Drug Week articles from June 2004

Drug Week archives from June 2004

Phase III Ampligen trial meets primary endpoint for CFS.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Hemispherx Biopharma, Inc., (HEB) announced that its pivotal phase III chronic fatigue syndrome (CFS) trial of Ampligen met its primary endpoint with patients receiving Ampligen for 40 weeks. A...

Combination therapy with Actos improves components of diabetic dyslipidemia.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Results of three studies show that the oral anti-diabetic agent Actos (pioglitazone HCl), in combination with a sulfonylurea, metformin or insulin, resulted in triglyceride decreases and high-density...

FDA grants approval for new indication for Hectorol.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Bone Care International, Inc., (BCII) announced that the U.S. Food and Drug Administration approved a new indication and strength for Hectorol (doxercalciferol) capsules. Hectorol, a novel...

Data: ZOMIG (zolmitriptan) nasal spray provides fast, lasting migraine relief.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Results of a new multicenter U.S. study of almost 1900 patients experiencing more than 3400 migraine attacks confirm that treatment with ZOMIG (zolmitriptan) Nasal Spray provides a very fast onset of...

Coated aspirin less effective for anticlotting than uncoated aspirin.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Enteric-coated aspirin is less potent than plain aspirin, which may make it less effective in preventing heart disease, according to a preliminary small study presented at the American Heart...

Wild-type CCR5 confers HIV-1 cross-clade resistance.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Scientists describe risk associated HIV-1 cross-clade resistance of whole peripheral blood mononuclear cells from exposed uninfected individuals with wild-type CCR5. According to a study from the...

Maternal malaria and perinatal HIV transmission interaction complicated.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- The interaction between maternal malaria infection and perinatal HIV transmission is complicated. According to recent research from an international team of scientists, "To determine whether...

CTL ontogeny and viral escape have implications for HIV vaccine design.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Cytotoxic T lymphocyte (CTL) ontogeny and viral escape have implications for HIV vaccine design. According to recent research published in the journal Trends in Immunology, "The protective role of...

Components of HIV vaccine are recognized by T-helper cells.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Minor components of a multi-envelope HIV vaccine are recognized by type-specific T-helper cells. "HIV has thus far evaded control by vaccines, in part due to the high diversity among viral...

IL-15 may be beneficial for AIDS immunotherapy.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Interleukin-15 (IL-15) may be beneficial for AIDS immunotherapy. According to recent research published in the journal Trends in Immunology, "The current antiretroviral therapy has improved the...

Neutralizing antibodies against HIV-1 tat antigen characterized.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Scientists have characterized neutralizing human monoclonal antibodies against human immunodeficiency virus type 1 tat antigen. According to a study from France, "The human immunodeficiency virus...

Role of therapeutic vaccines for the control of HIV-1 reviewed.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Scientists review the role of therapeutic vaccines for the control of HIV-1 in a recent issue of the Journal of Antimicrobial Chemotherapy. According to recent research from England, "The recent...

Virus-like particles rich in HIV-1 envelope gp120 developed.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Researchers have developed virus-like particles rich in HIV-1 envelope gp120. "In order to improve the immunogenicity of HIV-1 envelope glycoproteins, we have fused gp120 to a carrier protein,...

DNA testing delivers first anti-acne therapy for adults.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- LAB21, Inc., announced a new anti-aging anti-acne therapy for adults based on its patent-pending DNA technology. At its research and development laboratories on the campus of Stony Brook...

Family history predicts alcohol relapse after liver transplantation.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Family history predicts alcohol relapse after liver transplantation. "Alcoholic liver disease has become a major indication for liver transplantation in the United States. Factors that predict...

Central obesity increases risk for elevated liver enzymes and disease.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Central obesity is an independent risk factor for elevated liver enzymes and liver disease. "Regional body fat distribution may represent an independent risk factor for several conditions,...

Doxorubicin engenders paradoxical signals in the heart.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Doxorubicin engenders paradoxical signals in the heart. According to a study from Italy, "the cardiotoxicity induced by the anticancer anthracycline doxorubicin (DOX) is attributed to reactions...

Encouraging data reported from phase I study of asthma/allergy drug.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Avanir Pharmaceuticals (AVN) announced the completion of the initial phase I clinical trial for its experimental asthma/allergy drug, AVP 13358. The study included 54 healthy volunteers and was...

Phase I trial of CRX-675 initiated in patients with seasonal allergic rhinitis.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Corixa Corporation (CRXA), a developer of immunotherapeutics, announced the initiation of a phase I clinical trial to test the safety and immune response activity of CRX-675 for seasonal allergic...

Allergic fungal rhinosinusitis occurs in 6% of chronic rhinosinusitis.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Allergic fungal rhinosinusitis occurs in 6% of chronic rhinosinusitis. "Chronic rhinosinusitis (CRS) is a disease very frequently encountered by otorhino-laryngologists. According to Ponikau et al.,...

Increased atopy caused by development of Th2 immune response to allergens.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Increased atopy may be caused by the development of a Th2 immune response to environmental allergens. "Developed nations are experiencing a marked increase in prevalence of the familial allergic...

Unknown mechanism of action involved in expression of cytokines in mast cells.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- An unknown mechanism of action is involved in the expression of cytokines in mast cells. Scientists in Japan reported, "Olopatadine hydrochloride (olopatadine) is an anti-allergic drug that...

Antihistamine ready-spray bottle introduced.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- MedPointe Pharmaceuticals announced the introduction of a new 30 mL bottle featuring a convenient, preassembled spray pump for the company's prescription intranasal antihistamine, Astelin (azelastine...

APP contributes to inflammatory condition in Alzheimer disease.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Amyloid precursor protein contributes to the inflammatory condition in Alzheimer disease. "Alzheimer's disease is a progressive neurodegenerative disorder characterized by extracellular deposition...

Data highlight positive effect of Namenda on brain activity in AD patients.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Forest Laboratories, Inc., (FRX) announced the results of a randomized, placebo-controlled, PET (positron emission tomography) imaging pilot study designed to measure the effect that Namenda (memantine...

Glutamate receptor upregulates amyloid precursor protein secretion.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Metabotropic glutamate receptor stimulation upregulates soluble amyloid precursor protein fragment secretion in the rat retina in vivo. According to recent research from England, "Using the novel...

Patient enrollment initiated for Alzheimer disease product candidate trial.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Saegis Pharmaceuticals, Inc., announced that patient enrollment has begun in a phase II trial of its lead product candidate, SGS742, for Alzheimer disease. SGS742 is a selective, orally active...

Plans to further develop Alzheimer disease gene therapy confirmed.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Ceregene, Inc., announced that based on preliminary findings in a study conducted at the University of California, San Diego (UCSD), it will advance its gene therapy for Alzheimer disease into further...

Rab6 membrane association dependent on cellular phosphorylation events.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Rab6 membrane association is dependent on Presenilin 1 and cellular phosphorylation events. "Processing of the amyloid precursor protein (APP) by alpha-secretase precludes the formation of...

Opioid peptide with mu agonist/delta antagonist properties reported.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Scientists have identified a chimeric opioid peptide with mixed mu agonist/delta antagonist properties. According to a study from Canada, "There is evidence to indicate that opioid compounds with...

Neuropeptide Y is sympathetic modulator in saphenous vein biopsies.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Researchers report the release and functional role of neuropeptide Y as a sympathetic modulator in human saphenous vein biopsies. "Transmural electrical stimulation of the sympathetic nerve endings...

Origin of lateral costal artery investigated.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- The origins of the lateral costal artery (LCA) have been investigated. The LCA, "a supernumerary branch of the internal thoracic artery (ITA), occurs in several ethnic groups on one side of the...

Patients with moderate thrombocytopenia do not require treatment.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Patients with moderate thrombocytopenia do not require treatment. "To define usefulness and response to therapy and outcome in adults with idiopathic thrombocytopenic purpura (ITP) in clinical...

Hamster model for Chlamydia pneumoniae infection developed.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Scientists have developed a hamster model for Chlamydia pneumoniae infection. "We report that intraperitoneal injection of Chlamydia pneumoniae purified elementary bodies (EBs) in the hamster causes...

Animal studies used to determine risks of environmental toxicants.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Animal studies should be used with caution in determining risks of environmental toxicants. According to published research from the United States, "Toxicology studies using animals and in vitro...

NERD is DNA processing-related domain in anthrax virulence plasmid.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- NERD is a DNA processing-related domain present in the anthrax virulence plasmid, pXO1. "We have identified a new domain in a broad range of bacterial, as well as single archaeal and plant...

Membranal polypeptides of Bacillus anthracis identified.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Scientists have identified chromosomally encoded membranal polypeptides of Bacillus anthracis through a proteomic analysis. "Bacillus anthracis is the causative agent of anthrax disease....

Data: Avelox remains active against bacterial strains.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- North American surveillance data presented at the 14th annual European Congress of Clinical Microbiology and Infectious Diseases showed the antibiotic Avelox (moxifloxacin HCl) was still active against...

Novel inhibitors of bacterial RNA polymerase I characterized.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Scientists have characterized novel inhibitors of bacterial RNA polymerase I. According to recent research from Italy, "GE 23077 factors A1, A2, B1, and B2 are novel antibiotics isolated from...

Pharmaceutical company to discontinue development of ceftriaxone.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Cubist Pharmaceuticals, Inc., (CBST) announced that results from human clinical research studies examining the bioavailability of a variety of oral formulations of ceftriaxone, a broad-spectrum...

Inhibitors of cAMP phosphodiesterase possess antidepressant effects.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Inhibitors of cAMP phosphodiesterase (PDE4) possess antidepressant effects. "Despite initial promise, the development of type 4 phosphodiesterase (PDE4) inhibitors as antidepressants has not...

Animal microbes pass glycopeptide resistance genes to humans.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Animal microbes pass glycopeptide resistance genes to humans. According to recent research from Canada, "avoparcin, a glycopeptide antimicrobial agent related to vancomycin, has been used...

Inhibitors target phosphorelay signal transduction systems of microbes.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Researchers discuss issues related to developing inhibitors to selectively target two-component and phosphorelay signal transduction systems of pathogenic microorganisms in a recent issue of Current...

Anti-infective applications sought for antiseptic nasal spray product.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- SinoFresh HealthCare, Inc., (SFSH) has entered into a research and development agreement with the Lovelace Respiratory Research Institute, focusing on joint-sponsored programs designed to find new...

Case of anxiety disorder related to diabetes reported.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Researchers report a case of anxiety disorder related to diabetes. According to recent research published in the journal Behaviour Research and Therapy, "This study extends the data on the efficacy...

Fas-mediated apoptosis enhanced in ageing human keratinocytes.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Fas-mediated apoptosis is enhanced in ageing human keratinocytes. "Cellular senescence and apoptosis are two metabolically related and seemingly synergistic processes that are involved in tissue...

Ghrelin receptor activity is signaling set-point in appetite regulation.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Constitutive ghrelin receptor activity is a signaling set-point in appetite regulation. According to a study from Denmark, "Ghrelin plays a key role as the major orexigenic hormone from the...

Staphylococcal protease does not affect outcome of infectious arthritis.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Staphylococcal protease expression does not affect outcome of infectious arthritis. "The exoproteases of Staphylococcus aureus have been proposed as virulence factors during S. aureus infections. To...

Flow visualization useful for predicting thrombus formation in blood pump.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Flow visualization provides valuable information about the development of thrombi in an artificial heart prototype. Researchers in Japan conducted a study "to eliminate fluid dynamic causes of...

FDA approval granted for Theophylline tablets.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Able Laboratories, Inc., (ABRX) announced that it has received U.S. Food and Drug Administration (FDA) approval for its Abbreviated New Drug Applications for Theophylline Extended-Release Tablets, 300mg...

Study shows potential of new asthma formulation using Captisol.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- CyDex, Inc., presented results of a preclinical study demonstrating the potential of its proprietary Captisol-Enabled formulation of budesonide, a widely used asthma medicine, for delivery by a variety...

Early childhood ear infections linked to asthma.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Children with recurrent ear infections may have an increased risk of developing asthma, according to a new study. Results of the study, published in the May 2004 issue of Chest, showed that...

Antioxidant corrects neurobehavioral defect in ataxia-telangiectasia.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice. According to a study from the United States, "Ataxia-telangiectasia is caused by mutations...

Survey: Lack of public awareness about strokes related to AF.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Results from a new national survey conducted by the not-for-profit Alliance for Aging Research to mark National Stroke Awareness Month show that about 80% of a thousand people polled were not aware...

Study suggests investigational ADHD drug d-MPH-ER safe and effective in adults.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- An investigational medication may help adults with Attention Deficit Hyperactivity Disorder (ADHD), according to new data presented at the annual meeting of the American Psychiatric Association. In...

Focalin LA capsules improve ADHD symptoms in adult study patients.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Study data support the safety and efficacy of Focalin LA (dexmethylphenidate extended release) capsules, an investigational treatment for attention-deficit/hyperactivity disorder (ADHD), in managing...

ADHD study patients fall asleep faster on Strattera versus methylphenidate.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Twice-daily treatment with Strattera (atomoxetine HCl), approved for the treatment of attention-deficit/hyperactivity disorder (ADHD), resulted in children with ADHD falling asleep nearly 10 times...

Avian influenza may be new pandemic threat.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Avian influenza may be a new pandemic threat. According to a study from the United States, "In December 2003, the largest outbreak of highly pathogenic avian influenza H5N1 occurred among poultry...

Site-directed mutagenesis of conserved residues in Bacillus reported.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Researchers report the site-directed mutagenesis of the conserved threonine, tryptophan, and lysine residues in the starch-binding domain of Bacillus species strain TS-23 alpha-amylase. "The...

Wisconsin chemists find a new chink in TB's armor.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- The family of bacteria that causes tuberculosis (TB) and leprosy are notoriously sturdy. And although the diseases they cause have been held in check for the past 50 years by antibiotics, some strains...

Hedgehog-interacting protein prevents basal cell carcinoma.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Recombinant hedgehog-interacting protein provides immunoprevention of basal cell carcinomas. "Basal cell carcinomas (BCCs) are driven by abnormal hedgehog signaling and highly overexpress several...

Computer simulation predicts microvascular patterning in mammals.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Computer simulation predicts microvascular patterning in mammals. "Remodeling of microvascular networks in mammals is critical for physiological adaptations and therapeutic revascularization....

Micropatterned hyaluronan surfaces orient lymphatic endothelial cell growth.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Micropatterned hyaluronan surfaces orient lymphatic endothelial cell growth. "The implant of a biocompatible device capable of guiding lymphatic vessel regeneration in patients who underwent removal...

Native cell membranes deposited on biocompatible micropatterns.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Native cell membranes have been selectively deposited on biocompatible micropatterns. According to recent research published in the Journal of the American Chemical Society, "We establish two...

Bothrops jararaca venom targets tumor cells and their mediators.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Bothrops jararaca venom targets tumor cells and their mediators. According to a study from Brazil, "snake venoms have been used as antineoplastic substances in several experimental models. We...

Symbyax reduces suicidal ideation symptoms in bipolar depression, studies show.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- New data show that Symbyax (olanzapine and fluoxetine HCl) reduced the symptoms associated with suicidal ideation (having thoughts of suicide), a predictor of suicidal behavior, in bipolar depressed...

Long-term treatment with Lamictal not associated with significant weight gain.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Results from an analysis presented at the recent American Psychiatric Association meeting in New York, New York, showed that long-term treatment with Lamictal (lamotrigine) is not associated with...

Studies examine Seroquel monotherapy remission rates in bipolar mania.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- AstraZeneca (AZN) announced data at the American Psychiatric Association's annual meeting from a pooled analysis of two double-blind, placebo-controlled studies that examined the effectiveness of...

Dalbavancin superior to vancomycin for bloodstream infections, data shows.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Vicuron Pharmaceuticals Inc. (MICU) announced the presentation of phase II data demonstrating superior efficacy of dalbavancin, the company's next-generation injectable glycopeptide antibiotic, compared...

Marrow adipocytes lacking in hydroxysteroid dehydrogenase deficiency.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Mice deficient in 11-beta-hydroxysteroid dehydrogenase type 1 lack bone marrow adipocytes, but maintain normal bone formation. According to a study from Denmark, Scotland, and Switzerland,...

Inverse relation found between leptin and BMD in hip-fractured women.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- An inverse association exists between leptin and bone mineral density (BMD) in hip-fractured women. According to recent research published in the Journal of Endocrinological Investigation, "Fat...

Human frontal cortex development depends on G protein-coupled receptor.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- The development of the human frontal cortex is G protein-coupled receptor-dependent. "The mammalian cerebral cortex is characterized by complex patterns of anatomical and functional areas that...

VP025 reduces perinatal hypoxic-ischemic brain injury in animal study.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Vasogen Inc. (VSGN) announced that preclinical findings demonstrating the ability of the company's phospholipid-based drug, VP025, to reduce perinatal hypoxic-ischemic brain injury were presented at the...

Radiation-induced activation of caspase-9 blocks glioma invasion.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Radiation-induced activation of caspase-9 blocks glioma invasion. "Glioblastoma multiforme, the most common brain tumor, typically exhibits markedly increased angiogenesis, which is crucial for...

Cyclin D1 overexpression appears to predict tamoxifen resistance.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Overexpression of the cell-cycle regulator and estrogen-receptor alpha co-factor, cyclin D1, appears to predict tamoxifen resistance in breast cancer tumors, pathologists in Sweden report. ...

Cyclin-dependent kinase 2 activated by cyclin E in breast cancer cells.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Cyclin-dependent kinase 2 is activated by full length and low molecular weight forms of cyclin E in breast cancer cells. According to a study from the United States, "Cyclin E, a positive regulator...

Cytological and histological diagnostic markers compared.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Diagnostic markers of breast cancer detectable through cytologic and histologic tests have been identified. "Although fine-needle aspiration cytology is a routine procedure for the diagnosis of...

Diagnosis of breast cancer more difficult in obese Korean women.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- The diagnosis of breast cancer is more difficult in obese Korean women. According to a study from South Korea, "This study was carried out to test the hypothesis that palpation for lumps may be more...

More research needed on adjuvant endocrine therapy of breast cancer.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- More clinical research is needed to advance knowledge of adjuvant and neoadjuvant endocrine therapy of breast cancer. "Adjuvant endocrine therapy following surgical resection of early,...

Nuclear receptor LRH-1 regulates aromatase expression in adipose tissue.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- The nuclear receptor LRH-1 regulates aromatase expression in adipose tissue. According to recent research from Australia, "Aromatase is the enzyme responsible for estrogen production, and is the...

Ovarian ablation as a treatment for breast cancer.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Ovarian ablation is an effective treatment for premenopausal women with hormone receptor positive breast cancer. "It can be achieved permanently by surgery or radiotherapy and reversibly by LhRH...

Protective role of fibulin-1 elucidated.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- The protective role of fibulin-1 (Fbln-1) in breast cancer patients has been elucidated. According to recent research from Italy, Fbln-1 is "an immunogenic breast cancer-related glycoprotein...

Radiation improves survival in node-positive breast cancer patients.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Postmastectomy radiotherapy improves overall survival in node-positive breast cancer patients. "Postmastectomy irradiation substantially reduces the risk of locoregional recurrences (LRR) of breast...

Study discusses the molecular biology of the estrogen receptors.
June 4, 2004... 2004 JUN 4 - (NewsRx.com & NewsRx.net) -- Researchers review the newer anti-estrogens in treating breast cancer. "Evidence for a role of ovarian factors in the growth of metastatic breast cancer was first recognized over 100 years ago....