AIDS Vaccine Week articles from December 2004

AIDS Vaccine Week archives from December 2004

CD4+ T cell depletion in HIV occurs predominantly in gastrointestinal tract.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. "The mechanisms underlying CD4+ T cell depletion in human immunodeficiency virus (HIV)...

Novel and promiscuous CTL epitopes in conserved regions of Gag identified.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Scientists have identified novel and promiscuous CTL epitopes in conserved regions of Gag targeted by individuals with early subtype CHIV type infection from southern Africa. "Characterization of...

Therapeutic HIV vaccines reviewed.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Scientists review therapeutic AIDS/HIV vaccines in a recent issue of the journal Vaccine. According to a study from, "The goal of a therapeutic HIV vaccine is to attenuate HIV disease progression in...

Vaccine provides T-cell-mediated protection in monkeys after SIV challenge.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A systemic vaccine approach provided T-cell-mediated protection in cynomolgus monkeys after SIV mucosal challenge. According to recent research from Italy, the Netherlands, Germany, and Sweden,...

Role of gastrointestinal T cells in HIV pathogenesis reviewed.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Scientists review the role of gastrointestinal T cells in HIV pathogenesis in a recent issue of the Journal of Experimental Medicine. According to a study from the United States, "Two groups have...

HIV linked to depletion of CD4+ T cells from effector sites in GI tract.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. According to a study from the United States and Germany,...

Nuclear localization of adenovirus E4orf4 protein correlates with cell death.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Nuclear localization of adenovirus E4orf4 protein correlates with cell death. "The adenovirus E4orf4 protein induces p53-independent death of human cancer cells by a mechanism requiring interactions...

Fluid diagnostics company receives award.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- OraSure Technologies announced that its OraQuick Advance Rapid HIV-1/2 Antibody Test has been awarded a 2004 "Best of What's New" award by Popular Science magazine in the Personal Health category. ...

Glycerol plus polyvinylpyrrolidone optimally preserves frozen bone marrow cells.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Glycerol plus polyvinylpyrrolidone optimally preserves frozen bone marrow cells. According to a study from the Netherlands, "Quantitative studies are presented of the effect of different storage...

Biopharma reports third quarter 2004 results, clinical achievements.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Progenics Pharmaceuticals, Inc., (NASDAQ: PGNX) announced its results of operations for the third quarter ended September 30, 2004, and for the first 9 months of 2004. Revenues for the third...

Molecular diagnostics company announces expansion of diagnostic pipeline.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Third Wave Technologies Inc. (TWTI) provided new details about the expansion of the company's molecular diagnostic pipeline and issued preliminary guidance for 2005 clinical molecular diagnostic...

Cryptococcus neoformans outbreak at Vancouver Hospital between 1997-2002.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A Cryptococcus neoformans outbreak at Vancouver Hospital between 1997-2002 was note retrospectively. According to a study from Canada, "An outbreak of infections due to a rare subspecies of...

Cytomegalovirus inhibits cytokine-induced macrophage differentiation.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Cytomegalovirus inhibits cytokine-induced macrophage differentiation. According to a study from Sweden, "Human cytomegalovirus (HCMV) infection in immunocompromised patients is associated with...

Novel chemiluminescent immunosensor assay detects serum CA19-9 levels.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A novel chemiluminescent immunosensor assay detects serum CA19-9 levels. "A novel chemiluminescent immunosensor for carbohydrate antigen 19-9 (CA19-9) based on the immobilization of CA19-9 on the...

African leaders, health activists push for money to fight disease.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Four African presidents appealed November 17, 2004, for new grants from a fund set up to combat three of the world's deadliest diseases, while the United States has called for restraint in spending...

Biotechnology company reports improved third quarter results.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Lipid Sciences, Inc., reported financial results for the quarter ended Sept. 30, 2004. For the third quarter of 2004, Lipid reported a net loss of $3.2 million, or $.13 per share, on a basic and...

Monoclonal antibody among HIV therapies discussed at human virology meeting.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Tanox, Inc. (TNOX) medical director Stanley Lewis recently presented findings from the phase 1 clinical trial of TNX-355 for the treatment of human immunodeficiency virus (HIV) at the 2004 International...

Men and women equally distressed by sexual infidelity within the context of AIDS.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Men and women are equally distressed by sexual infidelity within the context of AIDS. "Context effects on men's and women's reactions to infidelity were studied in a laboratory experiment....

Family home AIDS care in rural sub-Saharan Africa is a minimal burden.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Family home AIDS care in rural sub-Saharan Africa is a minimal burden. According to recent research from the United States, "In rural sub-Saharan Africa, most care for patients with AIDS is provided...

Level of HIV/AIDS patient care better if health facility funded by CARE Act.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The level of HIV/AIDS patient care is better if the health facility is funded by the Ryan White CARE Act. "The Ryan White Comprehensive AIDS Resources Emergency Act 1990 (CARE Act) is one of the...

HIV-infected patients with CNS HSV coinfection have varied presentations.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- HIV-infected patients with a CNS HSV coinfection have varied presentations. According to recent research published in the International Journal of STD & AIDS, "We report clinical, radiological and...

Household costs attributable to AIDS in Chad are devastating.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Household costs attributable to AIDS in Chad are devastating. "This paper assesses the economic costs of AIDS at the household level in Chad, one of the poorest countries in the world. "One...

HAART adherence shifts during HIV infection course for women caring for children.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- HAART adherence shifts during the course of HIV infection for women caring for children. "Few studies have directly focused on adherence to highly active antiretroviral medication (HAART) in HIV...

HIV drug resistance not a problem if immune response maintains above threshold.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- HIV drug resistance is not a problem if immune response is maintained above threshold. "The treatment of viral infections using antiviral drugs has had a significant public health benefit in the...

Expenditure more sensitive indicator of economic impact of HIV/AIDS than income.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Expenditure is a more sensitive indicator of economic impact of HIV/AIDS than income. According to a study from England, "We compared 202 households with an HIV-infected member, and 202 unaffected...

Men who have sex with men less likely to use HIV partner notification service.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Men who have sex with men are less likely to use an HIV partner notification service than people diagnosed with other risk factors. According to recent research published in the International...

Most recent common ancestor of HIV subtype C appeared in mid to late 1960s.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The most recent common ancestor of HIV subtype C appeared in the mid- to late 1960s. "Human immunodeficiency virus type 1 (HIV-1) subtype C is responsible for more than 55% of HIV-1 infections...

Reduction in new HIV infections in Southeast Spain.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- There is a reduction in new HIV infections in Southeast Spain. "We analyze the characteristics of patients diagnosed with HIV infection in the highly active antiretroviral therapy era in the...

HIV/AIDS patients in Malawi seek hospital healthcare as a last resort.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- HIV/AIDS patients in Malawi seek hospital healthcare as a last resort. According to a study from the United States, "Health-seeking practices in Malawi are not well understood and it is not clear...

Gay sex workers play important role as sex educators on the Internet.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Gay sex workers play an important role as sex educators on the Internet. According to published research from the United States, "While prior studies have targeted street-based male sex workers as...

Russian government lacks will to combat spread of HIV/AIDS, experts say.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- AIDS and the HIV virus are spreading at an alarming pace in Russia, but the government lacks the political will to combat the epidemic that may claim tens of thousands of lives within the next few...

STD/HIV prevention website navigation tools not helpful enough for teenagers.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- "Little is known about the quality and usability of online health information. This analysis evaluated STD prevention websites' content quality and usability. "Thirty-six sites were analyzed to...

Internet is a viable recruitment tool for reaching HIV at-risk individuals.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- According to published research from the United States, "Although use of the Internet as a vehicle for HIV/STI research is increasing, its viability to recruit at-risk populations such as Hispanic men...

Complement mediates HIV binding to erythrocytes.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Complement mediates HIV binding to erythrocytes. According to a study from Switzerland, "A fraction of HIV is associated with erythrocytes even when the virus becomes undetectable in plasma under...

Distinct mechanisms of HIV-1 Nef action in different populations of target cells.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- There are distinct mechanisms of HIV-1 Nef action in different populations of target cells. According to a study from Canada, "HIV-1 Nef is a critical determinant of pathogenicity in humans and...

Entry/transcription key determinants of CD4 T-cell permissiveness to HIV-1.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Entry and transcription are the key determinants of CD4 T-cell permissiveness to HIV-1 infection. According to recent research from Switzerland, "Isolated primary human cells from different donors...

Fluorescent-labeled HIV-1 developed to investigate interaction with live cells.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A fluorescent-labeled HIV-1 was developed in order to investigate its interaction with live cells. According to recent research published in the Journal of Virology, "The introduction of a label...

Prostratin antagonizes HIV latency by NF-kappa B activation.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Prostratin antagonizes HIV latency by NF-kappa B activation. According to recent research from the United States, "A subset of quiescent memory CD4 T cells harboring integrated but...

Raft-promotion of virion-associated cholesterol determines HIV-1 infectivity.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Raft-promotion of virion-associated cholesterol determines HIV-1 infectivity. According to a study from Australia, "Lipid rafts are enriched in cholesterol and sphingomyelin and are isolated on the...

Riboswitch regulates RNA dimerization and packaging in HIV-1 virions.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A riboswitch regulates RNA dimerization and packaging in HIV-1 virions. According to investigators in the Netherlands, "The genome of retroviruses, including human immunodeficiency virus type I...

High-risk sexual behavior prevalent among drug users in Pakistan.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- High-risk sexual behavior is prevalent among drug users in Pakistan. According to recent research from the United States, "Our objective was to describe HIV/STD risk behaviors and awareness among a...

Online choice for sex-seeking among gay males varies with education level.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The online choice for sex-seeking among gay males varies with their level of education. According to investigators in the United States, "Research has shown that online sex-seeking among men who...

Risky sex behavior among men associated with alcohol/drug use and other factors.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Risky sex behavior among men is associated with alcohol and drug use, as well as other factors. "This paper describes drug and sexual risk behaviors during a six-month period in 2001 of 2,916 gay...

Synchronous online interviews inherently unsuitable for exploring HIV risk.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- According to a study from England, "This paper considers some of the strengths and weaknesses of conducting synchronous online interviews for qualitative research. It is based on a study among...

Diagnostics-focused biotech company receives U.S. FDA CLIA waiver for HIV test.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Trinity Biotech plc (TRIB) announced that the U.S. Food and Drug Administration (FDA) has approved a waiver under the Clinical Laboratory Improvements Amendments of 1988 (CLIA) for the Uni-Gold...

Measuring validity of self-reported symptoms among people with HIV.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Symptoms are important indicators of health and treatment for people with HIV. Symptoms are measured by patient self-report, but there has been...

Many people in the U.K. do not need to access HIV test results in person.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Many people in the U.K. do not need to access HIV test results in person. "With the changes in the nation's sexual health needs and the introduction of the Government's Sexual Health Strategy, GU...

Antiretroviral use differs by sociodemographic differences.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The use of antiretroviral drugs vary by sociodemographic differences. According to published research from Canada, "The objective of this study was to examine the level of antiretroviral use and...

Canadian HIV partnership lends financial support to phase 2 clinical drug trials.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The Immune Response Corporation (IMNR), a biopharmaceutical company specializing in immune-based therapy in HIV and multiple sclerosis, announced that the Canadian HIV Trials Network (CTN) has approved...

Clinical study results build case for expanded use of FUZEON.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Earlier use of FUZEON (enfuvirtide) in treatment-experienced HIV patients results in better treatment outcomes and preserves future drug options, according to new data presented at the 44th Interscience...

Data involving Combivir presented at recent meeting.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A significant number of abstracts that include Combivir (lamivudine 150 mg and zidovudine 300 mg) Tablets were presented at the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy in...

HIV CCR5 antagonist GW-873140 shows potent activity against primary isolates.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The HIV CCR5 antagonist GW-873140 shows potent activity against primary isolates. According to a study from Spain, "The human immunodeficiency virus (HIV) is a highly mutative virus, representing a...

Racivir phase II HIV study initiated.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Pharmasset, Inc., has initiated a phase II clinical study to assess the safety, tolerability, and antiviral effect of substituting Racivir (RCV) for Epivir (lamivudine, 3TC) in treatment-experienced...

Discreet species of gp41 high-MW aggregates present in HIV-related dementia.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Discreet species of gp41 high-molecular weight aggregates are present in HIV-related dementia. According to investigators in the United States, "Accumulation of the HIV envelope protein gp41 is...

Inflammatory responses in cervical neoplasia suppressed in HIV-positive women.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Inflammatory responses in cervical intraepithelial neoplasia are suppressed in HIV-positive women. "The role of mucosal immunity in human papillomavirus (HPV)-related cervical diseases is poorly...

Herpesvirus saimiri ORF73 modulates tumor suppressor proteins p53 and pRb.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Herpesvirus saimiri ORF73 modulates the tumor suppressor proteins p53 and pRb. "All known DNA tumor viruses are known to target and inactivate two main cell cycle regulatory proteins, retinoblastoma...

Cell-free systems compare capsid assembly of genetically diverse lentiviruses.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Cell-free systems were developed to compare capsid assembly of genetically diverse lentiviruses. "We recently demonstrated that capsids from three main primate lentiviral lineages appear to form...

Lentivirus clone SIVmac239 does not complete capsid assembly in cell-free system.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A lentivirus clone, SIVmac239, does not complete capsid assembly in a cell-free system. According to published research from the United States, "We have previously described a cell-free system that...

Self-inactivating lentiviral vectors resist proviral methylation.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Self-inactivating lentiviral vectors resist proviral methylation. "Oncoretroviral expression is transcriptionally silenced in embryonic and hematopoietic stem cells (HSCs). This is associated with...

Syringe maker announces sales, distribution partnership with Chinese producer.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Unitract Ltd. has signed a Heads of Agreement with Shanghai Kindly Enterprise Development (Group) Co., Limited (KDL), a medical device and syringe manufacturer and distributor in China, forming a...

Biotechnology company amends merger agreement with HIV-focused pharm firm.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- V.I. Technologies, Inc. (VITX), a biotechnology company that develops anti-infective technologies, has amended the terms of the merger agreement with privately held Panacos Pharmaceuticals, a...

Company amends merger agreement with V.I. Technologies.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Panacos Pharmaceuticals, Inc., a privately held company developing novel therapeutics for the treatment of HIV and other major human viral diseases, announced that it has amended the terms of its merger...

p107 regulates neural precursor cells in the brain.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- p107 regulates neural precursor cells in the brain. "Here we show a novel function for Retinoblastoma family member, p107 in controlling stem cell expansion in the mammalian brain. Adult p107-null...

TWEAK induces neuronal cell death and is involved in neurodegeneration.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Tumor necrosis factor-like weak inducer of apoptosis induces neuronal cell death and is involved in neurodegeneration. According to a study from Germany, "Tumor necrosis factor-like weak inducer of...

Macrophage IL-1 beta production inhibits caspase-1 after nitrite inhalation.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Macrophage IL-1 beta production inhibits caspase-1 after nitrite inhalation. "Epidemiological studies have identified abuse of nitrite inhalants as an independent co-factor in HIV infection and in...

Despite setbacks, strong growth seen in $7 billion vaccine market.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The worldwide market for preventive vaccines will total nearly $7 billion in 2004 despite the widely reported supply interruptions of flu vaccine in the United States, according to a new study from...

WHOQOL-HIV field test instrument promising for HIV/AIDS QOL assessment.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- The WHOQOL-HIV field test instrument is promising for the assessment of quality of life in HIV-infected persons. "Assessment of quality of life (QoL) in persons living with HIV/AIDS (PLWHA) is...

Novel assay identifies compounds that enhance rituximab anti-lymphoma activity.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A novel assay identifies compounds that enhance rituximab anti-lymphoma activity. "In this report, we describe a new flow cytometry technique termed flow cytometric high-content screening (FC-HCS)...

Novel SARS-CoV entry inhibitor may be a viable candidate therapy for SARS.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A novel SARS coronavirus entry inhibitor may be a viable candidate therapy for SARS. "Infection of receptor-bearing cells by coronaviruses is mediated by their spike (S) proteins. The coronavirus...

CD3/MHC-I/MHC-II/Ii surface expression modulation insufficient for SIV virulence.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- CD3/MHC-I/MHC-II/Ii surface expression modulation alone is insufficient for SIV virulence. "A variety of simian immunodeficiency virus (SIVmac) nef mutants have been investigated to clarify which in...

Real-time PCR independently samples single SIV genomes from range of viral loads.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- A real-time PCR assay independently samples single SIV genomes from macaques with a range of viral loads. According to a study from the United States, "The generation of a diverse population of...

SIV-induced blood-brain barrier activation requires cell-associated virus.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- SIV-induced blood-brain barrier activation requires cell-associated virus. According to a study from the United States, "It has never been determined if activation of the blood-brain barrier (BBB)...

Tuberculosis and HIV co-infection is a symbiotic relationship.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Tuberculosis and HIV co-infection is a symbiotic relationship. "The HIV epidemic is currently in its third decade without any sign of abating. Tuberculosis (TB) is responsible for a third of all...

Forced selection of HIV-1 variant uses a non-self tRNA primer for RT.
December 6, 2004... 2004 DEC 6 - (NewsRx.com & NewsRx.net) -- Forced selection of an HIV-1 variant uses a non-self tRNA primer for reverse transcription. "Human immunodeficiency virus type 1 uses the tRNA(3)(Lys) molecule as a selective primer for reverse...

Correlation between IFN-gamma secretion and cytotoxicity in memory T cells.
December 13, 2004... 2004 DEC 13 - (NewsRx.com & NewsRx.net) -- Scientists have discovered a correlation between interferon-gamma (IFN-gamma) secretion and cytotoxicity in virus-specific memory T cells. According to recent research from the United States,...

Depo-Provera before SIV challenge eliminates lentivirus-induced protection.
December 13, 2004... 2004 DEC 13 - (NewsRx.com & NewsRx.net) -- Administration of Depo-Provera before intravaginal challenge with simian immunodeficiency virus mac239 eliminates attenuated lentivirus-induced protection in rhesus macaques. According to recent...

Non-neutralizing anti-HIV-1 antibody becomes neutralizing antibody.
December 13, 2004... 2004 DEC 13 - (NewsRx.com & NewsRx.net) -- A non-neutralizing anti-HIV-1 antibody turns into a neutralizing antibody when expressed on the surface of HIV-1-susceptible cells. According to published research from the United States, "During...

Recall antigen activation induces prompt release of CCR5 ligands from PBMC.
December 13, 2004... 2004 DEC 13 - (NewsRx.com & NewsRx.net) -- Recall antigen activation induces prompt release of CCR5 ligands from PBMC. "CCR5 ligands RANTES, macrophage inflammatory protein (MIP)-1alpha and MIP-1beta are potent and specific inhibitors of...

Seventeen SIV-derived CD8+ T cell Mamu-A*02-restricted epitopes identified.
December 13, 2004... 2004 DEC 13 - (NewsRx.com & NewsRx.net) -- Researchers have identified 17 new simian immunodeficiency virus-derived CD8+ T cell epitopes restricted by the high frequency molecule, Mamu-A*02. According to a study from the United States, "MHC...

Antigenicity of HIV-1 p24 produced in high yields from plants was preserved.
December 13, 2004... 2004 DEC 13 - (NewsRx.com & NewsRx.net) -- The antigenicity of HIV-1 p24 produced in high yields from plants inoculated with a tobacco mosaic virus -derived vector was preserved. "Production of structural proteins from foot-and-mouth...

Tat protein elicits production of neutralizing antibodies.
December 13, 2004... 2004 DEC 13 - (NewsRx.com & NewsRx.net) -- The Tat protein or synthetic Tat peptide combination elicits the production of neutralizing antibodies. "The Tat regulatory protein of human immunodeficiency virus type 1 (HIV-1) is secreted by...

Three vectors encoding SIV antigens protected against SIV CD4+ T-cell loss.
December 13, 2004... 2004 DEC 13 - (NewsRx.com & NewsRx.net) -- Vaccine protection from CD4+ T-cell loss caused by simian immunodeficiency virus (SIV) mac251 is afforded by sequential immunization with three unrelated vaccine vectors encoding multiple SIV antigens....

Novel compounds have antiretroviral and antibacterial activity.
December 13, 2004... 2004 DEC 13 - (NewsRx.com & NewsRx.net) -- Novel compounds have antiretroviral and antibacterial activity. "The reaction of 5 -(1-adamantyl)-1, 3,4-oxadiazoline-2-thione 2 with iodoethane, 2-dimethylaminoethyl chloride hydrochloride or...

Pharmaceutical company announces new research collaboration.
December 13, 2004... 2004 DEC 13 - (NewsRx.com & NewsRx.net) -- Locus Pharmaceuticals, Inc., announced the initiation of a multi-stage research collaboration with Dow AgroSciences LLC, a subsidiary of The Dow Chemical Company, focused on agrochemicals and...