Medical Letter on the CDC & FDA articles from November 2008

Medical Letter on the CDC & FDA archives from November 2008

Akorn, Inc. Announces the Launch of Akten Gel 3.5%.
November 2, 2008... Akorn, Inc. (NASDAQ: AKRX) announced the commercial launch of Akten(TM) Gel 3.5%, a topical ocular anesthetic ophthalmic drug product. Akten(TM) represents the first FDA approved drug product indicated for use as an ocular anesthetic in four...

PAREXEL Consulting Quantifies Speed to Market: First-Cycle Approval for NME Produces $640 Million in Incremental Revenue on Average.
November 2, 2008... Gaining a first-cycle approval for a new molecular entity (NME) is worth an estimated $640 million in incremental revenue on average, according to a new analysis from PAREXEL Consulting, a business unit of PAREXEL International (NASDAQ:PRXL)...

BioTrove Announces Agreement with BD to Boost Drug Discovery Research Efficiency.
November 2, 2008... BioTrove, Inc. announced an exclusive alliance with BD (Becton, Dickinson and Company) to provide customers with a complete solution for sample preparation and data analysis of high-throughput in vitro ADME assays (see also BioTrove, Inc.). ...

Studies conducted at Virginia Commonwealth University on capillary electrophoresis recently published.
November 2, 2008... According to a study from the United States, "Clinically used low molecular weight heparins (LMWH) are anticoagulants of choice and are phenomenally complex mixtures of millions of distinct natural and unnatural polymeric sequences. The FDA...

Findings from University of North Carolina, Medical Department in depression reported.
November 2, 2008... "Quetiapine is an atypical antipsychotic drug that is also US FDA approved for treating bipolar depression, albeit by an unknown mechanism. To discover the potential mechanism for this apparently unique action, we screened quetiapine, its...

Reports outline enzyme research study results from New York Medical College, Medical College.
November 2, 2008... According to recent research published in the journal Nucleic Acids Research, "Among bacterial topoisomerase I enzymes, a conserved methionine residue is found at the active site next to the nucleophilic tyrosine. Substitution of this...

'Poetry From the Heart By an Alzheimer's Caregiver': Touching New Poetry Collection Explores Devastating Emotional Experience.
November 9, 2008... With grace and a heart, Carolyn A. Haynali presents "Poetry From The Heart By An Alzheimer's Caregiver" (published by AuthorHouse - http://www.authorhouse.com/), the new collection of poems for family caregivers of Alzheimer's patients (see...

Research from Chonnam National University in the area of behavior published.
November 9, 2008... According to recent research from South Korea, "Chinese cabbage has long been consumed as a staple food by the Koreans in various forms of fresh, salted, or fermented as kimchi. To fulfill the off-season demand for this crop, it has become a...

New research on cancer from University of California summarized.
November 9, 2008... "Fifteen epidemiologic studies have associated hypnotic drugs with excess mortality, especially excess cancer deaths. Until recently, insufficient controlled trials were available to demonstrate whether hypnotics actually cause any cancers,"...

E. coli O157 Vaccine Efficacy Reinforced by Study Published in Foodborne Pathogens and Disease.
November 9, 2008... Bioniche Life Sciences Inc. (TSX: BNC), a research-based, technology-driven Canadian biopharmaceutical company, announced that the results of a large-scale commercial beef feedlot study with the Company's E. coli O157 vaccine have been...

Data on life sciences reported by S. Ekins and co-researchers.
November 9, 2008... "Very few antagonists have been identified for the human pregnane X receptor (PXR). These molecules may be of use for modulating the effects of therapeutic drugs, which are potent agonists for this receptor (e. g., some anticancer compounds and...

Researchers at State University of New York publish new data on plague.
November 9, 2008... According to recent research from the United States, "Pathogenic Yersinia species utilize a type III secretion system (T3SS) to translocate effectors called Yersinia outer proteins (Yops) into infected host cells. Previous studies demonstrated...

Research on west nile virus reported by scientists at State University of New York.
November 9, 2008... "An empirical model to forecast West Nile virus mosquito vector populations is developed using time series analysis techniques. Specifically, multivariate seasonal autoregressive integrated moving average (SARIMA) models were developed for...

Studies conducted at National Institutes of Health on physiology recently published.(Report)
November 9, 2008... According to a study from the United States, "Physiological fluctuations resulting from the heart beat and respiration are a dominant source of noise in fMRI, particularly at high field strengths. Commonly used physiological noise correction...

Duska Therapeutics Acquires Technology for ATPotent Sperm Motility Program.
November 16, 2008... Duska Therapeutics, Inc. (BULLETIN BOARD: DSKA) announced that it has entered into a series of agreements to acquire exclusive worldwide rights from several inventors to develop and commercialize technologies relating to the use of adenosine...

Research results from Midwestern University update understanding of drug resistance.
November 16, 2008... According to recent research published in the journal Annals of Pharmacotherapy, "To summarize the published clinical data on posaconazole, critically review the New Drug Application data submitted to the Food and Drug Administration, and...

Reports summarize torticollis research from S.J. Cano and co-authors.(Report)
November 16, 2008... According to recent research from London, the United Kingdom, "The United States Food and Drug Administration (FDA) are currently producing guidelines for the scientific adequacy of patient reported outcome measures (PROMs) in clinical trials,...

Research from N.T. Hong Kong SAR, Department of Biochemistry in the area of Alzheimer disease therapy published.
November 16, 2008... Fresh data on Alzheimer disease are presented in the report 'Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer's disease.' "Alzheimer's disease (AD) is a neurodegenerative disease characterized by...

Research from University of Siena in the area of cancer published.
November 16, 2008... According to a study from Siena, Italy, "Piroxicam H2PIR (H2PIR, 4-hydroxy-2-methyl-N-pyridin-2-y]-2H-1,2-benzothiazine-3-carboxamide 1,11-dioxide), [Cu(HPIR)(2)(H2O)(2)] previously prepared and tested from this laboratory and at National...

Research by L.A. Magnarelli and colleagues in west nile virus provides new insights.
November 16, 2008... "A polyvalent ELISA and plaque reduction neutralization tests (PRNTs) were used to measure serum antibodies to West Nile virus (WNV) in horses naturally exposed to or vaccinated against this flavivirus in Connecticut and New York State, USA....

Research from Centers for Disease Control and Prevention in plague provides new insights.
November 16, 2008... A new study, 'Detection of viable Yersinia pestis by fluorescence in situ hybridization using peptide nucleic acid probes,' is now available. According to a study from the United States, "A successful method has been developed for the detection...

Rapid test detects Legionnaires Disease in 15 minutes.
November 16, 2008... The BinaxNOW[R] Legionella test, available from Inverness Medical provides significant time saving advantages over traditional sputum culture. Providing results in fifteen minutes from urine samples, BinaxNOW Legionella enables initiation of...

Master-bilt Walk In Systems Put a Freeze On the Blood Plasma Industry.
November 16, 2008... As medical advancements involving human blood plasma increase, collection centers are popping up all over the country. Because blood plasma is such an important commodity, the FDA has strict regulations on the process by which the plasma is...

Research data from M. Spaeth and colleagues update understanding of fibromyalgia.
November 23, 2008... "The concept of fibromyalgia being one of several 'central sensitivity syndromes' has led to the use of centrally acting drugs in the treatment of this disorder. One such drug, pregabalin, has recently been approved by the US FDA for the...

Studies from Arizona State University add new findings in the area of fibromyalgia.
November 23, 2008... "The difficulties in finding successful treatments for patients with fibromyalgia are well known within the field of rheumatology. Indeed, only one drug has been approved by the FDA for the treatment of patients with fibromyalgia, and must be...

Long-Term Results of VisionCare's Implantable Telescope for End-Stage Macular Degeneration Published in the American Journal of Ophthalmology.
November 23, 2008... VisionCare Ophthalmic Technologies, Inc., a developer of advanced visual prosthetic devices for individuals with age-related macular degeneration (AMD), announced that the American Journal of Ophthalmology (AJO), a premier peer-reviewed medical...

New obesity findings from University of Pittsburgh, Western Psychiatric Institute published.
November 23, 2008... According to a study from the United States, "Weight gain is a significant problem for many patients taking various psychotropic medications. The U.S. Food and Drug Administration (FDA) has approved certain medications for the treatment of...

AZILECT Shown to Be a Selective MAO-B Inhibitor.
November 23, 2008... Teva Pharmaceutical Industries Ltd. (NASDAQ: TEVA) announced results of a study in which Azilect(R) (rasagiline tablets) demonstrated selective MAO-B inhibition at the approved dose of 1mg. Non selective MAO inhibitors may have some contra...

West Nile's North American spread described.
November 23, 2008... The rapid spread of West Nile virus in North America over the past decade is likely to have long-lasting ecological consequences throughout the continent, according to an article in the November issue of BioScience. The mosquito-borne virus,...

Findings from T. Abuladze and co-authors broaden understanding of Escherichia coli.
November 30, 2008... "A bacteriophage cocktail (designated ECP-100) containing three Myoviridae phages lytic for Escherichia coli O157:H7 was examined for its ability to reduce experimental contamination of hard surfaces (glass coverslips and gypsum boards),...

Researchers from Department of Agriculture detail new studies and findings in the area of Escherichia coli.
November 30, 2008... "The hide and carcass hygiene of cull cattle at slaughter in four geographically distant regions of the United States was examined from July 2005 to April 2006 by measuring the aerobic plate counts (APC) and the prevalences and loads of...

Studies from Department of Agriculture reveal new findings on Escherichia coli.
November 30, 2008... According to a study from the United States, "Weaned 3- to 4-month-old calves were fasted for 48 h, inoculated with 10(10) CFU of Shiga toxin-positive Escherichia coli (STEC) O157:H7 strain 86-24 (STEC O157) or STEC O91:H21 strain B2F1 (STEC...

Study findings from University of London, Imperial College provide new insights into Escherichia coli.
November 30, 2008... According to recent research from London, the United Kingdom, "Enterohemorrhagic Escherichia coli (EHEC) O157: H7 is an important human pathogen that colonizes the gut mucosa via attaching and effacing (A/E) lesions; A/E lesion formation in...

New hantavirus study findings reported from State University of New York.
November 30, 2008... According to a study from the United States, "Pathogenic hantaviruses replicate within human endothelial cells and cause two diseases, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. In order to replicate in endothelial...

Reports summarize plague study results from F. Pouillot and co-researchers.(Report)
November 30, 2008... According to recent research from Paris, France, "The transformation of the enteropathogenic bacterium Yersinia pseudotuberculosis into the plague bacillus, Yersinia pestis, has been accompanied by extensive genetic loss. This study focused on...

Investigators at Ondokuz Mayis University have published new data on life sciences.
November 30, 2008... A new study, 'Crimean Congo hemorrhagic fever and diffuse alveolar haemorrhage,' is now available. "Although the pathology of Crimean Congo haemorrhagic fever (CCHF) is mainly related to a haemorrhagic process with secondary cytokine storm,...