Drug Week articles from January 2004

Drug Week archives from January 2004

Higher dose of Gleevec leads to increased remission in CML patients.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Twice the standard daily dose of Gleevec results in a significantly higher response rate in treatment of chronic myeloid leukemia (CML), according to researchers at the University of Texas M.D. Anderson...

New drug may help cancer patients in need of stem cell transplants.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- A new drug may help patients restore their blood-forming system after high-dose chemotherapy, according to results from a clinical trial at the Kimmel Cancer Center at Thomas Jefferson University...

Docetaxel-based regimen improves survival and disease-free survival, data show.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- A docetaxel (Taxotere)-based regimen reduced the relative risk of death in women with early stage breast cancer by 30% and lowered the relative risk of the cancer returning by 28% when compared to a...

Safe and effective seizure treatment for elderly patients described.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- University of Miami researchers have found that the anti-epileptic drug (AED) Keppra (levetiracetam) controlled seizures and was well-tolerated by more than 70% of elderly patients with epilepsy...

Combination, order of anti-HIV drugs make a difference in first-time recipients.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- How anti-HIV drugs are combined and the order in which they are given are important factors to consider when designing treatment strategies for patients new to antiretroviral therapy, says a new study...

New drugs would help graft recipients with recurrent hepatitis C infection.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- New drugs would help liver graft recipients with recurrent hepatitis C infection. "Treatment responses are lower in immune compromised patients such as those with hepatitis C virus (HCV) disease...

MALDI-MS allows direct analysis of drug candidates in tissue.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Custom software was developed to facilitate the imaging of small molecules in tissue using the MALDI-QqTOF mass spectrometer, researchers report. According to recent research published in the...

Bill Gates foundation to give $25 million to southern Indian state.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- The Bill & Melinda Gates Foundation will give $25 million to a southern Indian state for AIDS prevention programs, state officials announced. The money will come from a $200 million grant pledged by...

Companies announce plans to fund HIV prevention and treatment programs in Africa.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Nine major international companies have initiated an effort to expand treatment and prevention programs for Africans with HIV, starting in some cases with their own employees. The companies will...

Pharmaceutical company and IBM collaborate to find cure for AIDS.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Locus Pharmaceuticals, a computational-based small molecule drug design and development company, announced a strategic collaboration with IBM's Deep Computing Capacity on Demand center to deploy...

Company launches primate studies in validation of viral immunotherapy platform.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Lipid Sciences, Inc., (LIPD) announced that with the recent completion of successful studies in a mouse animal model, it has achieved an important development milestone. Therefore, the company has...

Arbitrator: City council can't exclude voluntary procedure from health benefits.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Cincinnati, Ohio, must restore voluntary abortion coverage to city employee health benefits and reimburse any employee who has had an abortion since city council banned the coverage, an arbitrator...

Madison Keats to assist in identifying a licensing partner for PCL-016.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Novactyl, Inc., a biopharmaceutical company developing antiviral and antibacterial medicines, announced that it has engaged the investment banking firm of Madison Keats to assist in evaluating potential...

Gleevec shows promise in treating another form of leukemia.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Gleevec, which has produced striking results in patients with chronic myeloid leukemia (CML), is now demonstrating encouraging benefits in treating a different blood cancer, a type of acute lymphocytic...

TRAF6 has many essential functions spanning immune, bone, and nerve functions.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- TRAF6 has many essential functions spanning immune, bone, endocrine, and nerve functions. "Tumor necrosis factor (TNF) receptor associated factor 6 (TRAF6) is a crucial signaling molecule...

One in four companies less likely to hire a recovering addict.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Nearly one in four human resources (HR) professionals surveyed reveal that their companies are less likely to hire a job candidate if the person is in recovery from drug or alcohol addiction - even...

Low-calorie sweetener shipped commercially.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Spherix Incorporated (SPEX) has received its first commercial shipment of Naturlose, the firm's brand name for non-food uses of tagatose, its patented low-calorie sweetener. The initial order of...

Antiemetic improves control of chemotherapy-induced nausea, vomiting.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- A post-hoc analysis of two Phase III trials for Emend (aprepitant) showed that treatment with Emend in combination with a 5-HT3 receptor antagonist and a corticosteroid ("regimen with Emend ")...

Study probes drinking, brain tissue loss.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Low-to-moderate drinking may cause a loss of brain tissue in middle-aged people, a study found. The researchers also found that such alcohol consumption does not lower the risk of a stroke -...

Scientists identify molecular step that causes intoxication.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Scientists at the University of California San Francisco (UCSF) Ernest Gallo Clinic and Research Center have identified a single brain protein that can account for most of the intoxicating effects of...

Company discontinues development of Soltara brand allergic rhinitis treatment.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Sepracor Inc. (SEPR) has discontinued clinical development of Soltara brand tecastemizole for the treatment of allergic rhinitis. The U.S. Food and Drug Administration (FDA) issued a "not...

Polistes gallicus allergens have limited cross-reactivity with Vespids.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- The Polistes family of European and American wasp venoms have limited crossreactivity with Vespa wasp antigens; the finding may help improve diagnosis and therapy of patients sensitized by certain wasp...

Airborne substance makes asthmatics more sensitive to house dust mites.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Exposure to endotoxin, a bacterial substance found commonly in outdoor and indoor air, makes mite-allergic asthmatics more sensitive to house dust and may place them at increased risk of asthma attack....

Asthma, atopic dermatitis are strongly associated with an IL-13 polymorphism.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Allergic asthma, atopic dermatitis are strongly associated with Interleukin (IL)-13 promoter polymorphism designated IL-13-1024TT. According to recent research published in the European Journal of...

Atopic asthma in Italian families is not related to any IL4RA polymorphism.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Atopic asthma in Italian families is unrelated to any polymorphisms in the interleukin-4 receptor alpha gene. "The literature contains conflicting reports on the association of common variants of...

Chronic sinusitis is better understood, but therapeutic improvements are needed.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Chronic sinusitis is better understood, but therapeutic improvements are still needed. According to published research from Canada, "the development of chronic sinusitis is a complex multifactorial...

Skin testing strengths and weaknesses should be known before allergy diagnosis.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Doctors should know the range of available diagnostic skin tests for allergies, as well as strengths, weaknesses. "Practitioners who treat allergic patients must be familiar with the tests that are...

Wasp venom immunotherapy may work by increasing allergic patient CD86, IL-10.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Wasp venom immunotherapy may work by increasing CD86 and IL-10 in allergic patients. According to published research from Japan, "several studies have provided evidence that activation of...

"Metal-chelation" therapy may be helpful in Alzheimer patients.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- A preliminary study suggests that a novel therapy may help improve cognitive functioning in patients with Alzheimer disease by lowering levels of a protein that is involved in the development of the...

Alzheimer brain histology shows increased base excision repair enzyme Ref-1.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- In postmortem Alzheimer brains, Ku DNA binding to protein kinase is the same as controls, but base excision repair enzyme Ref-1 is upregulated. According to a study from the United States,...

Alzheimer patients have some decreased cytokine responses as disease progresses.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Alzheimer patients' PBMCs release lower amounts of some cytokines in response to LPS as AD severity progresses. "Various studies suggested that inflammation is involved in the pathogenesis of...

Canada approves start of human safety testing for GT 1061.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Anthony Giovinazzo, president and CEO of GB Therapeutics, Ltd., (GBt), announced that the Canadian Therapeutics Products Directorate has given approval for GBt to proceed with GT 1061 in a phase Ia...

Company presents animal data for antibodies to treat AD.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- MorphoSys, AG, (MOR) presented successful in vivo results of their collaboration with Roche regarding Alzheimer disease at the 33rd annual meeting of the Society for Neuroscience in New Orleans,...

LSU Health Sciences Center initiates clinical trial of COGNIShunt System.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Eunoe, Inc., announced the initiation of a clinical trial at Louisiana State University Health Sciences Center in Shreveport, Louisiana, to investigate the use of its COGNIShunt System in Alzheimer...

NSAIDS, PPAR-gamma agonists lower beta-secretase, amyloid precursor deposition.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Nonsteroidal anti-inflammatory drugs (NSAIDS), PPAR-gamma agonists lower beta-secretase, amyloid precursor protein (APP) deposition; thus slow Alzheimer disease (AD). According to published...

Proinflammatory cytokine interleukin-1B polymorphisms affects age of onset of AD.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Proinflammatory cytokine interleukin-1B polymorphisms affects age of onset of Alzheimer disease (AD) also, similar to IL-1alpha genes. "Interleukin-1alpha (IL-1alpha) and IL-beta are 2...

Researchers identify key enzyme involved in cell death.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Targacept, Inc., announced research results that identify a key enzyme implicated in cell death and are expected to have therapeutic application in a variety of neurodegenerative disorders such as...

Small company grows on success of transmitters for AD.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- The two old barns that house manufacturer Wildlife Materials, Inc., in a patch of woods near Carbondale, Illinois, are nothing much to look at. The sign out front looks homemade and the only guards...

Twin study finds genes are less significant than previously thought.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Genetic factors contribute to Alzheimer disease that appears after age 80, but half or more of the susceptibility can be attributed to factors other than genes, according to a new study y. The...

Stroke may increase risk of AD.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- People who have had a stroke are at an increased risk for developing Alzheimer disease (AD), especially if they also have cardiovascular disease, according to a new study. Alzheimer disease and...

FGF-2 levels are higher in serum and present in CSF of ALS patients.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Fibroblast growth factor 2 (FGF-2) levels are higher in serum and present in CSF of amyotrophic lateral sclerosis (ALS) patients; levels do not correspond with a specific disease state. "Lack of...

Standardized testing of muscle strength in ALS may help improve treatment.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- A recent study establishes an easy-to-use and uniform testing method for amytrophic lateral sclerosis (ALS), according to Dr. Eric J. Sorenson, assistant professor of neurology at the Mayo Clinic...

Testosterone therapy gaining advocates despite risks.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Still a young man in his mid-40s, Tom got up every day, went to work and came home exhausted, where he spent most nights in front of the TV. But what really bothered him was that he'd lost interest...

Late-life anemia identifies people at risk for mortality and hospitalization.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Anemia is common in old age and has been shown to affect the physical function of elderly adults. Researchers from Wake Forest University School of Medicine, Winston-Salem, North Carolina,...

Anaphylaxis is a dangerous risk in surgical patients undergoing anesthesia.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Anaphylaxis is one of the most dangerous risks in surgical patients undergoing anesthesia; muscle relaxants or latex are the most common triggers. "Anesthesiologists use a myriad of drugs during the...

Skin anesthesia achieved in 5 minutes with help of skin permeation device.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Sontra Medical Corporation (SONT) announced the completion of a phase III clinical study demonstrating that skin anesthesia from topical 4% lidocaine was achieved in 5 minutes following treatment with...

Data support durability endoluminal stent graft.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Endologix, Inc., (ELGX) announced that follow-up findings from a phase II study of the company's PowerLink endoluminal stent graft (ELG) for the treatment of abdominal aortic aneurysm (AAA) lends...

Bone marrow endothelial cells produce some SDF-1 in culture, also CXCR4 in vivo.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Bone marrow endothelial cells (BMECs) produce some stromal cell-derived factor-1 (SDF-1) in culture and will also produce CXCR4 in vivo. According to a study from South Korea, "this study...

Hypoxic myocytes produce growth factor that stimulates COX-2 production.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Hypoxic myocytes produce growth factor that stimulates COX-2 production. According to published research from the United States, "there is increasing evidence that cyclooxygenase (COX)-2 possess...

JAML protein expressed in leukemia, leukocytes enhances adhesion to endothelials.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Junctional adhesion molecule-like (JAML) protein expressed in leukemia and leukocytes is at plasma membrane cell contacts and enhances adhesion to endothelials; it may be involved in transmigration. ...

Knowledge of how hypoxia controls tumor angiogenesis should fuel new therapy.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Knowledge of how hypoxia controls tumor angiogenesis should fuel new therapy. According to recent research published in the journal Cell and Tissue Research, "the mechanisms by which tumors recruit...

Antibodies may provide option to vaccines, antibiotics.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Avanir Pharmaceuticals (AVN) presented positive new data on its panel of human antibodies against the key toxin of the Class A biowarfare agent anthrax at the IBC Antibody Engineering Meeting held in...

New weapon developed to combat resistant bacteria.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- The problem of hospital infection, a severe disease caused by antibiotic-resistant Staphylococcus bacteria, entails major costs and great suffering. Group A Streptococcus bacteria, also called...

Triclosan: The next new drug?
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- The antibacterial compound triclosan, used in dermatological and oral hygiene products as well as antibacterial soaps and cleaner, shows promise as a drug for treating systemic bacterial infections, say...

Triptonide biotransformation by Aspergillus niger yields less active drugs.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Triptonide biotransformation by Aspergillus niger yields less active drugs. "The diterpenoid triepoxides are the major active constituents of Tripterygium wilfordii, with potent antitumor and immune...

Tumor-up-regulated cytochrome P4501B1 enzyme can be targeted by cytotoxic T cells.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Cytochrome P4501B1, up-regulated in tumors to metabolize drugs, can be targeted by specific cytotoxic T cells. According to a study from Germany, "cytochrome P450 1B1 (CYP1B1), a drug-metabolizing...

The mevalonate synthesis pathway is a potential therapeutic target in cancer.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- New research highlights the mevalonate synthesis pathway as a target for anticancer therapies and suggest a greater role for geranylgeranylated proteins in cellular processes germane to cancer. ...

The immunoproteasome produces better MHC antigens than constitutive proteasome.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- The immunoproteasome produces better MHC antigens than the constitutive proteasome can. "Intracellular proteins are degraded largely by proteasomes. In cells stimulated with IFNgamma, the active...

Strawberry extract alters proliferation of HepG[subscript]2 human liver cancer in vivo.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Exposure to all strawberry cultivar extracts significantly inhibited the proliferation of HepG[subscript]2 human liver cancer cells, researchers report. "Strawberries contain high levels of...

Neomycin inhibits activation of cyclin D1; is antiproliferative to glioma cells.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Neomycin inhibits activation of cyclin D1; is antiproliferative to glioma cells in culture. "The progression of mammalian cells through G[subscript]1 phase of the cell cycle is governed by the...

Newly identified VE-statin inhibits smooth muscle cell migration.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Newly identified VE-statin inhibits smooth muscle cell migration. "The recruitment and proliferation of smooth muscle cells and pericytes are two key events for the stabilization of newly formed...

Asthmatic Caucasian children don't have an associated CD14 promoter polymorphism.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Asthmatic Caucasian children don't have an associated CD14 promoter polymorphism. According to a study from Germany, "several studies have investigated the association of a promoter polymorphism in...

Drug delivery company enters the dry powder inhalation - asthma market.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Inyx, Inc., (IYXI), a developer and manufacturer of specialized drug delivery pharmaceutical products with expertise in niche aerosol technologies, announced that its operating subsidiary, INyX Phama,...

Evidence-based conclusions on inhaled steroid treatment presented.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Inhaled corticosteroid (ICS) therapy remains the gold standard of asthma treatment, according to findings from a systematic evidence review released by the American College of Chest Physicians (ACCP),...

Novartis, SkyePharma plan new product for treatment of asthma and COPD.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- SkyePharma PLC (SKYE) announced an agreement with Novartis Pharma AG to jointly develop a new product for the treatment of asthma and chronic obstructive pulmonary disease (COPD). The product will...

Once-daily beta[subscript]2 agonists in development for asthma and COPD.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Theravance, Inc., announced that the lead compounds in its alliance with GlaxoSmithKline (GSK) to identify new long-acting, beta[subscript]2-agonists (LABAs) for the treatment of respiratory diseases,...

Xopenex Metered-Dose Inhaler well tolerated in phase III trials.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Sepracor Inc. (SEPR) announced results from its phase III clinical program of the Xopenex (levalbuterol tartrate) hydrofluoroalkane (HFA) metered-dose inhaler (MDI). In each of the three,...

Geldanamycin protects astrocytes from death, is involved in HSP70 up-regulation.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- In an oxygen-glucose deprivation model for stroke, geldanamycin protects astrocytes from death, most probably by induction of heat shock protein 70. According to a study from the United States,...

First phase II clinical trial of dermatology drug, NPI 32101, begins.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- NUCRYST Pharmaceuticals Corp., a subsidiary of The Westaim Corp., has begun its first phase II human clinical trial of a topical cream formulation of its nanocrystalline silver. The investigational...

CD8+ T cells, including CMV-specific ones, are altered in Wegener granulomatosis.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- All CD8+ T cells, including those specific for CMV, have altered phenotypes in Wegener granulomatosis (WG). According to recent research from Germany, "WG is an autoimmune disease of as yet unknown...

Pediatric mononeuritis multiplex can occur with vasculitis, autoimmune disease.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Pediatric mononeuritis multiplex is a rare nerve disease that can occur with vasculitis in autoimmune disease. "Mononeuritis multiplex results from disease processes causing multifocal injury to...

American Society of Hematology honors prominent researchers.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- The American Society of Hematology has announced the winners of two of the Society's highest honors. The William Dameshek Prize, endowed by the late Dr. William Dameshek, a past president of the...

ERIC-PCR genotype results may not be suitable for large-scale computer analysis.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- ERIC-PCR genotype results may not be suitable for large-scale computer analysis. In a recent study, scientists in the United States "analyzed a large collection of Escherichia coli isolates typed by...

Finger-stick test for Helicobacter pylori now available.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- York Nutritional Laboratories has introduced a simple, unique and revolutionary finger-stick test kit designed to detect whether Helicobacter pylori (H. pylori), a small spiral-shaped bacterium, is...

Extrahepatic biliary atresia diagnosis is aided by bile duct CD56 reactivity.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Extrahepatic biliary atresia can be distinguished from other liver diseases by strongly positive reactivity of bile ducts to CD56. "The diagnosis of extrahepatic biliary atresia can be challenging,...

Low-dose Imantinib with 5-FU holds potential for biliary tract cancers.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Imatinib (Glivec) alone exerts marked effects on c-kit+ biliary tract cancer cell lines only at intermediate and high concentrations, but there is a potential role of low-dose imatinib in combination...

NSAIDs may help prevent pancreaticobiliary maljunction carcinogenesis.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- COX-2 inhibitors such as NSAIDs may play an important role in preventing pancreaticobiliary maljunction (PBM) carcinogenesis, researchers report. According to recent research from Japan,...

The Th1/Tc1 circuit can produce tumor-specific CTL, even though Th2 can kill.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- The Th1/Tc1 cell therapy circuit produces tumor-specific CTL producing IFNgamma, even though Th2 cell therapy can kill and produce IL-4. "Th1 and Th2 cells obtained from OVA-specific T cell receptor...

Novel artificial myocardium system under development.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- A novel artificial myocardium system is currently under development. "Where is the place which should be helped in a patient with congestive heart failure? The answer may be contraction of the...

RODS surveillance system effective at 2002 Winter Olympics.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- The hastily designed RODS infectious disease surveillance system was effective during its debut at the Winter Olympics in Salt Lake City. "The 2002 Olympic Winter Games were held in Utah from...

FDA approves Risperdal as monotherapy or in combination with lithium, valproate.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- The U.S. Food and Drug Administration (FDA) has approved Risperdal (risperidone) as monotherapy (alone) or in combination with lithium or valproate for the short-term treatment of acute manic or mixed...

CD40 ligand immunogene therapy protects against bladder malignancies.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- CD40 ligand immunogene therapy protects against bladder malignancies. According to a study from Japan, "the interaction between CD40 ligand (CD40L) and CD40 on antigen-presenting cells is essential...

Few bladder cancer markers exist, new tissue analysis methods may help ID more.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- To date, only a few bladder cancer markers have been studied. But new tissue analysis techniques, including array testing, may help reveal further therapeutic markers. "With 15000 new cases each...

Online bladder cancer information often outdated.
January 2, 2004... 2004 JAN 2 - (NewsRx.com & NewsRx.net) -- Unlike more common cancers like breast cancer, prostate cancer or melanoma, few people understand the basic facts about what causes bladder cancer and how it is treated. So when patients are diagnosed...