Drug Week articles from July 2009

Drug Week archives from July 2009

Depression may increase risk of Alzheimer's disease in people with memory problems.
July 3, 2009... People with memory problems who are depressed are more likely to develop Alzheimer's disease compared to people who are not depressed, according to a study published in the June 16, 2009, print issue of Neurology®, the medical journal of...

Complaints of fatigue and tiredness in people with OSA improve with CPAP treatment.
July 3, 2009... A study in the June 15 issue of the Journal of Clinical Sleep Medicine shows that the complaints of fatigue and tiredness in patients with obstructive sleep apnea (OSA) improved significantly with good adherence to continuous positive airway...

Study shows transfer of heavy metals from water to fish in Huelva estuary.
July 3, 2009... A team of researchers from the University of Cadiz has confirmed that zinc, copper and lead are present at high levels in the water and sediments of the Huelva estuary, and have studied how some of these heavy metals are transferred to fish....

Cost-effective measures could stop child pneumonia deaths.
July 3, 2009... Implementing measures to improve nutrition, indoor air pollution, immunization coverage and the management of pneumonia cases could be cost-effective and significantly reduce child mortality from pneumonia, according to a study led by the Johns...

Hodgkin lymphoma survivors have increased risk of stroke and transient ischemic attack.
July 3, 2009... Patients treated for Hodgkin lymphoma with radiation therapy have a substantially higher risk of stroke, according to a new study published June 17 online in the Journal of the National Cancer Institute (see also Journal of the National Cancer...

Biopharmaceutical Contract Manufacturing Study Finds Industry Growth Over the Past Two Years and Expects to Continue Its Growth Trajectory.
July 3, 2009... The demand for biopharmaceutical contract manufacturing services is expected to grow at 16% annually over the next 5 years as biopharmaceutical business models shift toward more outsourcing of production requirements, as well as some large...

Sundia's Animal Facility Passed Client and Government Inspection.
July 3, 2009... Sundia MediTech Company, a Shanghai-based integrated pharmaceutical contract research company, announced that its animal facility in Shanghai has passed the audit from a major European Pharmaceutical Company. The Sundia management and staff are...

Smokefree Innotec, Inc. Products will Utilize Filters which Meet European and US Safety Recommendations.
July 3, 2009... Smokefree Innotec, Inc. (Pink Sheets:SFIO) (www.smokefree-innotec.com) announced that it has received confirmation that the filter cartridges which AHN Biotechnologie GmbH will produce in Germany for the imminent launch of Smokefree Innotec's...

New acidosis study results from T. Mouri et al described.(Report)
July 3, 2009... According to recent research published in the journal Hypertension Research, "Renal aquaporin-2 (AQP2) expression plays a key role in urine concentration. However, it is not known whether metabolic acidosis affects urine-concentrating ability...

Recent findings from National University, Medical Department highlight research in acute pancreatitis.
July 3, 2009... "Substance P is known to play a key role in the pathogenesis of acute pancreatitis. Src family kinases (SFKs) are known to be involved in cytokine signaling," researchers in Singapore, Singapore report (see also Acute Pancreatitis). ...

Research on acute pancreatitis reported by B.L. Love et al.
July 3, 2009... According to a study from the United States, "A 34-year-old woman presented with acute and progressive pain in the upper abdomen with worsening nausea, vomiting and diarrhoea. Her pain was described as severe, sharp and stabbing, with radiation...

Report summarizes controlled release study findings from M.R. Rekha and co-researchers.
July 3, 2009... "In this work a novel chitosan derivative, lauryl succinyl chitosan (LSC) was developed for the purpose of evaluating its applications towards oral peptide delivery system. Nano/microparticles were developed from this derivative by sodium...

Researchers from University of London provide details of new studies and findings in the area of controlled release.
July 3, 2009... "Therapeutic antibodies offer a potential treatment for, or means of protection against, airborne infections. For this application, it may be desirable to deliver the antibody directly into the nasal cavity, one of its potential sites of...

Studies by J.E. Stefano and co-authors describe new findings in controlled release.
July 3, 2009... According to recent research published in the Journal of Controlled Release, "Lysosomal storage diseases arise from a genetic loss-of-function defect in enzymes mediating key catabolic steps resulting in accumulation of substrate within the...

Findings in drug discovery and design reported from University of Auckland.
July 3, 2009... "Selective cyclo-oxygenase 2 inhibitors ('coxibs) have been demonstrated to increase cardiovascular risk, but the cumulative burden of adverse effects in the US population is uncertain. To quantify cardiovascular and gastrointestinal (GI)...

New findings in drug discovery and design described from University of London.
July 3, 2009... According to a study from London, the United Kingdom, "In the UK, treatment with antipsychotic medications for children is usually initiated by specialists in secondary care. Recent studies have shown an increase in the prescribing of atypical...

Data from Thomas Jefferson University advance knowledge in molecular pharmacology.
July 3, 2009... According to recent research from the United States, "The powerful metastasis suppressor function of KiSS1 gene products has been demonstrated in both clinical studies and experimental models, but its mechanism is still incompletely understood....

Data on molecular pharmacology detailed by I. Kalatskaya and co-authors.
July 3, 2009... According to recent research from Montreal, Canada, "The bicyclam AMD3100 is known as a small synthetic inhibitor of the CXCL12-binding chemokine receptor CXCR4. Here, we show that AMD3100 also binds to the alternative CXCL12 receptor CXCR7."...

New findings from Harvard University, Medical Department in the area of molecular pharmacology described.
July 3, 2009... "Azietomidate is a photoreactive analog of the general anesthetic etomidate that acts as a nicotinic acetylcholine receptor (nAChR) noncompetitive antagonist. We used rapid perfusion electrophysiological techniques to characterize the state...

New molecular pharmacology data have been reported by scientists at University of North Dakota.(Report)
July 3, 2009... "Activation of G protein-coupled alpha(2) adrenergic receptors (ARs) inhibits epileptiform activity in the hippocampal CA3 region. The specific mechanism underlying this action is unclear," scientists in the United States report (see also...

Recent findings from X.Q. Bao and co-authors highlight research in molecular pharmacology.(Report)
July 3, 2009... "Heat shock proteins (HSPs) are molecular chaperones critical for cell survival under adverse environmental conditions and for normal cellular homeostasis. Bicyclol, a novel antihepatitis drug, has been shown to protect against liver injury in...

Research from University of Reading provides new data on molecular pharmacology.
July 3, 2009... According to a study from the United Kingdom, "The L-glutamate transporter GLT-1 is an abundant central nervous system (CNS) membrane protein of the excitatory amino acid transporter (EAAT) family that controls extracellular L-glutamate levels...

Research on molecular pharmacology reported by scientists at McGill University.
July 3, 2009... According to recent research from Montreal, Canada, "Two structural models have been developed to explain how agonist binding leads to ionotropic glutamate receptor (iGluR) activation. At alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid...

Study results from University of Kansas broaden understanding of molecular pharmacology.
July 3, 2009... "Human cytochrome P450 3A (CYP3A) members are major drug-metabolizing enzymes in the liver. Two genes, CYP3A4 and CYP3A7, exhibit a developmental switch in gene expression during liver maturation," investigators in the United States report (see...

Reports outline pharmaceuticals study findings from Chonbuk National University.
July 3, 2009... According to a study from South Korea, "The psoralen, a furocoumarin derivative, on the cloned neuronal rat Kv3.1 channels stably expressed in Chinese hamster ovary cells was investigated using the whole-cell patch-clamp technique. Psoralen...

Researchers at Heilongjiang University have published new data on pharmaceuticals.
July 3, 2009... "A new coumarinolignan glucoside named yinxiancaoside C, along with five known benzofuran lignans, have been isolated from the whole plant of Chloranthus japonicus Sieb," scientists in Harbin, People's Republic of China report (see also...

Findings from Ehime University, Medical Department advance knowledge in pharmacological sciences.
July 3, 2009... "We have previously reported that sleep patterns are significantly affected by both physical and psychological stress induced by a communication box; however, the mechanism by which stress alters sleep patterns was not established. In the...

Research from S. Maeda and co-authors in the area of pharmacological sciences published.
July 3, 2009... According to recent research from Fukushima, Japan, "The expression levels of the Na+/Ca2+ exchanger type 1 (NCX1) change Under various cardiac pathophysiological conditions, but the mechanism is unknown. We previously demonstrated that...

Research from Y.Z. Wang and co-authors reveals new findings on pharmacological sciences.
July 3, 2009... "Ginsenoside Rg1 has been reported to improve cognitive function in many memory-impaired animal models. However, little is known about the bioactivity of its metabolites in the central nervous system in vivo," researchers in Beijing, People's...

Research reports from Osaka University provide new insights into pharmacological sciences.
July 3, 2009... "We studied the effects of tandospirone, a 5-HT1A agonistic anxiolytic agent, on haloperidol-induced catalepsy and forebrain Fos expression in mice. Haloperidol (0.5 mg/kg, i.p.) markedly increased the catalepsy time and enhanced Fos expression...

Studies from Chulalongkorn University yield new information about pharmacological sciences.(Report)
July 3, 2009... "Aloe vera has long been used as a traditional medicine for inducing Wound healing, Gingival fibroblasts (GFs) play an important role in oral wound healing. In this Study, we investigated the effects of acemannan, a polysaccharide extracted...

Study data from Chungbuk National University update understanding of pharmacological sciences.
July 3, 2009... According to a study from South Korea, "Manassantin A (MSA) inhibits nitric oxide production by macrophages through the inhibition of NF-kappa B activation, but the effect of MSA on dendritic cells has not been elucidated yet. Here we...

Findings from Y.D. Huang and co-authors broaden understanding of pharmacology and experimental therapeutics.
July 3, 2009... "The present study aimed to produce and pathophysiologically evaluate the metallothionein (MT) fusion protein. A recombinant plasmid containing DNA segment coding the pET-glutathione transferase (GST)-small ubiquitin-related modifier (SUMO)-MT...

New pharmacology and experimental therapeutics findings from Vrije University Amsterdam published.(Report)
July 3, 2009... "The chemokine receptor CXCR2 is involved in different inflammatory diseases, like chronic obstructive pulmonary disease, psoriasis, rheumatoid arthritis, and ulcerative colitis; therefore, it is considered an attractive drug target. Different...

New pharmacology and experimental therapeutics study findings reported from University of Washington.(Report)
July 3, 2009... According to a study from the United States, "Muscarinic receptors have been proposed to play an important role during brain development by regulating cell survival, proliferation, and differentiation. This study investigated the effect of...

Reports by P.M. Hawkins and co-researchers describe recent advances in pharmacology and experimental therapeutics.(Report)
July 3, 2009... According to recent research published in the Journal of Pharmacology and Experimental Therapeutics, "The treatment of brain malignancies with boron neutron capture therapy depends on their ability to cross the blood-brain barrier (BBB). An...

Reports outline pharmacology and experimental therapeutics study findings from University of Tokyo.
July 3, 2009... According to a study from Hongo, Japan, "Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 are responsible for the hepatic uptake of organic anions. They share similar sequences and structures with 12 putative transmembrane domains...

Reports summarize pharmacology and experimental therapeutics research from University of Washington.
July 3, 2009... "The solute carrier (Slc) superfamily is a major group of membrane transport proteins present in mammalian cells. Although Slc transporters play essential and diverse roles in the central nervous system, the localization and function of the...

Research findings from Y. Inokuchi et al update understanding of pharmacology and experimental therapeutics.(Report)
July 3, 2009... "Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, is used for the treatment of acute cerebral infarction. In this study, we investigated whether edaravone is neuroprotective against retinal damage," scientists in Gifu,...

Research from State University of New York broadens understanding of pharmacology and experimental therapeutics.
July 3, 2009... According to recent research from the United States, "We hypothesize that nitroglycerin (NTG) causes direct oxidation of multiple cellular sulfhydryl (SH) proteins and that manipulation of SH redox status affects NTG tolerance. In LLC-PK1...

Researchers at University of North Texas have published new data on pharmacology and experimental therapeutics.
July 3, 2009... According to recent research from the United States, "The actions of colchicine were examined with the two-electrode voltage-clamp technique and radioligand binding assays in mouse and human 5-hydroxytryptamine(3A) receptors (5-HT(3A)Rs)...

Studies conducted at University of Texas on pharmacology and experimental therapeutics recently published.
July 3, 2009... According to a study from the United States, "Activation of ventral tegmental area (VTA)-dopaminergic (DA) neurons by ethanol has been implicated in the rewarding and reinforcing actions of ethanol. GABAergic transmission is thought to play an...

Studies from National Institutes of Health in the area of pharmacology and experimental therapeutics published.
July 3, 2009... According to recent research published in the Journal of Pharmacology and Experimental Therapeutics, "Recent studies identified novel allosteric modulators of the dopamine (DA) transporter (DAT). N-(Diphenylmethyl)-2-phenyl-4-quinazolinamine...

Studies from T. Hiranita and colleagues yield new information about pharmacology and experimental therapeutics.
July 3, 2009... According to recent research published in the Journal of Pharmacology and Experimental Therapeutics, "Benztropine (BZT) analogs inhibit dopamine uptake but are less effective than cocaine in producing behavioral effects predicting abuse...

Studies from University of North Texas yield new data on pharmacology and experimental therapeutics.
July 3, 2009... "Carisoprodol is a frequently prescribed muscle relaxant. In recent years, this drug has been increasingly abused," scientists in the United States report (see also Pharmacology and Experimental Therapeutics). "The effects of carisoprodol...

Study data from University of Ferrara provide new insights into pharmacology and experimental therapeutics.
July 3, 2009... According to a study from Ferrara, Italy, "The effects of treatments with cannabinoid (CB)(1) and cholecystokinin (CCK)(2) receptor agonists and antagonists, as well as compounds that enhance endocannabinoid signaling by inhibiting degradation,...

Findings from Michigan State University broaden understanding of pharmacology and physiology.
July 3, 2009... According to a study from the United States, "Our goal was to investigate the body distribution of serotonin (5-hydroxytryptamine; 5-HT) in rats infused with 5-HT (25 mu g/kg per min) for 7 days and the contribution of the 5-HT transporter...

Studies from University of British Columbia further understanding of pharmacotherapy.
July 3, 2009... According to recent research published in the journal Annals of Pharmacotherapy, "The use of complementary and alternative medicine (CAM), including orally administered herbals, botanicals, vitamins, and supplements, may pose a risk to patients...

Findings from University of Sao Paulo in therapies reported.(Clinical report)
July 3, 2009... According to recent research from Brazil, "To evaluate subjective symptoms and clinical signs of tolerability and comfort in silicone and non-silicone hydrogel contact lens (CL) wearers using two different multipurpose solution (MPS) CL care...