Drug Week articles from December 2003

Drug Week archives from December 2003

New drug treats autoimmune disease that weakens eye and body muscles.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Under a new $4.7 million grant from the U.S. National Eye Institute, researchers from Case Western Reserve University School of Medicine and University Hospitals of Cleveland hope to develop in 5 years...

Antidepressants decrease chronic pain by inhibiting TNF production in brain.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Physicians have treated chronic pain with antidepressants for many years, knowing that the medications - particularly the drug with the scientific name amitriptyline - helped many sufferers, but they...

New TB vaccine shows promise in people with AIDS.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- An innovative vaccine against tuberculosis has shown promise in people with HIV, researchers from Dartmouth Medical School and the National Public Health Institute of Finland report. An...

Company reports positive phase II clinical trial results of Aquavan Injection.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Guilford Pharmaceuticals, Inc., (GLFD) announced that it has completed a preliminary analysis of results from two phase II clinical trials of Aquavan Injection, a novel sedative/hypnotic. The...

Rituximab shows promise for HIV patients with Castleman disease.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- The anti-CD20 monoclonal antibody rituximab shows promise for the treatment of Castleman disease in HIV patients. According to a study from France, "To assess the clinical benefit of rituximab for...

Company reports results of phase I clinical trial of Lymphostat-B.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Human Genome Sciences, Inc., (HGSI) announced the results of studies that support the ongoing clinical development of LymphoStat-B (a human monoclonal antibody to B-lymphocyte stimulator, BLyS) for the...

Aspirin may not be strong enough to prevent clots in some heart patients.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- While an aspirin a day helps keep a heart attack at bay, it may need reinforcement to totally prevent blood clots among patients with chest pain, a Johns Hopkins study shows. Researchers took blood...

Duloxetine significantly reduces stress incontinence episodes.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Duloxetine significantly reduces stress incontinence episodes. According to recent research from the United States, "stress urinary incontinence (SUI), the most common form of incontinence,...

Company works to amend its non-approvable New Drug Application.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Noven Pharmaceuticals, Inc., (NOVN) provided an update on the status of MethyPatch, its developmental methylphenidate transdermal system for attention deficit hyperactivity disorder. MethyPatch is...

Bisexuality, abuse, drugs behind AIDS spread among South's rural blacks.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Health officials have struggled for years to understand why blacks across the rural South are contracting AIDS at a faster rate than whites. A research scientist at the University of Alabama has...

Acquired factor VIII inhibitor-related can occur with myelodysplastic disorder.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Acquired factor VIII inhibitor can occur with myelodysplastic disorder, hemorrhage; therapy was able to resolve it. According to published research from England, "we report a 71 yr old man who...

Farnesyltransferase inhibitors in AML and myelodysplastic syndromes.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Farnesyltransferase inhibitors in AML and myelodysplastic syndromes. According to a study from the United States, "Farnesyltransferase inhibitors were initially developed as Ras inhibitors as they...

Drug proved to benefit heart attack victims vastly underused.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- After analyzing data of more than 56,000 U.S. patients who arrive at emergency rooms with heart attack symptoms, researchers from a Duke University Medical Center-led patient registry have found that...

Newer formulation of heparin improves outcomes for suspected MI patients.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- A newer, more convenient formulation of the blood thinner heparin appears to improve outcomes with fewer complications - when combined with a platelet receptor blocking drug and invasive management -...

Women and men differ in heart disease traits and treatment.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- A new study shows just how different men and women really are - when it comes to their hearts, that is. It also helps solve several mysteries about women and heart problems, and highlights the need for...

High-dose methadone linked to QT prolongation and Torsades de Pointes in HIV patients.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- High-dose methadone therapy may cause QT prolongation and Torsades de Pointes in HIV patients. According to published research from Spain, "Four patients infected with human immunodeficiency virus...

Methadone users need access to orthotopic liver transplantations.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Methadone users need access to orthotopic liver transplantations. According to a study from the United States, "cirrhosis resulting from hepatitis C virus is presently the most common indication...

Growth hormone therapy may kill; monocytes produce IL-1alpha, IL-6, TNFalpha.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Septic shock, uncontrolled infection, and death of adults given growth hormone while ill may be due to its effect on LPS-activated PBMC: It makes them produce increased IL-1alpha, IL-6, TNFalpha. ...

Eprex induces reversible antierythropoietin antibodies and red cell aplasia.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Eprex induces reversible antierythropoietin antibodies and red cell aplasia. "We describe a patient with end-stage renal failure (ESRF) who developed anti-erythropoietin (anti-EPO) antibodies and...

Domestic animals may be bioterrorism targets; broad health, economic damage possible.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Domestic animals may be bioterrorism targets; broad health, economic damage possible. According to a study from France, "after a brief historical introduction, the authors describe a list of...

Induced sputum can be used in PCR to assay for cytokines in airway inflammation.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Induced sputum having few cells can be used to assay for cytokines by PCR, to monitor airway inflammation noninvasively. According to recent research from France, "sputum examination is being...

Alexander disease with glial fibrillary acidic protein mutation reported.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Investigators report a case of adult-onset Alexander disease with a Arg416Trp human glial fibrillary acidic protein gene mutation. According to recent research published in the journal Neuroscience...

FDA approval granted for loratadine.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Andrx Corporation (ADRX) announced that the U.S. Food and Drug Administration (FDA) has approved the marketing of its Abbreviated New Drug Application (ANDA) for its loratadine orally disintegrating...

Alzhemed open-label phase II extension study demonstrates cognitive benefits.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Neurochem, Inc., (NRM) announced positive results on cognitive function as measured by ADAS-cog of patients suffering from mild-to-moderate Alzheimer Disease (AD) in an open-label phase II extension...

Beta-AP1-40 and beta-AP40-1 possess different selectivities to oxidation.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Neurotoxic beta-AP1-40 and non-toxic beta-AP40-1 possess remarkably different selectivities toward Cu(II)-catalyzed oxidation of beta-amyloid peptide. According to a study from the United States,...

Data reported on monthly injectable sustained-release formulation of ZT-1.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- At the 4th Neurobiology of Aging Conference in New Orleans, Louisiana, Debiopharm S.A. (Debiopharm) presented the results of an in vivo evaluation in rats of an injectable once-monthly sustained-release...

E2-25K/Hip-2 plays essential role in mediating amyloid-beta neurotoxicity.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- E2-25K/Hip-2 palys an essential role in mediating amyloid-beta neurotoxicity. "The ubiquitin/proteasome system has been proposed to play an important role in Alzheimer disease (AD) pathogenesis....

Imaging damaged brain cells in living mice provides clues to dementia.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Using recently developed techniques for imaging individual cells in living animals, a team led by researchers at Washington University School of Medicine in St. Louis has watched as Alzheimer-like brain...

Neprilysin inhibition raises amyloid beta levels in rabbit cortex.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Thiorphan-induced neprilysin inhibition raised amyloid beta levels in rabbit cortex and cerebrospinal fluid. "Studies on the pathogenesis of Alzheimer disease (AD) suggest overproduction of amyloid...

Pravastatin does not decrease amyloid-beta in humans.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Pravastatin at 10 mg/day does not decrease plasma levels of either amyloid-beta (A-beta) 40 or A-beta 42 in humans. "It has been assumed that statins work as a preventative drug for Alzheimer...

Three disease compounds acquired from Sankyo.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- BTG (BGC) has acquired the intellectual property rights to a portfolio of preclinical compounds designed to treat Alzheimer disease, from Sankyo Co., Ltd., Japan. The portfolio encompasses three...

Protein S deficiency presents as deep vein thrombosis.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Researchers report a case of protein S deficiency presenting as deep vein thrombosis. "A rare case of spontaneous bilateral internal jugular vein (IJV) thrombosis is presented in absence of oral...

CREST study finds cilostazol reduces restenosis by almost 40%.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- A new and highly effective weapon in the war on heart disease could be on the horizon, according to results of the "Cilostazol for RESTenosis" (CREST) study presented at the American Heart Association's...

Michigan project cuts problems and deaths.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Angioplasty patients in Michigan are getting far better care - and suffering far fewer complications - than they used to, thanks to a cooperative quality improvement project involving local hospitals...

Role of adipocytokines in anorexia nervosa reviewed.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Researchers review the role of the two adipocytokines, leptin and adiponectin, in anorexia nervosa in a recent issue of Hormone and Metabolic Research. "Adipose tissue secretes a large number of...

Adenosine receptors regulate oxidative stress in rat pheochromocytoma cells.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Adenosine A[subscript]2A receptors regulate oxidative stress formation in rat pheochromocytoma PC12 cells during serum deprivation. According to published research from Taiwan, "Activation of...

Improved diagnosis of fungal infections no longer requires preventive therapy.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Improved diagnosis of fungal infections no longer requires preventive therapy. According to recent research published in the journal Annals of Hematology, "invasive fungal infections are a primary...

Bis-eugenol protects against inflammatory cytokine expression in macrophages.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Bis-eugenol, a eugenol ortho dimer, exerted a protective effect on lipopolysaccharide-stimulated nuclear factor kappa B activation and inflammatory cytokine expression in macrophages. According to...

Human beta-defensin 3 possesses antibacterial activity against oral bacteria.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Human beta-defensin 3 possessed antibacterial activity against oral bacteria. "The in vitro activities of human beta-defensin 3 (hBD-3) alone or combined with lysozyme, metronidazole, amoxicillin,...

Peptides effective against Listeria monocytogenes listed.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Researchers have listed the antimicrobial peptides effective against Listeria monocytogenes in a recent issue of FEMS Microbiology Letters. According to published research from Spain, "We assessed...

Company updates positive clinical data on multiple antisense drugs.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Isis Pharmaceuticals, Inc., (ISIS) announced positive data from clinical trials of four antisense drugs for the treatment of four diseases. Final results from phase II studies of ISIS 104838 in...

Two CD95 tumor classes with different sensitivities to antitumor drugs.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Two CD95 tumor classes with different sensitivities to antitumor drugs. According to recent research from the United States, "CD95 type I and II cells differ in their dependence on mitochondria to...

Infusions of synthetic HDL may remove plaque from coronary arteries.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- A new study appearing in the November 5 edition of the Journal of the American Medical Association provides strong evidence that five weekly infusions of a synthetic form of "good cholesterol," or HDL,...

Phase II data from study of ETC-216 show plaque accumulation can be reversed.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Esperion Therapeutics, Inc., (ESPR) announced the results of a study providing significant evidence that its investigational product candidate, ETC-216 (ApoA-I Milano/phospholipid complex or AIM),...

Stimulation of reverse cholesterol transport can result in regression of plaque.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Lipid Sciences, Inc., (LIPD), announced that an article published on November 5, 2003, in the Journal of the American Medical Association (JAMA), supports the premise on which its Vascular Lipid Removal...

Smooth muscle cells infected with Chlamydia pneumoniae increase MMP-1, MMP-3.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Smooth muscle cells infected with Chlamydia pneumoniae increase MMP-1, MMP-3; not MMP-2, MMP-9, or TIMPs. According to recent research published in the journal Fems Immunology and Medical...

Warfarin efficacy matched by new thrombin inhibitor ximelegatran.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- by Richard Hyer, NewsRx correspondent - In the largest trial of atrial fibrillation ever conducted, the new oral direct thrombin inhibitor ximelegatran compared favorably with dose-adjusted warfarin in...

Myxoma of the right atrium could be due to fusion of giant cells.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Myxoma of the right atrium could be due to fusion of giant cells. "Myxoma is the commonest primary tumor of the heart, arising more frequently in the left than the right atrium," researchers in...

Iloprost therapy given once a month at maximal dose improves systemic sclerosis.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Iloprost therapy given once a month at maximal dose improves systemic sclerosis. According to recent research published in the journal Hautarzt, "systemic sclerosis is an autoimmune disease of...

Methanol extract of Bacopa monniera is antioxidant, protects from DNA damage.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Methanol extract of Bacopa monniera is antioxidant, protects from DNA damage. According to a study from Italy, "Bacopa monniera L. (family Scrophulariaceae) (BM) is an Ayurvedic medicine, clinically...

Transgenic work shows lack of lambda5 doesn't fully impair pro-B cell maturation.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Transgenic mouse work shows absence of lambda5 does not fully impair pro-B cell maturation, thus altering previous views on molecular interactions required for maturation to pre-B cells. "Pre-B...

Delta BAFF is an alternate splice isoform of BAFF that regulates B cells.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Follicular B cell survival and autoimmunity are both tied to BAFF; BAFF appears to be regulated by its alternative splice form, deltaBAFF. According to a study from the United States, "the tumor...

Nocardia puris characterized as a new species that can produce abscesses.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Nocardia puris is characterized as a new species that can produce abscesses in humans. "A bacterial isolate (IMMIB R-145(T)) from a human abscess was subjected to a polyphasic taxonomic study....

Stannous chloride affects adhesive properties of C. diphtheriae strains.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Stannous chloride influences the adhesive properties of Corynebacterium diphtheriae strains. According to a study from Brazil, "Stannous ion, as a chloride salt, influenced on the survival and...

Uroxatral launched in U.S. to treat symptoms of benign prostatic hyperplasia.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Sanofi-Synthelabo announced that Uroxatral (alfuzosin hydrochloride extended-release tablets) has been launched in the U.S. as a 10 mg, once-daily prescription alpha1-blocker that provides effective...

Benign prostatic hypertrophy drug available in U.S.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- SkyePharma PLC (SKYE) announced that Sanofi-Synthelabo (SNY) has launched Uroxatral (alfuzosin hydrochloride) in the U.S. market for the relief of urinary symptoms associated with benign prostatic...

Unresponsive thrombocytopenia patients may have GPIX mutation, Bernard-Soulier.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Unresponsive thrombocytopenia patients may have GPIX mutation, Bernard-Soulier. "Bernard-Soulier syndrome (BSS) is a rare inherited disorder with giant platelets, thrombocytopenia, and a prolonged...

Genome-wide human genetic variation map complete.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Applied Biosystems Group (ABI), an Applera Corporation business, announced that it has completed the development of a genome-wide human genetic variation map based on single nucleotide polymorphisms...

IL-1, B7 protein families expanded due to sequence search; function is needed.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- IL-1, B7 protein families expanded due to sequence search; function is needed. "Remarkable advances in our knowledge of the genome sequence have led to the creation of databases that afford the...

Perfluorocarbon-based blood substitute undergoes phase I clinical trial.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Synthetic Blood International Inc. (SYBD) announced that a phase I clinical trial of Oxycyte, its perfluorocarbon-based blood substitute, started on October 30, 2003, and believes that Oxycyte may be...

Methods to measure subcutaneous adipose tissue in children compared.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Scientists report the comparison between bioelectric impedance and subcutaneous adipose tissue thickness as measured by LIPOMETER and skinfold calipers in children. "The aim of this study was to...

Bordetella pertussis CyaA binds CD11b at different site than catalytic one.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- The CyaA toxin of Bordetella pertussis binds CD11b/CD18 at a site different from the catalytic domain. According to published research from France, "adenylate cyclase toxin (CyaA) is one of the...

Ruta 6 induces selective apoptosis in glioma cells.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- The novel agent Ruta 6 induces selective apoptosis in glioma cells. "Although conventional chemotherapies are used to treat patients with malignancies, damage to normal cells is problematic....

FDA gives approval for phase III registrational trial for breast cancer drug.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- YM BioSciences Inc. (YMBA) has received written confirmation from the U.S. Food and Drug Administration (FDA) that it may initiate a pivotal phase III, or registrational trial, for its lead...

Cancer registry useful for Florida breast cancer early detection program.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Investigators report results from a Florida breast cancer early detection program using the statewide cancer registry. According to recent research published in the journal Breast Cancer Research...

Burkholderia cepacia pneumonia can occur in immunocompetent patients.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Prior aspergilloma or Aspergillus infection may influence immunocompetent patients to develop Burkholderia cepacia pneumonia. "A 69 yr old man developed an episode of severe community-acquired...

Gene therapy containing p53 combines with CDDP to arrest liver tumor growth.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Gene therapy containing p53 combines with CDDP to arrest liver tumor growth. "Surgical resection is thought to be the best treatment for liver carcinoma, including hepatocellular carcinoma and...

COX-2, cAMP and protein kinase A traverse integrins to regulate angiogenesis.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- COX-2, cAMP and protein kinase A traverse integrins to regulate angiogenesis. According to recent research published in the journal Thrombosis and Haemostasis, "angiogenesis, the development of new...

Tumoral immune resistance based on tryptophan degradation by enzyme.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Researchers have found evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. According to a study from Belgium, "T lymphocytes undergo...

Free radicals mediate cardiac toxicity induced by adriamycin.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Free radicals mediate cardiac toxicity induced by adriamycin. "Anthracycline antibiotics, including adriamycin (ADM), are widely used to treat various human cancers, but their clinical use has been...

Electroporation improves DNAzyme delivery to vascular tissue.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Electroporation improves DNAzyme delivery to vascular tissue. According to published research from the United States, "the development of inexpensive and effective approaches to transiently...

Adenosine receptor stimulation attenuates myocardial hypertrophy in mice.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Adenosine receptor stimulation ameliorates myocardial hypertrophy in mice. "Sympathomimetic stimulation, angiotensin II, or endothelin-1 is considered to be an essential stimulus mediating...

Amino terminus of beta-ARK1 needed for beta-AR regulation.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- The amino terminus of beta-ARK1 plays a key role in beta-AR regulation. "The G protein-coupled receptor (GPCR) kinase beta-adrenergic receptor (beta-AR) kinase-1 (beta-ARK1) is elevated during heart...

Role of kinin system in cardiovascular disease reviewed.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- The role of the kinin system in the development of cardiovascular disease has been reviwed. "All the components of the kallikrein-kinin system are located in the cardiac muscle, and its deficiency...

Serum paraoxonase does not mediate cardioprotective effects of red wine.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Serum paraoxonase does not mediate the cardioprotective effects of red wine. "Although there is a general consensus concerning the lower risk for cardiovascular disease in moderate drinkers, the...

Enoxaparin improves vascular reactivity in aged and diabetic rats.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Enoxaparin treatment improves vascular reactivity in aged and diabetic rats. In a recent study, scientists in Romania sought to determine "whether the low molecular weight heparin enoxaparin acts...

Endostatin uses specific sulphates for endothelial heparan sulphate binding.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Endostatin uses specific sulphates for endothelial heparan sulphate binding. "Endostatin is a naturally occurring proteolytic fragment of the C-terminal domain of collagen XVIII. It inhibits...

Growth factor controls how endothelial cells recruit vascular muscle cells.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Growth factor controls how endothelial cells recruit vascular muscle cells. "Recruitment of vascular smooth muscle cells (SMC) by endothelial cells (EC) is essential for angiogenesis....

Trypanosoma cruzi antigens elicit strong humoral immune response in mice.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Immunization with the cytoplasmic repetitive antigen and flagellar repetitive antigen of Trypanosoma cruzi elicited a strong humoral immune response in mice. According to recent research published...

Niaspan launched in the United Kingdom.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Kos Pharmaceuticals, Inc., (KOSP) announced that Merck Pharmaceuticals, UK, a subsidiary of Merck, KGaA, Germany, has launched Niaspan (extended-release niacin) in the United Kingdom (U.K.), a...

Genetic background influences how VEGF promotes new vessel growth.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Genetic background influences how VEGF promotes new vessel growth. "Therapeutic angiogenesis has emerged as a promising therapy, but some patients are refractory to exogenous growth factors. In...

Company launches trial of gene-modulated tissue production of protein.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Medgenics, Inc., an early stage U.S./Israel biotechnology company, announced that it has launched its phase I clinical trial of its Biopump technology for delivery of Erythropoietin (EPO) in chronic...

Substance P regulates Th1-type colitis in IL-10 knockout mice.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Substance P regulates Th1-type colitis in IL-10 knockout mice. "Substance P (SP) is a proinflammatory molecule that interacts with a neurokinin 1 receptor (NK-1R), which is on T cells and helps...

Alliance targets siRNA research using GeneChip technology.
December 5, 2003... 2003 DEC 5 - (NewsRx.com & NewsRx.net) -- Qiagen N.V. (QGENF, QIA) and Affymetrix, Inc., (AFFX) announced that they have entered into a collaboration to optimize Qiagen siRNA-mediated gene silencing using Affymetrix GeneChip microarray...