Drug Week articles from December 2004

Drug Week archives from December 2004

U.S. FDA approves Evoclin for treating acne.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Connetics Corp. (CNCT), a specialty-pharmaceutical company that develops and commercializes dermatology products, announced that the U.S. Food and Drug Administration (FDA) has approved Evoclin...

Data show FG-3019 improves kidney function in late-stage disease model.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- FibroGen, Inc., announced that FG-3019, the company's lead investigational antifibrotic agent, significantly improved glomerular filtration rate (a measure of kidney function) and reduced proteinuria...

Drug combination shows promise in treating hepatitis C.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Interim study results indicate a certain drug combination treatment may suppress the hepatitis C virus more quickly than another. Researchers at Saint Louis University School of Medicine and six...

NDA submitted immunosuppressant for chronic lung-transplant rejection.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Chiron Corporation (CHIR) announced the submission of a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for marketing approval of Pulminiq (cyclosporine, USP) inhalation...

Positive phase II results reported on Rifalazil.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- ActivBiotics, Inc., announced results from a phase II trial of its investigational antibiotic, rifalazil, in the treatment of acute non-gonococcal urethritis (NGU). The trial met all primary...

Providers in Brazil following guidelines for management of HIV patients.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Providers in Rio de Janeiro, Brazil, are following national guidelines for the management of HIV-infected patients on antiretroviral therapy. According to recent research from the United States and...

Model of perinatal transmission of SHIV in macaques developed.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Scientists have developed a model of the perinatal transmission of SHIV-SF162P3 in Macaca nemestrina. "We developed a SHIV/macaque model of transmission from infected dams to their infants. Ten...

AIDS protection dependent on persistence of vaccine virus.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Protection against late-onset AIDS in macaques prophylactically immunized with a live simian HIV vaccine was dependent on persistence of the vaccine virus. According to published research from the...

Avoiding deceptive imprinting in AIDS vaccine development reviewed.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Scientists outline methods to avoid deceptive imprinting of the immune response to HIV-1 infection in vaccine development in a recent issue of International Reviews of Immunology. According to a...

HIV-1 Tat protein modulates generation of cytotoxic T cell epitopes.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- HIV-1 Tat protein modulates the generation of cytotoxic T cell epitopes by modifying proteasome composition and enzymatic activity. According to a study from Italy, "Tat, the trans activation...

HIV-1 Tat vaccine protects against SHIV89.6P replication in monkeys.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- HIV-1 Tat vaccinated cynomolgus monkeys were protected against SHIV89.6P replication. According to a study from Italy, "Vaccination with a biologically active Tat protein or tat DNA contained...

HIV-1 gp120 and immune network reviewed.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Researchers review HIV-1 gp120 and the immune network in a recent issue of International Reviews of Immunology. According to a study from Yugoslavia and the United Kingdom, "It has been...

Inflammatory stimuli increase neutrophil binding of HIV.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Activation by inflammatory stimuli increases neutrophil binding of human immunodeficiency virus type 1 and subsequent infection of lymphocytes. According to recent research from the United States,...

Pseudoviruses encoding gag induces HIV gag-specific mucosal immunity.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Oral immunization with papillomavirus pseudoviruses encoding gag induced HIV-1 gag-specific mucosal immunity. "Mucosal surfaces are the primary portals for human immunodeficiency virus (HIV)...

Recombination property of HIV-1 gp120 gene reported.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Researchers report the recombination properties of the HIV-1 gp120 gene in a recent issue of International Reviews of Immunology. According to a study from Yugoslavia, "Using a chimeric primer...

Retroviral vectors used to analyze SIV/HIV-specific T cell responses.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Researchers have used retroviral vectors for the analysis of SIV/HIV-specific CD8 T cell responses. "CD8+ T cell responses and particularly cytotoxic T lymphocyte (CTL) activity are critical...

nef-deleted SHIV protects against pathogenic virus infection.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- A nef-deleted simian and human immunodeficiency virus (SHIV) protected against pathogenic virus infection. According to published research from Japan, "To clarify the involvement of primitive...

High-dose melphalan and ASCT improves quality of life of AL amyloidosis patients.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- High-dose melphalan and autologous peripheral blood stem cell transplantation improves the quality of life of AL amyloidosis patients. According to a study from the United States, "Treatment of AL...

Advances in ALL treatment may lead to elimination of irradiation.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Improved risk classification for patients with acute lymphoblastic leukemia (ALL), coupled with more intensive intrathecal chemotherapy for high risk patients and the use of a drug called dexamethasone,...

AML samples with FLT3/ITD mutations preferentially killed by FLT3 inhibition.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Pediatric acute myelogenous leukemia samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibition. According to recent research from the United States, "Pediatric acute myelogenous...

Idarubicin and busulfan feasible for elderly AML patients undergoing ASCT.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Continuous infusion of idarubicin and oral busulfan is feasible for elderly patients with acute myeloid leukemia undergoing autologous stem cell transplantation. According to recent research from...

DMPA use associated with bone density deficit in young adult women.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- A new study of the affect of depot medroxyprogesterone acetate on bone mineral density confirms findings of some previous studies and refutes others. "Previous studies of the injectable...

Interferon alfa causes vitiligo and psoriasis in a patient with hepatitis B.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Interferon alfa causes vitiligo and psoriasis in a patient with hepatitis B. According to a study from Turkey, "well-known cutaneous side effects of interferon (IFN)-alfa therapy include dry skin,...

Trial aims for safer drug prescribing for institutionalized elderly.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Baycrest Center for Geriatric Care is the first long-term care facility in Canada, and one of the first in North America, to take a major leap forward in the use of health information technology to...

Drinking alcohol increases energy intake in human subjects.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Drinking alcohol increases energy intake in human subjects. "The effects of alcohol on food and energy intake in human subjects have been the subject of a number of controlled studies recently....

PPARalpha protects the liver from alcohol-induced injury.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- PPARalpha protects the liver from alcohol-induced injury. According to recent research from Japan, "the mechanisms underlying alcoholic liver disease are not completely understood, but lipid...

Company gets IRB approval for phase III clinical trials for PreHistin.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Cobalis Corp. (CLSC), a pharmaceutical company specializing in the development of antiallergy medications, announced that they have received approval from institutional review board (IRB) IntegReview,...

Beta-sheet breaker peptide prevents Alzheimer's memory impairments.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- A beta-sheet breaker peptide prevents A-beta-induced spatial memory impairments with partial reduction of amyloid deposits. "Current evidence supports the notion that beta-amyloid deposits or...

Biotechnology company receives royalty payment for Alzheimer product.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Neurobiological Technologies, Inc., (NASDAQ:NTII) announced that it had received a royalty payment of $694,000 from Merz Pharmaceuticals for sales in the second quarter of 2004 of Memantine for the...

Complications of Alzheimer vaccination in nonhuman primates modeled.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Scientists have modeled hemorrhagic and encephalitic complications of Alzheimer amyloid-beta vaccination in nonhuman primates. "The potential of amyloid-beta (A-beta) immunization as a...

Pharma company files amendment for urine NTP test kit.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Nymox Pharmaceutical Corporation (NASDAQ:NYMX) announced that it has filed an amendment to its premarket approval application (PMA) for the company's urine NTP test kit with the U.S. Food and Drug...

Aranesp trial launched to evaluate impact of treating anemia on cardiovascular risks.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Amgen, Inc., (AMGN) has initiated a landmark trial to evaluate the impact of treating anemia on cardiovascular outcomes in patients with chronic kidney disease (CKD) and type 2 diabetes. TREAT...

Effects of noxious stimulation during sevoflurane anesthesia characterized.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- The effects of noxious stimulation during sevoflurane anesthesia have been characterized using a novel technique. "In 21 patients given sevoflurane anesthesia," anesthesiologists in Sweden...

Propofol doesn't disrupt lidocaine metabolism during epidural anesthesia.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Propofol doesn't disrupt lidocaine metabolism during epidural anesthesia. According to recent research from Japan, "[p]ropofol is sometimes used in combination with epidural anesthesia with...

Volatile anesthetics cause blood flow-dependent changes in renal NO levels.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Volatile anesthetics cause blood flow-dependent changes in renal NO levels. Scientists in Japan "previously demonstrated that intrarenal nitric oxide (NO) levels and renal blood flow are reduced...

Primary endothelial cells show differential responses to hypoxia.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Primary endothelial cells show differential responses to hypoxia. According to recent research from Sweden, "changes in the local environment, such as reduced oxygen tension (hypoxia), elicit...

Alpha-synuclein induction produces Parkinson disease features in rodents.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Alpha-synuclein induction produces Parkinson disease features in rodents. "To elucidate the role of alpha-synuclein in the pathogenesis of Parkinson disease, both human alpha-synuclein transgenic...

Chronotropic incompetence to exercise indicates anorexia nervosa.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Chronotropic incompetence to exercise separates low body weight from established anorexia nervosa. According to a study from France, "Chronotropic incompetence (CI), characterized by an attenuated...

Company gets $877.5 million U.S. government contract to supply anthrax vaccine.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- VaxGen, Inc. (VXGN) announced that the U.S. government has awarded the company an $877.5 million contract to supply 75 million doses of anthrax vaccine for civilian defense. The contract, the first...

Plasmid DNA vaccine protects against aerosolized anthrax spores.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- A cationic lipid-formulated plasmid DNA vaccine confers sustained antibody-mediated protection against aerosolized anthrax spores. According to a study from the United States, "DNA vaccines provide...

Vaccine protects cheetah and black rhinoceros against anthrax.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Researchers have developed a vaccine that protects cheetahs and rhinoceroses against anthrax. According to a study from England, Namibia, and the United States, "Institution of a policy of...

Efficacy of heparin-coated angiographic catheters compared.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- The influence of coating method on the efficacy of heparin-coated angiographic catheters has been determined. In a recent study, radiologists in South Korea "evaluated in vivo anti-thrombogenic...

Inhaled CO has anti-inflammatory effects against ventilator-induced lung injury.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Inhaled carbon monoxide has antiinflammatory effects against ventilator-induced lung injury. "Ventilator-induced lung injury (VILI) is a major cause of morbidity and mortality in intensive care...

Antibiotics use alliance report reveals urgency of drug resistance worldwide.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- A new report released at a meeting of the American Society for Microbiology describes the ominous presence of disease-causing micro-organisms resistant to today's front-line drugs. "Shadow...

Study finds reduction in antibiotic overprescribing to limit growth of drug market.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Decision Resources, Inc., has found that pressure from expert panels, payers, and public health officials to reduce antibiotic overprescribing will limit growth of the acute exacerbations of chronic...

Trial information presented on treatement for intra-abdominal infections.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), recently presented exciting new phase III data about its investigational antibiotic, tigecycline, based on a clinical trial in patients with...

Company presents three posters on its antibacterial agent ECO-0501 at ICAAC.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Ecopia BioSciences, Inc., (EIA) presented data on ECO-0501 in the form of three posters at the annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) held in Washington, DC. ...

Inhibition of Kir3 channels by antidepressants may contribute to clinic effects.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Researchers have investigated the inhibition of G protein-activated inwardly rectifying K[superscript]+ channels by various antidepressant drugs. According to a study from Japan, "G...

Vancomycin therapy for neonates with late-onset septicemia may be justified.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Findings from a tertiary care hospital in India report the prevalence of methicillin-resistant, coagulase-negative staphylococci in neonatal intensive care units. According to research published in...

Mature yuzu could be a significant dietary source of antioxidants.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Researchers have reported on the variation in major antioxidants and total antioxidant activity of yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars. According to recent...

Suppressed E1AF limits the invasiveness of cervical cancer.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Suppressed E1AF limits the invasiveness of cervical cancer. According to a study from Japan, "E1AF/PEA3, a member of the Ets family of transcription factors, is associated with the malignant...

M4N induces growth arrest/apoptosis by inhibiting Cdc2 and survivin expression.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- M4N induces growth arrest and apoptosis by inhibiting Cdc2 and survivin expression. According to a study from the United States, "We previously reported that Sp1-dependent Cdc2 gene expression is...

New reimbursement policy increases patient access to REMICADE.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Centocor said that the new Medicare physician reimbursement policy announced by the U.S. Centers for Medicare and Medicaid Services (CMS) will facilitate increased patient access to REMICADE in a health...

Scientist claims Pfizer arthritis drug worse than Vioxx, spurs controversy.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- A scientist's claim of evidence that Pfizer Inc.'s Bextra might be even riskier for people with heart disease than rival arthritis drug Vioxx sparked controversy November 10, 2004, at a medical meeting...

Aspergillosis: Emerging infection in critically ill patients without malignancy.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Invasive apergillosis is an important emerging infection in critically ill patients without malignancy. "Using criteria designed for invasive aspergillosis (IA) in patients with cancer, we aimed to...

Allergic lung responses may involve interplay of diverse members of ADAM family.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Allergic lung responses seem to involve the interplay of diverse members of the ADAM family. According to recent research published in the United States, "Asthma, a complex chronic inflammatory...

Pharmaceutical company receives new drug approval for proprietary asthma product.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- IVAX Corporation (IVX) received approval from the U.S. Food and Drug Administration (FDA) for its New Drug Application (NDA) for its patented HFA (CFC-free) formulation of albuterol in a metered dose...

Pharmaceutical firm withdraws Symbicort file for European Union.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- AstraZeneca announced that it has withdrawn its Symbicort Single Inhaler Therapy file for the European Union. As a result of discussions during the Mutual Recognition Process, AstraZeneca expects a...

Reducing agent OTC may reduce airway inflammation, hyperresponsiveness.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Reducing agent OTC may reduce airway inflammation and hyper-responsiveness by regulating NF-kappaB activity. Researchers in South Korea report, "Oxidative stress plays an important role in the...

TGF-beta2 induces bronchial epithelial mucin expression in asthma.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "The transforming growth factor (TGF)-beta family is important for tissue repair in pathological conditions including asthma. However, little is known about...

Amlodipine may slow heart disease in patients with normal blood pressure.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- The calcium channel blocker amlodipine decreases the risk of cardiovascular events in patients with coronary artery disease and normal blood pressure, as does the ACE inhibitor enalapril, but to a...

Low-density lipoprotein receptor gene therapy improves hypercholesterolemia.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Low-density lipoprotein receptor gene therapy improves hypercholesterolemia. According to researchers in the United States, "we tested the efficacy of low-density lipoprotein receptor (LDLR) therapy...

Peptide from tarantula venom may have use as treatment for disparate conditions.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Little Miss Muffet probably would not sit on a tuffet in Frederick Sachs' lab, even if he had such a seat. He keeps spiders there. Tarantulas, to be exact. Sachs and his colleagues in the...

Virus-induced auto-antibody responses characterized.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Scientists have characterized virus-induced auto-antibody responses. "Here we present a comprehensive molecular mapping of virus-induced autoimmune B cell responses obtained by serological...

Interferon alpha is linked to the formation of systemic sclerosis.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Interferon alpha is linked to the formation of systemic sclerosis. "In 1992 interferon alpha (IFN-alpha) was approved by the U.S. Food and Drug Administration for the treatment of chronic viral...

Data shows Tamiflu is effective against human H5N1 and avian H5N1 influenza.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- New data presented confirms that oseltamivir (Tamiflu), an oral neuraminidase inhibitor (NAI), is effective against the human H5N1 and avian H5N1 influenza virus. Since the influenza virus is...

Clinical diagnostics company receives technology award.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- SomaLogic, Inc., a privately held proteomics company, announced that it has received Frost & Sullivan's 2004 Technology Innovation Award in the field of biomarkers. In its recent study, Biomarkers:...

Excellence in Biotechnology Award presented at BIOPHEX conference.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Terry Matsunaga, PharmD, PhD, vice president of research for ImaRx Therapeutics, Inc., received the Excellence in Biotechnology Award for Outstanding Achievement in Drug Delivery. Genetic...

Thin strips for cold and cough medicine delivery receive best product award.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Three weeks after their official launch, Triaminic and Theraflu Thin Strips have been named "Best Product of 2004" by Convenience Industry News (CIN) magazine. Thin Strips, a multi-symptom cough...

Infection poses tough new foe for Oregon teams.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- A Pendleton coach and two Oregon State athletes are the latest to suffer from a bacterial infection that may prey on turf burns. The infection first appeared in the 1990s among high school...

Indian Salmonella Typhi isolates have reduced ciprofloxacin susceptibility.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Salmonella Typhi isolates in India have reduced susceptibility to ciprofloxacin. "Typhoid fever continues to remain a health problem as the causative organism Salmonella Typhi has developed...

Bacterial resistance to solvents, biodesulfurization activity relation studied.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- The relation between bacterial strain resistance to solvents and biodesulfurization activity has been studied in organic media. According to researchers in France, "Microorganisms used in...

Bioreactor efficient, promising for study of chlororespiration enzymes.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- High biomass has been generated from chlororespiring bacteria using a continuous fed-batch bioreactor. According to recent research published in the journal Applied Microbiology and Biotechnology,...

Dehydration behavior of bacteria in liquid medium studied in drying process.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- A new drying process for lactic bacteria based on their dehydration behavior in liquid medium was the focus of a recent report. Researchers in France describe "the different stages of optimization...

High-throughput method for counting bacterial colonies developed.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Scientists have developed a method for high-throughput imaging of bacterial colonies grown on 96-well filter plates. "The ability to accurately enumerate viable bacteria has applications in...

NO-releasing sol-gel may aid in studies of localized NO release on other systems.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Nitric oxide-releasing sol-gel may be useful in studies of localized nitric oxide release on other chemical and biological systems. "Nitric oxide (NO) releasing sol-gel materials coated with...

Pneumococcal virulence factor contributions to pathogenesis studied in mice.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Tissue-specific contributions of pneumococcal virulence factors to pathogenesis have been studied in a murine mode. Scientists in the United States "assessed the ability of Streptococcus pneumoniae...

Synthetic peptide used to study antibacterial drug class activity.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Synthetic peptide has been used to study the activity of an antibacterial drug class. "The coumarin antibiotics are potent inhibitors of DNA replication whose target is the enzyme DNA gyrase, an...

Basal cell carcinoma rates continuously increasing in the Netherlands since 1973.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Basal cell carcinoma rates have been continuously increasing in the Netherlands since 1973. "This study is aimed to determine the characteristics of the trends in incidence of basal cell carcinoma...

Newly discovered genetic biomarkers separates BPH from prostate cancer.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Health Discovery Corporation (HDVY) announced the discovery of a new set of genetic biomarkers that are expected to lead to significant improvement in the diagnosis and treatment of benign prostatic...

MTT/ATP/calcein assays similarly predict potency of cytotoxic anticancer agents.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- MTT, ATP and calcein assays similarly predict the potency of cytotoxic anticancer agents. "Cell viability assays are important tools in oncological research and clinical practice to assess the tumor...

Murine model developed for bone marrow failure.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- A murine model was developed for bone marrow failure. According to a study from the United States, "Infusion of parental lymph node (LN) cells into sublethally irradiated hybrid F1 recipients...

Suicide gene constructs may be effective graft-versus-leukemia therapy.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Suicide gene constructs may be effective graft-versus-leukemia therapy. According to recent research from the United States, "suicide gene therapy is one approach being evaluated for the control of...

FDA grants priority review status for brain tumor drug; EMEA application made.
December 3, 2004... 2004 DEC 3 - (NewsRx.com & NewsRx.net) -- Schering-Plough Corporation (SGP) reported that the U.S. Food and Drug Administration (FDA) has granted 6-month priority review status to its supplemental new drug application (sNDA) for Temodar...