Proteomics Weekly articles from April 2004

Proteomics Weekly archives from April 2004

LDL receptor-related protein overexpression linked to memory deficits.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Amyloid model mice overexpressing the low-density lipoprotein receptor-related protein exhibit increased soluble amyloid-beta peptide and memory deficits. "Amyloid-beta peptide (A-beta) is central...

Alpha-synuclein overexpression involved in familial Parkinson disease.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Alpha-synuclein overexpression involved in familial Parkinson disease. "Genomic triplication of the alpha-synuclein gene recently has been associated with familial Parkinson disease in the...

Lack of repair of 8-oxoguanine involved in some DNA repair diseases.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Deficiency of transcription-coupled repair of 8-oxoguanine in human cells is involved in some DNA repair diseases. According to a study from France, "8-Oxoguanine (8-oxoG) is a major oxidized base...

MHC- and TCR-binding residues of myelin glycoprotein peptide characterized.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Scientists have characterized the MHC- and TCR-binding residues of the myelin oligodendrocyte glycoprotein 38-51 peptide. "Myelin oligodendrocyte glycoprotein (MOG) is a major experimental...

Surprising new functions found for the nuclear membrane protein emerin.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Scientists have identified multiple and surprising new functions for emerin, a nuclear membrane protein. "Emerin is an integral protein of the nuclear inner membrane. Emerin is not essential, but...

Mutation disrupts interaction of von Willebrand factor with platelets.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- C1272S is a new candidate mutation in type 2A von Willebrand disease that disrupts the disulfide loop responsible for the interaction of von Willebrand factor with platelet GP Ib-IX. According to a...

Endoglin is highly expressed in eyes with choroidal neovascularization.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Endoglin is highly expressed in eyes with choroidal neovascularization. "Endoglin (CD105) is a membrane protein involved in the transforming growth factor (TGF)-beta receptor signaling pathway with...

Chondroitin sulfate of appican interacts with neuroregulatory factors.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Chondroitin sulfate of appican, the proteoglycan form of amyloid precursor protein, produced by C6 glioma cells interacts with heparin-binding neuroregulatory factors. "Appican produced by rat C6...

Selective BACE-1 inhibitors synthesized.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Scientists have synthesized a series of selective beta-site amyloid precursor protein cleaving enzyme (BACE-1) inhibitors. According to a study from the United States, "An effective approach for...

Synaptic frailty and vesicle trafficking in Alzheimer disease reviewed.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Researchers review synaptic frailty and clathrin-mediated synaptic vesicle trafficking in Alzheimer disease in a recent issue of Trends in Neurosciences. "Loss of synapses contributes to the...

Microglial activation facilitates A-beta plaque removal.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Microglial activation facilitates A-beta plaque removal following intracranial anti-A beta antibody administration. According to a study from the United States, "The mechanisms by which anti-A-beta...

Green fluorescent protein causes mitochondria to aggregate with Bcl-2.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Green fluorescent protein causes mitochondria to aggregate in the presence of the Bcl-2 family proteins. "Green fluorescent protein (GFP) has been widely used in a variety of experiments in cell...

Cleavage of precursor enzyme causes amylase secretion by Aspergillus.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Researchers have found evidence that cleavage of the precursor enzyme by autocatalysis caused secretion of multiple amylases by Aspergillus niger. "The observation that a mutant strain of...

Bacteria manipulate Rho to enhance their survival.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Bacteria manipulate Rho to enhance their survival. According to a study from the United States, "Many features of cell behavior are regulated by Rho family GTPases, but the most profound effects of...

Britain restricts blood donations as a precaution against mad cow's disease.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- The British government said March 16, 2004, it would ban blood donations from people who had received transfusions since 1980, as a precaution against transferring the human form of mad cow's disease....

U.S. expands mad cow testing to cover 221,000 animals.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- The U.S. Agriculture Department will expand its testing for mad cow disease after the single U.S. case in December to more than 221,000 animals, 10 times the number tested last year, officials say. ...

Ritonavir treatment may benefit glioblastoma patients.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Ritonavir therapy may be beneficial for glioma patients. "Glioblastoma is a therapeutic challenge as a highly infiltrative, proliferative, and resistant tumor," scientists in France explained....

Breast biopsy specimens can be evaluated with proteomic analysis.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Researchers introduce a method of analyzing breast biopsy specimens using proteomic techniques. "Analysis of tumor samples by a proteomic technology, which combines two-dimensional gel...

Overexpressed VEGF[subscript]121 improves oxygenation in certain breast tumors.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Overexpressed VEGF[subscript]121 improves oxygenation in certain breast tumors. "Vascular endothelial growth factor (VEGF) is an intensively studied molecule that has significant potential, both in...

Thymidylate synthase mRNA predicts shorter survival in breast cancer.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- The expression of thymidylate synthase mRNA is associated with shorter survival in patients with breast cancer. "Thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine...

Electric pulses show promise for healing or killing unhealthy cells.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- A new technology that uses electric fields to alter the "guts" of a cell may lead to improved methods of treating diseases such as cancer and leukemia, according to researchers in the University of...

XR5967 alters tumor cell invasion and angiogenesis in vitro.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- XR5967 alters tumor cell invasion and angiogenesis in vitro. According to a study from England, "recent reports suggest that elevated levels of plasminogen activator inhibitor (PAI)-1 may...

AT1 receptor blocker increases efficacy of ACE inhibitors in murine DHF model.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- AT1 receptor blockade enhances the effects of ACE inhibitor treatment in a murine model of late-stage diastolic heart failure (DHF). DHF "has become a social burden; however, evidences leading to...

Cardioprotective effects of scavenger receptor SR-BI clarified.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- The multiple cardioprotective effects of scavenger receptor class B type I (SR-BI) have been characterized. SR-BI "is a multi-ligand receptor that can mediate the binding and bi-directional lipid...

Role of ABCA1 in cholesterol metabolism reviewed.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- The role of ABCA1 in cholesterol metabolism has been reviewed. "The ATP-binding cassette transporter A1 (ABCA1) is involved in the regulation of cholesterol efflux from cells," scientists in...

Cells induced to "de-differentiate" back into stem cells.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- For the first time, researchers have induced differentiating cells to revert back to being stem cells. Although such de-differentiation is known to occur in natural systems, scientists had never...

P-selectin plays key role in pathogenesis.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- P-selectin is heavily involved in the pathogenesis of cerebral malaria. According to scientists in the United States, "P-selectin is a leukocyte adhesion receptor expressed on the surface of...

CDH1 and CDH13 methylation is a marker for more aggressive cervical cancer.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Researchers find that cervical cancer patients with unmethylated CDH1/CDH13 had better disease-free survival. "Cervical cancer is the principal cause of death due to cancer in women. Five-year...

LSBC, partner to manufacture and distribute plant-produced recombinant aprotinin.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Large Scale Biology Corp. (LSBC) and Sigma-Aldrich Fine Chemicals, a division of Sigma-Aldrich Corp. (SIAL), have entered into an agreement under which LSBC will biomanufacture, for Sigma-Aldrich's...

Grape seed extract demonstrates antiangiogenic potential in cultured cells.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Grape seed extract demonstrates antiangiogenic potential in cultured cells. According to recent research from the United States, "the present study is focused on the investigation of in vitro...

Artificial prions created.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- The culprit behind mad cow disease (i.e., bovine spongiform encephalopathy) is the most infamous mammalian form of prions. Prions are misfolded proteins that are capable of growing, replicating, and...

Protein-only prions show diverse repertoire.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Prions, the infectious agents responsible for conditions such as Creutzfeldt-Jakob disease, are made entirely of protein. What's more, different prion strains are generated by particles of the same...

Nephrogenic fibrosing dermopathy linked to dysregulated matrix remodeling.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- A variant of nephrogenic fibrosing dermopathy with osteoclast-like giant cells may be a syndrome of dysregulated matrix remodeling. "Nephrogenic fibrosing dermopathy (NFD) is a disorder...

Sphingosine has cytotoxic effects on growth of keloid fibroblasts.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Sphingosine may have cytotoxic effects via apoptosis on the growth of keloid fibroblasts. According to a study from South Korea, "Keloids are often resistant to treatment, causing much suffering to...

Researchers identify gene as essential for vascular smooth muscle development.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Researchers at the University of Texas (UT) Southwestern Medical Center at Dallas have discovered a major mechanism to explain normal and abnormal smooth muscle growth, a finding that could help in the...

Low-protein diet alters gene expression in rat pancreatic islets.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- A low-protein diet alters gene expression in rat pancreatic islets. "Insulin secretion is regulated mainly by circulating nutrients, particularly glucose, and is also modulated by hormonal and...

Non-radioactive labeled hepatitis B virus probes are sensitive and inexpensive.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Non-radioactive labeled hepatitis B virus probes are sensitive and inexpensive. "A method using non-radioactive material alkaline phosphatase to label HBV DNA as probe has been studied and used in...

ProteinChip system receives medical device certification in China.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- The Ciphergen Diagnostics Division of Ciphergen Biosystems, Inc., (CIPH) announced that the ProteinChip System has been certified (certificate number SFDA(I) 20032400768) by the State Food and Drug...

Company announces in vivo proof of concept for Anticalins.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- PIERIS Proteolab, AG, a biopharmaceutical and protein engineering company, announced that one of its lead development candidates, Digical, completely neutralized lethal toxicity caused by an overdose of...

Method produces uniform, self-assembled nanocells.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Nanotechnology is about making improved products by building them from components hundreds of times smaller than a human blood cell. But how do you put things together at such a tiny scale? One way is...

Cell-penetrating, Rev-binding peptides can protect against HIV.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- A novel class of cell-penetrating, Rev-binding peptides may protect against HIV infection. "New therapeutic agents able to block HIV-1 replication are eagerly sought after to increase the...

Epidermal growth factor receptor inhibitors should stall cancer growth.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Epidermal growth factor receptor inhibitors should stall cancer growth. According to recent research published in the International Journal of Radiation Oncology, Biology, Physics, "in cancer cells,...

Fibrinolytic, cardioprotective enzyme derived from fermented shrimp paste.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- A fibrinolytic - and potentially cardioprotective - agent has been isolated from an unlikely source. In a recent study from Canada, a "novel fibrinolytic enzyme was purified from fermented shrimp...

Fungal derivatives show promise as HIV integrase inhibitors.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- A series of fungal derivatives are highly active against a key HIV enzyme. "HIV-1 integrase is a critical enzyme for replication of HIV, and its inhibition is one of the most promising new drug...

Lactating mammary glands respond to changes in extracellular calcium levels.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Lactating mammary glands respond to changes in extracellular calcium levels According to published research from the United States, "the transfer of calcium from mother to milk during lactation is...

The tyrosine kinase inhibitor PTK787/ZK222584 staunches thyroid cancer growth.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- The tyrosine kinase inhibitor PTK787/ZK222584 staunches thyroid cancer growth. According to recent research published in the journal Endocrinology, "the process of neoangiogenesis is induced by...

Study suggests arsenic exposure alters estrogen signaling.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Exposure of pregnant mice to arsenic results in the development of a range of tumor types, including hepatocellular carcinoma (HCC), in their adult offspring that are similar to those induced in adult...

Radio frequency radiation affects protein kinase C activity in rat brains.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Radio frequency radiation affects protein kinase C activity in rat brains. "The present work describes the effect of amplitude modulated radio frequency (rf) radiation (112 MHz amplitude-modulated...

Matrix metalloproteinase upregulation is fibronectin-dependent.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Upregulation of matrix metalloproteinases in hepatic stellate cells is fibronectin-dependent. "Activation and transition of hepatic stellate cells (HSCs) to myofibroblast (MFB)-like cells is...

Microarray distinguishes the molecular signatures of hepatocellular carcinomas.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Microarray distinguishes the molecular signatures of hepatocellular carcinomas. According to a study from Japan, "chronic infection with hepatitis B or C virus (HBV or HCV) is the most clearly...

Tumor necrosis factor-alpha reduces D-fructose intestinal transport.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Tumor necrosis factor-alpha reduced D-fructose intestinal transport in rabbits. According to a study from Spain, "Tumor necrosis factor-alpha (TNF-alpha) is an important immunoregulatory cytokine...

B cells develop and transcribe immunoglobulin despite Oct-1 deficiency.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- B cells develop and transcribe immunoglobulin despite Oct-1 deficiency. "The POU domain transcription factors Oct-1 and Oct-2 interact with the octAm element, a motif conserved within immunoglobulin...

Company launches Ovation Biotin System for Affymetrix GeneChip arrays.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- NuGEN Technologies, Inc., a privately held company developing and commercializing the new standard for nucleic acid amplification and labeling, announced the launch of its Ovation Biotin System for RNA...

Arginine-rich peptides stabilize polyplexed DNA to improve transduction.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Arginine-rich peptides stabilize polyplexed DNA to improve transduction. "In this study, we investigated to what extent the stability and transduction capacity of polyplexed DNA can be improved by...

phe67leu mutation found in SRY gene in patient with 46,XY gonadal dysgenesis.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Investigators have identified a de novo phe67leu mutation in the SRY gene in a patient with complete 46,XY gonadal dysgenesis. According to recent research published in the Journal of...

D-aspartyl endopeptidase scavenges noxious racemized proteins in aging.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Mammalian D-aspartyl endopeptidase is a scavenger for noxious racemized proteins in aging. "The accumulation of D-isomers of aspartic acid (D-Asp) in proteins during aging has been implicated in the...

Tumor cell p53 function mediates endothelial cell radiosensitivity.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Tumor cell p53 function mediates endothelial cell radiosensitivity. "We performed expressional profiling of isogenic glioblastoma cell lines U87-Lux8 and U87-175.4. These cell lines differ in that...

Soluble Fas levels in CSF correlate with HIV dementia severity.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Cerebrospinal fluid (CSF) sFas levels are correlated with the severity of HIV-associated dementia (HIV-D). "Soluble Fas (sFas) and soluble Fas ligand (sFasL) are associated with cellular...

Membrane-active gp41 regions identified.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Membrane-active regions of HIV gp41 have been identified using a novel technique. According to published research from Spain, the "identification of membrane-active regions of the ectodomain of the...

Mitochondrial-to-nuclear DNA ratio may mark mitochondrial toxicity.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- The ratio of mitochondrial DNA to nuclear DNA may mark mitochondrial toxicity in nucleoside-treated HIV patients. "Nucleoside analogues inhibit human DNA polymerase gamma. As a result, they can...

Plasma lipids augment post-infarction erythrocyte aggregation.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Plasma lipids augment red blood cell aggregation after myocardial infarction. "Increased erythrocyte aggregation (EA) has been observed in patients with ischemic heart disease (IHD), although most...

Fanconi anemia group C protein regulated through proteolytic modification.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- The Fanconi anemia group C protein is regulated through proteolytic modification. According to recent research published in the Journal of Biological Chemistry, "The function of the Fanconi anemia...

Novel thioredoxin-related protein expressed in plasma cells identified.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Scientists have identified a novel thioredoxin-related protein, PC-TRP, which is preferentially expressed in plasma cells. According to a study from Sweden, "Using cDNA subtraction we have...

P-selectin modulation involved in hemostasis.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- P-selectin modulation is involved in hemostasis. "Hemostasis and inflammation are tightly linked reactions primarily designated as post-traumatic protection mechanisms. Both reactions require the...

Heparin binds to the laminin alpha 4 chain LG4 domain at a unique site.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Heparin binds to the laminin alpha 4 chain LG4 domain at a site different from that found for other laminins. "We previously reported that the LG4 domain of the laminin alpha4 chain is responsible...

Hepatitis A peptide covalently linked to liposomes.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- A hepatitis A peptide has been covalently linked to liposomes. "In this work we have studied the conjugation of the immunogenic peptide sequence (110-121) belonging to the VP3 capsid protein of...

Bacteriophage-mediated nucleic acid immunization offers benefits.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Bacteriophage-mediated nucleic acid immunization offers benefits over naked DNA vaccines. "Whole bacteriophage lambda particles, containing reporter genes under the control of the cytomegalovirus...

Cells expressing herpesvirus entry mediator C are resistant to pseudorabies.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Transformed cell lines expressing a soluble form of porcine herpesvirus entry mediator C exhibit resistance to pseudorabies virus infection. According to published research from Japan, "Porcine...

Herpesvirus ICP0 RING finger domain inhibits interferon-stimulated genes.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- The herpes simplex virus ICP0 RING finger domain inhibits IRF3 and IRF7-mediated activation of interferon-stimulated genes. According to recent research published in the Journal of Virology, "Virus...

Seven new kinase assay toolboxes available.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- DiscoveRx Corporation announced the availability of a new range of kinase assay toolboxes to its expanding line of assays for high throughput screening. The ready-to-use toolboxes cover a broad...

SCA17 homozygote showing Huntington disease-like phenotype identified.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Researchers have identified a SCA17 homozygote showing a Huntington disease-like phenotype. "We report a homozygous case of spinocerebellar ataxia type 17 with 48 glutamines. The age of the patient...

Adaptive regulatory T cells suppress killing of persistently infected cells.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Scientists report that they have identified a cellular mechanism that prevents the immune system from destroying chronic, incurable viral infections such as herpes, hepatitis and human immunodeficiency...

CpG methylation of plasmid vectors circumvents immune response activation.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- CpG methylation of plasmid vectors circumvents immune response activation. According to a study from the United States, "gene therapy has the potential to cure inherited diseases if the delivered...

Data presented on molecular mechanism of action for HE2000.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Hollis-Eden Pharmaceuticals, Inc., (HEPH) announced the presentation of additional data relating to the molecular mechanism of action by which its immune regulating hormone IMMUNITIN (HE2000) may...

Effects of morphine on HIV gp160-induced monocyte apoptosis clarified.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- The effects of morphine on HIV gp160-induced monocyte apoptosis have been clarified. In a recent study, neuroimmunologists in New York examined "the effect of HIV-l gp160 protein and morphine on...

Expression by DNA-transfected DCs occurs through terminal differentiation.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Highly efficient expression of transgenic proteins by naked DNA-transfected dendritic cells (DCs) occurs through terminal differentiation. "Dendritic cells play a key role in the induction and...

Hepatitis C virus core protein thwarts effector cytotoxic T-cell differentiation.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Hepatitis C virus core protein thwarts effector cytotoxic T-cell differentiation. "In a companion study, we showed a dichotomy between the expansion of central memory (CCR7[superscript]+) hepatitis...

Rac controls cellular redox state.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Rac controls the cellular redox state. According to recent research published in the Journal of Cell Science, "In neutrophils and other phagocytic cells, the small GTPase Rac is an essential...

The 4H84 mAb can bind to non-HLA-G molecules.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- The 4H84 mAb can bind to molecules other than HLA-G. In a recent study, scientists in Slovenia found that the "4H84 monoclonal antibody (mAb) used for detection of beta[subscript]2m free HLA-G...

Vectors harboring liver-restricted promoter yield long term gene expression.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Vectors harboring liver-restricted promoter yield long-term gene expression. "The successful application of gene therapy for the treatment of genetic diseases such as Fabry is reliant on the...

p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells. "Of the three She isoforms, p66Shc is responsible for fine-tuning p52/p46Shc signaling to Ras and has been implicated in...

Transcription factor and PPAR interactions block response element binding.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Transcription factor and PPAR interactions block response element binding. "Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors, originally implicated in...

No insulin response within 4.0-kb region of human hexokinase II promoter.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- No insulin response within the 4.0-kb region of the human hexokinase II promoter. According to a study from Finland, "To locate regulatory elements that mediate the effect of insulin on hexokinase...

Structure of Leishmania adenine phosphoribosyltransferase solved.
April 5, 2004... 2004 APR 5 - (NewsRx.com & NewsRx.net) -- Scientists have determined the crystal structure of adenine phosphoribosyltransferase from Leishmania tarentolae. According to recent research published in the journal Biochimica et Biophysica Acta...