AIDS Vaccine Week articles from April 2003

AIDS Vaccine Week archives from April 2003

Body's own antibodies may drive new strains of HIV.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Scientists in California have provided the first detailed look at how human antibodies, proteins critical for the body's defense against invading pathogens, may actually drive human immunodeficiency...

"Partially effective" AIDS vaccine may be beneficial.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Even a "partially effective" AIDS vaccine may offer considerable benefits in combating the disease. According to a study from the United States, "A safe, effective, and affordable vaccine remains...

HIV-1 inactivated by the single-chain chimeric protein sCD4-17b.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- The human immunodeficiency virus type 1 was neutralized by sCD4-17b, a single-chain chimeric protein, through sequential interaction of gp120 with CD4 and coreceptor. According to a study from the...

HIV specific immune responses boosted by structured treatment interruptions.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Results of a study by Immune Response Corp. scientists back the idea that HIV specific immune responses play a role in control of viremia. "The immunologic correlates associated with control of...

Tat-neutralizing antibodies compared in vaccinated macaques.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Researchers at the Institute of Human Virology, at the University of Maryland, compared antisera of macaques immunized with Tat or chemically modified Tat toxoid having the same clade B sequence "for...

Genome sequences of three South African HIV type 1 subtype C isolates characterized.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- The near-full length genome sequences of three South African human immunodeficiency virus (H(V) type 1 subtype C isolates have been characterized. G.M. Hunt and colleagues at the University of...

Trials for South African-developed vaccine for AIDS expected next year.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Two South African universities expect to begin trials for an AIDS vaccine by next year, according to a statement released at the African Human Genome Initiative conference. The universities of...

UAB develops assay that could lead to HIV vaccine.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Tranzyme, Inc., a drug discovery and development company, announced that researchers at the University of Alabama at Birmingham (UAB) have developed a novel assay that may lead to an AIDS vaccine...

Dendritic cell markers altered during simian infection.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Dendritic cell (DC) markers are significantly altered in animals infected with the simian version of HIV. DCs "are potent antigen-presenting cells that likely play multiple roles in human...

Recombinant adeno-associated virus (rAAV)-based HIV vaccine shows promise.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Targeted Genetics Corp. (TGEN) announced promising data from its AIDS vaccine preclinical program at the annual Keystone AIDS Vaccine Conference, held in Banff, Alberta. In studies presented at...

Uninfected HIV vaccine recipients would be misdiagnosed as HIV-infected.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Western blot analysis would result in a significant percentage of uninfected HIV vaccine recipients being misdiagnosed as HIV-infected. "Since 1987, more than 10,000 individuals worldwide have...

Standard statistical methods may underrate efficacy.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Standard methods of statistical analysis may not provide an accurate measure of HIV vaccineefficacy, researchers in Seattle warn. "When describing...

T-cell responses in persistently seronegative women characterized.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Vaccine researchers in the United States and Thailand have elucidated the HIV-specific T-cell profile in "highly exposed but persistently seronegative" women...

Clinical research association doubles membership in first year.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Amid increasing awareness of the need for clinical research organizations to participate in health policy debates regarding drug development issues, the Association of Clinical Research Organizations...

Viral proprotein processing may be target.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- HIV proprotein processing is a promising target for gene therapy. "The central role of endoconvertases and HIV-1 protease (HIV-1 PR) in the processing of HIV proproteins makes the design of...

Exclusive rights obtained to HIV microbicide candidate.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Biosyn, Inc., announced that the company has acquired exclusive, worldwide rights from the U.S. National Institutes of Health (NIH) for the development and commercialization of the novel protein,...

"Glycan shield" may prevent antibody neutralization.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- A "glycan shield" may prevent antibody neutralization of HIV during acute infection. "Neutralizing antibodies (Nab) are a principal component of an effective human immune response to many...

Natural alpha interferon-producing cells mature in response to infection.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Natural alpha interferon (IFN-alpha)-producing cells (IPCs) produce their signature cytokine and mature to dendritic cells in response to HIV infection. According to recent research from Japan,...

Biotech company ships AIDS drug to Africa, Asia.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Gilead Sciences has begun shipping its new AIDS drug at cost to poor countries in Africa, Southeast Asia, and other regions hard hit by the disease. The Foster City, California-based company said...

Russia accepts World Bank loan to combat AIDS, tuberculosis.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Russia accepted a $150 million World Bank loan to combat the rapid spread of AIDS and tuberculosis in the country, World Bank officials said recently after 4 years of negotiations. The World Bank...

$50 million grant from Lilly endowment boosts genomics initiative.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- For the second time in three years, the Lilly Endowment, Inc., is demonstrating its strong commitment to Indiana University's flourishing role in life sciences education and research by awarding $50...