Drug Week articles from April 2004

Drug Week archives from April 2004

Studies reinforce potential benefits of new stroke-prevention drug.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Researchers at Mount Sinai School of Medicine announced an analysis of pooled data from two Phase III stroke prevention trials at the American College of Cardiology (ACC) annual meeting in New Orleans....

Drug can heal, reduce recurrence of fistulas.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- An international study has found that maintenance therapy with the drug infliximab, a monoclonal antibody used to treat Crohn disease, can prevent or delay the recurrence of fistulas, a common...

Company to advance LY519818 into phase III studies for type 2 diabetes.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Ligand Pharmaceuticals, Inc., (LGND) announced that Eli Lilly and Co. (LLY) has made the decision to advance LY519818 into phase III registration studies. LY519818 is an oral, once-daily peroxisome...

Drug appears safe for some men with congestive heart failure.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Carefully selected men with congestive heart failure appear to be able to safely take sildenafil, a drug used to treat erectile dysfunction (ED), if they are not taking nitrates to treat their heart...

Crystal structures of NNRT-resistant HIV RT characterized.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- The crystal structures of several forms of NNRT-resistant HIV RT have been characterized. "Leu100Ile, Val106Ala and Val108Ile are mutations in HIV-1 reverse transcriptase (RT) that are observed in...

Study: Cholesterol lowering with atorvastatin halts progression of heart disease.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- The first head-to-head comparison of two popular cholesterol-lowering medications showed only one of the statins successfully stopped the progression of heart disease. The Cleveland Clinic-led...

Peptide ester conjugates for ester prodrug stability developed.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Scientists have developed a general strategy for the preparation of membrane permeable fluorogenic peptide ester conjugates for in vivo studies of ester prodrug stability. According to published...

Ultrasounds are advised for all women who request pregnancy termination.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Ultrasounds are advised for all women who request pregnancy termination. According to new research from Scotland, "this prospective observational study aimed to determine the correlation between...

FDA approval granted for immune response modifier for precancerous skin lesions.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- According to the American Academy of Dermatology, actinic keratosis (AK) affects as many as 10 million Americans each year. Caused by chronic sun exposure, actinic keratoses are precancerous skin...

Analysis from TACTICS-TIMI 18 trial published.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Guilford Pharmaceuticals, Inc., (GLFD) announced the publication of new data in the journal, Circulation, demonstrating that the addition of AGGRASTAT Injection (tirofiban hydrochloride), along with...

GABA[subscript]B receptor agonists exert bidirectional effects on dopamine.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- GABA[subscript]B receptor agonists exert bidirectional effects on the mesolimbic dopamine system. According to a study from Switzerland and the United States, "The rewarding effect of drugs of...

Study: Alcohol treatment meds, behavioral therapy effective for cocaine addiction.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Results of a study funded by the National Institute on Drug Abuse (NIDA), U.S. National Institutes of Health, suggest that disulfiram, a medication used to treat alcohol addiction, is effective in...

Women, drinkers, and older people are at risk for prescription drug misuse.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Women, drinkers, and older people are at risk for prescription drug misuse. "We estimate the prevalence of and risk factors for the problem use of prescription drugs, overall and by therapeutic...

Beta-adrenergic receptor agonists increase apoptosis of adipose tissue.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Beta-adrenergic receptor agonists increase apoptosis of adipose tissue in mice. According to published research from the United States, "Beta-adrenergic receptor (beta-AR) agonists increase muscle...

Preadipose cell changes into smooth muscle-like cells investigated.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Aortic carboxypeptidase-like protein plays a role in the transdifferentiation of preadipose cells into smooth muscle-like cells. According to published research from France, "Adipocyte...

Macugen data presented at Aspen Retinal Detachment Society meeting.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Eyetech Pharmaceuticals, Inc., (EYET) presented additional data from the VEGF (vascular endothelial growth factor) Inhibition Study in Ocular Neovascularization (VISION) at the Aspen Retinal Detachment...

Alcoholism and obesity may involve overlapping neuropeptide pathways.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Alcoholism and obesity may involve overlapping neuropeptide pathways. "Ethanol is a caloric compound, and ethanol drinking and food intake are both appetitive and consummatory behaviors....

Increased thrombin activity occurs after allergen challenge.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Increased thrombin activity occurs after allergen challenge. "In addition to its central role in homeostasis, thrombin may play a role in inflammation and remodeling. To investigate the...

Phase II/III trial initiated for ragweed allergy immunotherapy.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Dynavax Technologies Corporation (DVAX) announced the start of a multi-site, phase II/III clinical trial to evaluate the safety and efficacy of its ragweed allergy immunotherapy product candidate, AIC....

A-beta antibody levels not changed in patients with Alzheimer disease.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- No difference in levels of antibodies to A-beta were found in people with and without Alzheimer disease. "To investigate the immune response to amyloid beta-peptide (A-beta: A-beta[subscript]40 and...

ACE gene polymorphism linked to damage in Alzheimer disease.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- A polymorphism in the angiotensin 1-converting enzyme (ACE) gene is associated with damage to cerebral cortical white matter in Alzheimer disease. "The impact of the insertion/deletion (I/D)...

Common bacteria linked to brain disease.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- The paper "Chlamydia pneumoniae induces Alzheimer-like amyloid plaques in brains of BALB/c Mice," shows a link between the bacteria C. pneumoniae and the amyloid plaques found in the brains of people...

Physiological role of beta-amyloid peptide explains Alzheimer disease.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- The physiological role of beta-amyloid peptide may explain Alzheimer disease. "The A-beta peptide, which is derived from the processing of the amyloid precursor protein APP, is the principal agent...

Vaccine shows promise in animal model.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- A new vaccine for Alzheimer disease created by researchers at the Farber Institute for Neurosciences at Thomas Jefferson University in Philadelphia has shown promise in initial testing in primates. ...

Studies support role of glutamate, RNA processing in muscle-wasting disease.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- The possibility that a central nervous system signaling chemical called glutamate has a role in the development or exacerbation of amyotrophic lateral sclerosis (ALS, or Lou Gehrig disease) has been...

Matrix metalloproteinase-9 is needed for revascularization after ischemic injury.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Matrix metalloproteinase-9 is needed for revascularization after ischemic injury. "Angiogenesis, an essential component of a variety of physiological and pathological processes, offers attractive...

Polymorphism in gene promoter linked to increased bilirubin and HDL levels.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- A microsatellite polymorphism in the heme oxygenase-I gene promoter is associated with increased bilirubin and HDL levels but not with coronary artery disease. "Heme oxygenase 1 (HO-1) is involved...

Angiotensin II attenuates caspase-3 activation in cortical neurons.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Angiotensin II attenuates chemical hypoxia-induced caspase-3 activation in primary cortical neuronal cultures. "In this study we determined whether caspase-3 is required in mouse cortical neurons...

FDA-licensed anthrax vaccine supplied to Taiwan.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- BioPort Corporation announced the sale of U.S. Food & Drug Administration (FDA)-licensed anthrax vaccine, BioThrax, to the Taiwanese government, marking the company's entry into the commercial market...

Phase I clinical trial results of anthrax vaccine candidate reported.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- VaxGen, Inc., (VXGN) announced results of its phase I trial of recombinant Protective Antigen anthrax vaccine, rPA102, at the International Conference on Emerging Infectious Diseases (ICEID) in Atlanta,...

Major determinants of activity of antibiotic peptide described.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Aggregation and water-membrane partition are major determinants of the activity of the antibiotic peptide trichogin GA IV. "Water-membrane partition and aggregation behavior are fundamental aspects...

Partnership to develop novel formulation of amoxicillin.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Par Pharmaceutical, Inc., the principal subsidiary of Pharmaceutical Resources, Inc., (PRX), has signed a letter of intent with Advancis Pharmaceutical Corporation (AVNC) to develop and market a novel...

Progress in development of blood substitutes reported.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Scientists are making progress in the development of blood substitutes. "Chemically modified or genetically engineered hemoglobins (Hbs) developed as oxygen therapeutics (often termed 'blood...

Inhaled steroid therapy does not reduce fetal growth.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Inhaled steroid therapy by pregnant women with asthma does not lead to a restriction in fetal growth, researchers report. In the largest sample to date examining the potential effects that inhaled...

Endothelial catalase overexpression attenuates oxidant-mediated injury.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Endothelial catalase overexpression attenuates oxidant-mediated injury. "In a variety of vascular disorders, endothelial cells (ECs) are exposed to high levels of reactive oxygen species (ROS)...

Better driving by teens with ADHD may be due Concerta.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- A medication that many teenagers with attention deficit/hyperactivity disorder (ADHD) take to manage the disorder may positively affect their driving performance and attentiveness behind the wheel. ...

Technology company receives award for pharmaceutical automated sales tool.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Synergistix Data Solutions was named the winner of the Microsoft Healthcare Users Group (MS-HUG) 2004 award as the best enabling technology for the health care industry. Synergistix was selected...

Method to identify protease genes from B. thuringiensis developed.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Researchers have developed a facile analytical method for the identification of protease gene profiles from Bacillus thuringiensis strains. "Five pairs of degenerate universal primers have been...

Acyl-homoserine lactone binding in Vibrio fischeri is reversible.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Researchers describe reversible acyl-homoserine lactone binding to purified Vibrio fischeri LuxR protein in a recent issue of the Journal of Bacteriology. According to recent research from the...

YefM antitoxin family carries novel antibacterial target.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- The YefM antitoxin family contains a promising antibacterial target. "Although natively unfolded proteins are being observed increasingly, their physiological role is not well understood,"...

Uroxatral marketed in U.S. for benign prostatic hyperplasia.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- SkyePharma PLC (SKYE) is to begin marketing Uroxatral (alfuzosin hydrochloride extended-release tablets), a treatment for benign prostatic hyperplasia (BPH), directly to primary care physicians (PCPs)...

The biosurfactant MEL-A cultivates vigorous liposomal transfection.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- The biosurfactant MEL-A cultivates vigorous liposomal transfection. According to published research from Japan, "biosurfactants, which are surface-active compounds produced by microorganisms growing...

Peptide array used to identify Ang II inhibitory peptide.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- An Ang II inhibitory peptide has been identified with the help of a novel peptide array system. In a recent study from Japan, a "peptide array consisting of hundreds of peptides spatially addressed...

SdFFF system aids study of PFC emulsion particle stability.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- A sedimentation field-flow fractionation (SdFFF)-based system facilitates the study of PFC emulsion stability in whole blood. Researchers in California conducted a study to determine if SdFFF...

A large-sample QTL study in mice examined body composition.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- A large-sample QTL study in mice examined body composition. According to recent research from the United States, "Using lines of mice having undergone long-term selection for high and low growth, a...

Low vitamin B-12 levels linked to bone loss in older women.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Older women with low levels of vitamin B-12 are more likely to experience rapid bone loss, according to new research published in The Journal of Clinical Endocrinology & Metabolism (JCEM). The new...

IL-2-activated NK cells enhance effect of tumor vaccine in brain cancer.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Intratumoral injection of IL-2-activated NK cells enhances the antitumor effect of intradermally injected paraformaldehyde-fixed tumor vaccine in a rat intracranial brain tumor model. "Combined...

Proton therapy offers advantages for children with brain tumors, study shows.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Proton beam therapy offers a clear advantage over both conventional external beam radiation therapy and intensity modulated radiation therapy for treatment of the posterior fossa and spinal column in...

Estrogen interacts with estrogen receptor and SP proteins to control VEGF.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Estrogen interacts with estrogen receptor and SP proteins to control VEGF. "Vascular endothelial growth factor (VEGF) is expressed in multiple hormone-dependent cancer cells/tumors. Treatment of...

Fulvestrant gains E.U. marketing approval.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- AstraZeneca has received European marketing approval for its new breast cancer drug Faslodex (fulvestrant). The novel drug is indicated for the treatment of postmenopausal women with...

Patients switched from tamoxifen to exemestane more likely to stay cancer-free.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- In a large clinical trial, postmenopausal breast cancer patients who switched from tamoxifen to exemestane tablets (Pfizer brand name: Aromasin) had a significantly reduced chance of recurrence and...

Antibody company files for initial public offering.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Inhibitex, Inc., has filed a registration statement on Form S-1 with the U.S. Securities and Exchange Commission. Piper Jaffray and Lazard will act as joint book-running managers, with Thomas...

Biosciences company updates stock plan, gets patent.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Aastrom Biosciences, Inc., (ASTM) announced that shareholders of the company who wish to enroll in its Direct Stock Purchase Plan (DSPP), but whose shares are held in "street name" through a broker or...

Dermatology company emerges from Chapter 11 protection with new owners.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- ATI Acquisition Company, LLC of Golden, Colorado, announced that it has acquired the assets of Aesthetic Technologies, Inc. The purchase is part of a Chapter 11 Plan of Reorganization that was...

Drug development company announces reduced loan principal.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- VaekstFonden has informed Pharmexa that the principal of a loan taken out by Pharmexa in 1997 will be written down from DKK 21 million to DKK 9 million. The DKK 12 million was used in the...

Drug development services provider expands facility and increases credit line.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- SFBC International, Inc., (SFCC) has expanded its Miami, Florida, facility by purchasing the property that houses its Miami operations and corporate headquarters, has increased its line of credit to $25...

Pharmaceutical company announces vitamin E contract.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Nutri Pharmaceuticals Research, Inc., (NRIP.PK) announced a new open-ended contract to supply high concentrate natural Vitamin E O2PT (oil to powder) product to International Specialty Botanical...

Pharmaceutical company enters agreement to sell MVI product business.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- aaiPharma Inc. (AAII) has entered into a definitive agreement to sell its MVI (multi-vitamin infusion) and Aquasol product business to Mayne Pharma (U.S.A) Inc., a subsidiary of Australia's Mayne Group...

Pharmaceutical company makes significant strides in 2003.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- IntraBiotics Pharmaceuticals, Inc., (IBPI) reported financial and operating results for the fourth quarter and year ended December 31, 2003. "We have made significant progress in 2003, advancing our...

Firm combines gene expression, proteomics and reagents businesses.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Agilent Technologies, Inc., (A) announced the formation of the Integrated Biology Solutions (IBS) unit within its Life Sciences and Chemical Analysis business group. This new unit consolidates...

Wellbutrin maker provides updated 2004 guidance.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Biovail Corporation (BVF) announced revised revenue and earnings guidance for 2004. The company believes that the financial guidance contained herein is conservative, achievable and reflects the...

Biopharmaceutical companies announce antibody collaboration.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Y's Therapeutics Co., Ltd., and Abmaxis, Inc., have entered into an agreement to collaborate on the development of a human monoclonal antibody drug targeting a specific antigen, which is overexpressed...

Pharmaceutical company provides update on second-generation TAPET vectors.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Vion Pharmaceuticals, Inc., (VION) announced an update on its development of second-generation tumor amplified protein expression therapy (TAPET) vectors. TAPET vectors are modified Salmonella...

Platelet-activating factor boosts the activation of proangiogenic cytokines.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Platelet-activating factor boosts the activation of proangiogenic cytokines. "Tumor-induced angiogenic responses lead to complex phenotypic changes in vascular endothelial cells, which must...

Advocacy group to accelerate the attack on cancer.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- C-Change, the first group to bring together the public, private and nonprofit sectors to address cancer as a societal problem, announced its historic collaboration and goal to prevent an additional one...

Movies of cells capture transmission of messages that control genes.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Researchers at Max Planck Institute in Germany have used a new nano-sized imaging tool to capture the first-ever movies of cells transmitting the messages that control genes. The breakthrough is...

Decoy receptor 3 can be suppressed to staunch tumor angiogenesis.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Decoy receptor 3 can be suppressed to staunch tumor angiogenesis. "TL1A is a member of the tumor necrosis factor superfamily and plays an important role in regulating endothelial cell apoptosis. A...

First KOS-862 phase Ib chemotherapy combination trial begins.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Kosan Biosciences, Inc., (KOSN) announced the start of a phase Ib clinical trial to evaluate KOS-862 (Epothilone D) as an anticancer therapy in combination with Gemzar (gemcitabine HCl) in patients with...

Higher doses would make taxane-mediated antiangiogenesis more effective.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Higher doses would make taxane-mediated antiangiogenesis more effective. According to a study from the United States, "paclitaxel (Taxol) and docetaxel (Taxotere) have been shown to inhibit...

Polo-like kinase 1 is a viable target for the treatment of prostate cancer.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Polo-like kinase 1 is a viable target for the treatment of prostate cancer. "Second only to skin cancer, cancer of the prostate gland (CaP) is the most commonly occurring cancer in American men....

Semaphorin-3F curtails tumor angiogenesis.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Semaphorin-3F curtails tumor angiogenesis. "The neuropilin-1 (np1) and neuropilin-2 (np2) receptors form complexes with type-A plexins. These complexes serve as signaling receptors for specific...

Spacer-containing doxorubicin prodrugs limit tumors without systemic toxicity.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Spacer-containing doxorubicin prodrugs limit tumors without systemic toxicity. "To generate doxorubicin (Dox) specifically at the tumor site, the chemotherapeutic agent was incorporated into a...

CG motifs in virus-like particles induce cytotoxic T cell responses.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic T cell responses in the absence of systemic side effects. According to a study from Switzerland, "DNA rich in...

New peptide derived from protein in saliva may be promising antifungal agent.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Searching for better treatments for oral infections that plague people with compromised immune systems, oral biologists at the University at Buffalo have developed a novel peptide that appears to be a...

Protease-inhibitor cocktail protects, increases antimicrobial action of new peptide.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- The antimicrobial activity of promising peptides shown in laboratory studies to kill several medically important fungi, some of which are resistant to current drugs, can be enhanced further by...

AT[subscript]2-receptor antagonists block Ang II effects on atrial noradrenaline release.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Both AT[subscript]1- and AT[subscript]2-receptor antagonists inhibit Ang II's effects on atrial noradrenaline release. According to recent research from Germany, it is "generally accepted that...

High heart rate reduces arterial distensibility.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Heart rate significantly influences human arterial distensibility. "In rats, an increase in heart rate by pacing is accompanied by progressive large-artery stiffening," researchers in Italy...

AT[subscript]1 receptors linked to insulin resistance-induced vascular dysfunction.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- AT[subscript]1 receptor expression has been linked to insulin resistance-associated vascular dysfunction. According to recent research from Japan, "Excess production of superoxide anion in response...

Angiotensin II causes oxidative stress in hypertension patients.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Oxidative stress is significantly increased in humans after infusion of angiotensin (Ang) II. According to recent research from Tennessee, Ang II "induces oxidative stress in vitro and in animal...

Antioxidant therapy helps manage diabetic cardiovascular disease.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- Antioxidant therapy helps in the management of diabetic cardiovascular disease. "The diabetic state confers an increased propensity to accelerated atherogenesis. In addition to the established risk...

Apolipoprotein risk factors for CVD reviewed.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- The apolipoprotein risk factors for cardiovascular disease have been reviewed. "Although LDL cholesterol (LDL-C) is associated with an increased risk of coronary heart disease, other lipoproteins...

CAC deposits linked to elevated LV mass in African-Americans.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- CAC deposits are associated with elevated LV mass in African-American patients. "Both coronary artery calcium (CAC) deposits and increased left ventricular (LV) mass are important risk factors for...

GATA-4 transcription factor regulates cardiac myocyte apoptosis.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- The GATA-4 transcription factor plays a key role in regulating cardiac myocyte apoptosis. "Apoptosis of cardiac muscle cells plays important roles in the development of various heart diseases...

GP Ialpha genotype affects CHD risk.
April 2, 2004... 2004 APR 2 - (NewsRx.com & NewsRx.net) -- GP Ialpha genotype has a significant effect on CHD risk. "Glycoprotein (GP) Ib-IX-V complex plays an important role in formation of platelet-fibrin clot at the area of damaged vessel wall,"...