Cancer Weekly articles from May 2000

Cancer Weekly archives from May 2000

Two Potent Anticancer Weapons Developed.(ecteinascidin and phthalascidin)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Two anticancer drugs, each estimated to be at least 100 times more powerful than the potent anticancer medication Taxol, have been synthesized by Harvard University chemist and Nobel laureate Elias J. Corey,...

Oral Chemotherapy Demonstrates Favorable Response Rates in Advanced Cancer Patients.(Xeloda may benefit colorectal cancer patients)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Patients with metastatic colorectal cancer may benefit from the oral anti-cancer agent Xeloda (capecitabine), according to a new study published in the March 2000 issue of the Journal of Clinical Oncology. ...

Segment Length in Barrett's Esophagus Irrelevant as Prognostic Factor.(for esophageal cancer development)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Significantly more people who suffer from Barrett's esophagus may be at high risk of developing esophageal cancer than previously thought, according to researchers at the Fred Hutchinson Cancer Research Center...

Iodine-131-Labeled Anti-Tenascin MAb 81C6 Therapy Evaluated.(monoclonal antibody therapy for gliomas)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Researchers in the United States evaluated iodine-131-labeled anti-tenascin monoclonal antibody (MAb) 81C6 therapy in patients newly diagnosed with malignant gliomas. "The objective of this study was to...

High Telomerase Activity Correlates with Extent of Malignancy.(in hepatocellular carcinoma)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Telomerase activity may predict the extent of malignancy in patients with hepatocellular carcinoma (HCC), scientists from Japan report in the American Journal of Gastroenterology. M. Shimada and associates...

Dietary Changes Don't Prevent Recurrent Polyps; Implications for Colon Cancer.(Polyp Prevention Trial)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- An eight-center study has shown that dietary changes don't prevent recurrent polyps. The Polyp Prevention Trial, one of the largest studies aimed at preventing colon cancer by dietary change, came to an...

Bioflavonoids May Contribute to DNA Damage Leading to Disease in Infants.(could cause the development of infant leukemias)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Scientists from the University of Chicago Medical Center have found molecular evidence that bioflavonoids, which are ordinarily considered quite beneficial, can cause breaks in DNA that could trigger the...

Drug Regimen Effective for Treating Mantle-Cell Lymphoma.(Dexa-BEAM (dexamethasone, carmustine [BCNU], etoposide, cytarabine, and melphalan) appears to be effective)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- The drug regimen known as Dexa-BEAM, consisting of dexamethasone, carmustine [BCNU], etoposide, cytarabine, and melphalan, appears to be an effective preliminary treatment for patients with mantle-cell...

Phase II Peptide Vaccine Trial Conducted.
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- A Phase II vaccination trial of tyrosinase peptides and granulocyte-macrophage colony-stimulating factor was conducted in patients with metastatic melanoma by researchers in Germany. "This Phase II study...

Drug Induces Apoptosis in Oral Cancer Cells.(5-fluorouracil)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- 5-Fluorouracil induces apoptosis in a variety of cell lines cultured in vitro, including oral cancer cells, scientists report in Oral Oncology. The scientists, led by D. Tong, studied the affect of...

Thoracoscopic Splanchnicectomy Can Alleviate Pain of Terminal Disease.(pancreatic cancer pain treatment)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Researchers writing in Archives of Surgery report that unilateral truncal thoracoscopic splanchnicectomy (TS) relieves the intractable pain suffered by many patients with terminal, unresectable pancreatic...

Combined Immunotherapy Evaluated in Metastatic Disease.(interferon-alpha and interleukin-2 therapeutics)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Researchers in Ireland have analyzed the toxicity and efficacy of combined interferon-alpha and interleukin-2 in a clinical trial of metastatic renal cell carcinoma patients. "Thirty-three patients with...

Eosinophils and C4 Predict Clinical Failure of Immunotherapy.(in renal cell carcinoma patients)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- The clinical failure of combination immunotherapy can be predicted by eosinophils and C4 in patients with renal cell carcinoma, researchers in Italy reported. "The clinical and immunologic activities of...

Stromas are Differentially Regulated.
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Investigators in Japan report that peritumoral and parenchymal stromas differ both in their regulation and function. Additionally, they found that host immune system factors are necessary for peritumoral...

Tandem-Diabodies Constructed for Immunotherapy.(German Cancer Research Center develops CD3xCD19 tandem-diabodies for treatment of Burkitt's lymphoma)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Burkitt's lymphoma was successfully cured in a murine model by the administration of CD3xCD19 tandem-diabodies. "Recently we described the construction of a new generation of tetravalent bispecific...

Genetic Immunization Aimed at Metastatic Disease.(use of tumor-specific cytolytic T lymphocytes and natural killer cells in genetic treatment of metastatic colon cancer)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Combined induction of tumor-specific cytolytic T lymphocytes and natural killer cells provides genetic immunization against metastatic colon cancer, according to Mt. Sinai School of Medicine researchers. ...

Cancer Cells Can Be Contained from Growing at Second Site.
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Researchers from Pennsylvania State University's College of Medicine have shown that specific tumor cells can be engineered in mice so that they can suppress growth to a secondary site. "As with most...

Milken Follows His Passion for Health onto the Internet.(Michael Milken)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Michael Milken once advised Bill Gates to "follow his passion." Milken, as the May 1 opening keynote speaker at eHealthcareWorld 2000, lets us in on some of his own passions. "As a longstanding leader...

Allogeneic Cell Vaccine Under Development.(Institute of Molecular Immunology)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Researchers in Germany are developing allogeneic cell vaccines for the treatment of renal cell carcinoma (RCC). "Because the molecular knowledge of RCC antigens is still limited, immunotherapy approaches...

Kininogen Domain 5 Peptides Inhibit Angiogenesis.
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Kininogen domain 5 peptides and monoclonal antibody (MAb) to kininogen domain 5 can be used to inhibit angiogenesis. "Recent studies from our laboratory have shown that cleaved high molecular weight...

Phase I/II Clinical Trials Initiated for Immune Stimulants.(by Coley Pharmaceutical Group Inc.)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Coley Pharmaceutical Group, Inc. (CPG), Wellesley, Massachusetts, has initiated the first of three Phase I/II trials of CpG DNA-based immune stimulants for the treatment of cancer, the company announced. ...

Stem Cell Transplantation Study Gives New Hope to Adult Patients.
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Hackensack University Medical Center, Hackensack, New Jersey, and Aastrom Biosciences, Inc. announced the publication of results from two adult patient case studies from a feasibility study evaluating the...

Treatment Guidelines Published in Patient-Friendly Version.(for colorectal cancer treatment)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Patients with colon and rectal cancer now have an invaluable resource in the fight against the disease, thanks to a collaborative effort between the National Comprehensive Cancer Network (NCCN) and the...

Multi-Center Phase II Clinical Trial Announced.(by SafeScience Inc.)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- SafeScience, Inc., Boston, Massachusetts, announced that the first patient has been dosed at the University of Chicago Medical Center site in its multi-center Phase II Clinical Trial of GBC-590 in patients with...

Drug Shows Efficacy Against Tumors Resistant to Standard Treatment.(N,N-Bis (Sulfonyl) Hydrazines)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Vion Pharmaceuticals, Inc. and Yale University announced that they have been granted an additional patent on a series of related compounds based upon their unique alkylating agent prodrug technology for the...

Surgical Simulator To Be Developed for Cryosurgical Cancer Treatment.(by Endocare Inc.)
May 2, 2000... 2000 MAY 2 - (NewsRx.com) -- Endocare, Inc., Irvine, California, announced it has signed an exclusive licensing agreement with George Washington University (GW), Washington, DC, under which GW will develop a surgical simulation software...

Phage-Selected Primate Antibodies Fused to Superantigens Used to Treat Melanoma.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Researchers from Sweden used phage-selected primate antibodies fused to superantigens for immunotherapy of malignant melanoma. "The high-molecular-weight melanoma-associated antigen, HMW-MAA, has been...

Viral DNA a Marker for Nasopharyngeal Cancer.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Researchers in Thailand have proposed that Epstein-Barr virus (EBV) DNA in serum and plasma is a reliable marker for nasopharyngeal cancer (NPC), based on results of a recent study. "Nasopharyngeal cancer...

Attenuated Virus Studied as Cancer Treatment in Phase I Trial.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Preliminary results of a Phase I trial conducted by researchers at CRC Beatson Labs in Scotland indicate that a E1B 55 kDa gene-deleted adenovirus, which kills p53-deficient cells, may show promise as an...

Hypermethylation at Gene Site is Possible Cause of Liver Pathogenesis.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- According to John's Hopkins University Hospital researchers, hypermethylation at GSTP1, the gene that encodes for pi-class glutathione s-transferase, may contribute to the development of hepatocellular...

Low Doses of Interleukin-4, Amifostine Can Reduce Leukemia Cell Factors.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Small doses of interleukin-4 (IL-4) or amifostine significantly affect critical leukemia cell behavior, say researchers. "High levels of telomerase activity and high rates of cell proliferation are...

'Obesity Gene' Causes Cancer of Fat Tissue.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- A gene previously identified as important in promoting obesity also appears to be responsible for causing a common human tumor. The gene, known as HMG I-C, causes tumors called lipomas, a common tumor in...

Vinyl Chloride Exposure Changes p53 Gene Structure.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Researchers in Germany recently reported a study of the relationship between exposure to vinyl chloride - a known carcinogen - and hepatocellular cancer. Genetic mutations from 18 patients with...

Monoclonal Antibodies Recognizing CD5, CD10, and CD23 Aid Diagnosis.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Researchers from the United Kingdom evaluated monoclonal antibodies (MAbs) recognizing CD5, CD10, and CD23 to determine their value in the diagnosis of small B-cell lymphoma. "Assessment of the expression...

Mutation in the 5' UTR May Increase Susceptibility.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- A mutation in the 5' UTR may predispose carriers to melanoma. Though many cases of melanoma are partially due to mutations of CDKN2A at 9p21, a large number of affected families have 9p21 linkage but no...

Endostatin May Aid Against Glioblastomas.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- The use of endostatin, a potent angiogenic inhibitor, as a vascular endothelial growth factor (VEGF) signal blocker was investigated in a murine study. Both the administration of endostatin as a direct...

Epithelial Ovarian-Cancer-Specific Promoter Helps Target Gene Therapy.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Researchers from the United States have found an epithelial ovarian cancer specific promoter that has the potential to help selectively target suicide gene therapy to cancerous cells. "Epithelial ovarian...

Monoclonal Antibody/Fusion Protein Eradicates erbB-2 Positive Tumors.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Researchers from Canada have developed a recombinant, humanized, single-chain Fv antibody/human interleukin-2 (IL-2) fusion protein for the treatment of tumors overexpressing erbB-2. "Increased gene copy...

'Stealth Compounds' Attack Cancer Cells.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Imagine ordering a part to repair your car, and having the new part delivered in pieces you must first assemble. A similar situation often occurs in treating cancer, because the components needed to put...

Antibody-Dependent Cellular Cytotoxicity Induced by MUC1 Peptide Vaccine.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- A MUC1 peptide vaccine induced antibody-dependent cellular cytotoxicity in breast cancer patients, researchers from The Netherlands and the United States reported. "Human polymorphic epithelial mucin...

Aetna U.S. Healthcare's InteliHealth Allies with Harvard, Johns Hopkins Dropped.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Consumer health information site InteliHealth will become the home of Harvard Medical School content on July 31, 2000, NewsRx.com reports. Harvard will replace Johns Hopkins as InteliHealth's primary...

Misdiagnosis of Skin Cancer Can Be Fatal.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Speaking at the American Academy of Dermatology's Melanoma/Skin Cancer Detection and Prevention Month Press Conference, held during April 2000, dermatologist Mark Lebwohl, MD, Mt. Sinai School of Medicine,...

Peptide-Pulsed Dendritic Cells Induce Immune Response Against Skin Cancer.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Peptide-pulsed dendritic cell vaccines induced antigen-specific immune responses in melanoma patients, reported researchers from the United Kingdom. "Dendritic cells (DC) are professional antigen...

Protecting Children from Skin Cancer.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Picnics, baseball games, and days at the beach are common recreational activities that many families enjoy during the summer. But are parents taking the appropriate actions during these activities to protect...

Dendritic Cell Vaccines Evaluated.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Researchers from the United States evaluated dendritic-cell-based vaccines for renal cell carcinoma (RCC) using tumor antigens. "Although RCC has been shown to respond to immunotherapy, RCC-specific...

Collaboration Tests New Cancer Treatments.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Protarga, Inc., Conshohocken, Pennsylvania, announced that it has entered into a Cooperative Research and Development Agreement (CRADA) with the U.S. National Cancer Institute (NCI) to accelerate the...

Hawaii Senate OKs Marijuana Bill.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- The Hawaii State Senate approved a bill April 25, 2000, allowing people with certain debilitating illnesses, including AIDS and cancer, to legally smoke marijuana to alleviate pain. The bill now goes to Gov....

FDA Approval Received for Hyperthermia + Chemotherapy Study.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- BSD Medical Corp. (BSDM), Salt Lake City, Utah, announced that it has received approval from the U.S. Food and Drug Administration (FDA) for Phase I/II clinical studies of hyperthermia in combination with...

Human Papillomavirus Type 68A Patent Exclusively Licensed.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Digene Corp. (DIGE), Beltsville, Maryland, announced that it has entered into an exclusive worldwide license with the Institute Pasteur, Paris, France to U.S. Patent No. 5,981,173, Genital Human Papillomavirus...

Randomized Phase II Trial Compares Combination Vaccine Therapy.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- A randomized Phase II trial compared two different sequence combinations of autologous vaccine and human recombinant interferon gamma and human recombinant interferon alpha 2b therapy in patients with...

p53 Codon 72 Variant Not Associated with Post-Transplant Skin Cancer.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Researchers writing in Transplantation report that codon 72Arginine, a common variant of the codon 72 of the tumor suppressor gene p53, does not appear to be associated with increased incidence of skin cancer...

Col-3 May be Useful in Intracranial Tumor Treatment.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Based on the results of a study in rats, researchers reported Col-3, a tetracycline analog, may be useful in treating intracranial tumors. Col-3 had previously been shown to inhibit angiogenesis in human...

Variables Identified as Predictors of Poor Adherence to Surveillance Recommendations.
May 16, 2000... 2000 MAY 16 - (NewsRx.com) -- Researchers have identified variables that may influence whether or not a patient will adhere to recommendations for follow-up surveillance for ovarian cancer. Paul Ritvo and colleagues from Cancer Care...

Dendritic Cells Undergo Pre-Clinical Evaluation for Glioma.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- A pre-clinical evaluation of dendritic cells as treatment for intracranial glioma has been conducted. "Since glioma patients are profoundly immunosuppressed, the question arises as to whether dendritic...

Cellular Senescence Pathway Associated with Important Human Tumor Suppressor Gene.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Lexicon Genetics Inc., The Woodlands, Texas, announced the publication of research describing a gene that controls how quickly mice age and its relationship to a pathway of cancer suppression in humans. ...

Interleukin 12 Blocks Growth of Pancreatic Cancer.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Researchers in Japan have found interleukin 12 (IL-12), a heterodimeric cytokine that exerts a potent antitumor effect through its pleiotropic actions, was able to block the growth of human pancreatic cancer...

Alpha(1,3)fucosyltransferase Antisense Impairs Colon Cancer Cells.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- The growth and tumorigenicity of human colon carcinoma cells can be blocked by transfection of alpha(1,3)fucosyltransferase antisense sequences, suggests a study from the United States. "Sialyl Lewis x...

Cancer Patients Benefit from Evaluation and Treatment by Orthopedic Surgeons.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- According to a study of 963 breast cancer patients reported in The Journal of Bone and Joint Surgery, patients who have spinal instability and pain due to the spread of the cancer to the spine can obtain pain...

Cytokine Gene Transfer Uses Epstein-Barr Virus-Derived Vectors.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Cytokine gene transfer using Epstein-Barr virus (EBV)-derived episomal expression vectors suppresses growth of Burkitt's lymphoma cells in a murine model, researchers in Germany report. "Epstein-Barr...

Promising Compound Could Cause Life-Threatening Liver Damage.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- A promising anti-cancer compound initially slated to enter clinical trials within months could kill rather than cure a patient, according to a University of Pittsburgh report in the May 2000 issue of Nature...

Immunity Induced by Tumor Lysate-Pulsed Dendritic Cells.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Tumor lysate-pulsed dendritic cells (DCs) induced cellular immunity in a parathyroid carcinoma patient, researchers in Germany reported. "Cytotoxic T-lymphocyte-mediated tumor immunity against major...

Intradermal RNA Inoculation Induces Anti-Tumor Immunity.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Intradermal RNA inoculation or vaccination with epidermal cells pulsed with tumor-derived RNA induces anti-tumor immunity in a murine model, according to Cornell University researchers. "The skin is...

CCAAT-Enhancer Binding Proteins Play Role in Tumor Invasiveness.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- CCAAT-enhancer binding protein (C/EBP) (beta) and C/EBP zeta (CHOP) play a key role in colorectal tumor invasion, according to researchers. The mechanisms regulating cell differentiation are frequently...

Immunohistochemical Evidence May be Useful for Prognostics.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Lymph node metatases detected immunohistochemically in patients with histologic node negative gastric cancer are indicative of poorer prognosis, report researchers in the United States. L.E. Harrison and...

Attenuated Virus G207 is Safe in Mice.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Mouse studies show that the attenuated herpes simplex virus type 1 (HSV-1) mutant, G207, is safe at doses that provide effective therapy, according to researchers at Georgetown University in Washington, DC....

Recombinant Virus Containing E2 Protein Regulates Oncogenic Proteins.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Preliminary results of an animal study have shown that a recombinant vaccinia virus containing papilloma E2 protein suppresses tumors in nude mice. The results of this study were published in the journal...

AML1 Gene May Be Target in 21q22 Amplicon.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- AML1 could be a target gene in the amplification in the 21q22 chromosomal region observed in pediatric acute lymphoblastic leukemia (ALL), researchers say. Building on previous work, in which they...

Risk Factors for Early Mortality Determined in HIV(+) with Lymphoma.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Scientists in France say that certain factors place HIV positive patients with non-Hodgkin's lymphoma at a greater risk for early mortality than others. "The prognosis for survival of patients infected...

Researcher Believes United Network for Organ Sharing Policy Needs Reform.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- An analysis of waiting times and tumor growth in patients needing liver transplants for hepatocellular carcinoma indicates national wait-listing policy should be changed, research from the University of...

Suramin Can Increase Quality of Life, Reduce Need for Pain Medication.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- The compound suramin can slow the progress of hormone-refractory prostate cancer (HFPC) and reduce patients' need for pain medication, according to a report in the Journal of Clinical Oncology. "A...

Adenovirus Mediated ATF Gene Transfer Inhibits Tumor Growth.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Adenovirus-mediated amino terminal fragment (ATF) gene transfer inhibited primary and metastatic tumor growth in a murine model, according to research colleagues in the United States and France. ...

Antibody Fragments Target Activated Form of Vitronectin.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- An anticancer therapy may target tumor vasculature using single chain antibody fragments. "Inhibition of angiogenesis and vascular targeting are considered new and promising anticancer therapies,"...

In vivo Response Mediated Through Fc Receptor Activation.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Fc receptor engagement is responsible for the anti-cancer responses activated by anti-cancer monoclonal antibodies (MAbs), researchers in the United States report. "MAbs have recently demonstrated...

Dendritic Cell Vaccine Provides Intracranial Protection.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- A dendritic cell (DC) vaccine pulsed with p53 mutant peptide demonstrates that intracranial protection against glioma is possible. "As approximately half of malignant gliomas exhibit p53 mutations, we are...

Interferon-(alpha) Demonstrates Powerful Adjuvant Effect.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Interferon-(alpha) (IFN(alpha)) has a powerful adjuvant effect when added to cancer vaccines, researchers in Italy reported. "Our group has recently demonstrated that the transduction of the IFN(alpha)1...

TNF(alpha) Vaccine Induces Immune Responses Against Self Proteins.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Vaccination against tumor necrosis factor alpha (TNF(alpha)) generates immune responses against self proteins, a recent study found. "We have developed a therapeutic vaccine approach that induces strong...

Phase II Clinical Data Presented on Antisense Oligonucleotides.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Isis Pharmaceuticals will present Phase II clinical data on its antisense oligonucleotides drug, ISIS 3521, at the Anti-Cancer Drug Discovery & Development Summit in Princeton, New Jersey, June 12-13, 2000,...

Quality of Life Returns to Normal in Year Following Brachytherapy.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- In the first study of its type, Wake Forest University investigators have reported that the quality of life for prostate cancer patients returns to normal within one year after implantation of...

Endostatin Safety Tests So Far Show Few Results.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Endostatin, a cancer drug discovered by doctors at Children's Hospital in Boston, Massachusetts, and once hailed as a possible cure, has yet to show dramatic benefits after seven months of safety testing. ...

Anticancer Drug Shows Promise Against Drug Resistance.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Supratek Pharma Inc., a Montreal-based pharmaceutical company, has developed a new drug based on Etoposide (also known as Vepesid(r) or VP-16) and the company's proprietary Biotransport(TM) carrier...

New Treatment Advances Towards Clinical Trials.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Select Therapeutics (SLPU) Cambridge, Massachusetts, announced that following its receipt of funding from a $9.5 million private placement which closed on March 30, 2000, it engaged a third party to...

Alliance Formed to Develop Tests for Residual Disease.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Epoch Biosciences (EBIO), Redmond, Washington, formerly Epoch Pharmaceuticals, and Specialty Laboratories, Santa Monica, California, announced that the companies will jointly develop highly sensitive assays...

Emerging Chemotherapeutic Agents Reported to Drive Growth of Therapy Market.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Decision Resources, Inc., Waltham, Massachusetts, announced the publication of "Acute Leukemias," a multiclient study that assesses a host of market-impacting factors (e.g., epidemiological trends, clinical...

Evaluation License Granted for Patented Real-Time in vivo Imaging Technology.(Brief Article)(Statistical Data Included)
May 23, 2000... 2000 MAY 23 - (NewsRx.com) -- Xenogen Corp., Alameda, California, announced it has entered into an evaluation licensing agreement with DuPont Pharmaceuticals. This evaluation license offers DuPont access to Xenogen's proprietary suite...