Drug Week articles from March 2003

Drug Week archives from March 2003

New drug targets cancer cells.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Researchers at the Ireland Cancer Center at University Hospitals of Cleveland (UHC) and Case Western Reserve University (CWRU) School of Medicine are, for the first time in human clinical trials, using...

Keppra offers sustained efficacy, reduction in seizure frequency.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- New long-term data show that Keppra (levetiracetam) offers sustained efficacy, as add-on, over the longer term - up to 54 months (4.5 years) - in reducing seizure frequency in adult patients with...

Liver X receptor agonist demonstrates antidiabetic action.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "The oxysterol receptors LXR (liver X receptor)-alpha and LXR-beta are nuclear receptors that play a key role in regulation of cholesterol and fatty acid...

Novel antiretroviral agent derived from Vicia faba seeds.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Researchers at the Chinese University of Hong Kong have identified a novel antifungal and anti-HIV agent derived from a bean plant. "A new trypsin-chymotrypsin inhibitor, with an N-terminal...

Insulin dysfunction linked to Alzheimer disease.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Insulin resistance may promote the development of Alzheimer disease, according to a report in the journal, CNS Drugs. "An emerging body of...

Atovaquone remains in human sera after treatment.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- "Published pharmacokinetic data indicate that after treatment of patients with therapeutic doses of atovaquone/proguanil hydrochloride (Malarone, GlaxoSmithKline Research Triangle Park, NC), the plasma...

Global Phase III clinical trials launched for non-peptidic protease inhibitor.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Boehringer Ingelheim announced the launch of the Phase III RESIST clinical trial program designed to further study the efficacy and safety of tipranavir for use in combination therapy for HIV-1...

Many promising new drugs on the horizon.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- A variety of highly effective new AIDS drugs are on the horizon, experts say, easing worries that the fast-mutating virus will outstrip doctors' ability to treat it. Ever since combinations of AIDS...

New antiretroviral drugs to expand HIV/AIDS therapies market potential.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- While antiretroviral (ARV) drugs in existing categories continue to be the mainstay of the HIV/AIDS therapies market in the United States, the development of new drugs in both existing and novel...

Private label gains marketing rights to loratadine 10 mg tablet equivalent.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Leiner Health Products has secured the marketing rights to the antihistamine loratadine immediate release 10 milligram tablets (Claritin 10 milligram tablets). Through an exclusive licensing...

Revotar amends license and research and development agreement.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Revotar Biopharmaceuticals, AG, a majority-owned affiliate of Texas Biotechnology Corp. (TXBI), announced that both parties have amended their license and research and development agreement to better...

Biopharmaceutical company names new CEO.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Auxeris Therapeutics, Inc., a St. Louis, Missouri-based seed-stage biopharmaceutical company, announced the appointment of Laurent Fischer, MD, to the position of president and chief executive officer...

Mania indication sought for Seroquel in Europe.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- AstraZeneca has submitted an application to the 14 European Member States involved in the Mutual Recognition Procedure for Seroquel (quetiapine) to be granted a license for the treatment of manic...

Some anticonvulsants appear promising for treatment of bipolar depression.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "The anticonvulsants carbamazepine and valproate are now widely recognized and used mood stabilizers as adjuncts or alternatives to lithium carbonate. Like...

Cyclooxygenase inhibitor shows additive effect against urological malignancy.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Research collaborators in the U.S. and Australia say mitoxantrone and piroxicam can generate remission in canine models of human invasive bladder cancer. ...

Micrologix completes full enrollment in pivotal phase III trial of MBI 226.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Micrologix Biotech, Inc., (MGIXF), in collaboration with Fujisawa Healthcare, Inc., has completed patient enrollment in the phase III clinical trial of MBI 226, a novel, topical, antimicrobial peptide...

Fulvestrant submitted for approval in Europe.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- AstraZeneca announced the submission in Europe of a Marketing Authorization Application for the use of Faslodex (fulvestrant) in the treatment of advanced breast cancer in postmenopausal women whose...

FDA grants Fast Track designation for investigational oral mucositis drug.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Aesgen, Inc., a privately held specialty pharmaceutical company, announced that the U.S. Food and Drug Administration (FDA) granted Fast Track designation to the company's investigational new drug,...

Antiangiogenesis antibody, 2C3, shown to inhibit tumor growth by 75%.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Peregrine Pharmaceuticals (PPHM) said that researchers at the University of Texas Southwestern Medical Center at Dallas (UT Southwestern) have published data detailing the antitumor effects of the 2C3...

Manufacturing process development completed for Reolysin.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Oncolytics Biotech, Inc., (ONCY) announced the successful completion of its program to developm a commercial process for the manufacturing of Reolysin. "The ability to manufacture a drug easily and...

Schering acquires Japan and Asia marketing rights to Campath.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Schering, AG, Germany, (SHR) and U.S. biopharmaceutical company ILEX Oncology, Inc., (ILXO) announced that Schering has acquired exclusive rights to develop, sell, and distribute ILEX's humanized...

Cox-2 inhibitor rofecoxib limits metastatic potential of colorectal carcinoma.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Cyclooxygenase (COX)-2 inhibition may decrease the metastatic potential of colorectal carcinoma via a number of avenues, including the prevention of...

Adrenal hormone and cortisol stress reactions were lowered by some GI drugs.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "Rikkunshi-to, a gastrointestinal function regulatory traditional Chinese herbal (Kampo) medicine, has recently been evaluated for its clinical usefulness in...

Phase II clinical data reported for 7-day patch.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Agile Therapeutics, Inc., announced that an analysis of data from the Phase II clinical trial of its seven-day translucent contraceptive patch indicates that ovulation was suppressed by more than 95%...

Biotech company discovers major depression gene, DEP1.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Myriad Genetics, Inc., (MYGN) announced the discovery of a new gene, named DEP1, that causes depression. The DEP1 gene will form the basis of a drug discovery and development program with Abbott...

Nateglinide provides rapid insulin stimulation in impaired glucose tolerance.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- "This study was designed to determine the effect of a novel insulin secretagogue, nateglinide, on the glycemic response curve and early insulin secretion following oral glucose load in impaired glucose...

Oleic acid might increase epidermal permeability to enhance transdermal delivery.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- According to a study from the Peoples Republic of China, "The epidermal permeability barrier appears to be regulated primarily by the lamellar arrangement of lipid bilayers between coneocytes of the...

Agreement grants access to clinical human disease tissue samples.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Ardais Corporation, a privately held clinical genomics company, announced that AstraZeneca, one of the five top global pharmaceutical companies, has licensed access to Ardais' library of...

Agreement signed to deliver next generation chemistry synthesis platform.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Discovery Partners International, Inc. (NASDAQ:DPII) has entered into an agreement with Glaxo SmithKline for the delivery of a next generation IRORI Combinatorial Chemistry Synthesis Platform. Over...

Patent expands broad intellectual property estate for JNKinase pipeline.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Celgene Corporation (NASDAQ:CELG) announced that its extensive intellectual property estate for JNK (c-Jun N-terminal Kinase) has been further strengthened with U.S. Patent No. 6,514,745 issued February...

Assay is better predictor of in vivo drug transfer than dialysis-based systems.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- According to recent research from Canada, "The therapeutic activity of numerous drugs can be dramatically improved by liposomal encapsulation. "However, this requires that liposomes retain their...

Testosterone gel launched for treatment of deficiency in men.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Auxilium Pharmaceuticals, Inc., announced the launch of Testim, a patented testosterone gel. Auxilium received U.S. Food and Drug Administration (FDA) approval to market Testim on October 31, 2002,...

Consumer groups accuse makers of Neurontin of "corrupt behavior".
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- A broad coalition of consumer and public interest groups announced that they have filed a lawsuit against Pfizer (NYSE:PFE) and its subsidiary, Parke-Davis, accusing them of circumventing U.S. Food and...

Drug discovery partner announces fourth quarter 2002 financial results.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Aclara BioSciences (NASDAQ:ACLA) has reported financial results for the three months and year ended December 31, 2002. Revenues for the three months ended December 31, 2002, were $752,000, compared...

SBIR grant awarded for development of neuroprotective drugs for glaucoma.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- MitoKor, Inc., announced that it has been awarded a phase I small business innovative research (SBIR) grant from the National Eye Institute of the U.S. National Institutes of Health. The grant,...

U50,488 inhibits Tat-induced brain inflammation.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- A novel kappa-opioid receptor (KOR) ligand may prevent HIV-induced brain damage, researchers in the United States say. KOR ligands "have been reported to alter many cell functions and to exert an...

Diverse repertoire of HIV-specific helper T cell clones seen after HAART.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- "HIV-1 Ag-specific CD4+ T cell proliferative responses in human subjects with advanced, untreated HIV-1 disease are often weak or undetectable," according to recent research from the United States. ...

Novel agents derived from Litsea verticillata.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Researchers at the University of Illinois have derived potential anti-HIV agents from a Chinese medicinal plant. "Bioassay directed-fractionation led to the identification of litseaverticillols A-H...

Protein-disulfide isomerase inhibitors block HIV cell entry.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Researchers at Boston University have described a novel class of HIV cell entry inhibitors. A. Gallina and coauthors "previously reported that monoclonal antibodies to protein-disulfide isomerase...

FDA approves digoxin, generic of Lanoxin.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Caraco Pharmaceutical Laboratories, Ltd. (Bulletin Board: CARA) has received approval from the U.S. Food and Drug Administration (FDA) to manufacture and market digoxin, a generic form of Glaxo...

Peroxisome proliferator fenofibrate inhibits growth of human hepatoma cells.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- "The aim of this work was to investigate the effects of hypolipidemic agent fenofibrate (FF), a peroxisome proliferator (PP), on human HepG2 cells and to characterize the intracellular events involved,"...

NOVP chemotherapy induces sperm aneuploidies.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- A chemotherapy regimen used to treat Hodgkin disease can damage sperm, researchers in California warn. S. Frias and colleagues at Lawrence Livermore National Laboratory conducted a study "to...

European patent granted for HspE7 and other human papillomavirus therapeutics.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Stressgen Biotechnologies Corp. (SSB) announced that the European Patent Office has granted patent number EP1002110 B1 covering compositions of fusion proteins composed of a human papillomavirus (HPV)...

Further progress reported on LAX-101 clinical development.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Amarin Corporation plc (NASDAQ:AMRN) and its partner, Laxdale Ltd., announced their intention to conduct an additional Phase III study to support a New Drug Application (NDA) for LAX-101. This was...

New study sheds light on responses to diuretics.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- The recent news from the U.S. National Heart, Lung and Blood Institute that diuretics are superior to newer drugs in lowering high blood pressure and preventing fatal complications was more than welcome...

Ceftazidime use raises risk of resistant Klebsiella pneumoniae in Taiwan.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Ceftazidime treatment may heighten the risk of developing drug-resistant pneumonia, researchers in Taiwan warn. M.F. Lin and colleagues at Hsin-Chu Hospital conducted a study "to find the risk...

Development cytomegalovirus vaccine announced.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Vical, Inc., (VICL) announced that a DNA-based vaccine against cytomegalovirus (CMV) will be its first independent development program focused on infectious diseases. Currently, there is no...

Phenothiazines, thioxanthenes block S. aureus drug efflux.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers have identified two classes of agents that inhibit staphyloccal drug efflux. "Efflux-related multidrug resistance (MDR) is a significant means...

RWJ-54428 effective against several forms of drug resistance.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in California have provided new information about a novel antibiotic active against several drug-resistant pathogens. RWJ-54428 "is a new...

Single-dose ornidazole effective for Turkish children with giardiasis.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- A single dose of ornidazole can resolve giardiasis in children, researchers in Turkey say. A. Ozbilgin and coauthors compared "the treatment efficacy of a single dose of ornidazole with five day...

Million-dollar grant awarded to identify inhibitors of chemokine receptors.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Icogen Corporation announced that it has received notice of award for a $1 million Phase II Small Business Innovative Research (SBIR) grant from the U.S. National Institute of Allergy and Infectious...

Fludara receives European marketing approval as first-line B-CLL treatment.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Schering AG (FSE: SCH, NYSE: SHR) announced that the European Union type II variation procedure for Fludara i.v. to extend the indication to first-line treatment of patients with B-cell chronic...

New HuMax-CD20 and HuMax-EGFr preclinical data presented.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Genmab A/S announced that its HuMax-CD20 human antibody appears to kill tumor cells that are resistant to rituximab, a marketed antibody directed to the same disease target. In preclinical testing,...

Novel triterpenes derived from Caloncoba echinata.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Researchers in Denmark have identified a trio of plant-derived anti-malarial agents. "Three novel triterpenes, (11R,20R)-11,20-dihydroxy-24-dammaren-3-one (1),...

Sulfadoxine-pyrimethamine-artesunate therapy planned for malaria in Peru.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States and Peru, "As part of an effort to assess antimalarial drug resistance in Peru, we carried out 14-day in vivo efficacy trials of chloroquine (CQ; 25...

Mania indication sought for Seroquel (quetiapine) in Europe.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- AstraZeneca announced that it has submitted an application to the 14 European Member States involved in the Mutual Recognition Procedure for Seroquel (quetiapine) to be granted a license for the...

Biomedical firm intends to acquire selected assets of drug company.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- LAM Pharmaceutical Corp. (OTC Bulletin Board: LAMP; Frankfurt: LAM; Berlin: LAM), a biomedical company focused on the development and commercialization of novel wound healing and transdermal drug...

European regulatory approval sought for Velcade.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Millennium Pharmaceuticals, Inc., (MLNM) announced that it has submitted a complete marketing authorization application (MAA) to the European Agency for the Evaluation of Medicinal Products (EMEA) for...

FDA fast track status granted for Revimid in relapsed or refractory disease.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Celgene Corporation (NASDAQ:CELG) announced that Revimid (CC-5013) received fast track designation from the U.S. Food and Drug Administration (FDA) for the treatment of relapsed or refractory multiple...

Interferon beta-1a formulation approved by FDA for early stage disease.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Biogen, Inc. (NASDAQ:BGEN) announced that the U.S. Food and Drug Administration (FDA) has approved Avonex (Interferon beta-1a) to include treatment of patients with a first multiple sclerosis (MS)...

Lower-dose Flexeril (cyclobenzaprine HCl) approved for muscle spasm.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- The U.S. Food and Drug Administration has approved Flexeril (cyclobenzaprine HCl) 5 mg tablets, a new lower-dose, less-sedating version of the most frequently prescribed muscle relaxant, as an adjunct...

Data reported from Phase II trial on amitriptyline plus ketamine.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- EpiCept Corporation, a specialty pharma company using topical drug delivery technologies to develop novel products for the treatment of pain, announced positive results from a Phase II...

Clinical trial of P. carinii pneumonia treatment completes enrollment.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Immtech International, Inc. (Bulletin Board: IMMT) announced that the Phase IIa pilot human clinical trial using the oral drug candidate DB 289 for the treatment of Pneumocystis carinii pneumonia has...

Repeated dosing causes clearance reduction, saturation of skeletal muscle pool.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- "Supplementation with exogenous creatine (Cr) has shown physiological benefits in humans, but little is known about the pharmacokinetics of Cr in humans," researchers in the United States report. ...

Mumie extract induces osteoblastic differentiation of mesenchymal stem cells.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Researchers in South Korea have identified an agent that may be useful for treating osteoporosis patients. "Mumie, a plant humus matter from rocks, is known as anabolic and a stimulator of bone...

Preos maker provides clinical update.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- NPS Pharmaceuticals (NPSP) briefed the investment community on its most advanced clinical development programs during its recent presentation at the Merrill Lynch Global Pharmaceutical, Biotechnology,...

The Michael J. Fox Foundation commits $2 million to study PD dyskinesia.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- The Michael J. Fox Foundation (MJFF) for Parkinson's Research announced that it has committed $2 million to a new research initiative to study dyskinesias, the involuntary, uncontrollable movements that...

Worm model could yield new drugs.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- The Michael J. Fox Foundation for Parkinson's Research has awarded one of its competitive fast track grants to Vanderbilt neuroscientist Richard Nass, PhD, to fund his search for drugs that will prevent...

Company transfuses initial patients in both phase III trials for Inactine.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- V.I. Technologies (Vitex), Inc., (VITX) announced that it is actively transfusing patients in the two pivotal, phase III clinical studies of the Inactine Pathogen Reduction System for red blood cells....

IND granted for phase I studies of NCX 1000.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- NicOx, SA, (NICOX) announced that an investigational new drug (IND) application has been accepted by the U.S. Food and Drug Administration (FDA) for the clinical testing of NCX 1000, its patented nitric...

Paragon's SI/BAKER joint venture awarded a $3.8 million contract.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Paragon Technologies, Inc., (PTG) announced that its SI/BAKER joint venture was awarded a contract for approximately $3.8 million to provide an automated prescription fulfillment system at a mail order...

Abbott Labs stops tests on key drug.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Abbott Laboratories halted a trial of a key drug after it failed to slow the progression of prostate cancer, the company said February 10, 2003. The drug Atrasentan was in a study for the treatment...

Raptiva agreement expanded to additional emerging markets in Asia.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Serono, S.A., (SRA) announced that Genentech, Inc., (DNA) has extended Serono's exclusive license to develop and market Raptiva (efalizumab) to include an additional 15 Asian countries. This...

Systemic thrombolytic therapy after recent abdominal aortic aneurysm repair.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Systemic thrombolytic therapy should be considered for some patients who suffer complications after abdominal aortic aneurysm surgery, researchers at the Mayo Clinic argue. "Systemic thrombolysis...

Clinical trial of antisense drug expanded to major U.S. oncology centers.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Lorus Therapeutics Inc. announced that it has expanded its ongoing clinical trial of its lead antisense drug, GTI-2040, in renal cell carcinoma to five major oncology centers in the United States. ...

Final ANDA approval granted for Vinorelbine.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Sicor, Inc., (SCRI) announced that the U.S. Food and Drug Administration (FDA) has issued final approval of an abbreviated new drug application (ANDA) submitted by its wholly owned subsidiary, Gensia...

Lack of synergy may be cause to avoid regimen to treat Staphylococcus aureus.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- According to recent research from France, "The in vitro activities of linezolid were determined alone and in combination with vancomycin, ciprofloxacin, gentamicin, fusidic acid, or rifampin against...

Etoposide alters dendritic cell mobilization.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - The use of the antineoplastic agent etoposide for stem cell mobilization affects dendritic cell (DC) levels in harvested grafts, according to researchers in the...

Company announces breakthrough using extended tethering.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Sunesis Pharmaceuticals, Inc., announced a drug discovery technology for the rapid, efficient identification of enzyme inhibitor molecules. The research program is directed at Caspases, an important...

Extension of research funding granted on thrombin collaboration.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- 3-Dimensional Pharmaceuticals, Inc. (3DP) (NASDAQ:DDDP), a drug discovery and development company, announced that the research term under its thrombin collaboration with Centocor, Inc., and Johnson &...

Nonsteroidal anti-inflammatory drugs suitable for pain relief.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- "The use of nonsteroidal anti-inflammatory drugs (NSAIDs) for analgesia after tonsillectomy is controversial because NSAIDS, through platelet inhibition, may increase the risk of perioperative...

Metagen Pharmaceuticals announces distribution agreement for Sparkling White.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Metagen Pharmaceuticals, a privately held company in Pompano Beach, Florida, announced an integrated sales and marketing agreement with Dexcel Pharma, Inc. Through its OTC division, Stellar...

Mycobacterial glutamine synthetase inhibition effective.
March 7, 2003... 2003 MAR 7 - (NewsRx.com & NewsRx.net) -- Researchers at the University of California have identified a novel and effective strategy for tuberculosis treatment. "Tuberculosis remains one of humankind's greatest killers, and new therapeutic...

New neurotransmitter drugs show promise.
March 14, 2003... 2003 MAR 14 - (NewsRx.com & NewsRx.net) -- Discovery of drugs to treat generalized epilepsy with febrile seizures (GEFS), a genetic disorder that affects 4 million Americans, could now advance more rapidly, predicts a Cornell University...