Drug Week articles from October 2003

Drug Week archives from October 2003

Drug developed for rare disease may help millions more as cancer treatment.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- An antiangiogenesis drug developed at the University of Michigan (U-M) is showing promise in studies of three different disease families, including multiple forms of cancer. The drug,...

New therapies look promising for the treatment of hepatitis C virus patients.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- New therapies look promising for the treatment of hepatitis C virus patients. "Chronic hepatitis C virus (HCV) infection is the cause of an emerging global pandemic of chronic liver disease. Current...

Clot-busters - do they work for all?
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Aspirin is given to patients at high risk of suffering an acute myocardial infarction (AMI), but researchers in Denmark have shown that in one-third of patients actually suffering an AMI no...

Ultrastructural changes may be due to acquired cisplatin resistance.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Ultrastructural changes in bladder cancer may be due to acquired cisplatin resistance. According to recent research published in the journal Oncology Reports, "Cis-diaminedichloroplatinum...

Two common diabetes drugs may cause heart failure and fluid buildup.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Two diabetes medications taken by more than 6 million Americans may lead to serious side effects, including the onset of congestive heart failure and pulmonary edema, according to researchers at...

CHARM Programme demonstrates benefits of Atacand.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Data presented at the European Society of Cardiology (ESC) annual meeting demonstrated that Atacand (candesartan cilexetil) reduces both cardiovascular deaths as well as hospital admissions for heart...

N-acetyl-L-cysteine does not affect busulfan pharmacokinetics.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- NAC treatment to prevent VOD in stem-cell graft recipients does not affect busulfan pharmacokinetics "Busulfan is currently used as a main component in the conditioning regimen prior to allogeneic...

Biopharma inks agreement with Guangdong Medicine Group Corp.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Hemispherx Biopharma, Inc., (HEB) announced that it has signed an agreement with Guangdong Medicine Group Corp. to organize clinical trials, marketing, sales, and distribution for both of its lead...

DHHS panel recommends Kaletra as part of protease inhibitor-based regimen.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- A panel convened by the U.S. Department of Health and Human Services (DHHS) has recommended Kaletra (lopinavir/ritonavir), in combination with zidovudine or stavudine plus lamivudine, as a preferred...

Different outcomes seen in patients from poor and rich countries.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Recent publications suggested different outcomes in patients admitted to hospitals with heart attacks between developed and developing countries. To clarify this point, ECLA (Estudios Clinicos...

Salbutamol use may increase eosinophil CXCL8 production, asthmatic response.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Regular salbutamol use may make eosinophil response to allergen stronger, increase airway inflammation via CXCL8/IL-8 increases in asthmatics. "Regular salbutamol use can exacerbate allergen-induced...

Restraint stress modulates regulation of inflammation and immunity.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Acute restraint stress in allergic contact dermatitis modulates regulation of sensitizer-induced inflammation and immunity. "Previously, we demonstrated that restraint stress applied before...

C766T polymorphism of LDL receptor protein gene linked to Alzheimer disease.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- The C766T polymorphism of the low-density lipoprotein receptor-related protein gene is associated with Alzheimer disease. According to recent research published in the American Journal of Medical...

Cerebrovascular factors play role in early-stage Alzheimer's dementia.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Cerebrovascular factors appear to play a role in early-stage Alzheimer's dementia. "The amyloid beta-peptide (A-beta) is involved in the mechanisms of Alzheimer dementia. This paper reviews...

Differences in beta-amyloid deposition exist in two transgenic models.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Differences in beta-amyloid production and deposition in brain regions exist in two transgenic models. "Mutations in the amyloid precursor protein (APP) gene are associated with altered production...

Galantamine study shows promising results for Alzheimer disease.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Treatment with Reminyl (galantamine) can reduce the cognitive deficits of Alzheimer's disease by more than 50% when used continuously for 4 years, according to research presented at the 7th Annual...

Methionine synthase polymorphism is a risk factor for Alzheimer disease.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- The methionine synthase polymorphism is a risk factor for Alzheimer disease. "Alzheimer disease (AD) patients show increased plasma levels of homocysteine, whose conversion to methionine is...

T-cell reactivity to amyloid beta increases with age.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- T-cell reactivity to amyloid beta increases with age in many people and may open avenues of therapeutic and preventive treatments for Alzheimer disease. According to published research from the...

Hepcidin is critical for iron transport, macrophage iron collection.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Hepcidin is critical for iron transport, macrophage iron collection; lack of it can produce hemochromatosis. According to recent research published in the journal Blood, "Human hepcidin, a 25-amino...

Trial findings mark "significant advance" in treatment.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Results from the INITIATIVE study, the largest phase III trial ever carried out for the treatment of stable angina, herald what has been described as a "significant advance" in the management of the...

Polymer-coated stents offer a way to delivery gene therapy to immune cells.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Polymer-coated stents offer a way to delivery gene therapy to immune cells. According to a study from the United States, "metallic stents coated with a polyurethane emulsion containing plasmid DNA...

Genome of bacteriophage infecting Pseudomonas aeruginosa reported.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Researchers have reported the genome of bacteriophage phi KMV, a T7-like virus infecting Pseudomonas aeruginosa. According to published research from Belgium and Russia, "The complete DNA sequence...

Ofloxacin receives FDA approval.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Ranbaxy Pharmaceuticals Inc. (RPI), a wholly owned subsidiary of Ranbaxy Laboratories Limited (RLL), has received final approval from the U.S. Food and Drug Administration (FDA) to manufacture and...

GABA(A) receptor blockade underlies cephalosporin-induced convulsions.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- GABA(A) receptor blockade underlies cephalosporin-induced convulsions. "There is accumulating evidence that most beta-lactam antibiotics (i.e, cephalosporins and penicillins) have some degree of...

Generic pharmaceutical company licenses clarithromycin XL.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Par Pharmaceutical, a subsidiary of Pharmaceutical Resources, Inc. (PRX), has entered into a licensing agreement with Advancis Pharmaceutical Corp. for clarithromycin XL, which is being developed as a...

Linezolid does not impair polymorphonuclear neutrophils activity.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Linezolid treatment does not impair the antimicrobial function of human polymorphonuclear leukocytes. In a recent study from Spain, "the effect of linezolid on the phagocytic and bactericidal...

Milestone achieved in development of peptide deformylase inhibitors.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Vicuron Pharmaceuticals Inc. (MICU) announced that the company has achieved the latest milestone in its ongoing research collaboration with Novartis Pharma AG, focused on the development of peptide...

Patent issued for antitumor agents.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- The U.S. Patent and Trademark Office (USPTO) issued a patent to Advanced Life Sciences (ALS) for a class of indolocarbazole compounds with a lead molecule, ALS-423, that blocks topoisomerase I, a...

Researchers search for new microtubule-interacting drugs for cancer treatment.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Researchers search for new microtubule-interacting drugs for cancer treatment. "Microtubule-interacting drugs are important agents in cancer chemotherapy. Some of these drugs alter microtubule...

Investigative cancer treatment undergoes two phase I trials.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Pharmacyclics, Inc., (PCYC) has opened two new phase I trials of its investigative drug Xcytrin (motexafin gadolinium) Injection in combination with Taxotere (docetaxel) for the treatment of advanced...

Styryl-lactone goniothalamin induces leukemia cell caspase-dependent apoptosis.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- The styryl-lactone plant derivative goniothalamin induces leukemia cell mitochondrial, caspase-dependent apoptosis. According to recent research published in the journal Toxicology In Vitro,...

Assay for itraconazole drug monitoring developed.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- An assay for determining itraconazole levels in treated patients has been developed. Published research from Germany described a "method for the simultaneous quantification of the antifungal drug...

Human intestinal mucosa is rich in antibacterial, antifungal peptides.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- The human colonic mucosa is rich in peptides that have antibacterial and antifungal properties. According to recent research published in the journal Peptides, "Antimicrobial peptides and proteins...

Pyrimidinone antibiotics exhibit improved antibacterial spectrum.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Pyrimidinone antibiotics exhibit an improved antibacterial spectrum. "We report the synthesis and pharmacological evaluation of new derivatives of the natural dipeptide antibiotic TAN 1057 A,B...

Oral melatonin reduces proinflammatory response induced by amyloid-beta protein.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Oral antioxidants melatonin and vitamins C and E reduced nitrites, lipoperoxides; but melatonin also reduced the proinflammatory response in an amyloid beta inflammation model. "To determine the...

Classical antisense PTOs used against key multimodal targets.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Antisense Pharma focuses on the drug development for cancer treatment by combining precise selection of key cancer target molecules and DNA based phosphorothioate oligonucleotides (PTO). Positive data...

Process helps achieve largest antisense oligonucleotide synthesis scale per run.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- The life sciences business of Amersham (AHM) announced that Isis Pharmaceuticals recently completed the world's largest antisense oligonucleotide synthesis scale per single run. Isis accomplished...

Cryptosporidiosis can produce arthritis, resolved by pathogen clearance.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Cryptosporidiosis can produce reactive arthritis; pathogen clearance resolves rheumatic disease. "In contrast to arthritic disease caused by different bacterial agents, reactive arthritis due to...

Asthma is exacerbated by eosinophilic pneumonia; corticosteroids may protect.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Asthmatics who get idiopathic chronic eosinophilic pneumonia have worsened asthma but fewer pneumonia recurrences later, perhaps because they are given more corticosteroids. "Since idiopathic...

Hepatic lipase expression in macrophages contributes to atherosclerosis.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice. "Hepatic lipase (HL) has a well-established role in lipoprotein metabolism....

Minnesota company inks agreement with LightWave Ablation Systems.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- MedicalCV, Inc., (MDCVU), a Minnesota-based cardiothoracic surgery device manufacturer, announced that it has signed an agreement to acquire a technology platform for the treatment of atrial...

SPORTIF III study shows potential for Exanta (ximelagatran).
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Latest data from the full presentation of the SPORTIF III study shows a net clinical benefit for Exanta (ximelagatran), the first in a new class of oral direct thrombin inhibitors (oral DTIs), compared...

DAT1 allele associated with methylphenidate response in children with ADHD.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- The 480 bp DAT1 allele was associated with methylphenidate response in a sample of Irish children with attention deficit hyperactivity disorder (ADHD). According to recent research from Ireland,...

BAFF regulates the number of B cells; high levels relate to autoimmune disease.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- BAFF is a member of TNF family that can alter the number of B cells; overexpression causes B-cell expansion and is related to autoimmune disease. According to recent research from Switzerland, "The...

Septicemia and bacterial DNA can cause autoantibodies and SLE-like symptoms.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Septicemia and bacterial DNA can cause autoantibodies and some systemic lupus erythematosus-like symptoms. According to recent research from Japan, "Recent evidence has revealed that bacterial DNA...

Transcription coactivator OCA-B gene may be involved in B-cell expansion.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- The OCA-B gene is needed after B-cell receptor ligation and T helper costimulation, and appears to be involved in signaling B-cell expansion. "The tissue-specific transcriptional coactivator OCA-B...

Mutant Bacillus subtilis glutamyltranspeptidase specializes in hydrolysis.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- A mutant Bacillus subtilis gamma-glutamyltranspeptidase specializes in hydrolytic activity. "Gamma-glutamyltranspeptidase (GGT) catalyzes the hydrolysis of gamma-glutamyl compounds and the transfer...

Alpha-proteobacterium in an immunocompetent geriatric patient causes bacteremia.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Bacteremia in an immunocompetent geriatric patient is caused by a new organism, an alpha-proteobacterium. According to recent research from North Ireland, "An 89-year-old male with pyrexia and...

Catecholamines enhance growth of E. coli but not some other bacteria.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Catecholamines increase growth of E. coli but not some other bacterial species, including oral anaerobes. "The purpose of this study was to examine the effects of catecholamines on in vitro growth...

Shigella serotype conversion due to single amino acid substitution.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Conversion of Shigella flexneri serotype 2a to serotype Y in a shigellosis patient was due to a single amino acid substitution in the protein product of the bacterial glucosyltransferase gtrII gene. ...

Cellular prion protein ablation impairs behavior as a function of age.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Cellular prion protein ablation impairs behavior as a function of age. According to a study from Brazil, "Cellular prion protein (PrP[superscript]c) has been associated with some physiological...

Changes in chronic heating alter the dynamics of tissue perfusion.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Changes in chronic heating alter the dynamics of tissue perfusion. According to recent research published in the journal Annals of Biomedical Engineering, "thermal models are used to analyze...

Conformational analysis of trisaccharides conducted.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- NMR, molecular simulation, and hydrodynamics were applied to the conformational analysis of trisaccharides. "The preferred conformations and conformational flexibilities of the trisaccharides...

Subgroup analysis can be planned for with a useful method in clinical trials.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Subgroup analysis is a common secondary objective in clinical trials. In oncology, where the outcome is often binary (such as tumor response) or...

Biodefense proteomics collaboration receives NIAID funding.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Ciphergen Biosystems, Inc., (CIPH) announced that the University of Texas Medical Branch-Galveston (UTMB) and Ciphergen have received funding from the National Institute of Health (NIAID) to develop new...

Lithium more effective than common medication for reducing risk of suicide.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Patients with bipolar disorder who take divalproex, the most commonly prescribed mood-stabilizing drug in the United States, have about a 2.5 times higher risk of suicide death, than if they take...

Oral efficacy study on a novel antidiabetic agent reported.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Cengent Therapeutics, a structure-guided drug discovery company, announced the successful completion of an oral efficacy study on a novel small molecule inhibitor of PTP-1B. The inhibitor is one of...

Novel LC-based assay detects Hemopure doping in athletes.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- A novel liquid chromatography (LC)-based assay can be used to detect Hemopure doping by athletes. "Since January 2000, hemoglobin-based oxygen carriers, such as Hemopure, belong to the list of...

Trials for investigational pathogen inactivation system halted.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Cerus Corporation (CERS) and subsidiaries of Baxter International, Inc., (BAX) announced that they are voluntarily halting phase III trials for their pathogen-inactivated red blood cell program. ...

BMI affects weight changes and mortality of patients on hemodialysis.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Initial body mass indexes have contrary effects on change in body weight and mortality of patients on maintenance hemodialysis treatment. According to a study from Austria, "Malnutrition is a...

Joint venture wins $11M award to expedite production of botulinum vaccine.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Computer Sciences Corporation (CSC) announced that DynPort Vaccine Company LLC (DVC), a joint venture between CSC and Porton International, Inc., has been awarded an $11 million grant from the National...

Data shows efficacy of using PI3k inhibitor in treating malignant gliomas.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- ComChem announced that Cancer Research published the results of preclinical research performed in the lab of Donald L. Durden, MD, PhD, of the Indiana University School of Medicine (IUSM). The...

Data from Theratope vaccine trial to be presented at breast cancer symposium.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Biomira, Inc., (BIOM, BRA) announced that data from the final analysis of its Theratope vaccine phase III clinical trial in metastatic breast cancer will be presented at the 26th Annual San Antonio...

Metastasis to the breast of other cancers are rare but should be recognized.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Metastasis of other tumors to the breast is rare, but cytologists should be aware of distinguishing features. According to a study from England, "The occurrence of metastatic tumors in the breast...

The hepatocyte growth factor antagonist NK4 reduces breast malignancies.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- "Hepatocyte growth factor/scatter factor (HGF/SF) is a cytokine primarily produced by stromal fibroblasts and is a known angiogenic and invasion-inducing factor. It is increased in patients with breast...

Weekly low-dose docetaxel maintains activity and is less myelosuppressive.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Weekly low-dose docetaxel maintains activity and is less myelosuppressive in breast cancer. "The purpose of this study was to evaluate the efficacy and toxicity of weekly docetaxel in metastatic...

Study of ON-Q pain relief device begins.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- I-Flow Corp. (IFLO) announced that the University of Texas M. D. Anderson Cancer Center has commenced a study with the ON-Q Post-operative Pain Relief System in women undergoing breast reconstruction...

A dipstick assay works well to detect Brucella specific IgM serum antibodies.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- A dipstick assay for detection of Brucella IgM in serum works as well as an agglutination test, and not as well as culture in early brucellosis, but the culture assay works far better on patients sick...

Infection leading to autoimmune disease may also induce retinal vasculitis.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Infection leading to autoimmmune disease may also induce retinal vasculitis. "Retinal vasculitis is a rare, but potentially blinding intraocular inflammatory condition with diverse etiology....

Drug receives FDA approval to treat HIV-associated wasting and cachexia.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Serono, Inc. announced that the U.S. Food and Drug Administration (FDA) has granted full approval for Serostim (somatropin [rDNA origin] for injection), which is indicated for the treatment of HIV...

Par Pharmaceutical announces agreement with Bristol-Myers Squibb for Megace.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Par Pharmaceutical, Inc., the principal subsidiary of Pharmaceutical Resources, Inc. (PRX), has entered into an agreement with Bristol-Myers Squibb Company (BMY) to license the Megace trade name to be...

Caldendrin splice variants occur in neurohypophyseal axons and the pituitary.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Caldendrin splice variants are found in the retina, neurohypophyseal axons, and pituitary cell secretory granules. "Caldendrin is a neuronal calcium-binding protein, which is highly enriched in the...

Company licenses colon cancer diagnostic patent rights to LabCorp and Baylor.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Genzyme Genetics, a business unit of Genzyme Corp. (GENZ), announced that it has entered into two licensing agreements that provide access to its cancer diagnostic patent rights related to the APC and...

Data from phase III study of Combidex published.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Advanced Magnetics, Inc., (AVM) and Cytogen Corporation (CYTO) announced that data from the phase III clinical study of Combidex (ferumoxtran-10) in lymph nodes were published in the September issue of...

Primary central nervous system lymphoma can have cryoglobulin deposits.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Primary CNS lymphoma can have associated cryoglobulins too. "Primary central nervous system lymphomas (PCNSLs) represent malignant non-Hodgkin B-cell lymphomas confined to the central nervous...

HSP10, HSP60 increase during progression of large bowel, uterine cancer.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Heat shock proteins HSP10 and HSP60 become increasingly overexpressed as progression of large bowel cancer and uterine cancer occurs; could make good markers. "In the present study, we evaluated the...

Dosing regimens polarize the mobility and viability of vessel progenitor cells.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Dosing regimens polarize the mobility and viability of vessel progenitor cells. According to published research from Italy, "there is growing evidence that vasculogenesis (progenitor cell-derived...

Inactivation of rac GTPases promotes apoptosis in human lymphoma cells.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Caspase 3-mediated inactivation of rac GTPases promotes drug-induced apoptosis in human lymphoma cells. "The Rac members of the Rho family GTPases control signaling pathways that regulate diverse...

The vitamin E compound tocotrienol has significant antiangiogenic properties.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- The vitamin E compound tocotrienol has significant antiangiogenic properties. "The antiangiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, has been investigated in...

All-trans-retinoic acid improves effect of tumor vaccination.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination. "Tumor-induced immunosuppression is one of the crucial mechanisms of tumor...

Cancer vaccines present unique challenges.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Cancer vaccines present unique challenges. According to a study from the United States, "Whether vaccines are designed to prepare the immune system for the encounter with a pathogen or with cancer,...

HPV-16-transformed cells expressing herpes thymidine kinase induce immunity.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Immunization with live HPV-16-transformed mouse cells expressing the herpes simplex thymidine kinase and either granulocyte-macrophage colony stimulating factor (GM-CSF) or interleukin-2 (IL-2) had...

Immunization in tumor prevention reviewed.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Researchers have published a review of immunization for tumor prevention in the journal International Immunopharmacology. According to a study from Italy, "Recent experimental data suggest that...

Progress in field of cancer vaccines reported.
October 3, 2003... 2003 OCT 3 - (NewsRx.com & NewsRx.net) -- Progress in the field of cancer vaccines has been reported in a recent issue of the journal Cellular and Molecular Life Sciences. According to a study from France, "The observation that in some...