Tranzyme, Inc., has been awarded two grants from the U.S. National Institutes of Health (NIH) totaling approximately $300,000. The first is a phase I Small Business Technology Transfer (STTR)...

$16.7M NIH contract to develop HIV vaccine.
October 27, 2003... 2003 OCT 27 - (NewsRx.com & NewsRx.net) -- Epimmune, Inc., (EPMN) announced that it has received a 5-year, $16.7 million contract from the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH),...

Biopharmaceutical company awarded $19M contract to develop HIV vaccine.
October 27, 2003... 2003 OCT 27 - (NewsRx.com & NewsRx.net) -- Novavax, Inc., (NVAX) was awarded a 5-year $19 million contract from the U.S. National Institute of Allergy and Infectious Diseases (NIAID) for the design and development of a new class of human...