Cancer Weekly articles from May 2003

Cancer Weekly archives from May 2003

Sequence matters when using novel agent.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- An experimental agent that targets a cancer cell's protein shredding machinery (the proteasome) should be given either before or with taxane-based chemotherapy drugs, but not after, say researchers at...

Common thyroid cancer gene mutation found.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Researchers at the Johns Hopkins Kimmel Cancer Center have found that a single genetic mistake causes about two-thirds of papillary thyroid cancers. Their research may lead to new therapies that could...

The P54-cleaved tyrosine kinase Lyn stops B cell receptor induced apoptosis.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- B cell receptor engagement and cell death of B lymphoma is self limiting due to the caspase-generated cleavage of Lyn which then acts as a negative regulator on the process. According to a study...

Transdermal gene delivery eradicates tumors expressing hepatitis C proteins.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer-A series of research experiments has demonstrated that hepatitis C virus (HCV) DNA vaccine can suppress tumor growth. The vaccine, developed by researchers at...

COX-2 correlates with cancer mechanisms in esophageal squamous cell carcinoma.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- COX-2 correlates with cancer mechanisms in esophageal squamous cell carcinoma. "Cyclooxygenase (COX) is a key enzyme in the conversion of arachidonic acid to prostanoids. COX-2 expression has been...

The wine derivative resveratrol alters genetic expression in cancer cells.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- The wine derivative resveratrol alters genetic expression in cancer cells. "Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural compound found in large quantities, most notably in grapes and...

Some ATM carriers are predisposed to cancer.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Some ATM carriers are predisposed to developing cancer. According to published research from Israel, "Maintenance of genome stability is essential for avoiding the passage to neoplasia. "The...

Standardized serum-free culture for tumor cells developed.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- An optimized serum-free culture system has been developed for the study of acute lymphoblastic leukemia (ALL) cells In a recent study conducted to "standardize in vitro culture conditions," ALL...

Compound triggers release of nitric oxide to fight leukemia and tumors.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Researchers from the University of Utah and the National Cancer Institute (NCI) have developed an experimental drug that reacts with a substance inside cancer cells, releasing nitric oxide to kill the...

Genetic risk factors identified in mice.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Genetic risk factors for acute myeloid leukemia have been identified in mice. "Inbred CBA/H mice are susceptible to radiation-induced acute myeloid leukemia (r-AML), and C57BL/6 mice are resistant,"...

t(10;16)(Q22;p13) and MORF-CREBBP fusion is a recurrent event in AML.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- t(10;16)(Q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia (AML). "Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood...

Roadblocks to tumor vaccines could be overcome with interleukin-2.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Roadblocks to tumor vaccines could be overcome with interleukin-2. "Transforming growth factor-beta (TGF-beta), found at the site of most tumors, has been recognized as one of the mechanisms...

A new assay can be used for evaluating substances that halt angiogenesis.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- A new assay can be used for evaluating substances that halt angiogenesis. According to a study from Australia, "the chicken chorioallantoic membrane (CAM) has been extensively used in the study of...

Anticancer drug mithramycin is associated with H1-depleted chromatin.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Anticancer drug mithramycin is associated with H1-depleted chromatin. "Depletion of histone H1 after covalent modification from chromatin is a key step in eukaryotic transcription initiation. We...

A novel atypical retinoid is endowed with proapoptotic and antitumor activity.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- A novel atypical retinoid is endowed with proapoptotic and antitumor activity. According to recent research published in the Journal of Medicinal Chemistry, "The novel atypical retinoid...

A disaccharide anthracycline, MEN 10755, can binds 2 DNA helices simultaneously.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- A disaccharide anthracycline with broad antitumor activity can form a structure involving two DNA helices. "The crystal structure of the complex formed between the anthracycline antibiotic...

Spike, a novel BH3-only protein, mediates proapoptotic signals.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Spike, a novel BH3-only protein, mediates proapoptotic signals. According to a study from Germany, "We have isolated Spike, a novel and evolutionary conserved BH3-only protein. BH3-only proteins...

TERT requires reverse transcriptase activity and 14-3-3 protein binding ability.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- TERT can suppress apoptosis early and the mechanism needs its reverse transcriptase ability as well as ability to bind 14-3-3 protein. "The catalytic subunit of telomerase (TERT) is a reverse...

Epigallocatechin-3 gallate can activate p53 and induce apoptosis.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Green tea catechin may prevent atherosclerosis, as it can activate p53 and induce apoptosis of proliferating smooth muscle cells. According to a study from the United States, "Green tea polyphenols...

MUC-1 mucin protein expression is common in any state of disease.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- MUC-1 mucin expression is correlated only with lymphoma, and not a particular cell type or disease status, nor was there a correlation with the rearrangement of the gene. "We have recently shown...

Pten in B cells controls homeostasis and IgG class switch recombination.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- The tumor suppressor Pten has roles in B cells ranging from B cell development and homeostasis to control of autoantibody production. "Pten is a tumor suppressor gene mutated in human cancers. We...

Metaplasia and carcinogenesis may result from increased metallothionein.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Increased metallothionein expression protects cells from apoptosis, leading to progression of Barrett metaplasia. According to a study from the United States, "Barrett esophagus is the...

The molecular pathogenesis of BCC differs markedly from most other cancers.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- The molecular pathogenesis of basal cell carcinomas (BCC) differs markedly from most other cancers. "Abnormal hedgehog signaling, most commonly caused by loss of PTCH1 inhibitor activity, drives...

A comparison of drug therapies based on toxicity and efficacy has been developed.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- A mathematical method for comparing two treatments in which toxicity and drug concentrations are taken into account has been developed to analyze clinical trials. "The primary goal of anticancer...

8q24 amplification occurs in transitional cell carcinoma of bladder.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- 8q24 amplification occurs in transitional cell carcinoma of bladder. According to recent research published in the journal Applied Immunohistochemistry & Molecular Morphology, "Genomic...

Adamantinoma was found with discrete osteofibrous dysplasia in an ulna.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Evidence of concurrent adamantinoma and osteofibrous dysplasia in an ulna further shows the lesions may be related. "An adamantinoma is a rare, low-grade malignant, osteolytic bone tumor occurring...

Donor T cell-derived TNF is required for graft-versus-host disease.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Donor T cell-derived TNF is required for graft-versus-host disease after bone marrow transplantation. According to published research from the United States, "Previous studies in murine bone marrow...

Patients receiving a Gliadel wafer have a higher incidence of infection.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Patients receiving a Gliadel wafer for treatment of brain tumors have a higher incidence of infection. "Gliadel wafers (1,3-bis [2-chloroethyl]-1-nitrosourea Guilford Pharmaceuticals) are approved...

An antisense gene targeting strategy could make breast tumors chemosensitive.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- An antisense gene targeting strategy could make breast tumors chemosensitive. "Overexpression of the HER-2 correlates with drug-resistance and a poor prognosis in breast cancer, however the...

Bidirectional signaling between EGFR and ER contributes to pathophysiology.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Bidirectional signaling between EGFR and ER contributes to pathophysiology. "Interactions between the estrogen receptor (ER) and the epidermal growth factor receptor (EGFR) contribute to the...

Caelyx - a novel agent in the fight against metastatic breast cancer.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Caelyx (pegylated liposomal doxorubicin hydrochloride) is a novel anthracycline that was specifically designed to address the side effects associated with conventional anthracyclines, including the risk...

Data support an important role for TP53 in mammary carcinogenesis.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Data support an important role for TP53 in mammary carcinogenesis. "The TP53 gene (p53) is found altered in breast carcinomas in approximately 20% - 40% of all cases depending on tumor size and...

Decision tool benefits women considering adjuvant chemotherapy.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Women with breast cancer who are considering treatment with adjuvant chemotherapy may benefit in decision making from the use of a formal decision aid, according to a new study. The study found...

Discovery of how prolactin travels to gene's machinery helps explain role.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Prolactin, a naturally occurring peptide hormone needed for milk production following pregnancy, has been found to play a major role in the development and spread of breast cancer. More recently,...

In breast cancers, 24 genes showed significant overexpression.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Twenty-four genes showed significant overexpression in breast cancers. "Chromosome region 17q12-23 commonly shows an increase in DNA copy number in breast cancers, suggesting that several oncogenes...

Isoliquiritigenin in licorice has estrogenic and antiproliferative activities.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- At lower levels, licorice root's isoliquiritigenin is an estrogenic agonist and at higher levels it is cytotoxic. According to a study from Italy, "Licorice root contains chemically diverse...

Organized mammography screening does not result in overdiagnosis of cancer.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Organized mammography screening does not result in overdiagnosis of breast cancer. "Mammography screening may lead to overdiagnosis of asymptomatic breast cancers, that would otherwise not have...

Percutaneous 4OHTam may be a useful alternative to tamoxifen.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Percutaneous 4OHTam may be a useful alternative to tamoxifen in breast cancer prevention. "In the search for a breast cancer prevention strategy which would avoid undesirable effects of orally...

Peroxisome receptor gamma agonists reduce estrogen receptor alpha.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- The mode of action of peroxisome proliferator activated receptor gamma agonists is to induce degradation of cyclin D1 and estrogen receptor alpha and thus decrease breast cancer cell proliferation. ...

Rare metaplastic breast malignancies often reveal extensive vascularity.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Rare metaplastic breast malignancies often reveal extensive vascularity. According to recent research from Italy, "Metaplastic breast carcinomas are rare neoplasms showing both carcinomatous and...

TP53 mutations may occur in familial breast cancer.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- TP53 mutations may occur in familial breast cancer. According to recent research from England, "Mutation in p53 (TP53) remains one of the most commonly described genetic events in human neoplasia....

There is tight correlation between the expression of HGF, matriptase, and MET.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- There is tight correlation between the expression of hepatocyte growth factor (HGF), matriptase, and MET in breast cancer outcome. According to published research from the United States, "Numerous...

Tumor cells in blood may indicate more aggressive cancer.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- If patients with breast cancer have tumor cells circulating in the blood, they may have a more dangerous form of the disease, according to a study by researchers at the University of Texas M.D. Anderson...

Tumor suppressors p16INK4a and p14ARF are linked and not inactivated by mutation.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Two tumor suppressor proteins involved in cell cycle control in breast cancer are linked, and their inactivation is due to hypermethylation or deletion. "The INK4a/ARF locus encodes 2 tumor...

Two biomarkers are valuable for predicting women's response to tamoxifen.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer-A new study of patients with advanced breast cancer has shown that at least two markers are useful for predicting the therapeutic value of tamoxifen. The...

Levels of pain associated with mammography low.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- The low level of pain reported after mammography is useful information for patients and practitioners and may increase adherence to screening recommendations, according to new research. Breast...

Vaccine elicits tumor-specific antibodies in patients with breast cancer.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Researchers have identified tumor-specific antibodies in patients with breast cancer vaccinated with gene-modified allogeneic tumor cells. "Thirty HLA-A2+ women with metastatic breast cancer...

The prodomain of IL-1 alpha interacts with RNA processing elements.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Selective apoptosis of a wide range of tumor cells is obtained with the IL-1alpha precursors' leftover component, the "prodomain"; this component interacts with RNA splicing and processing elements. ...

4-Hydroxymethyl-3-aminoacridine derivatives are new anticancer agents.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- 4-Hydroxymethyl-3-aminoacridine derivatives are new anticancer agents. According to published research from France, "3-Amino- and 3-alkylamino-4-hydroxymethylacridines bearing various substituents...

Understanding cancer requires new statistical and computational approaches.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Understanding cancer requires new statistical and computational approaches for analysis of the genetic and signaling networks that orchestrate cancer susceptibility. "The past decade has seen great...

Hue-Saturation-Intensity (HSI) works better than the gold standard.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Histochemical staining of lung cancer tissue by hue saturation density for levels of proliferating cells with Ki-67 worked better than the gold standard. "We tested a recently developed flexible...

Noncovalent scFv multimers of tumor-targeting humanized antibody constructed.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- According to a study from Australia, "Single-chain variable fragments (scFvs) of anti-Lewis(y) hu3S193 humanized antibody were constructed by joining the V-H and V-L domains with either +2 residues, +1...

Interleukin-8 may potentially be responsible for invasive pancreatic cancer.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Interleukin-8 may potentially be responsible for invasive pancreatic cancer. "The purpose of the present study was to examine the expression of interleukin (IL)-8 and IL-8 receptors and to evaluate...

Better directions and practice screens would improve PAINReportIt questionnaire.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Better directions and practice screens would improve PAINReportIt questionnaire. "We examined usability (completion time, acceptability, and completeness of information) of a computerized format for...

Researchers demonstrate broad use of Ciphergen's SELDI ProteinChip Technology.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Ciphergen Biosystems, Inc., (CIPH) announced that more than 45 studies highlighting the use of its SELDI ProteinChip platform in cancer research were published in the Proceedings of the American...

Mammalian Exo1 functions in mutation avoidance.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Mammalian Exo1 functions in mutation avoidance and is essential for male and female meiosis. "Exonuclease 1 (Exol) is a 5'-3' exonuclease that interacts with MutS and MutL homologs and has been...

Agents resembling 2-methoxyestradiol may be able to combat tumor growth.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer-Novel analogues of 2-methoxyestradiol could be of valuable for fighting tumor growth because of the way they block angiogenesis. "2-Methyoxyestradiol (2-ME2)...

Angiogenesis targeting is one way that immunotherapy could fight cancer.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Angiogenesis targeting is one way that immunotherapy could fight cancer. According to a study from Australia, "one of the most controversial issues in immunology for over a century has been whether...

Company provides update on pipeline of marine compounds.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- The latest preclinical data on five PharmaMar compounds were published in the Proceedings for the 94th Annual Meeting of the American Association for Cancer Research (AACR). These findings provide...

Data on TLK286 and TLK199 reported.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Telik, Inc., (TELK) announced a series of preclinical studies of its TLK286 product candidate, currently in a phase III registration trial for ovarian cancer, and in clinical trials in non-small cell...

Lung cancer study combines gene expression and protein expression.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Ciphergen Biosystems, Inc., (CIPH) announced that Dr. Lin Ji from the University of Texas M. D. Anderson Cancer Center published work in the Proceedings of the American Association for Cancer Research's...

New findings published on diagnostic applications of HAAH Oncology Program.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Panacea Pharmaceuticals, Inc., announced that new important findings on the diagnostic applications of its HAAH Oncology Program were published in the Proceedings of the 2003 Annual Meeting of the...

Novel dihydroartemisinin ethers cytotoxic to tumor cells.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Derivatives of antimalarial dihydroartemisinin ethers kill a variety of malignant cells. In a recent study from China, "a new type of ether of dihydroartemisinin containing cyano and aryl groups...

Programmable antibodies described by scientists.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- A group of scientists at The Scripps Research Institute (TSRI) has designed a "hybrid" anticancer compound that physically combines the potent punch of a cancer cell-targeting agent with the...

Study offers new insights into angiogenesis inhibitors.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- In working to halt the overgrowth of blood vessels that feed cancerous tumors, the antiangiogenic molecules endostatin and tumstatin take two distinct and very different tactics, according to a new...

CD4+ cells play critical role in tumor immunity against simian virus 40 antigen.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- CD4+ T lymphocytes played a critical role in antibody production and tumor immunity against simian virus 40 large tumor antigen. According to recent research published in the journal Cancer...

CTLA-4 blockade enhances effect of poxvirus vaccine targeting p53 in tumor model.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- A CTLA-4 blockade enhanced the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model. "p53 is overexpressed by half of all cancers, and is an...

Tumor therapy with epidermal growth factor receptor vaccine investigated.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Immunogene therapy of tumors was investigated with a vaccine based on xenogeneic epidermal growth factor receptor. "The breaking of immune tolerance against self epidermal growth factor receptor...

DOCK4, a GTPase activator, is disrupted during tumorigenesis.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- DOCK4, a GTPase activator, is disrupted during tumorigenesis. "We used representational difference analysis to identify homozygous genomic deletions selected during tumor progression in the mouse...

Some mucinous colon cancers have less angiogenic phenotypes.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Some mucinous colon cancers have less angiogenic phenotypes. "We determined the association between cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF) expression, microvessel...

ELF-electromagnetic fields induce apoptosis.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- ELF-electromagnetic fields induce apoptosis and may be a first step for a noninvasive treatment of cancer tissue. According to a study from Germany, "Weak and low-frequency pulsating...

P27(Kip1)/cyclin-dependent kinase/retinoblastoma pathway is regulatory.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Vascular occlusive disorders may be based on Kip1 cyclin dependent kinase inhibitor malfunction, as the protein appears to be involved in the control of cell proliferation and locomotion. According...

Mutation of p53 appears to be unrelated to the presence or absence of HPV.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Mutation of p53 appears to be unrelated to the presence or absence of human papillomavirus (HPV). "Functional loss of the tumor suppressor p53 by alterations in its TP53 gene is a frequent event in...

New approaches to cervical screening may lead to clinical benefit.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- New approaches to cervical screening may lead to clinical benefit. "Screening programs for cervical cancer using the current test - the Pap smear - have markedly reduced the incidence of the...

Antiangiogenic drugs improve survival of metastatic colon cancer in mice.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Antiangiogenic drugs improve survival of metastatic colon cancer in mice. According to a study from the United States, "Integrin alpha(5)beta(1) is expressed on activated endothelial cells and plays...

Tetrathiomolybdate prevents bleomycin-induced pulmonary fibrosis.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Tetrathiomolybdate prevents bleomycin-induced pulmonary fibrosis. "Tetrathiomolybdate, a drug developed for the treatment of Wilson's disease, produces an antiangiogenic effect by reducing systemic...

Supplement reduced chemotherapy induced fatigue.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- A new study using the CTF (Chemotherapy Fatigue) nutritional supplement protocol during chemotherapy demonstrated that a properly administered nutritional protocol materially enhanced chemotherapy...

Therapy-related myelodysplastic syndrome can occur by rearrangement of MOZ gene.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Therapy-related myelodysplastic syndrome can occur by rearrangement of the MOZ gene. "In this study, we examined a pediatric case of therapy related myelodysplastic syndrome (tMDS). The symptoms...

Post-transplant blast crisis can mimic de novo lymphoma.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Blast crisis after stem cell transplantation can mimic de novo lymphoma in some leukemia patients. Researchers in Germany described "the case of a 42-year-old male patient who was diagnosed with a...

Heat shock prevents release of apoptosis-inducing factor and caspases in cells.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- A study by cancer researchers in India led to two discoveries: 1) sensitivity to curcumin-induced apoptosis differs among human colon cancer cells, and 2) heat shock protects colon cancer cells by...

Intestinal lymphomas should be diagnosed following universal standards.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Intestinal lymphomas should now be classified worldwide by the same universal means, the WHO standards. According to recent research from Austria, "Intestinal lymphomas are almost exclusively...

Red meat doneness and panfrying are associated most with risk.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Red meat doneness and panfrying were associated with colon cancer, and a particular heterocyclic amine tested most responsible, regardless of cooking method. "The authors examined the association...

Study questions interval for screening sigmoidoscopy.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- A new study suggests that screening sigmoidoscopy is associated with a long-term reduction in the incidence of colorectal cancers for up to 16 years - a finding that suggests that the currently...

Colorectal cancer prognosis has improved.
May 6, 2003... 2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Colorectal cancer prognosis has improved because of chemotherapeutic agents and earlier diagnosis. "In the last two decades the prognosis of colorectal cancer has improved for two reasons: (I) the...