Drug Week articles from February 2004

Drug Week archives from February 2004

Sequence motif crucial for binding adenosyl derivatives.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- CBS domains were originally identified as sequence motifs occurring within cystathione beta-synthase (CBS) and several other proteins, and they occur in all organisms from bacteria to humans. While...

MRP3 linked to drug resistance in pediatric ALL.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- The MRP3 protein appears to contribute to drug resistance in pediatric ALL. According to a study from Germany, "The family of multidrug resistance-associated proteins (MRPs) belongs to the...

Company reports positive phase III studies of Namenda.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Forest Laboratories, Inc., (FRX) announced that results of a U.S. phase III study of Namenda (memantine HCl) as monotherapy in mild-to-moderate Alzheimer disease show that the drug demonstrated a...

Cancer researchers unlock secrets of how tumors hide.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Researchers at the H. Lee Moffitt Cancer Center & Research Institute have unlocked at least part of the mystery of how tumors flourish undetected by keeping their presence a secret from the sentries of...

Fludarabine-based regimens are effective but toxic in elderly patients with CLL.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Reducing fludarbine and using myeloid growth factors and antibiotics are necessary to maintain quality of life in elderly patients with chronic lymphocytic leukemia (CLL). According to recent...

IND filed to initiate human trials of ThermoDox.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Celsion Corp. (CLN) announced plans to undertake human clinical trials to treat liver cancer. On December 22, 2003, Celsion filed an investigational new drug application (IND) with the U.S. Food...

Inhibition of SARS coronavirus with Neugene antisense drugs reported.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- AVI BioPharma, Inc., (AVII) presented confirmatory positive results on the inhibition of the SARS coronavirus using its Neugene antisense drugs. Michael Buchmeier, PhD, of The Scripps Research...

Partnership extended with vaccine research groups.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Targeted Genetics Corporation (TGEN) announced a 3-year extension of its collaboration agreement with the International AIDS Vaccine Initiative (IAVI) and Columbus Children's Research Institute (CCRI)...

Company submits Powerlink PMA to the FDA.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Endologix, Inc., (ELGX) announced that it has filed its completed premarket approval (PMA) submission with the U.S. Food and Drug Administration (FDA) for the PowerLink System, an endoluminal stent...

Atrisone completes pivotal phase III studies.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Atrix Laboratories, Inc., (ATRX) announced that the company's proprietary acne drug, Atrisone (5% topical dapsone gel) has successfully completed two pivotal phase III clinical efficacy studies. ...

Patient enrollment completed in trials for Velac gel.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Connetics Corporation (CNCT), a specialty pharmaceutical company focused on the development and commercialization of dermatology products, announced that it has completed enrollment in its two phase III...

Analysis of CD8+ T-cell response after adenovirus vaccination presented.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Scientists provide a detailed analysis of the CD8+ T-cell response following adenovirus vaccination in a recent issue of the Journal of Virology. According to a study from Canada, "We examined CD8+...

Life satisfaction and suicide among high school adolescents explored.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Investigators explored the relation between life satisfaction and suicide among high school adolescents in a recent issue of the journal Social Indicators Research. According to recent research...

Study looks at teens' use of contraceptives in first relationship.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Among teens who have sex, what influences decision-making about using contraceptives during their first sexual relationship? Being in a longer relationship? Having an older partner? Virginity pledges?...

Fluconazole induces torsades de pointes in intensive care unit patient.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Fluconazole and levofloxacin induced torsades de pointes in an intensive care unit patient. According to a study from the United States, " Patients initiated on fluconazole and levofloxacin should...

Inorganic arsenic therapies may have toxic side effects.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Inorganic arsenic therapies may have toxic side effects. According to published research from the United States, "trivalent inorganic arsenic (arsenite, arsenic trioxide, As (III) is currently...

Lamivudine prevents rituximab-induced hepatitis B virus reactivation.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Lamivudine prevents rituximab-induced hepatitis B virus reactivation. According to researchers in Japan, "we used regimens containing rituximab in the treatment of five hepatitis B virus surface...

Steatohepatitis and excessive weight-gain complicate risperidone therapy.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Steatohepatitis and excessive weight-gain complicate risperidone therapy. "We report on a 17-year-old girl who developed steatohepatitis and marked weight gain during risperidone treatment for...

Medicis announces first shipment of RESTYLANE to physicians.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Medicis (MRX) has made its first shipment of RESTYLANE to physicians. Each initial order includes a comprehensive training disk that is designed to assist physicians with procedure techniques. ...

Adolescent rodents experience milder hangover effects than do adult rodents.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Many people begin to experiment with alcohol use during adolescence, yet relatively little is known about alcohol's effects during this critical stage of development. A study in Alcoholism:...

Genetic variation may influence drinking to relieve social anxiety, improve mood.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Alcohol researchers already know that people who expect positive results from drinking - a better mood or social ease - are more likely than other drinkers to develop alcohol problems. Conversely, those...

Cilomilast modifies dendritic cell migration through skin.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Cilomilast modifies the dendritic cell migration through skin. According to a study from Germany, "The phosphodiesterase 4 inhibitor cilomilast demonstrated strong inhibitory effects in a model of...

The bronchovideoscope detects increased vessel growth in new asthma patients.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- The bronchovideoscope detects increased vessel growth in new asthma patients. "Hypervascularity in the bronchial wall is part of airway remodeling, but has remained an ill-defined process in asthma...

New drug improves outcomes when added to existing therapy for AD.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- The drug memantine lessens the decline in cognition and activities of daily living for patients with moderate to severe Alzheimer disease (AD) who are also receiving donepezil (another drug used to...

Understanding normal aging may provide the key to AD prevention.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Our improved understanding of how to maintain normal brain health is providing tantalizing clues about what may prevent or reduce the likelihood of developing Alzheimer disease (AD), according to...

Using vitamin E and C supplements together may reduce AD risk.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Elderly people who take individual vitamin E and C supplements together may reduce their risk of Alzheimer disease (AD), according to a new report. The public health threat of AD will continue to...

Hemopure regulatory status updated following FDA meeting.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Biopure Corporation (BPUR) reported that, on January 6, 2004, the company and the U.S. Food and Drug Administration (FDA) met at Biopure's request to discuss its reply to the FDA complete response...

Medication reduces angina attacks, increases exercise capacity for patients.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Taken with other anti-anginal medications, the drug ranolazine reduces the frequency of angina and increases exercise capacity in patients with severe chronic angina, according to a new study. ...

Estrogen protects cells from certain death after an ischemic stroke.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Estrogen protects cells from certain death after an ischemic stroke. "Estradiol is a known neurotrophic and neuroprotective factor. Our previous work demonstrated that replacement with physiological...

Tryptophanyl-tRNA synthetase fragments control response to shear stress.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Tryptophanyl-tRNA synthetase fragments control response to shear stress. According to recent research from the United States, "human tryptophanyl-tRNA synthetase (TrpRS) is active in translation and...

Subcontract given to develop anthrax vaccines using nanotechnology.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- BioSante Pharmaceuticals, Inc., (BPA) announced that it has been awarded a subcontract valued at $658,207 for the development of anthrax vaccines for delivery via alternative routes of administration....

Prostaglandin may worsen lung injury induced by lipopolysaccharide.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- 15-Deoxy-Delta[superscript]12,14-prostaglandin J[subscript]2 may exacerbate acute lung injury induced by lipopolysaccharide in mice. According to recent research published in the European Journal of...

Reversible anosmia reported after amikacin therapy.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Reversible anosmia is possible after amikacin therapy. "Olfactory disorders are among the rare adverse effects of antibiotic therapy," scientists in Switzerland explained. "To date, olfactory...

Cisplatin does not directly effect mitochondrial oxygen consumption.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Study finds that exposures to alkylating agents and anthracyclines produce immediate and dose-dependent impairment of mitochondrial oxygen consumption. According to recent research published in the...

ABC multidrug efflux pump identified in Enterococcus faecalis.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- An ABC multidrug efflux pump, EfrAB, has been identified in Enterococcus faecalis. According to recent research published in the journal Antimicrobial Agents and Chemotherapy, "A DNA fragment...

HSCT safe and effective for Taiwanese SAA patients.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Hematopoietic stem-cell transplantation is safe and effective for Taiwanese SAA patients. According to research from Taiwan, HSCT "is an accepted treatment strategy for patients with severe...

Th1 polarization underlies hematopoietic dysfunction in AAA patients.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Th1 polarization underlies hematopoietic dysfunction in AAA patients. "Immune dysfunction, which leads to the suppression of hemopoiesis by cytokines that are secreted by activated T lymphocytes,...

Improved insulin sensitivity seen in sleep apnea patients.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Investigators from Friedrich-Alexander University, Erlangen, Germany, have demonstrated that continuous positive airway pressure (CPAP) treatment rapidly improves insulin sensitivity in patients with...

Lecithins and bile salts inhibit apoptosis in mouse cholangiocytes.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Lecithins and cytoprotective bile salts inhibit bile salt-induced apoptosis in immortalized mouse cholangiocytes. "Bile duct epithelium is physiologically exposed to high concentrations of bile...

Ethnicity may affect allergies in children with asthma.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Puerto Rican and African American children with asthma may be at risk for multiple indoor and outdoor allergies, says a new study. The study found that Puerto Rican children with asthma were up to...

Apolipoprotein-E-deficient mice resistant to atherosclerosis.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Mice deficient in apolipoprotein E but not LDL receptors are resistant to accelerated atherosclerosis associated with obesity. "The aims of this study were to determine whether mice induced to...

Benefits of niacin treatment reviewed.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- The oft-overlooked cardiovascular benefits of niacin have been reviewed. "Cardiovascular event reduction in hypercholesterolemic subjects appropriately emphasizes the prominent role of statin...

Redundancy defines complex nature of cytokines and autoimmunity.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Redundancy defines the complex nature of cytokines and autoimmunity. According to recent research published in the journal Current Opinion in Immunology, "Cytokines are critical mediators in...

Women with systemic lupus erythematosus are at risk for losing bone density.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Women with systemic lupus erythematosus are at risk for losing bone density. According to recent research from Bulgaria, "the aim of this study was to analyze the heterogeneity of bone mineral...

Oxford bioincubator wins international recognition.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- The highly successful bioincubator, the Oxford BioBusiness Center, has won the prestigious international award Best Science-Based Incubator 2003. The annual conference Best Practice in Science-Based...

Wang recognized for contributions to molecular biology.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Dr. Xiaodong Wang, professor of biochemistry at the University of Texas (UT) Southwestern Medical Center at Dallas, has been awarded the prestigious National Academy of Sciences Award in Molecular...

Amino acid sequences of subtilisin from alkaliphilic Bacillus reported.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Researchers have published the nucleotide and deduced amino acid sequences of a high-molecular-mass subtilisin from an alkaliphilic Bacillus isolate in a recent issue of Biochimica et Biophysica Acta -...

TetL tetracycline efflux protein from Bacillus subtilis is dimer in membrane.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- The TetL tetracycline efflux protein from Bacillus subtilis is a dimer in the membrane and in detergent solution. According to recent research published in the journal Biochemistry, "The TetL...

EpiCept provides update on two deals made in 2003.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- EpiCept Corp., a privately held specialty pharmaceutical company, reported that two corporate deals completed in 2003 have the potential, if certain conditions are met, to generate in excess of $100...

A new computer model simulates the mechanics of bone turnover at menopause.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- A new computer model simulates the mechanics of bone turnover at menopause. "Antiresorptive drugs are widely used to prevent osteoporotic fractures in men and women. Large clinical trials have shown...

CD105/endoglin is a marker for endometrial cancer angiogenesis.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- CD105/endoglin is a marker for endometrial cancer angiogenesis. "Angiogenesis is a key process in tumor growth and metastasis, and factor-VIII microvascular density has been found to influence...

Bipolar I disorder biobank collection launched.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- PrecisionMed Inc. announced the launch of its new PrecisionMed Sample Bank collection of DNA, RNA, plasma, serum and urine from 200 subjects with bipolar I disorder and 200 matched controls. This...

Women reminded of folic acid's benefits in preventing birth defects.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Pennsylvania Health Secretary Dr. Calvin B. Johnson reminded all women of child-bearing age of the importance of folic acid and its role in preventing neural tube birth defects (NTDs), which are defects...

Karyometry can detect abnormalities in normal urothelium near carcinoma.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Study finds that karyometry can detect an abnormal chromatin pattern and distribution in the normal-looking urothelium adjacent to papillary carcinoma. According to a study from Italy, "This study...

$1.1M contract awarded to study counter-bioterrorism vaccine.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Covalent Group, Inc., (CVGR) announced that it has signed a new contract with DynPort Vaccine Company, LLC, (DVC) for a phase I study in the development of a recombinant vaccine designed to provide...

Gliadel prolongs survival and time to relapse in some glioma patients.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Study finds that Gliadel improves survival and time to relapse, and that possibly expanding the indications for its use should be investigated. According to recent research from Scotland, "The...

Idarubicin unlikely to be used for treating primary CNS tumors.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Study results indicate that it is unlikely that Idarubicin (IDA), daunomycin, or other related anthracyclines will be useful for treating primary CNS tumors," researchers say. "IDA, the 4-demethoxy...

Anthracyclines activate antiapoptotic phosphorylation in breast cancer.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Studies support the ability of anthracyclines to activate antiapoptotic p44/42-MAPK phosphorylation in breast cancer, possibly via the novel mechanism of repression of MKP-1 transcription. ...

Beta[subscript]3 integrin expression can lead to increased tumor cell aggressiveness.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Study suggest that increased expression of the alpha[subscript]vbeta[subscript]3 integrin during breast cancer progression can result in increased tumor cell aggressiveness. "Osteopontin (OPN) is a...

Breast cancer resistance protein is a MTX and MTX-polyglutamate transporter.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Study data show that that breast cancer resistance protein (BCRP) is a methotrexate (MTX) and MTX-polyglutamate transporter and reveal a possible mechanism by which it confers resistance. According...

NSAIDs may have chemopreventive effect against breast cancer.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Preliminary results from the Women's Health Initiative (WHI) indicate that regular use of aspirin, ibuprofen, or other NSAIDs may have a significant chemopreventive effect against breast cancer. ...

Nematode finding could shed light on BRCA1-involved cancers.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Our common evolutionary heritage with the humble nematode worm is helping unravel one of the key genetic puzzles in breast cancer. For the first time, Cancer Research UK researchers have found a...

P1 homozygosity may be a potential risk factor in breast carcinogenesis.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Research suggests that P1 homozygosity could possibly be a risk factor in breast carcinogenesis. According to a study from Greece, "H-ras is a member of the ras superfamily of genes. This gene...

Risk differs among specific ethnic subgroups of South Asian women in U.K.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Cancer Research UK scientists have discovered that the risk of breast cancer among South Asian women in Britain differs according to their specific ethnic subgroup. Published in the January 6,...

Sequential drugs followed by TRAIL may be a new therapeutic approach for cancer.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Researchers report that sequential administration of chemotherapeutic drugs followed by TRAIL may be an effective new therapy for cancer. "According to published research from the United States,...

Side effects make physicians, patients reluctant to use tamoxifen for DCIS.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Physicians and patients alike are reluctant to use tamoxifen, an adjuvant therapy in the treatment of the very earliest form of breast cancer - ductal carcinoma in situ (DCIS) - because of its side...

Steroid hormone-resistant breast cancer can be sensitive to growth factors.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Researchers establish numerous regulatory links between signal transduction pathways elicited by peptide growth factors and progesterone receptors (PR). "Breast cancers often have increased...

Underarm cosmetics with estrogen may contribute to breast cancer.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Further work is needed to determine whether the use of underarm cosmetics (particularly containing estrogenic formulants) contributes to the rising incidence of breast cancer. "A recent review by...

Kahalalide F preferentially induces cell death via oncosis in tumor cells.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Study show that Kahalalide F (KF) induces cell death via oncosis preferentially in human and prostate cancer cell lines. According to a study from Spain, "Kahalalide F is a novel antitumor drug of...

Pharmaceutical distribution contract renewal announced.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Healthcare services company McKesson Corporation (NYSE:MCK) has signed a 5-year pharmaceutical distribution contract renewal with prescription benefit manager Caremark Rx, Inc. The agreement calls...

Prescription benefits manager cleared for military contract.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Congressional investigators cleared the way for a $245 million U.S. military contract with Missouri-based Express Scripts Inc. Express Scripts is the third-largest manager of prescription drug...

Retail chain drops three pharmacy benefit plans.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- CVS Corp. said January 9, 2004, it will not participate in three pharmacy benefit plans administered by National Medical Health Card Systems Inc. because those plans require that patients fill...

Type 1 diabetes increases cancer risk.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- A population-based cohort study in Sweden revealed that type 1 diabetes increases the risk of several types of cancer. According to recent research from Sweden, "Although patients with type 2...

Canstatin-N fragment stops endothelial cell proliferation and tumor growth.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Canstatin-N fragment stops endothelial cell proliferation and tumor growth. "Type IV collagen is one of the components of vascular basement involved in regulation of angiogenesis. Canstatin, the...

Computerized clinical reminders are helpful for physician prescribing behavior.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Study finds that clinical reminders to physicians helped patients receive treatment with erythropoietin. "The objective of this study is to examine the impact of a clinical reminder generated by an...

Data shows CF101 to be effective in restraining growth of certain cancers.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Can-Fite BioPharma announced new preclinical study results, published in three peer reviewed, high score scientific journals: the Journal of Biological Chemistry, the British Journal of Cancer, and...

Enrollment complete for phase II clinical study in non-Hodgkin lymphoma.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Favrille, Inc., has completed enrollment for its current phase II clinical trial (FavId-04) with the company's lead investigational agent, FavId. This agent is under clinical development for the...

FLAG[+ or -]Ida suitable for induction chemo in high-risk leukemia, MDS patients.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- FLAG[+ or -]Ida is safe and effective as induction chemotherapy in high-risk leukemia and MDS patients. According to recent research from England, "The combination of fludarabine (FDR), high dose...

Fusion proteins steer tumor necrosis factor-alpha to tumor blood vessels.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Fusion proteins steer tumor necrosis factor-alpha to tumor blood vessels. According to researchers writing in the journal Blood, "we sought to enhance the selective toxicity of tumor necrosis factor...

Granulocyte colony-stimulating factor reduces complications in elderly patients.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Further research studies are needed to identify the elderly patients who will benefit most from prophylactic granulocyte colony-stimulating factor (G-CSF). "According to recent research from Italy,...

Standard chemotherapies target specific sectors of the angiogenic cascade.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Standard chemotherapies target specific sectors of the angiogenic cascade. According to a study from Sweden, "tumors are angiogenesis dependent. Some chemotherapeutics have been shown to be able to...

Tumor cells plus adjuvant induced immunity against hepatoma.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Fixed tumor cells in combination with adjuvant induced protective antitumor immunity in a murine hepatoma model. According to recent research published in the journal Cancer Letters, "We previously...

Arsenic accumulates in mouse organs after repeated oral exposure.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Murine study finds that tissue accumulation of arsenic after repeated oral exposure to arsenate in the mouse corresponds to the known human target organs for arsenate-induced carcinogenicity. ...

Arsenite boosts the expression of proliferation factors in prostate cancer cells.
February 6, 2004... 2004 FEB 6 - (NewsRx.com & NewsRx.net) -- Arsenite boosts the expression of proliferation factors in prostate cancer cells. According to recent research published in the journal Molecular and Cellular Biochemistry, "arsenite is ubiquitous...