Drug Week articles from June 2003

Drug Week archives from June 2003

Antiepileptic drug could be future treatment option.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Authors of a U.S. study provide evidence that the antiepileptic drug topiramate could be an effective future treatment for alcohol dependence. Bankole A. Johnson from the University of Texas Health...

Secrets of drug resistance revealed.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- In the race to stay one step ahead of drug-resistant bacteria, scientists from Lawrence Berkeley National Laboratory and the University of California at Berkeley obtained high-resolution images of a...

Micellar nanocontainers distribute agents to defined cytoplasmic organelles.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Pharmacologists at McGill University report that block copolymer micelles localize in certain organelles, but not the cell nucleus, and that they alter the cellular distribution and increase the amount...

Study documents national trends in use of antiobesity medications.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- The use of antiobesity drugs peaked in 1997 and decreased after the withdrawal of fenfluramine-phentermine combination therapy (fen-phen, a prescription appetite suppressant) from the market (in 1997...

Cidofovir effective but toxic for adenovirus-infected patients.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Cidofovir is effective but toxic for stem cell graft recipients with posttransplant adenovirus infections. "Adenovirus is an important cause of morbidity and mortality after allogeneic...

H[subscript]1-histamine receptor affinity predicts weight gain for antipsychotic drugs.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- HI-histamine receptor affinity predicted short-term weight gain for typical and atypical antipsychotic drugs. "As a result of superior efficacy and overall tolerability, atypical antipsychotic...

Pharmaceutical industry improving quality of anti-infectious drugs.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Efforts made by the pharmaceutical industry to improve the quality of anti-infectious drugs has been outlined in a recent issue of Medecine Et Maladies Infectieuses. According to a study from...

Amphotericin B deoxycholate dose can be escalated in patients with neutropenia.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Patients with neutropenia can have dosage of amphotericin B doubled if given continuous infusion therapy. According to recent research from the United States, "Amphotericin B deoxycholate (AmB-d)...

Antithymocyte globulin and cyclosporine can lead to Merkel cell carcinoma.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Antithymocyte globulin and cyclosporine therapy can lead to development of Merkel cell carcinoma. According to published research from Japan, "We report a patient who developed Merkel cell...

Short-term treatment for sleep disorder acquired.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Bristol-Myers Squibb Company (BMY) announced that its subsidiary Mead Johnson & Company has signed a purchase agreement with OPR Development, L.P. to acquire Cafcit (caffeine citrate) Injection and Oral...

Drug fails key test.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- The biologically engineered drug Raptiva failed to effectively treat rheumatoid arthritis patients in a key experiment, its manufacturers say. The companies said they are halting further tests on...

Theophylline induces progenitor cell apoptosis.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Theophylline lowers hematopoietic progenitor cell levels in asthma patients. This agent "possesses anti-inflammatory activities in asthma," researchers in Taiwan explained. In a recent study,...

Phase I clinical trials of a second UltiMAb antibody begin.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Medarex, Inc., (MEDX) announced that its licensee, Novartis Pharma, AG, has commenced phase I clinical trials of a fully human antibody product candidate for the treatment of autoimmune disease. ...

Dexamethasone and anti-IgM apoptosis will not occur if Ik-6 is overexpressed.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Overexpression of Ik-6 appears to confer resistance to apoptosis in 2 different cell lines with differing mechanisms. "In previous studies, we demonstrated an over-expression of the...

Permission given to initiate LEP-ETU clinical trial.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- NeoPharm, Inc., (NEOL) announced that it has received permission from the U.S. Food and Drug Administration (FDA) to proceed with planned phase I clinical trials for LEP-ETU, the company's NeoLipid...

Tentative O.K. given for manufacturing and marketing of Fluconazole Tablets.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Ranbaxy Pharmaceuticals, Inc., (RPI), a wholly owned subsidiary of Ranbaxy Laboratories, Ltd., (RLL) announced that RLL has received tentative approval from the U.S. Food and Drug Administration for...

Calcitriol launched for hypocalcemia.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- American Pharmaceutical Partners, Inc., (APPX) announced the launch of calcitriol for injection with shared 180-days of marketing exclusivity. Calcitriol, the generic equivalent of Abbott Laboratories,...

Technology provider selected to deliver comprehensive infrastructure.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- eResearchTechnology, Inc., (eRT) (ERES), an e-research technology and services provider, announced that it has entered into an agreement with Endocyte, Inc., to provide an integrated technology and...

Recruitment services help enroll more than 100 protocols to date.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Acurian announced that since launching AcuPatient, its Direct-to-Patient (DTP) recruitment service for the rapid enrollment of clinical trials, and AcuSite, its database service for the identification...

R&D alliance to focus on cell, gene therapy at Baylor College of Medicine.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Hemispherx Biopharma, Inc., (HEB) announced that it has entered into a Research Project Agreement with the prestigious Center for Cell and Gene Therapy at the Baylor College of Medicine in Houston,...

Doxorubicin causes CHF more often and at lower doses than previously reported.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Doxorubicin, an effective, common chemotherapy drug for cancer, causes congestive heart failure (CHF) more often and at lower cumulative doses than reported in prior studies according to a review study....

Monoclonal antibody may reduce need for steroids in children with CD.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- A monoclonal antibody shows promising results in treating children with Crohn disease (CD), a painful inflammation of the digestive tract, according to a multicenter study conducted at five medical...

NIH grant awarded to generate antibodies to CMV; 1Q finances reported.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Avanir Pharmaceuticals (AVN) announced it has been awarded a grant from the U.S. National Institutes of Health (NIH) under its phase I Small Business Innovation Research (SBIR) program. The company also...

Neurochem licenses its diabetes technology.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Neurochem, Inc., (NRM) and Innodia, Inc., announced the conclusion of an agreement whereby Neurochem has licensed to Innodia, Inc., its intellectual property rights relating to Neurochem's preclinical...

Positive preclinical results reported for microplasmin.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Results were shown for the first time evaluating the potential of microplasmin for the induction of posterior vitreous detachment (PVD) at a presentation at the Association for Research in Vision and...

HPLC/electrospray ionization MS detects choline, acetylcholine in preparations.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- GlaxoSmithKline scientists have described "a sensitive, rapid, and specific method for the detection of choline and acetylcholine in a pharmaceutical preparation." R. Dunphy and colleagues...

Method for determination of fluconazole in human plasma described.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- A bioanalytical method that uses automated sample transferring, automated liquid/liquid extraction (LLE) and hydrophilic interaction liquid chromatography-tandem mass spectrometry has been developed by...

Quantification of roxifiban's active metabolites in human plasma described.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Quantifying the active metabolites of roxifiban, a glycoprotein IIb/IIIa antagonist, has presented some challenges, but scientists at Palatin Technology (New Jersey, USA) have developed an assay that...

Clinical studies initiated for a new insulin capsule; financial results reported.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Emisphere Technologies, Inc., (EMIS) announced that it is initiating clinical testing of an oral insulin formulation in type 2 diabetic patients in the United States under an Investigational New Drug...

Development program to develop water soluble polymer technology.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Carrington Laboratories, Inc., (CARN) announced the formation of a relationship between its DelSite Biotechnologies, Inc., subsidiary and the University of Southern Mississippi (USM) to initiate a...

Polymeric renal drug carrier synthesized.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- "We have synthesized a polymeric drug carrier, polyvinylpyrrolidone-co-dimethyI maleic anhydride [poly(VP-co-DMMAn)], for use in renal drug delivery," reported Osaka University pharmacologists. H....

Repetitive coulomb-controlled iontophoresis delivers medications topically.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Repetitive coulomb-controlled iontophoresis has potential to deliver topical drug therapy to the eye without the side effects that can occur with systemic delivery of nonsteroidal anti-inflammatory...

Surface-engineered nanospheres improve lymphatic distribution.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- A study from the University of Brighton, U.K., compared the effect on lymphatic distribution of surface-engineered nanospheres with different surface configurations of ethylene oxide chains. ...

Kidney-based transgenic bioreactor studied for production of complex drugs.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Urologists at the New York University School of Medicine have shown that a kidney-based bioreactor in transgenic mice produces human growth hormone gene expression followed by secretion of hGH protein...

Antimicrobial drug prescriptions on the rise in ambulatory care settings.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- The number of prescriptions for antimicrobial drugs is increasing in ambulatory care settings, prompting researchers to issue a warning about drug resistance. According to recent research published...

Update provided on regulatory filings for diabetes drug in Mexico.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Robert Rieveley, president of Biotech Holdings, provided an update on regulatory filings in Mexico for Sucanon, Biotech's type II diabetes drug. We are pleased to report that we have filed, as...

Scientists throw light on drug-induced weight gain.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Researchers at the University of Sheffield have identified two genes that could prevent millions of patients from gaining weight as a result of their medication. Their work was presented at the...

Cardiovascular disease clinical trial initiated with NIH grant.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Juvenon, Inc., announced the initiation of a clinical trial to evaluate the effect of Juvenon Energy Formula on cardiovascular disease patients. The trial, funded by a grant from the U.S. National...

Newer drug has worse side effects than older drug.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Two commonly prescribed epilepsy drugs have varied cognitive side effects, report doctors from Georgetown University Medical Center. In a double-blind, randomized study, researchers looked at two...

$8.1M raised in private placement financing at biotech company.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Genelabs Technologies, Inc., (GNLB) announced that it has completed the sale of 8.1 million shares of its common stock to institutional and accredited investors at a price of $1.00 per share, for gross...

Aldurazyme maker reports loss of $0.35 per share.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- BioMarin Pharmaceutical, Inc., (BMRN; BMRN) announced financial results for its first quarter ended March 31, 2003. The company incurred a loss of $19.7 million ($0.35 per share) in the first...

Antiangiogenic drug maker has $0.04 per share loss; clinical progress updated.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Genaera Corporation (GENR) announced its financial results for the quarter ended March 31, 2003, and promising early results for the phase I-II clinical trial of its anti-angiogenic drug, squalamine,...

Biotech company reports results in line with guidance for first quarter.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Array BioPharma, Inc., (ARRY) reported financial results for the third quarter of fiscal 2003, ended March 31, 2003. During the third quarter of fiscal 2003, Array reported total revenue of $8.0...

Biotech firm president, CEO express confidence in company.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Cel-Sci Corporation (CVM) reports that Cel-Sci's president Maximilian de Clara and Cel-Sci's CEO Geert Kersten have elected to take 6 months of salary in the form of company stock. This stock is...

Cancer drug maker reports first quarter results, adoption of stockholder rights plan.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Allos Therapeutics, Inc., (ALTH) reported financial results for the first quarter 2003. For the 3 months ended March 31, 2003, the company reported a net loss of $7.1 million, or $0.28 per share....

Final repayment, cancellation of convertible debentures announced.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Biomira, Inc., (BIOM; BRA) announced that it has repaid in full the outstanding principal and interest with respect to its U.S. $15 million private financing of convertible debentures announced on...

Genomics company reports net loss of $0.03 per share.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Epoch Biosciences, Inc., (EBIO), a provider of proprietary products that accelerate genomic analysis, reported that revenues for the first quarter increased to $2.4 million compared to $2.3 million in...

Hepatitis C drug maker reports quarterly loss, provides program updates.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Isis Pharmaceuticals, Inc., (ISIS) announced its financial results for the first quarter of 2003. Total revenue for the 3 months ended March 31, 2003, totaled $14.0 million, compared with $18.0...

Net loss reported at $0.11 per share by catalytic antioxidants developer.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Incara Pharmaceuticals Corporation (INCR) announced the financial results for its second quarter of fiscal 2003, the 3-month period ended March 31, 2003. Incara reported a net loss attributable to...

Net losses reported at $0.15 per share for biotech company.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Epimmune, Inc., (EPMN) announced its financial results for the first quarter ended March 31, 2003. During the quarter, cash and cash equivalents declined $2.2 million to an ending balance of $7.6...

Pharmaceutical firm reports net loss of $0.34 per share.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Amylin Pharmaceuticals, Inc., (AMLN) reported a net loss of $30.8 million, or $0.34 per share, for the first quarter ended March 31, 2003, compared to a net loss of $22.1 million, or $0.30 per share,...

Provigil maker reports product sales of $137.6M.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Cephalon, Inc., (CEPH) reported results for the first quarter of 2003, which included total revenue of $144.7 million, product sales of $137.6 million, and diluted earnings per share of $0.21. ...

Revenue climbs 85% for drug delivery company.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Carrington Laboratories, Inc., (CARN) reported that first quarter revenues climbed nearly 85% to $6.9 million from $3.7 million a year earlier. The net loss for the quarter ended March 31, 2003,...

Second quarter of profitability reported by cholesterol drug maker.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Kos Pharmaceuticals, Inc., (KOSP) announced financial results for the first quarter ended March 31, 2003. For the first quarter of 2003, revenue increased 101% to a record $68.3 million, up from...

Specialty pharmaceuticals company reports first quarter profit.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- ICN Pharmaceuticals, Inc., (ICN) announced first quarter 2003 results. For the quarter ended March 31, 2003, revenues were $158.7 million, compared with $185.0 million in the same period last year....

Vaccine producer provides updates on corporate programs.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Acambis plc (ACAM) announced its results for the first quarter ended 31 March 2003. During the first quarter of 2003, there were a number of positive developments relating to our smallpox vaccine...

Lantus receives FDA approval for flexible administration.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Aventis announced that its basal insulin, Lantus, has been approved by the U.S. Food and Drug Administration for flexible administration at any time of day. Lantus is the first and only basal...

Sustained-release bupropion effective.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Sustained-release bupropion shows promise for the treatment of depression in HIV patients. Researchers at the University of Miami conducted a study "to evaluate the efficacy and tolerability of...

Low adiponectin levels linked to HAART-induced insulin resistance.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Low adiponectin levels may play a role in insulin resistance induced by HIV treatment. "Highly active antiretroviral therapy (HAART) has dramatically reduced HIV-related mortality, but is associated...

Novel agent disrupts viral capsid protein function.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- A novel antiviral agent disrupts the activity of the HIV capsid protein. "During the assembly stage of the human immunodeficiency virus (HIV) replication cycle, several thousand copies of the viral...

Oxidized DNA metabolite levels do not rise during antiretroviral treatment.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Oxidized DNA metabolite levels do not rise during antiretroviral treatment for HIV. "Mitochondrial toxicity of nucleoside analogues has been proposed to be the etiology of a range of side-effects...

Infant dietary supplementation results in reduced blood pressure.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Martek Biosciences Corporation (MATK) commented on the results of a study published in the May 2003 edition of the British Medical Journal. Data from the study demonstrated that infants fed formula...

PLT 732 unveiled at AOCS meeting.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Pilot Therapeutics Holdings, Inc., (PLTT) announced that scientists from Pilot Therapeutics presented data at the 94th annual meeting of the American Oil Chemists Society (AOCS) in Kansas City,...

Experts examine global progress in vaccines.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Many of the world's vaccine scientists met at the National Foundation for Infectious Diseases' (NFID) Sixth Annual Conference on Vaccine Research to present the latest research on vaccines against...

Brazilian medicinal plants active against methicillin-resistant Staphylococcus aureus.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- South American medicinal plants have yielded agents active against drug-resistant staphylococci. According to recent research from Brazil, "fourteen extracts from Brazilian traditional medicinal...

Nasal vaccine delivery platform data presented at vaccine conference.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Carrington Laboratories, Inc., (CARN) announced that results of an initial study sponsored by its subsidiary DelSite Biotechnologies, Inc., were presented at the 6th Annual Conference of Vaccine...

Drug treatment successful for lupus-associated insulin resistance.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Drug treatment with cyclophosphamide and mycophenolate mofetil was successful for treating systemic lupus erythematosus-associated type B insulin resistance syndrome. "Systemic lupus erythematosus...

Federal district court upholds Ceftin patent.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- GlaxoSmithKline (GSK) announced that a federal judge for the United States District Court for the Northern District of Illinois in Chicago has ruled in patent litigation involving GSK's drug Ceftin...

Lawsuit filed over intellectual property.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Biolase Technology, Inc., (BLTI) filed suit against Diodem LLC on May 2, 2003, to reinforce Biolase's intellectual property position in the marketplace. Diodem, LLC is a small, recently formed...

Sitofloxacin effective for treatment.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Sitofloxacin is effective for the treatment of leprosy, alone or in combination with other antimycobacterial agents. According to a study from the United States, "the antimicrobial effects of...

Dexamethasone induced leukemic cell apoptosis and decreased cell count.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Dexamethasone induced leukemic cell apoptosis and decreased cell count. According to recent research from Turkey, "This study was performed to investigate the effects of dexamethasone on acute...

Magnolol induces apoptosis in human leukemia cells.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Magnolol induces apoptosis in human leukemia cells. "Magnolol, isolated from the stem bark of Magnolia officnalis, was found to inhibit proliferation of human HL-60 cells and Jurkat T leukemia...

Green tea constituent inhibits hep G2 cell proliferation, induces apoptosis.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- (-)-Epigallocatechin-3-gallate (EGCG), a polyphenolic compound found in green tea, inhibited the proliferation of a human liver cancer cell line by inducing apoptosis and blocking cell cycle progression...

Coexposure with magnetic fields and vinblastine increases effect on lymphocytes.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Low frequency magnetic fields can increase cell proliferation in normal lymphocytes and even enhances micronucleus and apoptosis frequency in lymphocytes given vinblastine. "Interference of 50 Hz,...

Iressa approved by FDA.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- AstraZeneca Pharmaceuticals (AZN) announced that the U.S. Food and Drug Administration (FDA) has granted approval for Iressa (gefitinib) for the treatment of advanced non-small-cell lung cancer (NSCLC)....

Oculex announces positive clinical results for Posurdex.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Oculex Pharmaceuticals, Inc., a developer of therapeutic products for the treatment of major, sight-threatening diseases of the eye, announced that results were presented from a phase II clinical trial...

Enrollment has resumed in phase I glioma study.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Oncolytics Biotech, Inc., (ONCY) announced that enrollment has resumed in the phase I component of its clinical study examining the use of Reolysin in the treatment of recurrent malignant glioma, the...

Positive phase II/III trial results reported for estradiol topical gel.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- BioSante Pharmaceuticals, Inc., (BISP) announced that an effective dose of Bio-E-Gel (estradiol topical gel) has been identified in its phase II/III clinical trial for the treatment of...

Pharmaceutical company reaffirms intent not to proceed; reports 1Q financials.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- King Pharmaceuticals, Inc., (KG) reaffirmed its position that the asset purchase agreement dated January 30, 2003, with Elan Corporation, plc, concerning the purchase of Elan's primary care business,...

Immune cells may help deliver cancer vaccines for children.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- In a finding that could lay the groundwork for future cancer vaccines for children, cancer researchers working in cell culture have shown that modified immune cells can efficiently deliver genetic...

Memantine fails to demonstrate efficacy.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Forest Laboratories, Inc., (FRX) announced that a just completed pivotal placebo-controlled study of memantine in the treatment of neuropathic pain in diabetic patients had failed to demonstrate a...

Dextromethorphan alters gene expression in certain areas of the brain.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Dextromethorphan alters gene expression in certain areas of the brain. According to a study from South Korea, "dextromethorphan is a widely used antitussive drug with non-competitive antagonistic...

Fast track SBIR grant awarded to develop therapeutics for genetic diseases.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- PTC Therapeutics announced that the company has been awarded a fast track (combined phase I/II) small business innovation research (SBIR) grant from the National Institute of Diabetes and Digestive and...

Acarviosine-simmondsin reduces food intake and hyperglycemia.
June 6, 2003... 2003 JUN 6 - (NewsRx.com & NewsRx.net) -- Acarviosine-simmondsin, a novel compound obtained from acarviosine-glucose and simmondsin by Thermus maltogenic amylase, reduced food intake and hyperglycemia. According to a study from South...