Drug Week articles from November 2003

Drug Week archives from November 2003

New medicines at risk from biodiversity loss.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Three scientists warn that biodiversity loss could have devastating consequences for drug discovery and the development of new medicines. "Tropical cone snails may contain the largest and most...

Once-a-day "smart drug" testing expands.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- It is a drug suffused in promise, a next-generation therapy that has shown glimmers of powerful potential. Iressa is the kind of treatment that oncologists dream of - a pill that can be swallowed once a...

Luminescent imaging is a useful tool for evaluating anticancer drugs in vivo.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Luminescent imaging is a useful tool for evaluating anticancer drugs in vivo. "Human DU-145 prostate and MCF-7 breast tumor cell lines were stably transfected with plasmid pcDNA3.1-Luc expressing...

New inducible HIF-1 alpha is a tool for studying normoxic gene regulation.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- New inducible HIF-1 alpha is a tool for studying normoxic gene regulation. According to recent research published in the journal Pharmacology, "the hypoxia-inducible factor 1alpha (HIF-1alpha), a...

Combination hormone therapy does not benefit patients.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Combining two hormone therapies to treat the psychological effects of hypothyroidism may not be more effective than using a single therapy, according to new research articles published in the Journal of...

Insight into mechanism of cladribine is crucial for its optimal use.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Insight into the mechanism of action and resistance to cladribine is crucial for its optimal use. "The inherent or acquired resistance of leukemic cells to cytostatic agents is a major clinical...

Raloxifene stimulates osteoprotegerin and blocks interleukin-6 production.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Raloxifene stimulates osteoprotegerin and blocks interleukin-6 production. "Raloxifene reduces bone loss and prevents vertebral fractures in postmenopausal women. Its skeletal effects are mediated...

FDA grants anti-CD4 drug fast-track status for the treatment of HIV-1.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Tanox, Inc., (TNOX) announced that the U.S. Food and Drug Administration (FDA) has granted fast-track status to TNX-355 for the treatment of patients with human-immunodeficiency virus 1 (HIV-1)...

Cell infusions boost heart function, revive damaged heart muscle.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Infusing a patient's own cells into a heart artery several days after a heart attack speeds the healing process and strengthens the heart's pumping power, researchers report. In a small study of...

Parental education is significant for preventing inhalant abuse.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Parental education is significant for preventing inhalant abuse. According to a study from the United States, "inhalant abuse is a prevalent and often overlooked form of substance abuse in...

Treatment for substance abuse during pregnancy improves infant outcomes.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Treatment for substance abuse during pregnancy improves infant outcomes. "The objective of this study was to analyze the effects of residential substance abuse treatment on pregnancy outcome among...

Adipose tissue and women's health discussed.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- The view of adipose tissue and its role in women's health is discussed in a recent issue of the journal Pathologie Biologie. "Nowadays, in industrialized societies, it is fashionable for women to...

5-FU infusion plus CPT-11 is an active and safe regimen in advanced CRC.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- 5-FU infusion plus CPT-11 is an active and safe regimen in advanced colorectal cancer (CRC). "We carried out a single-center series with the combination of irinotecan (CPT-11) plus protracted...

Liver transplant tacrolimus neurotoxicity may be preceded by leukoencephalopathy.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Liver transplant neurotoxicity following tacrolimus may be preceded by leukoencephalopathy. According to recent research published in the journal Liver Transplantation, "Neurotoxicity is a...

Medical Mutual to use RationalMed to prevent drug-induced problems.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Medical Mutual is introducing RationalMed, a health and safety system from Medco Health Solutions, Inc. The system uses integrated medical and pharmaceutical data to prevent unnecessary...

Families with periodontitis have elevated levels of IgG2 that are inherited.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Families with aggressive periodontitis are found to have elevated levels of IgG2 that are inherited. According to a study from the United States, "IgG2 is elevated in localized but not in...

Asthma may occur due to vagal reflex stimulation from gastroesophageal reflux.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Vagal reflex stimulation may be involved in the airway hyperresponsiveness that can accompany gastroesophageal reflux. "Airway hyperresponsiveness is among the defining phenomena in asthma. In this...

Tri-Nasal Nasal Spray acquired from Muro Pharmaceutical.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Collegium Pharmaceutical, Inc., a closely held specialty pharmaceutical company, announced that it has acquired from Muro Pharmaceutical, Inc., all rights to Tri-Nasal (triamcinolone acetonide, USP)...

APOE epsilon4 associated with shorter lifespan.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- APOE epsilon4 was associated with a shorter lifespan in elderly adults. "Over 30% of normal elderly people have cerebral amyloid angiopathy (CAA). Possession of APOE epsilon4 is associated with...

APOE expression increases Alzheimer disease risk.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- APOE expression increases the risk of Alzheimer disease risk and is predictive of a poor outcome after head injury. "The APOE-epsilon4 allele is associated with risk for Alzheimer disease (AD) and...

CBP binding transcriptional repressor inhibited by PS1FAD mutations.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1FAD mutations. According to published research from the United States, "Presenilin1...

G-protein alpha-subunits decline as Alzheimer disease progresses.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- The levels of G-protein alpha-subunits decline as Alzheimer disease progresses. "G-protein alpha-subunits (G-alpha[subscript]o, G-alpha[subscript]i, G-alpha[subscript]s, G-alpha(q)) and adenylyl...

Inhibition of NF-kB promotes apoptosis induced by amyloid beta peptides.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Inhibition of NF-kB renders cells more vulnerable to apoptosis induced by amyloid beta peptides. According to recent research from Portugal, "One of the mechanisms leading to neurodegeneration...

Melatonin inhibition of beta-amyloid peptide attenuated by bicuculline.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- The melatonin inhibition of beta-amyloid peptide overexpression could be attenuated by bicuculline treatment. According to recent research from People's Republic of China, "Melatonin deficiency in...

Biologic marker specific for the diagnosis of Alzheimer disease.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Berlex Pharmaceuticals, a U.S. affiliate of Schering AG Germany (SHR), announced that it has discovered that a receptor protein molecule, CCR1, that is usually found on the surface of white blood cells...

Massachusetts General to battle ALS with RNAi technology.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Massachusetts General Hospital and CytRx Corp. (CYTR) have jointly initiated a broad-based research program for the use of RNAi gene-silencing technology in the development of a drug for the prevention,...

Research program funded for study of RNAi technology in ALS.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- CytRx Corporation (CYTR) announced that it has agreed to fund a sponsored research program at the University of Massachusetts Medical School (UMMS) for the use of RNAi gene silencing technology in the...

Erythropoietin treatment could worsen cancer prognosis.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Results of a European study cast doubt over the value of treating anemia with erythropoietin (epoetin beta) among patients who have cancer. Results of the study show that anemic patients fare better in...

No association found between serum hepcidin and markers of anemia.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- No significant association exists between serum hepcidin and other markers of iron status or anemia. "The hepatic antimicrobial protein, hepcidin, is implicated in duodenal iron absorption and...

CD226 is on nonresting human endothelial cells, allows adhesion of leukocytes.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- The transmembrane glycoprotein CD226 is involved in adhesion of leukocytes to endothelial cells and in endothelial cells it is an inducible molecule. According to recent research published in the...

P-glycoproteins for multidrug resistance are in Haemonchus contortus, eggs.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Nematode eggshells and adults of Haemonchus contortus contain P-glycoproteins involved in multidrug resistance, although individual parasites have different degrees of it. "The multidrug resistance...

Phase I trial yields positive results for the prevention of serious infections.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Ipsat Therapies presented positive Phase I clinical trial data for its lead product, P1A, at the BioPartnering Europe Conference in London. This product fulfils many of the criteria for fast-track...

IL-17 alone may enhance osteosarcoma cell lysis by natural killer cells.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Osteosarcoma cells have receptors to IL-17; IL-17 alone may enhance lysis by NK cells, but with IFNgamma they resist NK more. "We investigated the effect of the proinflammatory cytokine interleukin...

Ligand-targeted liposomal anticancer drugs may be developed soon.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Ligand-targeted liposomal anticancer drugs may be developed soon. "Antibody or ligand-mediated targeting of liposomal anticancer drugs to antigens expressed selectively or over-expressed on tumor...

Researchers develop an anticancer agent of marine origin.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Researchers develop an anticancer agent of marine origin. According to recent research from Netherlands, "Yondelis (trabectedin, ET-743) is a novel antitumor agent derived from a marine source, the...

Passive immunotherapy appears to be an effective way to treat melanoma.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Passive immunotherapy should soon be a recognized way of effectively treating melanoma. According to recent research published in the journal Bulletin du Cancer, "The protocols of tumor...

On-X prosthetic heart valve maker begins aspirin study.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Medical Carbon Research Institute, L.L.C., (MCRI), manufacturer of the On-X prosthetic heart valve, announced the initiation of a clinical study under an aspirin-only anticoagulation protocol. The...

The asparaginyl endopeptidase inhibitor, acyloxymethylketone, is cell-permeable.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- The potent asparaginyl endopeptidase inhibitor, acyloxymethylketone, is cell-permeable; alters antigen presentation. "Mammalian asparaginyl endopeptidase (AEP) or legumain is a recently identified...

The C-terminal domain of human CAP18 was used to develop more active analogues.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- The C-terminal domain of human antibacterial protein CAP18 was used as a base to develop 2 proteins with stronger antibacterial effect. "This paper reports the effect of the synthesized 27-amino...

Pacidamycin derivatives active against drug-resistant bacterial pathogens.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- A series of pacidamycin derivatives have demonstrated activity against drug-resistant bacterial pathogens, including E. coli and M. tuberculosis. According to a recent study from California,...

Innate antimicrobials are important, despite some bacterial immune evasion.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Antimicrobial peptides are involved in innate immune defense against bacteria, and bacteria have evolved some ways to evade these molecules. According to recent research published in the journal...

Aggregated antibiograms useful for monitoring drug-resistant Streptococcus.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Aggregated antibiograms are useful for the monitoring of drug-resistant Streptococcus pneumoniae. "Community-specific antimicrobial susceptibility data may help monitor trends among drug-resistant...

Mechanism of metronidazole-resistance by Enterococcus proposed.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Researchers propose a mechanism for metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract. ...

Ganoderma lucidum, a mushroom, may prevent cisplatin-induced nephrotoxicity.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Ganoderma lucidum, a mushroom, may prevent cisplatin-induced nephrotoxicity. According to recent research published in the journal Current Science, "Cisplatin (cisplatinum (II) diamine dichloride)...

Interferons alpha and beta act on p53; do have antitumor, antiviral activities.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Interferons alpha and beta collaborate with p53, effecting tumor suppression and antiviral effects; new types of interferon or better targeted delivery may be clinically effective. "In the recent...

Plasmid-driven siRNAs useful for controlling viral pathogen gene expression.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Plasmid-driven siRNAs offer extensive control over the gene expression of viral pathogens. In a recent study from St. Louis, "Short interfering double-stranded RNAs (siRNAs) expressed under the...

Parents favor counseling over meds for kids.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- New research suggests that parents would rather send their children to counseling than give them medication for social anxiety disorder, a preference that has also been noted for childhood depression...

Rheumatoid arthritis treatment studied in phase II trial.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Regeneron Pharmaceuticals, Inc., (REGN) announced that the company's IL-1 Trap demonstrated evidence of efficacy and safety in patients with rheumatoid arthritis (RA) in a phase II dose-ranging study in...

Cellular fat sensor slows heart disease.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- A cellular sensor of dietary fats slows the development of lesions that lead to heart disease, a Salk Institute study has found. The study, which appears in Science, uncovers a unique pathway that...

Phase II study initiated to evaluate recombinant alpha 1-antitrypsin gel.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- ProMetic Life Sciences (TSX: PLI) and Arriva Pharmaceuticals, Inc., announced that their joint venture company, Arriva-ProMetic, Inc., (JV), has opened a phase II clinical study to evaluate its lead...

Two phase IIa trials initiated in dermatology.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Encysive Pharmaceuticals (ENCY) announced that its majority-owned German affiliate, Revotar Biopharmaceuticals AG, initiated two double-blind, placebo, and standard drug controlled phase IIa clinical...

B7-H3 may be a negative Th1 regulator and may prevent some autoantibodies.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- B7-H3 is involved in downregulation of Th1 responses and lack of it can produce more autoantibodies, experimentally. "We investigated the in vivo function of the B7 family member B7-H3 (also known...

Regulatory T cells have role in protection from autoimmunity.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Regulatory T cells are a diverse population of T cells involved in protecting against autoimmunity, and may be used therapeutically in the future. According to recent research published in the...

AID may not need cofactors in somatic hypermutation, but may in class-switch.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Activation-induced cytidine deaminase does not appear to need cofactors in B-cell somatic hypermutation signalling but may need them in class switch. "Activation-induced cytidine deaminase (AID) is...

Fas can induce apoptosis in B cells, but other surface receptors may intervene.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Fas can induce apoptosis in B cells, but other surface receptors determine to susceptibility to it, unlike other cells. "Engagement of the cell surface receptor Fas/APO-1 (CD95) initiates a...

Dendritic cells battle meningococcal, listerial meningitis two separate ways.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Dendritic cells function by two different pathways to combat bacterial meningitis from Listeria monocytogenes and Neisseria meningitides. "Few bacteria are capable of causing infections of the...

Anaerobic bacterium from dermatitis in Michigan dairy cows characterized.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Scientists have characterized the predominant anaerobic bacterium recovered from digital dermatitis lesions in three Michigan dairy cows. "Digital dermatitis is a superficial epidermatitis of the...

Complete genome sequence of Porphyromonas gingivalis strain W83 reported.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- The complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83 has been published in a recent issue of the Journal of Bacteriology. "The complete 2,343,479-bp...

Overproduction of inactive variants of murein synthase lyses E. coli.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Overproduction of inactive variants of the murein synthase PBP1B causes lysis in Escherichia coli. "Penicillin-binding protein 1B (PBP1B) of Escherichia coli is a bifunctional murein synthase...

Unique FauI restriction-modification system characterized.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Researchers have characterized the unique FauI restriction-modification system. "The nucleotide sequence was established for the full-length Flavobacterium aquatile operon coding for the FauI...

Transoral CO[subscript]2 laser excision of laryngeal paraganglioma is effective.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Transoral CO[subscript]2 laser excision of laryngeal paraganglioma is effective. According to a study from Germany, "Paragangliomas are rare benign neoplasms arising from the neural crest-derived...

Services launched for biorepository management.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Ardais Corporation announced the availability of its Biomaterials and Information for Genomic Research (BIGR) Biospecimen Management System (BMS), a comprehensive set of services and licenses that...

Scanning array-designed antisense oligonucleotides predict effective therapy.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Scanning array-designed antisense oligonucleotides predict effective therapy. According to a study from England, "scanning oligodeoxynucleotide (ODN) arrays appear promising in vitro tools for the...

New drug-and-psychotherapy program for children described.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- A psychiatrist at the University of Illinois at Chicago (UIC) has devised a promising drug regimen for children with bipolar disorder. In preliminary studies, the regimen, coupled with a...

Inflammatory marker levels associated with body mass index.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Inflammatory marker levels are associated with body mass index. "Obesity is a risk factor for venous and arterial thrombosis. We examined relationships between body mass index (BMI) and a number of...

Brachytherapy seed company receives European CE Mark.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- IsoAid, LLC, announced receipt of its European CE Mark. Through the German organization, DQS, the company has demonstrated that it has implemented and maintains a quality-management system, in...

Local minocycline and systemic BCNU combine to curb intracranial glioma.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Local minocycline and systemic BCNU combine to curb intracranial glioma. "Minocycline, a tetracycline derivative, has been shown to inhibit tumor angiogenesis through inhibitory effects on matrix...

Apoptosis assays could be used to detect selective toxicity of anticancer drugs.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Apoptosis assays could be used to detect selective toxicity of anticancer drugs. "The goal of our study was to determine whether an apoptosis assay used after short-term drug exposure could predict...

Study of novel anticancer agent gets boost from $3M grant.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Roswell Park Cancer Institute (RPCI) has been awarded a Clinical Translational Research Grant of $3,089,794 by the Breast Cancer Research Program of the U.S. Department of Defense for the study of a...

Tissue to be used to determine genetic cause of cancer.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Asterand, the Detroit-based human tissue bank, is re-examining research materials and data donated over 30 years ago for new clues to the genetic causes of breast cancer. "October is breast cancer...

Brucellosis patient sera reacts to aminopeptidase N purified from Brucella.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Acute and chronic brucellosis patient sera reacts to an aminopeptidase N purified from Brucella. According to a study from Mexico, "An immunogenic aminopeptidase was purified from Brucella...

C. jejuni cytolethal distending toxin subunits A, C allow binding to cells.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Campylobacter jejuni cytolethal distending toxin subunits CdtA and CdtC allow the complex to bind to cells; they also can compete with the active complex that includes the CdtB nuclease. ...

Chronotherapy network involving institutions with expertise is being developed.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Chronotherapy network involving institutions with expertise is being developed. According to a study from France, "The EORTC Chronotherapy Group (CTG) stemmed from the International Organization for...

Peptides derived from VEGF receptor 2 diminish angiogenesis in lab tests.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Peptides derived from VEGF receptor 2 diminish angiogenesis in lab tests. According to published research from Europe, "vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial...

Antitumor agent has promising pharmacological profile.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Modern methods of "high-throughput screening" make it possible to search for new pharmaceuticals in giant - though sometimes quite randomly compiled - substance libraries. In contrast, an...

Biotech-based anticancer therapies becoming more prevalent.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- New figures released today by Pharmaprojects show that a quarter of all anti-cancer therapies in development are based on biotechnology. Pharmaprojects analyzed the number of biotechnology products...

Imatinib suppresses marrow cell monocyte/macrophage differentiation.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Imatinib suppresses marrow cell monocyte/macrophage differentiation. "The antileukemic tyrosine kinase inhibitor, imatinib, has been reported to inhibit specifically the growth of bcr-abl expressing...

Molecular test measures extent of remission, potential for relapse.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- An international consortium of researchers reported the first use of a sensitive molecular test to measure the precise extent of remission or the likelihood of relapse in cancer patients being treated...

Phase I trials with HDAC inhibitor initiated.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- TopoTarget has initiated a Phase I clinical study of PXD101, its histone deacetylase (HDAC) inhibitor, in patients with advanced cancers. The two-center trial is being carried out by investigators...

Antigen-specific immunotherapy and cancer vaccines reviewed.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Scientists have published a review of antigen-specific immunotherapy and cancer vaccines in a recent issue of the International Journal of Cancer. "The specific activation of the immune system to...

Clinical studies of vaccines targeting breast cancer reviewed.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Investigators have published a review of clinical studies of vaccines targeting breast cancer in a recent issue of the journal Clinical Cancer Research. "Many clinical studies have been undertaken...

Dendritic cell vaccine induces T-cell immunity in stage IV melanoma patients.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Single injection of CD34+ progenitor-derived dendritic cell vaccine can lead to induction of T-cell immunity in patients with stage IV melanoma. According to a study from the United States, "There...

Heat shock protein from a non-autologous tumor used as anti-tumor vaccine.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- Heat shock protein derived from a non-autologous tumor can be used as an anti-tumor vaccine. According to published research from Ireland, "Antigenic cross-reactivity between certain tumors has...

Her-2/neu is potential vaccine target for acute lymphoblastic leukemias.
November 7, 2003... 2003 NOV 7 - (NewsRx.com & NewsRx.net) -- The Her-2/neu antigen is a potential vaccine target for acute lymphoblastic leukemias. "Her-2/neu is a tumor-associated antigen that is expressed on several adenocarcinomas and correlates with poor...