Drug Week articles from July 2002

Drug Week archives from July 2002

Opioid-induced immune suppression can be prevented.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States and Europe may have found to a way to prevent the mediating effects of opioids on HIV proliferation. "Opioids potentiate...

Filgrastim is beneficial after stem cell transplantation.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in Spain say that filgrastim (granulocyte colony-stimulating factor, or G-CSF) treatment can help breast cancer patients recover from hematopoietic...

Nevirapine tolerance induction safe, effective.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Allergic reactions to the antiretroviral agent nevirapine can be prevented in high-risk patients, researchers in France report. "The most frequent...

Phase II study results using the Aerodose ipratropium inhaler reported.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- Aerogen, Inc. (AEGN) announced the results of its phase II clinical study using the Aerodose ipratropium inhaler at the American Thoracic Society 2002 International Conference in Atlanta, Georgia. ...

Antitumor activity of Erbitux as a single-agent and in combination.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- ImClone Systems Inc. (IMCL) and Bristol-Myers Squibb (BMY) announced data suggesting that the investigational monoclonal antibody, Erbitux (cetuximab), had antitumor activity as a single-agent in...

Seroquel may help patients achieve a more successful recovery.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- Use of the atypical antipsychotic Seroquel (quetiapine) may help schizophrenia patients achieve a better outcome in their treatment, according to new research published in the latest Annals of Clinical...

FDA approves second formulation of Retin-A Micro for U.S. market.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- Ortho Neutrogena announced that the U.S. Food and Drug Administration (FDA) has granted marketing approval for Retin-A Micro 0.04% (tretinoin gel) microsphere, a new, lower-dose formulation of Retin-A...

Antex presents preclinical results at conference.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- Antex Biologics Inc. (NX) presented preclinical results at the annual meeting of the American Society of Microbiologists held in Salt Lake City. The presentation outlined immunogenicity and protective...

Reduction of financial risk in clinical trials motivates simulation technology.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- By promising to reduce the financial burden of clinical trials, technologies that use computers to model and simulate biochemical studies are in great demand from drug discovery firms. Though...

Centocor presents long-term data from trial with Remicade in Crohn patients.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- New 54-week data from the ACCENT II clinical trial assessing the effectiveness of maintenance therapy with REMICADE(infliximab) in sustaining closure of draining fistulas in Crohn disease (CD) were...

Caraco Pharmaceutical files FDA drug application.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- Caraco Pharmaceutical Laboratories, Ltd., (CARA) has filed another generic drug application with the U.S. Food and Drug Administration (FDA), raising to seven the number of Caraco drugs pending...

Viagra in black men is effective and well tolerated.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- In the first study to evaluate the efficacy and safety of Viagra (sildenafil citrate) in black men with erectile dysfunction (ED), approximately 8 out of 10 patients reported improvement in their...

Blood pressure medication not prescribed to best protect against stroke, heart attack.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- A majority of physicians tell patients to take their antihypertensive medication at a time of day that may not adequately protect them against potentially dangerous surges in blood pressure. ...

Biosearch Italia completes enrollment for study of once-weekly Dalbavancin.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- Biosearch Italia SpA (BIO) announced that enrollment has been completed for a phase II clinical trial with Dalbavancin, for the treatment of complicated skin and soft tissue infections in hospitalized...

Favorable effect of Tegaserod in treating IBS with constipation.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- Zelnorm (tegaserod maleate), an investigational gastrointestinal serotonin receptor agonist (GI-SRA), was found to be well tolerated and significantly more effective than placebo at providing patients...

BioNumerik and Grelan present data on novel chemoprotecting agent.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- BioNumerik Pharmaceuticals, Inc., and Grelan Pharmaceutical Co., Ltd. announced results from a phase 1 clinical study of the novel investigational drug BNP7787 at the 38th Annual Meeting of the American...

Combination chemotherapy should be standard of care for lung cancer.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- Combination chemotherapy should be the standard treatment for patients with advanced non-small cell lung cancer, according to a study presented at the 38th annual meeting of the American Society of...

Genaera announces positive lung cancer clinical trial results for Squalamine.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- Genaera Corp. (GENR) announced positive final results for its antiangiogenic drug, squalamine, in its phase 2a non-small cell lung cancer (NSCLC) clinical trial. The multicenter open-label design...

Interim clinical data shows Onco TCS potential in lymphoma combination therapy.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- Inex Pharmaceuticals Corp. (INEX) presented interim results of an ongoing clinical trial at the annual meeting of the American Society of Clinical Oncology in Orlando, Florida, that demonstrate the...

Phase II combination trial for Endostatin begins.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- EntreMed, Inc., (ENMD), a biopharmaceutical leader in angiogenesis research and product development, began a phase II clinical trial with Endostatin for the treatment of stage IV metastatic melanoma,...

Endeavor Pharmaceuticals announces acceptance of NDA filing for Enjuvia.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- Endeavor Pharmaceuticals, Inc., announced that the U.S. Food and Drug Administration (FDA) accepted for review the company's new drug application (NDA) for Enjuvia tablets. Enjuvia has been developed...

Pivotal clinical study with platelet-derived growth factor initiated.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- BioMimetic Pharmaceuticals, Inc., (BMPI) and ZymoGenetics, Inc., (ZGEN) announced the initiation of human clinical studies with recombinant human platelet-derived growth factor (PDGF) for the treatment...

New palliative treatment now available.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- Atrix Laboratories, Inc., (ATRX) announced that Eligard 7.5 mg (leuprolide acetate for injectable suspension), the first of its new prostate cancer products which use the company's proprietary Atrigel...

Zometa effective for treating bone complications in prostate cancer patients.
July 5, 2002... 2002 JUL 5 - (NewsRx.com & NewsRx.net) -- The Novartis drug Zometa (zoledronic acid for injection) is effective for the treatment of potentially debilitating skeletal related events from bone metastases in prostate cancer patients, according to...

Two-drug therapy significantly delays progression of prostate enlargement.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- by Lynn Yoffee, senior medical writer - Researchers at the 97th annual scientific meeting of the American Urological Association (AUA) in Orlando, Florida presented news that two drugs commonly used to...

Novel vitamin E analog may be effective for treatment.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in Taiwan have identified a novel agent that shows promise for treatment of thrombosis. Dr. George Hsiao and colleagues working at Taipei...

Minority and HMO-insured patients poorly represented in HIV drug trials.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in California argue that participants in HIV clinical trials are not representiative of the population at large. "Although there is concern...

Phenprocoumon superior to acenocoumarol.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Phenprocoumon is a superior alternative to acenocoumarol for long-term oral anticoagulant therapy (OAT), researchers in the Netherlands argue. Dr. Alain...

Topical solution improves response in women.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- by Lynn Yoffee, senior medical writer - Women with female sexual arousal disorder (FSAD) showed increased subjective and objective sexual responses after using topical alprostadil solution, which...

Study suggests combination treatment.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- by Lynn Yoffee, senior medical writer - Combination chemotherapy with carboplatin plus paclitaxel increases response rates of non-small cell lung cancer (NSCLC) patients, helps more of them survive the...

Lopinavir can enhance safety, efficacy of antiretroviral regimens.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States say that a novel HIV protease inhibitor could make a valuable addition to antiretroviral drug regimens. Dr. Akhteruzzaman...

Neurobiological Technologies announces approval of memantine (Ebixa) in Europe.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- Neurobiological Technologies, Inc., (NTII) announced that memantine has been approved for the treatment of Alzheimer disease by the regulatory authorities in the European Union. "We are delighted...

Research shows promise for new class of anti-inflammatory drug.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- A new type of anti-inflammatory painkiller is showing promise in experiments on people with arthritis in their knees. Research presented at a conference in Stockholm indicated that the drug works...

Thousands of people at risk for drug complications.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- Thousands of people with arthritis are at risk from drug complications A new survey by Arthritis Care, the U.K.'s leading arthritis support group, has revealed that only 4% of U.K. general...

Medinox initiates phase I trial of MX-1094,.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- Medinox, Inc., announced the start of a phase I safety trial of MX-1094, an NSAID prodrug in development for the treatment of arthritis. The trial is being conducted in the Netherlands and is...

BPH trial verifies flomax (tamsulosin HCL) significantly improves patient 'quality of life' scores.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- New studies presented at the American Urological Association (AUA) annual meeting show that Flomax (tamsulosin HCL), the first selective alpha1A blocker treatment for benign prostate hyperplasia (BPH),...

Taxotere works against early breast cancer.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- by Lynn Yoffee, senior medical writer - A chemotherapy drug used to treat metastatic breast cancer significantly reduces the risk of recurrence and improves survival in women with early stage breast...

Genetic engineering could salvage once-promising anticancer agents.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- A group of anticancer agents that once produced dismal results in clinical trials could once again be a promising tool in fighting the deadly disease, thanks to research by a team of chemists at the...

Pilot study suggests potential of Campath to prevent another relapse in advanced CLL patients.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- A pilot study presented at the American Society of Clinical Oncology (ASCO) annual meeting by a team of medical professionals from Long Island Jewish Medical Center (LIJ) describes the successful...

Medinox initiates phase I trial of NOX-700.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- Medinox, Inc., announced the start of a phase I clinical trial of NOX-700, an orally active nitric oxide (NO) blocking agent in development for diabetes mellitus. The trial is being conducted in the...

American Pharmaceutical Partners launches pamidronate disodium in liquid form.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- American Pharmaceutical Partners (APPX) announced it has begun marketing and selling pamidronate disodium injection in 30 mg and 90 mg strength single-dose 10mL vials. Approval from the U.S. Food and...

Oral insulin candidate looks promising in early studies.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- by Lynn Yoffee, senior medical writer - Insulin delivery has always been a challenge for patients who struggle with painful injections every day. Of the more than 17 million Americans who have...

New therapy for 'black fever' is 95% effective.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- Scientists have developed a new treatment for the 500,000 people who develop visceral leishmaniasis each year, a disease also known as "black fever" and "kala azar." The new drug, miltefosine...

L.A.M.P. study reports improved survival with combined chemotherapy and radiation.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- The use of Taxol (paclitaxel) plus Paraplatin (carboplatin for injection) combined with radiation is producing promising results in late-stage lung cancer patients, according to a study presented...

ALR Technologies signs agreement with Macromed.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- ALR Technologies, Inc., (ALRT) has signed a business agreement with Macromed, a medical industry consulting/service company based in New York. Macromed provides consulting services to many of the...

Researchers make use of Botox for bladder dysfunction.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- by Lynn Yoffee, senior medical writer - Botulinum toxin A (Botox) injections are now being used successfully in patients to treat various lower urinary tract skeletal and smooth muscle dysfunctions...

Pemetrexed shows significant survival benefit in patients.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- by Lynn Yoffee, senior medical writer - Patients with pleural mesothelioma live longer and have less pain and shortness of breath if they receive the new chemotherapy drug pemetrexed (Alimta),...

FDA gives nod to Remodulin for PAH.
July 12, 2002... 2002 JUL 12 - (NewsRx.com & NewsRx.net) -- United Therapeutics Corp. (UTHR) announced that the U.S. Food and Drug Administration (FDA) has approved Remodulin (treprostinil sodium) Injection as a continuous subcutaneous infusion for the...

Caspase inhibitors may help eradicate viral reservoirs.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Agents that disrupt caspase signaling may be valuable for flushing out viral reservoirs in HIV patients with latent infection, researchers in Germany say. ...

New medication is effective in half of study patients.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- by Lynn Yoffee, senior medical writer - Researchers unveiled for the first time phase III data for a new treatment for stress urinary incontinence in a Late-Breaking Podium Session at the 97th annual...

Ritonavir can reduce Kaposi sarcoma risk.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - The antiretroviral agent ritonavir may help prevent the development of Kaposi sarcoma (KS) in HIV patients, researchers in the United States report. ...

STI571 reduces proliferative advantage of malignant progenitor cells.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States have shed new light on the mechanisms of a powerful and novel treatment for leukemia. "Imatinib mesylate (STI571) is a...

Mupirocin nasal ointment cuts infections in surgical patients at risk.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- A new study in the New England Journal of Medicine reports that use of mupirocin nasal ointment (Bactroban Nasal [mupirocin calcium]) in the noses of patients before surgery significantly reduces the...

TAP Pharmaceutical Products among first to adopt PhRMA marketing code of ethics.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- TAP Pharmaceutical Products, Inc., announced the adoption of the Pharmaceutical Research and Manufacturers of America's (PhRMA) Code on Interactions with Healthcare Professionals. The Code, which has...

Peroxisome proliferator-activated receptor (gamma) agonists show promise.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Agents which improve the function of peroxisome proliferator-activated receptor (gamma) (PPAR(gamma)) may be valuable for treating HIV infection, according to...

Unsuccessful antiretroviral therapy can lead to brain damage.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Unsuccessful antiretroviral therapy for HIV infection can trigger a severe neurological disorder, researchers in the United States warn. T. Dianne...

New low dose data presented for Paxil CR.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- Low dose (12.5 mg/day) controlled-release paroxetine (Paxil CR) was significantly superior to placebo in treating depression, according to data presented at the National Institute of Mental Health's...

New small molecule development program offered by MDS Pharma Services.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- MDS Pharma Services announced the introduction of its new Small Molecule Development Program aimed at providing high quality science in a timely fashion, while increasing efficiency and limiting the...

Plexxikon chooses Sun Microsystems to power innovative drug discovery platform.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- Sun Microsystems, Inc., (SUNW), and Plexxikon announced that Sun has been selected by Plexxikon as its strategic technology partner, providing the life sciences company with an end-to-end IT solution...

Phase II/III clinical trial of Neurodex completed.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- Avanir Pharmaceuticals (AVN) announced the completion of a phase II/III clinical trial investigating the safety and effectiveness of Neurodex in treating emotional lability in 116 patients with...

PCO's Eye Institute provides key research on delaying onset of glaucoma.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- The Eye Institute of the Pennsylvania College of Optometry (PCO) provided key research for a landmark study showing that eye drops used to treat elevated pressure inside the eye can be effective in...

Preliminary clinical trials encouraging for investigational therapy.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- Transkaryotic Therapies, Inc., (TKTX) announced that trial results show iduronate-2-sulfatase (I2S) to be generally well-tolerated and clinically active in patients with Hunter syndrome, also referred...

Medarex and IDM announce partnership to develop cell drugs.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- Medarex, Inc., (MEDX) and Immuno-Designed Molecules S.A. (IDM), have entered into a joint development and supply agreement for the use of Medarex's MDX-010, an anti-CTLA-4 blocking antibody, in...

Study supports IVF indication for Bravelle.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- According to a study published in the June issue of Fertility and Sterility, Bravelle (urofollitropin for injection, purified), a highly purified human-derived follicle-stimulating hormone (hFSH),...

Phase III trial of Neovastat set for 2003.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- At the annual general meeting of AEterna Laboratories, Inc., (AEL, AELA) Eric Dupont, chairman of the board and CEO, told the shareholders that "Our phase III clinical study of Neovastat in kidney...

Phase I/II clinical trial of CpG 7909 initiated.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- Coley Pharmaceutical Group, Inc., announced that it has initiated a phase I/II clinical trial of its lead product candidate, CpG 7909, as a monotherapy for the treatment of patients with stage IV...

Phase I/II clinical trial for gas-dispensed headache remedy completed.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- Capnia, Inc., announced that it has completed its phase I/II migraine headache clinical trial (double-blind, randomized, parallel- and crossover-controlled). Capnia has developed a revolutionary drug...

Licofelone could rival COX-2 inhibitors.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- The results of the first of the phase III trials for licofelone have shown comparable efficacy to conventional NSAIDs but with excellent gastrointestinal (GI) and general tolerability. These...

NPS update on Preos manufacturing.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- NPS Pharmaceuticals, Inc., (NPSP) provided additional information regarding the problem with the manufacture of clinical supplies of Preos, its proprietary drug candidate for the treatment of...

Phase III data for D2E7 (adalimumab) support promise.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- Results from phase III and ongoing clinical trials of Abbott Laboratories' investigational fully human monoclonal antibody, D2E7 (adalimumab), show a statistically significant reduction in the signs...

Enbrel treatment shows improvements in patient functionality.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- Immunex Corporation (IMNX) presented data on patients receiving Enbrel (etanercept) and experiencing improvement in physical functioning measurements as assessed by a validated health assessment...

Phase III clinical trial of Extina initiated.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- Connetics Corporation (CNCT), a specialty pharmaceutical company focused on the development and commercialization of dermatology products, announced the initiation of a phase III clinical study of...

Entropin reports additional Esterom discoveries, provides phase II/III clinical trial update.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- Entropin, Inc., (ETOP)(ETOPW), a specialty pharmaceutical company developing new topical therapeutics for painful soft tissue injuries and diseases, reported new mechanism of action discoveries for its...

Risk of development reduced in acarbose clinical trial.
July 19, 2002... 2002 JUL 19 - (NewsRx.com & NewsRx.net) -- Results from the Study to Prevent Non-Insulin Dependent Diabetes Mellitus (STOP-NIDDM), demonstrated that the use of acarbose (Precose, acarbose tablets) reduced the risk of developing type 2 diabetes...

Conserved staph protein may be therapeutic target in drug-resistant infections.
July 26, 2002... 2002 JUL 26 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States have identified a Staphylococcus aureus protein that may represent a therapeutic target in drug-resistant infections. ...

CYP26 mediates rapid ATRA tolerance.
July 26, 2002... 2002 JUL 26 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States may have identified the reason for the rapid development of tolerance to all-trans-retinoic acid (ATRA). This agent...

Isotretinoin has little impact on cervical cancer risk.
July 26, 2002... 2002 JUL 26 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - The retinoid isotretinoin offers little benefit to HIV[superscript]+ women with precancerous cervical lesions, researchers in the United States argue. ...

Researchers reveal how nitroglycerin works and why patients develop tolerance.
July 26, 2002... 2002 JUL 26 - (NewsRx.com & NewsRx.net) -- For more than 130 years, doctors have prescribed nitroglycerin for relief of chest pain without a clear knowledge of how it actually worked. Now, not only have researchers from Duke University Medical...

Antivascular agents effective in combination with other anticancer drugs.
July 26, 2002... 2002 JUL 26 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Drugs which target blood vessels providing tumors with needed nourishment work well in combination with conventional chemotherapy agents, researchers in the...

Exogenous melatonin protects peripheral blood cells.
July 26, 2002... 2002 JUL 26 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Melatonin could be useful for protecting peripheral blood cells from the damaging effects of radiation therapy, researchers in Turkey report. "Melatonin...

Interleukin-7 increases risk of naive T-cell infection.
July 26, 2002... 2002 JUL 26 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - The immunomodulatory cytokine interleukin (IL)-7 potentiates HIV infection of some cells thought to be safe from the virus, researchers in the United States...

P-glycoprotein inhibitors can increase antiretroviral CNS delivery.
July 26, 2002... 2002 JUL 26 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Agents that block the effects of P-glycoprotein can enhance the delivery of HIV drugs into the brain, researchers report. "Most of the existing anti-human...

Rapid viral resistance seen in response to fusion inhibitor treatment.
July 26, 2002... 2002 JUL 26 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - A novel and promising HIV inhibitor may be subject to rapid viral resistance when administered alone, researchers in the United States warn. "The...

Isis expands therapeutic potential of antisense technology to cardiovascular disease.
July 26, 2002... 2002 JUL 26 - (NewsRx.com & NewsRx.net) -- ISIS 147764, an antisense inhibitor of ApoB-100, normalized or lowered cholesterol levels in animal models of cardiovascular disease, according to data presented at the 11th International Congress on...