Drug Week articles from May 2009

Drug Week archives from May 2009

Biological FM signal maintains inflammation in cancer, asthma and other diseases.
May 1, 2009... A study published (10 April) in Science examines a key player in conditions such as cancer, inflammatory bowel disease, rheumatoid arthritis and asthma and has shown that cells use a sophisticated communication system to coordinate responses to...

By shutting down inflammation, agent reverses damage from spinal cord injury in preclinical studies.(Report)
May 1, 2009... Researchers at Georgetown University Medical Center (GUMC) have been able to speed recovery and substantially reduce damage resulting from spinal cord injury in preclinical studies (see also Georgetown University Medical Center). Their...

Study finds cognitive behavioral therapy can alleviate nonepileptic seizures.
May 1, 2009... Researchers at Rhode Island Hospital have found that cognitive behavioral therapy (CBT) can reduce the frequency of seizures in patients with psychogenic nonepileptic seizures (PNES), along with improving their overall quality of life. The...

Gene fusion discovery may lead to improved prostate cancer test.
May 1, 2009... A newly discovered gene fusion is highly expressed in a subset of prostate cancers, according to a study by researchers at Weill Cornell Medical College. The findings, reported in the April 1 issue of Cancer Research, may lead to more accurate...

OHSU School of Dentistry finds some orthodontic appliances are more prone to bacteria.
May 1, 2009... Researchers at the Oregon Health & Science University School of Dentistry (www.ohsu.edu/sod) have found the majority of patients with self-ligating orthodontic brackets retain fewer bacteria in plaque than patients with elastomeric orthodontic...

Study findings from N. Nagata et al provide new insights into life sciences.
May 1, 2009... According to recent research from Takayama, Japan, "Amphiphilic bis(imidazolyl)tris(porphyrinatozinc) complexes having omega-carboxyalkyl meso substituents were prepared." "The barrel-type porphyrin macroring organized through their...

Studies in the area of complementary and alternative medicine reported from B. Hazra and co-researchers.
May 1, 2009... "Many diseases are associated with oxidative stress caused by free radicals. Current research is directed towards finding naturally-occurring antioxidants of plant origin," investigators in Calcutta, India report (see also Complementary and...

Data on drug discovery and design published by researchers at Josai University.
May 1, 2009... According to recent research from Sakado, Japan, "The effects of several electrolyzed waters were evaluated on the permeation of model base, acid and non-ionized compounds, lidocaine (LC), benzoic acid (BA), and isosorbide mononitrate (ISMN),...

New drug discovery and design data have been reported by scientists at University of Minnesota.
May 1, 2009... "Chlorhexidine (CHX) is effective in treating oral bacterial infections. The solubility was shown to be highly dependent on the salt present in solution," researchers in the United States report (see also Drug Discovery and Design). ...

New drug discovery and design research from Wuhan University discussed.
May 1, 2009... "Ursolic acid (UA) is a poor soluble natural triterpenoid. It has a wide variety of antitumor activities," investigators in Wuhan, People's Republic of China report (see also Drug Discovery and Design). "We extracted it from Crataegus...

New findings from University of Ferrara in the area of drug discovery and design published.(Report)
May 1, 2009... According to recent research published in the journal Drug Development and Industrial Pharmacy, "The sunscreen agent, butyl methoxydibenzoylmethane (BMDBM), one of the most widely used UV-A filter, undergoes decomposition under sunlight...

New findings from Y.Z. Zhao and co-authors describe advances in drug discovery and design.(Report)
May 1, 2009... According to a study from Wenzhou, People's Republic of China, "The objective of this study was to investigate the possibility of increasing the entrapment of protein-loaded liposomes with a modified freeze-thaw technique. Blank liposomes were...

Report summarizes drug discovery and design study findings from G.V. Shavi and co-researchers.(Report)
May 1, 2009... According to a study from Manipal, India, "The aim of this study was to develop an enteric-coated multi-unit dosage form containing aceclofenac, a nonsteroidal anti-inflammatory drug. The pellets were prepared by using extrusion/spheronization...

Reports from Tsinghua University highlight recent research in drug discovery and design.
May 1, 2009... According to recent research from Beijing, People's Republic of China, "A novel monolithic osmotic tablet composed of solid dispersion of water-insoluble 10-hydroxycamptothecin (HCPT) was prepared." "The tablet core was made of a...

Research from J.P. Anais and colleagues has provided new data on drug discovery and design.
May 1, 2009... "We studied different methods of preparing alpha-tocopherol acetate (ATA) nanoparticles, which are to be used in targeting the lungs as aerosols in order to prevent cigarette smoke toxicity," scientists in Creteil, France report (see also Drug...

Research on drug discovery and design detailed by scientists at University of Sao Paulo.
May 1, 2009... "Rutin, one of the major flavonoids found in an assortment of plants, was reported to act as a sun protection factor booster with high anti-UVA defense, antioxidant, antiaging, and anticellulite, by improvement of the cutaneous...

Researchers at King Saud University target drug discovery and design.(Report)
May 1, 2009... According to recent research from Riyadh, Saudi Arabia, "The basic objectives of this study were to prepare and characterize solid dispersions of poorly soluble drug spironolactone (SP) using gelucire carriers by spray-drying technique. The...

Scientists at King Saud University discuss research in drug discovery and design.
May 1, 2009... "The study evaluated different mucoadhesive polymeric hydrogels for nasal delivery of acyclovir. Gels containing poly-N-vinyl-2-pyrrolidone (PVP) were prepared with crosslinking achieved by irradiation with a radiation dose of 15 kGy being as...

Scientists at University of Texas report research in drug discovery and design.
May 1, 2009... "Aqueous suspensions of crystalline naproxen nanoparticles, formed by antisolvent precipitation, were flocculated with sodium sulfate, filtered, and dried to form redispersible powders for oral delivery. The particles were stabilized with...

Studies by M.M.A. Abdelmottaleb and co-authors describe new findings in drug discovery and design.(Report)
May 1, 2009... According to recent research from Dusseldorf, Germany, "The aim of this study was to develop fluconazole in an ultrapure polyvinyl alcohol (PVA) hydrogel able to deliver the drug in a sustained release pattern for local treatment of skin fungal...

Studies from Y. Javadzadeh and co-researchers yield new data on drug discovery and design.(Report)
May 1, 2009... "The technique of liquisolid compacts is a promising method toward enhancing the dissolution of poorly soluble drugs. Lower flowability and compressibility is one of the limitations of this technique," scientists writing in the journal Drug...

Studies in the area of drug discovery and design reported from Sichuan University.
May 1, 2009... "A step nonisothermal experiment under high oxygen pressure and a new computation with optimization for step nonisothermal experiment on stability study of drugs was introduced. The kinetics parameters of captopril oxidation in aqueous solution...

New research on drug discovery and development from Cipla Ltd. summarized.
May 1, 2009... According to recent research from India, "The study was conducted in order to assess the bioequivalence of three capsule formulations containing 100 mg of ciclosporin (CAS 59865-13-3). 24 Healthy volunteers, 20 to 37 years of age (mean 26, SD...

Research from A. Marzo and co-researchers yields new findings on drug discovery and development.
May 1, 2009... "In planning comparative bioavailability and bioequivalence trials, the half-life of the parent compound and metabolites included in the active moiety requires careful attention. Drugs cleared with long or very long half-lives, mainly in cases...

Investigators at Tohoku University zero in on molecular pharmacology.
May 1, 2009... According to recent research from Sendai, Japan, "Pregnane X receptor (PXR) has been shown to form a heterodimer with retinoid X receptor alpha(RXR alpha) and to bind to the distal nuclear receptor-binding element 1 and an everted repeat...

Investigators at University of Regensburg target molecular pharmacology.(Report)
May 1, 2009... "Previous studies revealed that phenylhistamines and histaprodifens possess higher potency and affinity at guinea pig histamine H-1-receptor (gpH(1)R) than at human histamine H-1-receptor (hH(1)R). However, we recently identified an...

New molecular pharmacology study results reported from H. Orcel et al.
May 1, 2009... "We show here that the rat vasopressin V-1b receptor simultaneously activates both the G(q/11)-inositol phosphate (IP) and G(s)-cAMP pathways when transiently expressed in Chinese hamster ovary, human embryonic kidney (HEK) 293, and COS-7 cells...

Research from Vanderbilt University in the area of molecular pharmacology published.
May 1, 2009... According to a study from the United States, "Activators of M-1 muscarinic acetylcholine receptors (mAChRs) may provide novel treatments for schizophrenia and Alzheimer's disease. Unfortunately, the development of M-1-active compounds has...

Researchers' work from University of Wurzburg focuses on molecular pharmacology.
May 1, 2009... According to recent research from Wurzburg, Germany, "Several lines of evidence suggest that G-protein-coupled receptors can adopt different active conformations, but their direct demonstration in intact cells is still missing. Using a...

Scientists at University of Cincinnati discuss research in molecular pharmacology.
May 1, 2009... "In the past, CYP1A1 protein was known to be located in the endoplasmic reticulum (ER; microsomes). More recently, CYP1A1 was shown also to be targeted to the inner mitochondrial membrane; mitochondrial import is dependent on NH2-terminal...

Studies from A.J. Copik et al provide new data on molecular pharmacology.
May 1, 2009... According to recent research from the United States, "Agonist occupied alpha(1)-adrenoceptors (alpha(1)-ARs) engage several signaling pathways, including phosphatidylinositol hydrolysis, calcium mobilization, arachidonic acid release,...

Study data from Johnson & Johnson update knowledge of molecular pharmacology.
May 1, 2009... "The molecular mechanisms governing calcium signal transduction of corticotropin-releasing factor (CRF) receptors CRF1 and CRF2(a) stably expressed in human embryonic kidney (HEK) 293 cells were investigated. Calcium signaling strictly depended...

Study findings from University of Michigan, Medical Department broaden understanding of molecular pharmacology.
May 1, 2009... According to recent research from the United States, "The human dopamine transporter (hDAT) regulates synaptic dopamine (DA) levels and is the site of action of abused and therapeutic drugs. Here we study the effect of a threonine residue...

Study results from Thomas Jefferson University provide new insights into molecular pharmacology.
May 1, 2009... "Dopamine activates phospholipase C in discrete regions of the mammalian brain, and this action is believed to be mediated through a D-1-like receptor. Although multiple lines of evidence exclude a role for the D-1 subtype of D-1-like receptors...

Study results from University of Virginia provide new insights into molecular pharmacology.
May 1, 2009... "Previous data have indicated that T-type calcium channels (low-voltage activated T-channels) are potently inhibited by volatile anesthetics. Although the interactions of T-channels with a number of anesthetics have been described, the...

Data on pharmacology and experimental therapeutics detailed by F. Sotty and co-authors.
May 1, 2009... "Dopaminergic (DAergic) neurons in the ventral tegmental area express both KCNQ2 and KCNQ4 channels, which opening is expected to decrease neuronal excitability via neuronal hyperpolarization. Because psychotic symptoms are believed to be...

Data on pharmacology and experimental therapeutics detailed by researchers at University of Kuopio.
May 1, 2009... "The permeability estimation from cell monolayer permeation data is usually based on 100% recovery assumption. However, poor recovery is often seen in such experiments in practice but often neglected in data interpretation," scientists writing...

New findings from University of Cambridge describe advances in pharmacology and experimental therapeutics.
May 1, 2009... "The monoamine, 5-hydroxytryptamine (5-HT), stimulates contraction of human uterine smooth muscle (myometrium), but the receptor subtypes involved have not been characterized. We studied the effects of a range of 5-HT receptor subtype-selective...

New pharmacology and experimental therapeutics findings from Vanderbilt University published.(Report)
May 1, 2009... "Diabetic patients treated with inhaled insulin exhibit reduced fasting plasma glucose levels. In dogs, insulin action in muscle is enhanced for as long as 3 h after insulin inhalation," scientists in the United States report (see also...

New pharmacology and experimental therapeutics research reported from University of Texas.(Report)
May 1, 2009... "Discriminative stimulus effects of the serotonin (5-HT) receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) have been studied in rats and, more recently, in rhesus monkeys. This study examined DOM,...

New research on pharmacology and experimental therapeutics from N.S. Gould and co-authors summarized.
May 1, 2009... "Sulfur mustards (SMs) have been used as warfare agents since World War I and still pose a significant threat against civilian and military personnel. SM exposure can cause significant blistering of the skin, respiratory injury, and fibrosis,"...

Reports summarize pharmacology and experimental therapeutics study results from University of Kentucky, Medical Department.(Report)
May 1, 2009... According to a study from the United States, "Methamphetamine abuse is a significant public health concern. Although widely studied in laboratory animals, little is known about the abuse-related behavioral effects of methamphetamine relative to...

Research from University of Kentucky in the area of pharmacology and experimental therapeutics described.
May 1, 2009... "Previous research shows that nicotine increases dopamine (DA) clearance in rat prefrontal cortex (PFC) and striatum via a nicotinic receptor (nAChR)-mediated mechanism. The present study investigated whether activation of nAChRs regulates DA...

Research on pharmacology and experimental therapeutics reported by scientists at University of North Texas.
May 1, 2009... "We have reported that the major endogenous estrogen, 17 beta-estradiol (E2), protects against oxidative injury during ethanol withdrawal (EW) in a cultured hippocampal cell line (HT22). Here, we investigated whether the pro-oxidant nature of...

Studies from B. Gonzalez et al provide new data on pharmacology and experimental therapeutics.
May 1, 2009... According to a study from Mexico, "The motor effects of cannabinoids in the globus pallidus appear to be caused by increases in interstitial GABA. To elucidate the mechanism of this response, we investigated the effect of the selective...

Studies from Columbia University further understanding of pharmacology and experimental therapeutics.(Report)
May 1, 2009... "Eszopiclone (Lunesta; Sepracor, Marlborough, MA) and zolpidem [N,N,6-trimethyl-2-(4-methylphenyl)-imidazo(1,2-a)pyridine-3-acetamide] are among the most commonly prescribed hypnotics in use in the United States. The thalamus plays a pivotal...

Studies from University of Pittsburgh yield new data on pharmacology and experimental therapeutics.
May 1, 2009... According to a study from the United States, "We recently developed a sensitive assay for 3',5'-cAMP using high-performance liquid chromatography-tandem mass spectrometry. Using this assay, we investigated the release of 3',5'-cAMP from...

Studies from University of Pittsburgh yield new information about pharmacology and experimental therapeutics.(Report)
May 1, 2009... "Disorazoles comprise a family of 29 macrocyclic polyketides isolated from the fermentation broth of the myxobacterium Sorangium cellulosum. The major fermentation product, disorazole A(1), was found previously to irreversibly bind to tubulin...

Study findings from University of Washington broaden understanding of pharmacy research.
May 1, 2009... According to a study from the United States, "The grantsmanship process is described from the perspective of the investigator. Successful grant writing involves considerable preparation." "There are thousands of grant-making agencies, both...

New therapeutic patents findings from Dublin City University published.
May 1, 2009... According to recent research from Dublin, Ireland, "The application is in the field of neuronal growth and the activity of brevetoxins and their derivatives. It aims to characterize the activity of four generic formulae of brevetoxin...

Commonly used ulcer drugs may offer treatment potential in Alzheimer's disease.
May 8, 2009... In a new study, published in the May issue of Elsevier's Experimental Neurology (www.elsevier.com/locate/yexnr), scientists at the University of British Columbia have discovered that drugs commonly used to treat ulcers have significant...

Treating addiction by eliminating drug-associated memories.(Report)
May 8, 2009... Addicts, even those who have been abstinent for long periods of time, are often still vulnerable to their own memories of prior drug use. For example, exposure to the same environment in which they commonly used drugs - a contextual memory -...

Our brains make their own marijuana: We're all pot heads deep inside.
May 8, 2009... U.S. and Brazilian scientists have just proven that one of Bob Dylan's most famous lines--"everybody must get stoned"-- is correct. That's because they've discovered that the brain manufactures proteins that act like marijuana at specific...

News coverage of trans fat prompts shoppers to avoid certain products.
May 8, 2009... News coverage about the harmful effects of trans fat, combined with labeling information, may influence consumers' short-term purchases of foods high in trans fat, but is not enough to prompt shoppers to avoid these potentially artery-clogging...

Ancient ecosystem thrives millions of years below Antarctic glacier.
May 8, 2009... Scientists have found an ancient ecosystem below an Antarctic glacier and learned that it survived millions of years by transforming sulfur and iron compounds for growth (see also Montana State University). Described in the April 17 issue...

Research in the area of gene therapy reported from Doshisha University.
May 8, 2009... "Two amphiphilic zinc porphyrins were incorporated into liposomal bilayer membranes, egg phosphatidylcholine (Egg PC) and dipalmitoylphosphatidylcholine (DPPC). Binding free energy of alkylpyridines to the zinc porphyrins linearly increased as...

New clinical pharmacology study findings have been reported by V.F. Marijic and co-researchers.(Clinical report)
May 8, 2009... "The structural requirements relevant for protective efficacy against cisplatin-induced renal toxicity was studied for seven newly synthesized pyrazolone compounds. Since tetrahydroindazolonedicarboxylic acid (HIDA) has shown potential...

Reports summarize clinical pharmacology study results from L. Young and co-researchers.(Clinical report)
May 8, 2009... According to a study from Dunedin, New Zealand, "WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT center dot Children have reduced access to medicines because of inadequate prescribing information and paucity of suitable formulations. center dot The...

Studies from M.R. Sulaiman et al further understanding of clinical pharmacology.(Clinical report)
May 8, 2009... "Trigonopleura malayana L. (Euphorbiaceae) resin, locally known as Gambir Sarawak, has been used traditionally to alleviate pain associated with insect bites, muscle ache, toothache and minor injuries. The present study was carried out using...

Studies from M. Joshi et al provide new data on complementary and alternative medicine.
May 8, 2009... According to recent research from India, "The study was conducted to compare the P300 event-related potentials recorded before and after (1) high-frequency yoga breathing (HFYB) and (2) breath awareness. The P300 was recorded in participants of...

Data from Fudan University advance knowledge in controlled release.(Report)
May 8, 2009... According to recent research from Shanghai, People's Republic of China, "The lactoferrin (Lf) conjugated poly (ethyleneglycol)-poly (lactide) nanoparticle (Lf-NP) was constructed in this paper as a novel biodegradable brain drug delivery system...

Investigators at University of Oklahoma publish new data on hormones.
May 8, 2009... "Ghrelin, the natural ligand of the growth hormone secretagogue receptor (ghrelin receptor), is an orexigenic gut hormone with prokinetic action in the upper gastrointestinal tract Previously we have shown in a rodent model of postoperative...

Recent findings in controlled release described by researchers from Northeastern University.
May 8, 2009... "Antigen presenting cells (APC) are among the most important cells or the immune system since they link the innate and the adaptative immune responses, directing the type of immune response to be elicited. To modulate the immune response in...

Reports from A. Dalpiaz and colleagues advance knowledge in drug delivery science and technology.
May 8, 2009... "Aspirin and its prodrug obtained as conjugate with vitamin C (AA-Asp) were evaluated on human retinal pigment epithelium (HRPE) cells to investigate their ability to interact with the ascorbate transporter SVCT2 and their cellular uptake,...

Reports summarize drug delivery science and technology study results from Kumamoto University.
May 8, 2009... "The membrane transport properties of 5-FU and its prodrugs were investigated using Caco-2 cell monolayers. To elucidate a membrane transport of prodrug itself, 2-O-alkoxy-5-fluoropyrimidone (2-O-alkoxy-5FP) derivative, which was stable in...

Researchers from Bharati Vidyapeeth describe findings in drug delivery science and technology.
May 8, 2009... According to a study from Pune, India, "The objective of the present work was to investigate the targeting potential of L-glutamine utilizing concept-based mutual prodrug design for the delivery of meselamine to colon." "Meselamine was...

New drug discovery and design data have been reported by I. Izcobasurko and co-authors.
May 8, 2009... According to recent research from Barcelona, Spain, "The 6th World Stroke Congress was organized by the World Stroke Organization (WSO) and took place in Vienna on September 24-27, 2008." "The biennial meeting was attended by approximately...

Researchers from University of Wisconsin report recent findings in pharmaceutical education.
May 8, 2009... Researchers in the United States conducted a study "To create, implement, and assess an elective course on the principles and applications of personal finance. A 1.5 unit (15 hours total) elective course was designed using active-learning...

Study results from Northeastern University broaden understanding of pharmaceutical education.
May 8, 2009... "Determine the quantitative and qualitative value of a lecture-laboratory course with standardized patients on student communication skills. A blinded retrospective analysis was conducted on the counseling tapes of 127 students who took a...

New pharmaceutical research reported from University of Akron.
May 8, 2009... "Current delivery devices for drugs and genes such as films and microspheres are usually formulated from polymers that degrade over a period of months. In general, these delivery systems are designed to achieve an extracellular release of their...

New pharmaceutical research study results from Kaohsiung Medical University described.
May 8, 2009... According to recent research published in the journal Pharmaceutical Research, "A novel naringenin-loaded nanoparticles system (NARN) was developed to resolve the restricted bioavailability of naringenin (NAR) and to enhance its...

Research from Graz University broadens understanding of pharmaceutical research.(Report)
May 8, 2009... According to a study from Graz, Austria, "Nimodipine is used parenterally to treat ischemic neurological deficits caused by subarachnoid haemorraghe. Infusion of nimodipine should be continued during anaesthesia, surgery or angiography." ...

Research from S. Songkro and co-authors reveals new findings on pharmaceutical research.
May 8, 2009... According to a study from Songkhla, Thailand, "The objective of this work was to investigate the effect of oxygen containing terpenes (carvacrol, menthol and carvone) at 5%w/v in hydroalcoholic mixtures (40% ethanol) on the permeation of LHRH...

Researchers at Gazi University target pharmaceutical research.
May 8, 2009... According to a study from Ankara, Turkey, "The transport of alendronate through Caco-2 monolayers in the absence and presence of absorption enhancers (sodium taurocholate-STC and dimethyl-beta-cyclodextrin-DM-beta-CD) was studied. The viability...

Researchers from Medical University of South Carolina report recent findings in pharmaceutical research.
May 8, 2009... "The present study was undertaken to determine whether d-threo-(R,R)-methylphenidate (MPH) was exerting binding activity as an agonist or antagonist of 5-HT1A and 5-HT2B receptors. [S-35]guanosine5'[gamma-thio]triphosphate ([S-35]GTP gamma S)...

Findings from Fukuyama University provide new insights into pharmacological sciences.
May 8, 2009... "We analyzed the expression of 5-HT2 receptors and proteins related to inactivation of 5-HT in primary cultures of mouse osteoblasts. The mRNA for the 5-HT2A receptor was detectable in anaplastic osteoblasts as well as in differentiated and...

New pharmacological sciences research from Shiga University described.
May 8, 2009... According to recent research from Japan, "Articular chondrocytes play an important role in maintaining the structure and function of the cartilage in synovial joints, which is closely influenced by mechanical or osmotic stress. In the present...

Recent findings in pharmacological sciences described by researchers from Kitasato University.(Report)
May 8, 2009... According to a study from Aomori, Japan, "Methylglyoxal (MGO) is a metabolite of glucose. In addition to evidence that increased plasma MGO level is associated with diabetic vascular complications, recent studies demonstrated that MGO...

Researchers at Federal University have published new data on pharmacological sciences.
May 8, 2009... According to recent research from Brazil, "The immunophilin 12-kDa FK506 binding protein (FKBP12) stabilizes intracellular Ca2+ release channel (CRC) activity in different tissues. In this work, the presence of FKBP12 in rat vas deferens (RVD)...

Beyond associations: Colorectal cancer culprit found.
May 15, 2009... Genetics plays a key role in determining risk for colorectal cancer, the second leading cause of cancer-related deaths in the United States. Several common genetic markers have been found to be associated with the disease, but finding the...

Parkinson's: Neurons destroyed by 3 simultaneous strikes.
May 15, 2009... In a study that reveals the clearest picture to date of neuron death in Parkinson's disease, researchers at Columbia University Medical Center have found that a trio of culprits acting in concert is responsible for killing the brain cells (see...

Oxytocin: Love potion #1?
May 15, 2009... Relationships are difficult and most of us probably think at some point that communicating positively with our partner when discussing stressful issues, like home finances, is an impossible task. What if there was a safe way to take the "edge"...

Nondrug treatment of Alzheimer's disease: Long-term benefit not proven.
May 15, 2009... Whether people with Alzheimer's disease benefit in the long term from non-drug treatment interventions remains an unanswered question. This unsatisfactory finding is mainly due to the fact that convincing studies are lacking so far. For...

Gene alterations associated with response to anthracycline therapy for breast cancer.
May 15, 2009... Alterations in the topoisomerase II alpha (TOP2A) gene were associated with better patient outcomes following anthracycline-based therapy compared with non-anthracycline-based regimens, according to a study in the April 28 online issue of the...