Cancer Weekly articles from November 2000

Cancer Weekly archives from November 2000

Improving Quality of Life is Reasonable Goal.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- In the first study of its kind, Duke Comprehensive Cancer Center researchers have used standardized methods to identify neurologic and psychiatric problems in adult brain tumor patients shortly after...

Combination of Therapy and Surgery Could Save Thousands of Lives.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Adding radiation therapy and chemotherapy to surgery for locally advanced stomach cancer nearly doubles the patient's chance that his or her cancer will not return, a new study shows. Stomach cancer is the...

Promising Results Reported from Xcytrin Phase III Trial for Brain Tumors.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Pharmacyclics, Inc. (PCYC) reported results from the lead-in phase of its ongoing randomized Phase III clinical trial of Xcytrin (motexafin gadolinium) Injection for the treatment of cancer patients with brain...

Depressed Patients Less Likely to Accept Chemotherapy.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Depression is strongly linked to the failure of patients with early-stage breast cancer to accept chemotherapy, according to a research letter published in the October 14, 2000, issue of The Lancet. About...

Radiation Safe and Effective for Patients with BRCA1 or BRCA2 Mutations.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- To address concerns of patients and physicians, researchers in the United States and Canada examined whether radiation therapy could be safely delivered to women with early stage breast cancer and BRCA1 or...

Transgenic Mice Aid Research.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Scientists will be better able to fight Burkitt's lymphoma, a rare but deadly cancer that attacks children and AIDS patients, now that they have achieved a decades-long goal of genetically engineering mice to...

Radiation Therapy Controls Voicebox Tumors and Saves Voice.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Radiation therapy controls tumors of the voicebox almost as well as surgery, according to a new study at Washington University School of Medicine in St. Louis, Missouri. The treatment also restores the...

Accelerated Treatment Improves Local Control.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Twice-a-day radiation therapy given over a shorter period is better than conventional treatment in destroying a primary head and neck tumor and any disease that has spread nearby, a new study shows. The...

CD437 Can Exert Anti-Cancer Effects Through Separate Mechanisms.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- The powerful anti-cancer effect of the retinoid CD437 is mediated with and without the receptors to which it binds, researchers writing in the journal Molecular Pharmacology report. "The synthetic retinoid...

Coincidence Gamma Camera Effective for Detection, Diagnosis.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Coincidence gamma cameras apparently are a useful tool for detecting head and neck tumors and metastases that are missed by many conventional detection techniques. S. Perie and colleagues at the University...

Intensity-Modulated Radiation Therapy Improves Quality of Life.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- A new radiation treatment technique that targets head and neck tumors without completely destroying the salivary glands saves patients long-term discomfort and enables them to function more normally, a study...

Positron Emission Tomography Effective for Diagnosis.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Researchers writing in the journal Laryngoscope report that positron emission tomography is superior to other diagnostic tools for diagnosing patients with recurrent cancer of the head and neck M. Lonneux...

More Intense Radiation Treatments Offer Greater Benefit to Patients.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Patients with locally advanced laryngeal or pharyngeal cancer treated with more intense radiation therapy have a better chance for survival, as well as a better chance of preserving their voice box or pharynx,...

Aggressive Treatment Offers Striking Improvement in Infants with Acute Disease.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Infants with acute leukemia do not have as favorable a prognosis with conventional chemotherapy as older children. A study suggests that high-dose chemotherapy (HDC) with stem cell transplantation can...

Enhanced Imaging Improves Effectiveness of Radiation Therapy.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Doctors at Memorial Sloan-Kettering Cancer Center, Boston, Massachusetts, are developing new ways to more effectively treat lung cancer with radiation therapy by using enhanced imaging to better define tumors...

Scientists Zeroing in on Cellular Pathway.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- In a major step toward understanding how air pollutants injure the lungs and trigger the cascade of molecular events leading to lung cancer, scientists at the Johns Hopkins School of Public Health have spelled...

Concurrent Chemotherapy and Radiation Therapy Increases Patient Survival.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Patients with locally advanced non-small cell lung cancer live longer if they are treated with radiation therapy and chemotherapy at the same time rather than by chemotherapy first followed by radiation...

Elevated Serum Micronutrients May Explain Lower Leukoplakia Risk for Some Japanese Men.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Higher levels of serum antioxidant micronutrients such as beta-carotene may translate into a decreased risk of pre-cancerous oral growths, at least for Japanese males. T. Nagao and colleagues at Aichi...

Several Factors Useful in Predicting Outcome of Mucoepidermoid Salivary Cancer.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Mucoepidermoid carcinomas of the salivary glands have several characteristics that can be used to predict patient outcome, according to researchers in Japan. "The oncoproteins Bcl-2 and Bax, the tumor...

Indian Tobacco Habits Increase Risk.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Methods of tobacco use popular in India produce the same elevated risks of oral, oropharyngeal, and lung cancer development as Western-style cigarette smoking and snuff dipping. "Tobacco habits in India...

Radiation Therapy is Less Costly.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- In the fight against early-stage prostate cancer, radiation therapy is significantly less expensive than radical prostatectomy for primary curative treatment, researchers have found. A examination of...

High-Dose Chemotherapy Effective in Patients with Recurrent Disease.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- High-dose chemotherapy followed by stem-cell transplantation offers new hope to testicular cancer patients who experience cancer recurrence. For these patients, such intensive therapy can achieve a durable...

Total-Body Radiation Treatment Innovation Eases Care for Patients.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Researchers at Montefiore Medical Center, New York, New York, have developed a method that could ease the pain for several thousand patients with blood cancer who undergo total-body radiation treatment each...

Differences in Estrogen Metabolism May Affect Disease Risk.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Researchers at the University at Buffalo, New York, have found that the development of breast cancer appears to be related to how the body breaks down estrogen. In only the second prospective study to...

Study: Adjuvant Therapy Can Prevent Late Recurrences.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Adjuvant treatments prevent late relapses in breast cancer patients, according to new study results from England. Breast cancer is an unusual disease because it can come back 10 or 15 years later. The new...

Corporate Alliance Expanded.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Therion Biologics Corp., Cambridge, Massachusetts, and Aventis Pasteur Limited, Toronto, Ontario, Canada, have agreed to expand the length and scope of their existing collaboration for development of cancer...

Study Offers Insight Into Cancer Development, Resistance to Therapy; Finding Focuses on Ras Oncogene.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- University of California, San Francisco (UCSF)-led scientists have determined that under certain conditions the Ras oncogene, a key culprit in many cancers, suppresses the function of the p53 tumor-suppressor...

Early Detection and Reducing Risk Key to Reduction in Mortality Rate.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Since 1955 the death rate from uterine cervical cancer in the United States has dropped about 74%, primarily due to the widespread use of the Pap test. However, 4,600 American women will still die from the...

Growth Factor Elevated with Barrett's Esophagus.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Vascular endothelial growth factor (VEGF) is elevated in patients with a type of cancer called Barrett's esophagus, but those elevated levels do give not give a good indication of patient prognosis, scientists...

Scientists Find Potential New Target for Treatment of Pediatric Cancer.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- In a new finding that could lead to more effective and novel cancer treatments, scientists at the Albert Einstein College of Medicine in New York reported that they have implicated a specific gene in the...

Experimental Oncolytic Virus Demonstrates Antitumor Activity and Acceptable Safety Profile.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Twenty men with prostate cancer who failed radiation therapy have completed a clinical trial at Johns Hopkins University with an experimental oncolytic virus that kills targeted cancer cells, while leaving...

System That Repairs DNA Damaged by Radiation Under Study.
November 7, 2000... 2000 NOV 7 - (NewsRx.com) -- Powerful radiation needed to kill cancer cells also can break DNA and researchers want to understand the natural response that rapidly repairs the damage. "The best thing that happens when DNA doesn't...

DNA Test Could Significantly Change Current Screening Methods.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Mayo Clinic, Rochester, Minnesota, researchers working in collaboration with scientists at EXACT Laboratories, Inc. of Maynard, Massachusetts, have developed a new, non-invasive test that proved 91% sensitive...

Gallium Citrate Augments the Effects of Hyperthermic Treatment on Cells in vitro.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Elevated levels of heat - hyperthermia - have been used in one form or fashion for a number of therapeutic uses. New findings support the use of gallium citrate as a way to increase heat-killing properties in...

PC-SPES Lowers Prostate Specific Antigen Levels but Induces Estrogenic Effects.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- In humans, in an animal model, and in in vitro analysis, the herbal therapeutic PC-SPES diminishes evidence of prostate cancer, but at the cost of generating estrogen-type side effects. PC-SPES is a...

New Study Finds Veggies Don't Stop Colon Cancer; More Research Needed.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- A diet rich in fruits and vegetables helps protect against heart disease and diabetes, but it has no effect against colon and rectal cancer, according to a new study. Harvard researchers report in the...

Study Finds Endoscopic Laser Surgery Best Choice for Treatment.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Researchers writing in the journal Tumori argue that endoscopic laser resection is the best treatment modality for patients with cancer of the glottis. "Among the different laryngeal neoplasms, glottic...

Carotid Stenting Can Improve Tumor Resection.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Using a carotid stent can allow surgeons to resect tumors of the head and neck while preserving the internal carotid artery (ICA), according to a report in the October 2000 issue of the journal Neurosurgery....

Postoperative Radiotherapy Often Unnecessary.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Oncologists in the United States argue that the routine use of radiotherapy following surgery for advanced head and neck melanomas is only justified in a small subset of patients. "Postoperative...

Diet Affects Risk of Precancerous Growths.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Researchers writing in Cancer Causes & Control argue that diet can increase - or reduce - the risk of developing abnormal oral growths that can be precursors to full-fledged oral carcinomas. "Oral...

Mushroom Compound Studied as Treatment.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Irofulven, a compound derived from the Jack O'Lantern mushroom (Omphalotus olearius), is being tested by MGI Pharma for the treatment of cancer. It is the first in a potential new class of treatments...

Phase I Study of Monoclonal Antibody Begins.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Xoma Ltd. (XOMA) announced that it has initiated a Phase I study of its ING-1 Human Engineered(TM) monoclonal antibody in cancer patients. ING-1 could potentially treat a number of adenocarcinomas,...

Thioplatin Platinum-Based, Targeted Anti-Cancer Therapy In-Licensed.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Antisoma plc (ASM, ASOM), London, United Kingdom, announced that it has in-licensed an innovative version of a proven anti-cancer agent developed by the German Cancer Research Centre (Deutsches...

Approval Received To Initiate PG-TXL Trial in U.S.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Cell Therapeutics, Inc. (CTIC), Seattle, Washington, received notification from the U.S. Food and Drug Administration (FDA) that its Investigational New Drug application for CT-2103 (PG-TXL) has been reviewed...

Phase II Study Results of Photodynamic Therapy Reported.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- QLT Inc. (QLTI; QLT), Vancouver, British Columbia, announced positive results for its Phase II study using photodynamic therapy with verteporfin to treat non-melanoma skin cancer, the most common form of skin...

Human Papillomavirus-Associated Cancers Occur More Frequently in AIDS Patients.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- In situ human papillomavirus (HPV)-associated malignancies in HIV/AIDS patients may be more frequent due to immunosuppression, report researchers in Denmark. "HPV-associated anogenital malignancies occur...

Cancer Gene Therapy Successful in Preclinical Models.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) Preclinical models of anti-angiogenesis gene therapy for cancer suggest this therapeutic modality has a promising future. "Because tumors require angiogenesis for growth, inhibiting angiogenesis is a...

Benefits of IL-2-Transduced Cells Must Be Balanced By Toxic Complications.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- According to a study from Austria, the benefits of interleukin (IL)-2-transduced bone marrow cells must be balanced by dose-limiting toxicities. "The purpose of this study was to investigate the effects...

Phase II SBIR Grant Awarded by National Cancer Institute.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Eukarion, Inc., announced that it has been awarded a Phase II Small Business Innovative Research (SBIR) grant from the U.S. National Cancer Institute for the development of its synthetic catalytic scavenger...

IMiDs Mechanism of Action Against Multiple Myeloma Cells Reported.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Celgene Corp. (CELG), Warren, New Jersey, reported on the results of laboratory studies evaluating the activity of IMiDs on multiple myeloma cells. IMiDs are structural analogs of thalidomide that have...

Monoclonal Antibody Enters Phase II Clinical Trials for Breast and Colorectal Cancer.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Seattle Genetics, Inc., announced the initiation of Phase II clinical testing with one of its lead monoclonal antibody drug conjugates, SGN-15. Two Phase II efficacy studies are being conducted, one for...

Study Approval for Cell Therapy Program.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Hemosol Inc. (HML), Toronto, Ontario, Canada, announced on October 17, 2000, that it has been granted regulatory approval for the Investigational New Drug (IND) submission for its cell therapy program to...

ONYX-015 Adenovirus Can Enhance Chemotherapy Effectiveness.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- The adenovirus ONYX-015 has potential to provide effective control of carcinomas of the head and neck, particularly when combined with a chemotherapy regimen, researchers report. "The E1-b attenuated...

Phase III Clinical Trial Data Indicate Vaccine Benefits Patients with Specific HLA Types.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Corixa Corporation (CRXA), a research and development-based biotechnology company, announced that additional data from its Phase III, randomized trial to evaluate Corixa's therapeutic vaccine Melacine(R), for...

Liposomal Vaccine is Immunotherapeutic at Higher Dose.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- A liposomal vaccine targeting the MUC1 peptide stimulated immune responses in non-small cell lung cancer (NSCLC) patients enrolled in a Phase I study. "A liposomal formulation of a 25-amino acid MUC1...

Report Evaluates the Potential for Genomics-Based Therapy.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- "Oncogenomics" is a forthcoming study from Decision Resources, Inc., that evaluates the potential for genomics-based therapy to treat cancer. In another Decision Resources study, "Genomics and Drug...

Alterations in p53 Gene Have Diagnostic and Prognostic Value.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Epithelial ovarian carcinoma is the most lethal gynecologic malignancy of the female genital tract. Mortality trends for ovarian carcinoma in the U.S. have not exhibited any significant changes since 1979,...

Special Protein Could Be Related to Vascular Changes in Tumors.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- New findings provide evidence that a special type of protein could play a significant role in the vascular changes observed in ovarian cancer tumors. The protein, called secreted protein, acid and rich in...

Bleach Technology Donated for Research.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Technology developed by the Procter & Gamble Co. (P&G) to bleach clothes as they hang in the sun could be used to fight cancer. P&G on October 25, 2000, donated the technology, named Apollo for the Greek...

Phase II Trial Combines Immunotherapy and Chemotherapy.
November 14, 2000... 2000 NOV 14 - (NewsRx.com) -- Results of a Phase II trial suggest that 5-fluorouracil is not beneficial in combination with recombinant interleukin 2 (rIL-2) and interferon-alpha 2B (IFN-alpha 2B) for the treatment of metastatic renal...

Researchers Develop Method to Predict Response to Chemotherapy.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Researchers at the Johns Hopkins Oncology Center have uncovered a genetic alteration that appears to predict how individuals with an aggressive type of brain cancer will respond to chemotherapy. The...

Targeted Chemoradiation Therapy Effective for Advanced Disease Control.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- A combination of radiation therapy and chemotherapy targeted directly to tumors can provide effective control for patients with advanced head and neck cancer, researchers in the United States report. K.T....

Central Nervous System Toxicity Not a Problem.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Patients who undergo total body irradiation (TBI) in the course of cancer treatments do not appear to be at significant risk for cognitive impairments resulting from TBI-induced central nervous system (CNS)...

Phase III Trial Results for Gliadel Wafer Announced.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Guilford Pharmaceuticals Inc. (GLFD), Baltimore, Maryland, announced that Gliadel Wafer (polifeprosan 20 with carmustine implant) prolonged survival and improved neurological outcomes in patients who were...

Possible Link Between Avascular Necrosis and Interferon Identified.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- A review of the major scientific databases has indicated the possibility of a relationship between a condition called avascular necrosis and a therapy used to treat patients with chronic myeloid leukemia. ...

Study Defines Complexities of New Modality in Radiotherapy.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- As Intensity Modulated Radiation Therapy, or IMRT, emerges in the treatment of cancer, doctors have had little or no data to support accurate treatment planning in homogeneous media. At the American...

Clinical Trial Shows Irofulven Holds Promise.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Results from a Phase II clinical trial of irofulven, an anti-cancer agent developed by MGI Pharma, Inc. (MOGN), demonstrated anti-tumor activity in patients with advanced pancreatic cancer who were refractory...

Depleting Glutathione Levels Could Enhance Apoptotic Therapy.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Glutathione is said to play a role related to increased cell proliferation in tumors. Researchers predict that by depleting glutathione levels, chemotherapy agents used in the fight against pancreatic cancer...

Tumor Cells with Structurally Compact DNA are More Sensitive to Radiation Treatment.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Radiation treatment for prostate cancer is more effective in tumor cells in which the DNA is structurally compact. That is the result of a study presented at the American Society for Therapeutic Radiology...

Biological Traits May Explain Higher Survival Rates in Asian-Americans.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Asian-American stomach cancer patients have tumors with biological traits that differ from tumors in non-Asians, which may explain why they have better survival rates from stomach cancer than non-Asians,...

Reduced CD44H Expression Can Predict Late Nodal Metastases.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Decreased expression of the cell adhesion molecule CD44H can be used to predict patients at a high risk for late nodal tongue cancer metastases after radiotherapy, study findings suggest. "Late nodal...

Structural Bioinformatics Awarded SBIR Grant for Bcl2 Inhibitors.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Privately-held Structural Bioinformatics Inc. (SBI) announced the award of a $100,000 Phase I Small Business Innovation Research (SBIR) grant from the U.S. National Cancer Institute, a division of the...

Updates Presented for Enzyme Inhibitor.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- OSI Pharmaceuticals, Inc. (OSIP), Uniondale, New York, announced updated findings from two on-going clinical studies using OSI-774 as a single agent. Data showed that 48% of 56 patients with advanced,...

Endostatin Well Tolerated, But No Cure-All.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Study findings on EntreMed Inc.'s anti-angiogenic drug, Endostatin, indicate that while it appears to be safe and well-tolerated, its actual effects on tumor growth are not particularly notable, so far. ...

Flavonoid Antioxidant Silymarin Stunts Growth Factor in Tumor Cells.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Silymarin, a natural substance derived from Silybum marianum, also known as milk thistle, is a flavonoid with antioxidant properties. Studies conducted at the AMC Cancer Research Center in Colorado indicate...

Phase I/II Angiozyme Cancer Trial Data Presented.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Results of an open-label, Phase I/II clinical trial with Angiozyme from Ribozyme Pharmaceutical, Inc., were reported by Dr. David Weng at the Annual European Organization for Treatment of Cancer Conference,...

Cancer Vaccine Stimulates Tumor-Specific Immune Responses.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Clinical trial data show that vaccination of patients with recurrent malignant astrocytoma with autologous tumor cells and granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulate immune responses,...

Combination Chemo/Immunotherapy Evaluated in Metastatic Disease.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Pilot trial data from a combined modality high-dose chemotherapy regimen with stem cell transplantation and adoptive immunotherapy for breast cancer are encouraging. "We have previously demonstrated that...

Femara Trial Results Challenge Tamoxifen as First-Line Treatment for Advanced Disease.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- New clinical findings from two studies presented for the first time in the U.S. show Femara (letrozole tablets) to be significantly more effective than tamoxifen - the current gold standard - in treating...

Drosophila melanogaster Deoxyribonucleoside Kinase is an Effective Suicide Gene.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK) is a candidate gene for suicide gene therapy of cancer, researchers in Sweden announced. "Transduction of tumor cells with the gene encoding...

Combined Cytosine Deaminase/Thymidine Kinase Gene Therapy Eradicates Glioma in Animal Model.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Combination suicide gene therapy using the cytosine deaminase and the thymidine kinase gene was more effective than single gene suicide therapy in a rat model of glioma, researchers in South Korea report. ...

More Data Describing Mechanism of Action of TLK286 in Human Cancer Cells Presented.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Telik, Inc. (TELK) announced the presentation of data supporting the mechanism of cancer cell targeting for Telik's TLK286 cancer product candidate. The results were presented in Amsterdam, The...

Connective Tissue Growth Factor Helpful Tool for Assessing Cartilage Cancer.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- Researchers in Japan have found evidence that connective tissue growth factor (CTGF) is a useful marker for determining the clinical extent of chondrosarcoma, a type of cancer that originates in cartilage...

Pentostatin Produced "Durable Complete Responses" in Follow-Up Study.
November 21, 2000... 2000 NOV 21 - (NewsRx.com) -- SuperGen Inc. (SUPG; SUPGZ), San Ramon, California, announced that its anticancer compound pentostatin (Nipent) produced "durable complete responses" in patients diagnosed with hairy cell leukemia, according...