Drug Week articles from March 2004

Drug Week archives from March 2004

Injection drug use attenuates HAART benefits.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Injection drug use attenuates the benefits of HAART. "There is evidence that HIV-positive injecting drug users benefit less than other risk groups from highly active antiretroviral therapy that has...

Lucky number? Seven factors may increase clot-buster use for stroke.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Seven factors, including written procedures for treating stroke and a responsive emergency room staff, may increase the odds that ischemic stroke patients will receive clot-busting drugs, researchers...

Three-year data highlight Viread efficacy, safety, and side effect profile.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Gilead Sciences, Inc., (GILD) announced preliminary 3-year (144-week) data from a double-blind, phase III clinical trial (Study 903) suggesting that Viread (tenofovir disoproxil fumarate) is associated...

FDA accepts NDA with priority review for RSR13.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Allos Therapeutics, Inc., (ALTH) announced that the Division of Oncology Drug Products at the U.S. Food and Drug Administration (FDA) has accepted for review the company's New Drug Application (NDA)...

Clinical results from botulinum toxin type A study announced.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Inamed Corp. (IMDC), a global healthcare company, and its partner Ipsen, a European midsized specialist pharmaceutical company, reported the phase II dosing study of their botulinum toxin type A product...

FDA approves Caduet as dual therapy.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Pfizer, Inc., said that it has received approval from the U.S. Food and Drug Administration (FDA) to market its dual therapy medicine Caduet (amlodipine besylate/atorvastatin calcium) for the...

Construction of a reporter system can detect fine differences in p53 activation.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Researchers propose constructs for generating reporter cell lines from various cultures in order to identify the genetic or chemical factors that modulate the p53 activity and may be employed in new...

FDA approves Syneron Aurora for dermatological use.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Syneron Medical, Ltd., and its North American subsidiary Syneron, Inc., announced that the U.S. Food and Drug Administration (FDA) has granted 510K marketing clearance to Syneron's Aurora AC system for...

FDA urged to crack down on Internet sales of isotretinoin.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- In a letter sent to the U.S. Food and Drug Administration (FDA), the American Academy of Dermatology Association (AADA) called on the FDA to halt Internet sales of isotretinoin, commonly known as...

Specialized services benefit pregnant opioid dependent women in Ireland.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Specialized services benefit pregnant opioid dependent women in Ireland. "The health needs of pregnant opioid dependent women are increasingly being recognized by health care professionals. These...

FDA approves Genasense NDA.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Genta, Inc., (GNTA) and Aventis (AVE) announced that the U.S. Food and Drug Administration (FDA) has accepted the new drug application (NDA) for Genasense (oblimersen sodium), the first systemic...

Atorvastatin causes asymptomatic elevations of liver enzyme levels.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Atorvastatin causes asymptomatic elevations of liver enzyme levels. "The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (also known as statins) are associated with elevated transaminase...

APOE genotypes may influence a person's response to interferon-alpha.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- APOE genotypes may influence a person's response to interferon-alpha. According to recent research published in the journal Psychosomatics, "neuropsychiatric complications are common in patients...

Bone is a target for the antidiabetic compound rosiglitazone.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Bone is a target for the antidiabetic compound rosiglitazone. According to a study from the United States, "Rosiglitazone is an FDA-approved oral antidiabetic agent for the treatment of type 2...

Gastrointestinal side effects from alendronate require additional medication.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Gastrointestinal side effects from alendronate require additional medication. According to research from Turkey, "the aim of our study was to evaluate the upper gastrointestinal (GI) tract side...

Germline transfection is possible after intramyocardial gene delivery.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Germline transfection is possible after intramyocardial gene delivery. According to published research from the United States, "intramyocardial injection of adeno-associated virus (AAV) has been...

Moving non-sedating antihistamines to third-tier status yields greatest savings.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Health plan sponsors that did not cover over-the-counter (OTC) Claritin (loratadine) and moved other prescription non-sedating antihistamine (NSA) drugs to third-tier status under a three-tier drug...

Pathological amyloid formation orchestrated by secretory pathway.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Pathological and functional amyloid formation is orchestrated by the secretory pathway. According to recent research from the United States, "Amyloidogenesis has historically been associated with...

Scientists identify compound that may offer new Alzheimer treatment.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Samaritan Pharmaceuticals Inc. (SPHC) and Samaritan Research Labs, Georgetown University, announced that its research, published in the journal Steroids suggests that 22R-hydroxycholesterol derivatives...

Final efficacy results awaited as ALS trial of Ikomio moves forward.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- ExonHit Therapeutics, a privately held drug discovery company, announced it has received recommendation by an independent Data Safety Monitoring Board (DSMB) to continue its clinical trial for Ikomio, a...

Popular drug for chest pain may promote blood vessel damage.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Nitroglycerin, a drug commonly prescribed for the treatment of chest pain in patients with heart conditions, has the frustrating property that its beneficial effects are short-lived. Now, new...

Mechanisms of testosterone-induced coronary artery relaxation clarified.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- The mechanisms of testosterone-induced coronary artery relaxation have been clarified. "The relationship between the level of testosterone and the incidence of coronary heart disease is still...

Phase III trial initiated to explore use of Humira.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Abbott Laboratories (ABT) announced the initiation of a global phase III study evaluating the potential of Humira (adalimumab) in treating ankylosing spondylitis. Ankylosing spondylitis (AS), or...

Betula platyphylla var. japonica extract may have anticancer properties.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Animal model shows that Betula platyphylla var. japonica has potential anticancer and antioxidant properties, researchers report. "The antioxidant and anticancer properties of a medicinal plant,...

Genetic element linked to streptococcal macrolide resistance characterized.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- A chimeric genetic element linked to streptococcal macrolide resistance has been characterized. According to recent research from the United States, "The resistance of group A Streptococcus (GAS)...

Anti-infective technology licensed to GMP.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- The Procter & Gamble Co. (PG) and GMP Cos., Inc. announced that P&G has licensed to GMP its newly developed, topical anti-infective technology for exclusive worldwide use in medical settings and...

Antioxidants effectively prevent protein damage in OLN 93 cells.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Antioxidants effectively prevent oxidation-induced protein damage in OLN 93 cells. According to recent research published in the journal Archives of Biochemistry and Biophysics, "Oxidative stress is...

Interactions between ibuprofen and lipoproteins in blood plasma discovered.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Researchers have found evidence of interactions between ibuprofen and lipoproteins in human blood plasma using [superscript]1H NMR spectroscopy. According to published research from China, "Recent...

Monocyte-derived superoxide anions contribute to atherosclerosis.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Monocyte-derived superoxide anions contribute to atherosclerotic lesion formation. According to a study from the United States, "Monocyte extravasation into the vessel wall has been shown to be a...

Hepatocyte growth factor prevents and ameliorates scleroderma symptoms.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Hepatocyte growth factor prevents and ameliorates scleroderma symptoms. "Systemic sclerosis (SSc) is a connective tissue disorder with an unknown etiology. There are currently no effective therapies...

Structure of key autoimmune disease target discovered.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Xencor reported the structure of BAFF, also called BLyS or TALL-1, a key regulator of immune function and an important target in autoimmune disease. Scientists from Xencor demonstrated that BAFF's...

Avian flu virus continues to spread in Asian countries.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Despite massive efforts to stamp out the virulent avian influenza virus, the disease continues to spread in poultry-producing areas in some Asian countries, the UN Food and Agriculture Organization...

Pediatric bipolar disorder has unique symptoms.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- For too many years, symptoms of severe moodiness in children were dismissed as being due to attention deficit disorder or poor parenting. A dramatic shift has led to greater recognition of bipolar...

Hsp70 protects against cerebral ischemia through many mechanisms.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Hsp70 protects against cerebral ischemia through many mechanisms. "Overexpression of inducible Hsp70 has been shown to provide protection from cerebral ischemia both in animal models of stroke and...

An informational video can improve breast cancer clinical trial knowledge.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Study shows that viewing an informational video about participation in clinical trials is beneficial in educating patients about potential participation in a trial. "A total of 262 women in the USA...

Combo GET therapy well tolerated in metastatic breast cancer.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Clinical trial finds that the combination of gemcitabine, epirubicin and paclitaxel (GET) has acceptable toxicity and is active in patients with metastatic breast cancer. "In this phase II,...

Gabapentin reduces tamoxifen-induced hot flashes in women with breast cancer.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- A pilot study finds that gabapentin administration in women with breast cancer significantly improved tamoxifen-induced hot flashes. "In this pilot study, 22 women with breast cancer on tamoxifen...

Immune response to telomerase tumor antigen studied as possible vaccine.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Researchers at the Abramson Cancer Center of the University of Pennsylvania have begun a Phase I clinical trial to evaluate the effectiveness of a telomerase peptide as a possible vaccine against breast...

Much breast cancer treatment in clinical practice does not follow guidelines.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Study finds that there is poor adherence to guidelines for breast cancer treatment in clinical practice. "There is sparse evidence on community practice patterns in treating women with breast...

Mutations, especially 11q loss, may be involved in early-onset breast tumors.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- The combined use of genomic patterns and molecular targets may provide a useful tool for diagnostic, therapeutic, and prognostic purposes in early-onset breast tumor development in Taiwanese women. ...

New estrogen inhibitor in phase II development.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Ascend Therapeutics, Inc., announced that it has obtained exclusive North American development, marketing and commercialization rights to the developmental pharmaceutical product, TamoGel...

Biotech begins the year with a bang.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- "Bolstered by good news at the clinic as well as the announcement of a number of promising collaborations, biotech's appeal on Wall Street grew significantly stronger in January," said G. Steven...

Cialis maker reports results for 2003.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- ICOS Corp. (ICOS) summarized 2003 highlights, released its financial results for the year and fourth quarter ended December 31, 2003, and provided guidance regarding financial performance expectations...

Company to close Palo Alto facilities, cut workforce, focus on drug discovery.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Incyte Corp. (INCY) announced that it will close its Palo Alto, California, research facilities and headquarters, effective April 2, 2004, completing its transition to a drug discovery and development...

Drug discovery company announces 2003 financial results, research collaboration.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Pharmacopeia, Inc., (PCOP) announced results for the fourth quarter and 12 months ended December 31, 2003, and announced that it has entered into a research collaboration with Taiho Pharmaceutical Co....

Inspection of drug-eluting stent facility completed; finances reported.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Boston Scientific Corporation (BSX) announced that an inspection team from the U.S. Food and Drug Administration (FDA) has completed its inspection of the company's drug-eluting stent manufacturing...

NASDAQ completes favorable review of company's new board.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- eXegenics, Inc., (EXEG) announced that NASDAQ has notified eXegenics that a NASDAQ internal staff review concluded that the newly constituted board and its audit committee satisfy the independent...

Pharmacy-services provider boosts profit.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Accredo Health Inc., which provides pharmacy services and treatment programs for chronic diseases, reported on February 2, 2004, that net income for its latest quarter jumped 13% on greater sales of...

Plan announced to post ads in 20 New York City hospitals.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Advertisements will begin appearing in public hospitals across New York City in summer 2004, according to the New York City Health and Hospitals Corp. (HHC). The ads will be placed in hospital...

Rural pharmacies say insurers squeezing them out of business.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Independent pharmacists in west-central Minnesota say large health insurance companies are unfairly squeezing them out of business, and that rural consumers will ultimately suffer by losing local access...

Small molecule drug company files registration statement for IPO.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Metabasis Therapeutics, Inc., announced in February 2004 that it has filed a registration statement with the U.S. Securities and Exchange Commission relating to an initial public offering (IPO) of its...

Drug discovery company announces name change, new appointments.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Semafore Pharmaceuticals, Inc., announced the company's name change from ComChem Technologies to better reflect the company's strategic focus. Semafore's therapeutic programs are based on...

House of Brussels forms medical research subsidiary.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- House of Brussels Chocolates (HBSL), through its CEO Grant Petersen, announced several major corporate developments. Firstly, HBSL has incorporated a subsidiary company, ChocoMed, Inc., to act as...

Pharmaceutical company announces dismissal of all lawsuits.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Titan Pharmaceuticals, Inc. (TTP) announced that all of the class action and derivative lawsuits filed against the company have been dismissed without prejudice. In every case, the plaintiffs...

New research may lead to orally administered small-molecule cancer drug.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- New insights into a key cancer pathway - known as p53 - have been uncovered by scientists at Roche. In a paper published in the February 6 issue of Science and Sciencexpress, for the first time,...

Fourth phase II trial initiated for new stem cell transplantation drug candidate.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- AnorMED, Inc., (AOM) announced the initiation of its fourth phase II clinical trial to evaluate AMD3100 as a new stem cell transplantation drug candidate for cancer patients. Clinical data to date...

IRESSA (gefitinib) added to ASCO practice guidelines.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- An expert panel of the American Society of Clinical Oncology (ASCO) has updated their "Clinical Practice Guidelines" for the treatment of non-small cell lung cancer (NSCLC). For the first time the...

Proteasome is target for cancer therapy.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- The proteasome is a target for cancer therapy. According to published research from the United States, "The proteasome is a multicatalytic proteinase complex responsible for the degradation of most...

Selective cytokine inhibitors staunch VEGF and interleukin-6 to quell myeloma.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Selective cytokine inhibitors staunch VEGF and interleukin-6 to quell myeloma. "Myeloma cells and human umbilical vein endothelial cells (HUVECs) were cocultured to model in vitro the interactions...

TNP-470 blocks carcinosarcoma-induced tube formation.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- TNP-470 blocks carcinosarcoma-induced tube formation. According to researchers in Japan, "we evaluated the usefulness of TNP-470 as an anticancer agent on a human uterine carcinosarcoma cell line...

The ZD55-gene therapy system is a potent anticancer tool.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- The ZD55-gene therapy system is a potent anticancer tool. According to recent research published in the journal Cell Research, "ONYX-015 is an attractive therapeutic adenovirus for cancer because...

Tumor cell-specific therapy shows preclinical promise.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Cancer often begins with mutations in tumor suppressor pathways. Tumor suppressor genes - such as p53 - arrest cell growth and induce apoptosis (programmed cell death) in response to cellular stress,...

Tumor growth is inhibited by targeted alliinase delivery.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Allilcin resulted in tumor growth arrest in a human tumor cell line xenograft in nude mice. "Allicin (diallyl thiosulfinate), a highly active component in extracts of freshly crushed garlic, is the...

Update provided on Polymer Platinate AP5346 program.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Access Pharmaceuticals, Inc., (AKC) provided an update on the status of its AP5346 Polymer Platinate Program, including the patent status, preclinical data, and the progress of the phase I clinical...

Cancer vaccines use high molecular weight stress proteins.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Scientists are developing cancer vaccines using autologous and recombinant high molecular weight stress proteins. According to published research from the United States, "High molecular weight heat...

ER packaging chaperone determines virulence of Candida albicans.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- An ER packaging chaperone determines the amino acid uptake capacity and virulence of Candida albicans. "The Candida albicans CSH3 gene encodes a functional and structural homologue of Shr3p, a...

ISOL myocyte apoptosis screening leads to fewer false-positive results.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- ISOL screening for myocyte apoptosis leads to fewer false-positive results than ISEL or TUNEL testing. In a recent study, scientists in Italy "assessed the efficiency of detecting myocyte apoptosis...

Medium perfusion enables functional cardiac tissue engineering.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Medium perfusion enables the engineering of functional cardiac tissue. Scientists in the United States "hypothesized that functional constructs with physiological cell densities can be engineered in...

The nitric oxide synthase pathway could be co-opted for angiogenic regulation.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- The nitric oxide synthase pathway could be co-opted for angiogenic regulation. "Angiogenesis requires the elaboration of endothelium-derived nitric oxide (NO). Angiogenic factors induce the release...

The pyridoxine 5'-phosphate oxidase gene may be linked to hypertension.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- The pyridoxine 5'-phosphate oxidase gene may be linked to hypertension. According to a study from Japan, "to identify candidate genes responsible for hypertension in Dahl salt-sensitive rats...

Transcatheter repair of traumatic ventricular septal defect reported.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Successful transcatheter-based repair of extensive ventrical septal trauma has been reported. Cardiologists in the United States reported "the first successful transcatheter closure of a large...

Calcineurin protects against ischemia-induced myocardial apoptosis.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Calcineurin signaling protects against ischemia-induced myocardial apoptosis. "Cardiovascular disease is the leading cause of mortality and morbidity within the industrialized nations of the world,...

Familial aggregation of left-sided obstructive heart defects confirmed.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Significant familial aggregation has been observed for a number of left-sided obstructive heart defects. "Cardiovascular malformations (CVM) are the most common birth defects and carry significant...

Hand-held echocardiography devices feasible for LVH testing.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Hand-held echocardiography devices are suitable for use in community-based LVH screening. "Left ventricular (LV) hypertrophy (LVH) confers increased cardiovascular risk on patients with...

Hostility and anxiety differentially predict CVD in men and women.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Hostility and anxiety differentially predict CVD in men and women. "Consideration of the psychosocial contributions to cardiovascular disease (CVD) remains an ongoing focus of research in the...

Hyperhomocysteinemia activates endothelial cell NF-kappaB via oxidative stress.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Hyperhomocysteinemia activates NF-kappaB in endothelial cells through oxidative stress. According to recent research from Canada, "Hyperhomocysteinemia is an independent risk factor for...

Murine ACE gene mutations influence cardiac fibrosis development.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Mutations in the ACE gene significantly influence the extent of myocardial fibrosis in rats. "In humans, the effect of angiotensin-converting enzyme (ACE) gene polymorphisms in cardiovascular...

NAD(P)H oxidase inhibitor prevents aldosterone-induced hypertension.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- An NAD(P)H oxidase inhibitor prevents aldosterone-induced hypertension and cardiac hypertrophy in a murine model. According to a study from South Korea, heightened "bioavailability of reactive...

PET can elucidate regional sympathetic function during heart disease.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Positron emission topography (PET) imaging can be used to elucidate the effects of heart disease on regional sympathetic function. In a study from the United States, PET "was used to measure global...

Regurgitant valvular heart disease risk elevated in acromegaly.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- The risk of regurgitant valvular heart disease is elevated in acromegaly patients. "Cardiac involvement is common in acromegaly, but the prevalence of valvular abnormalities in patients with...

Cellular growth factors join to antagonize iatrogenic apoptosis.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Cellular growth factors join to antagonize iatrogenic apoptosis. "To study the effect of growth factors on iatrogenic apoptosis, we examined the influence of vascular endothelial growth factor...

Ras activation causes endothelial cells to acquire an angiogenic phenotype.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- Ras activation causes endothelial cells to acquire an angiogenic phenotype. "Angiogenic factors alter endothelial cell phenotype to promote the formation of new blood vessels, a process critical for...

Synthetic prototype of P. falciparum GPI developed.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- A synthetic prototype of P. falciparum glycosylosphatidylinositol (GPI) has been developed. Scientists in North Carolina developed a technique for the "synthesis of a fully lipidated and...

Publication points to increasing use of HPV testing in cervical cancer screening.
March 5, 2004... 2004 MAR 5 - (NewsRx.com & NewsRx.net) -- The first consensus guidance on the most effective way to use HPV DNA testing for cervical cancer screening has been published in the February issue of Obstetrics & Gynecology, announced Digene Corp....