Cancer Weekly articles from March 2003

Cancer Weekly archives from March 2003

Gene loss creates age- and gender-dependent cancer syndrome in mice.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Researchers at the Johns Hopkins Kimmel Cancer Center have discovered that loss of a gene already implicated in human cancers also leads to age- and gender-linked cancers in mice. The findings validate...

Structure of key receptor determined.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- A team of scientists from Johns Hopkins and the biotechnology company Genitope has unlocked the 3-D structure of a receptor that goes awry in 20-30% of breast cancers. The scientists also figured...

Cyclooxygenase inhibitor shows additive effect against urological malignancy.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Research collaborators in the U.S. and Australia say mitoxantrone and piroxicam can generate remission in canine models of human invasive bladder cancer. ...

Deacetylase inhibitor FK228 suppresses hypoxia induced activity.(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a study from South Korea, "hypoxia is generally detected in central regions of solid tumors and regulates a variety of transcription factors including hypoxia-inducible factor-1 (HIF-1)....

Peroxisome proliferator fenofibrate inhibits growth of human hepatoma cells.(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "The aim of this work was to investigate the effects of hypolipidemic agent fenofibrate (FF), a peroxisome proliferator (PP), on human HepG2 cells and to characterize the intracellular events involved,"...

CXCRA is a major chemokine receptor and mediates survival.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to recent research from Canada, "Chemokines were described originally in the context of providing migrational cues for leukocytes. They are now known to have broader activities, including...

Cell density determines extent of damage caused by cigarette smoke exposure.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- First- or second-hand exposure to cigarettes can lead to a variety of diseases, including tissue destruction found in pulmonary emphysema and osteoporosis. Also included among cigarette smoking-induced...

Quality of life and psychosocial burden should be seen as clinical problem.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "Few studies have examined relationships and differences in reported results between the parent, child, and clinician. We examined parent proxy and clinician reported functional status, and health...

Real-time multiplex RT-PCR useful for t(15;17) analysis.(reverse transcriptase-polymerase chain reaction)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Researchers in California have developed a novel assay to aid monitoring of acute promyelocytic leukemia (APL) patients. "Individuals with acute promyelocytic leukemia (APL) usually express one of...

Polyps linked with colorectal carcinoma via microsatellite instability pathway.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "The ''hyperplastic polyp'' is considered a benign lesion with no malignant potential, whereas ''serrated adenoma'' is a precursor of adenocarcinoma. The morphologic complexity of the serrated adenoma...

Spectrum broadens as cases reveal previously undescribed mucinous subtype.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- A study from Peoples Republic of China reports "2 cases of primary thymic adenocarcinoma, a very uncommon neoplasm with limited information in the literature. Both patients were men; aged 15 and 39...

RNA degradation by hPNPase(')(Old-35) is common maintenance factor.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Terminal differentiation and cellular senescence display common properties including irreversible growth arrest. To define the molecular and ultimately the...

Capsaicin induces ras-transformed cell apoptosis by upregulating JNK-1 and MAPK.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a study from South Korea, "Efforts have been made to develop a chemoprevention strategy that selectively triggers apoptosis in malignant cancer cells. Previous studies showed that...

Use of soluble B7RP-1-Fc may have value in generating, enhancing activity.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "We have characterized a receptor:ligand pair, ICOS:B7RP-1, that is structurally and functionally related to CD28:B7.1/2. We reported previously that B7RP-1...

Natural killer cells with IL-18 receptors respond effectively to IL-18.(interleukin)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "IL-18 administration promotes innate immunity resulting in significant antitumor effects in multiple murine tumor models. Here, we examined the effector...

Transforming growth factor-beta a potential target for treating brain tumors.(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "Dramatic therapeutic benefits of targeting specific signal transduction pathways in some cancers have pushed rational molecular targeting to the forefront of cutting-edge cancer therapy. The...

Ischemic cause is suggested by brain oxygen pressure values obtained in surgery.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "Brain edema and swelling often complicate surgery for brain tumors. Its pathophysiology is unclear, as is the relationship with brain tissue oxygenation. Our hypothesis was that brain edema around...

Tumor grading from magnetic resonance spectroscopy.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a study from England, "Magnetic resonance spectroscopy (MRS) provides a noninvasive measurement of the biochemistry of living tissue. "However, signal variation due to tissue...

Correlation of core biopsies, therapeutic excisions high in higher grade disease.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "Breast core biopsy is one of the major nonoperative methods of diagnosis. Increasingly, there is also a need to provide prognostic data to facilitate timely patient management," researchers in England...

Degradation of ER-alpha by TGF-beta 1 could control tumor growth.(estrogen receptor, transforming growth factor)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "Normal mammary epithelial cells are rapidly induced to G; they arrest by the widely expressed cytokine transforming growth factor beta (TGF-beta1). Studies in established breast cancer cell lines that...

Fulvestrant submitted for approval in Europe.(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- AstraZeneca announced the submission in Europe of a Marketing Authorization Application for the use of Faslodex (fulvestrant) in the treatment of advanced breast cancer in postmenopausal women whose...

Immunohistochemical distinction of invasive from noninvasive breast lesions.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to recent research in the United States, "Identification of myoepithelial cells using antibodies to cytoskeletal proteins, such as smooth muscle myosin heavy chain (SMM-HC) and calponin, can...

Mutation in BRCA2 compromises the interaction with replication protein A.(breast cancer)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "Mutations in the BRCA1 and BRCA2 genes predispose women to familial, early onset breast cancer. Both the BRCA1 and BRCA2 proteins appear to function in the homologous recombination pathway of DNA...

Protein is overexpressed in endothelial cells of mouse breast tumor vessels.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to recent research from Switzerland, "angiogenesis is a key process in a variety of human diseases, including cancer. The ability to target selectively the tumor vasculature is potentially...

Relief for radiation therapy sought on the grapevine.(grape seed properties)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- The humble grape could tackle a painful side effect of breast cancer radiotherapy for which there is currently no effective treatment. A clinical trial funded by Cancer Research U.K. and conducted...

System detects fluorescent compounds in diagnostic process.(breast cancer)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Imaging Diagnostic Systems, Inc. (Bulletin Board: IMDS) announced that it has delivered their CTLM system to the Robert Roessle Clinic in Berlin, Germany, as part of their collaboration agreement with...

Foreign DNA prevents mammary adenocarcinoma in transgenic mice.(antisense oligodeoxynucleotides)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Researchers in Italy have identified antisense oligodeoxynucleotides that not only treat but also prevent mammary adenocarcinomas in transgenic mice by heightening the innate immune response system. ...

Molecular genetic diagnosis of a primary central nervous system T cell disease.(lymphomas)(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "Primary central nervous system T cell lymphomas are rare tumors. Histologically, they may be indistinguishable from other entities like inflammatory processes," researchers in Germany report. "In...

FDA grants Fast Track designation for investigational oral mucositis drug.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Aesgen, Inc., a privately held specialty pharmaceutical company, announced that the U.S. Food and Drug Administration (FDA) granted Fast Track designation to the company's investigational new drug,...

Calculating expected number by looking at chances of getting, dying of disease.(cancer risk factors)(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a study from England, "A comparison of expected number of deaths with the observed is a widely used method with an extensive history. Epidemiologists often study the mortality rate from a...

Taking the study of cancer cell survival to a new dimension.(apoptosis)(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "Apoptosis plays a key role in the development of cancer and the response of tumor cells to therapeutic intervention," researchers in the United States report. "Recent work using three-dimensional...

Patent issued for cancer therapeutic focuses on DNA core of drug.(Introgen Therapeutics Inc.)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Introgen Therapeutics, Inc. (NASDAQ:INGN) and the Board of Regents of The University of Texas System announced that the U.S. Patent and Trademark Office has issued to the Board of Regents U.S. patent...

Domain of matrix metalloproteinase 9 domain demonstrates novel properties.(tumor growth and metastasis)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a study from Germany, "matrix metalloproteinases (MMPs) are involved in the remodeling processes of the extracellular matrix and the basement membrane. Most MMPs are composed of a...

Preneoplastic cells show relevance to risk for human liver cancer.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Performing liver biopsies to check for preneoplastic lesions affords physicians a useful way to assess the risk for liver cancer in patients with diseases such as chronic viral hepatitis, researchers in...

Rheumatic syndromes are associated with malignancy.(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "The relation between rheumatic syndromes and an underlying malignancy is a complex one. As a result of autoimmunity, an aberrant immune response, or the use of immunomodulatory drugs, many of the...

Company increases focus on cancer, eliminates broad-based gene therapy research.(Cell Genesys Inc. )
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc. (NASDAQ:CEGE) announced its decision to decrease further resource investment in broad-based gene therapy programs in order to increase the focus on the company's clinical programs...

Antiangiogenesis antibody, 2C3, shown to inhibit tumor growth by 75%.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Peregrine Pharmaceuticals (PPHM) said that researchers at the University of Texas Southwestern Medical Center at Dallas (UT Southwestern) have published data detailing the antitumor effects of the 2C3...

Ganglioside GD3 acts on mitochondria to protect from hepatoma resistance.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to recent research from Spain, "Ganglioside GD3 (GD3) has emerged as a modulator of cell death pathways due to its ability to interact with mitochondria and disable survival pathways. Because...

MR-controlled hyperthermia demonstrated successful local control of tumor.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "The efficiency of MRI-guided focused ultrasound (FUS) hyperthermia with continuous sonication was investigated for the treatment of VX2 carcinoma implanted in rabbit thigh muscle," researchers in...

New drug targets cancer cells.(Pc 4)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Researchers at the Ireland Cancer Center at University Hospitals of Cleveland (UHC) and Case Western Reserve University (CWRU) School of Medicine are, for the first time in human clinical trials, using...

Second phase I trial of VNP40101M in solid tumors begun.(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Vion Pharmaceuticals, Inc., (VION) announced that it had initiated a new multicenter phase I trial of VNP40101M in patients with solid tumors. In this trial patients will receive weekly intravenous...

Safety group links playground equipment to cancers.(arsenic-treated wood)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Children could face an increased lifetime risk of developing lung or bladder cancer from using playground equipment made of wood treated with arsenic, the nation's top product safety official says. ...

Gene discovered by Temple researchers found to be multifunctional.(Temple University)(tumorigenesis and cell differentiation)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- A gene discovered by Temple University researchers a decade ago has proved to be multifunctional, with the discovery of its important roles in cell differentiation, HIV transcription, and tumorigenesis....

Notch-1 induction required for growth of SV40-transformed mesothelial cells.(simian virus type 40)(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "We show that SV40 infection of human mesothelial cells directly causes overexpression of Notch-1, a key cell regulatory gene. "Notch-1...

TNF-alpha-stimulated neutrophil death can increase with caspase inhibition.(tumor necrosis factor)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "It is increasingly clear that there are caspase dependent and independent mechanisms for the execution of cell death and that the utilization of these...

Abl kinase inhibitor induces differentiation of v-Abl-transformed pre-B cells.(murine leukemia virus)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Abelson murine leukemia virus-transformed cell lines have provided a critical model system for studying the regulation of B cell development. ...

Induction of apoptosis-modulating p202 occurs, contributing to cell survival.(oncogenes)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a report from the United States, "Previous studies have revealed that p202 (52 kDa), an interferon (IFN) and differentiation-inducible protein, negatively regulates cell proliferation and...

Papillomavirus' E6 and E7 proteins differentially protect from cell apoptosis.(cervical cancer)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Cervical cancer cells express high risk human papillomavirus (HPV) E6 and E7 proteins, and repression of HPV gene expression causes the cells to...

A variation of the Bethesda system could be used in diagnostics.(cervical cancer)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "During the past 50 years, the histologic classification of cervical intraepithelial neoplasia (CIN) has evolved to incorporate the entire spectrum of...

Bethesda and other grading terminology should remain in the interim.(cervical intraepithelial neoplasia)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a study from Germany, "The criteria currently used for grading cervical intraepithelial neoplasia (CIN) are arbitrary and subjective with consequent considerable observer variability. None...

Family history doesn't predict genes, behavior.(colon cancer)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Although certain genes and some behaviors, like eating well-done red meat, are associated with a family history of colon cancer, that history is not a good tool for predicting whether an individual will...

COX-2 inhibitor rofecoxib limits metastatic potential of colorectal carcinoma.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Cyclooxygenase (COX)-2 inhibition may decrease the metastatic potential of colorectal carcinoma via a number of avenues, including the prevention of...

Fetal hemoglobin can be used as a marker in children receiving valproic acid.(malignant tumor cells)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to recent research from Germany, "Differentiation induction is a distinct concept in the treatment of malignant diseases, considering that malignant cells share many features with immature...

Highlights of the nonionizing field.(cancer cell surface chemistry)(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "In this acceptance address for the Bioelectromagnetics Society's 2001 d'Arsonval Award, Dr. Tenforde reviews the highlights of the nonionizing field...

Estrogen modulation of growth factor not controlled through classic pathway.(pituitary tumors)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "17alpha-E-2, a weak estrogen, exhibited both agonistic and antagonistic effects, and caused a time- and dose-dependent induction of VEGF-A mRNA...

Estrogen can stimulate an ERE-driven gene to promote DNA synthesis.(estrogen response element in adenocarinoma)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "Estrogen 17beta-estradiol (E2) rapidly modulates several signaling pathways related to cell growth, preservation, and differentiation. The physiological role of these nongenomic effects with regard to...

Fallout from nuclear tests killed 11,000, CDC concludes.(U.S. Centers for Disease Control and Prevention)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- A draft report that estimated 11,000 people died from cancers related to nuclear testing during the Cold War was well done and should be published, the U.S. National Research Council says. The...

Lytic reactivation in infected B cells selectively arrests host functions.(viral and cancer research)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Researchers in Japan report that "Productive infection and replication of herpesviruses usually occurs in growth arrested cells, but there has been no direct evidence in the case of Epstein-Barr virus...

TEL accelerates differentiation of cells.(erythroleukemia )
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "TEL belongs to a member of the ETS family transcription factors that represses transcription of target genes such as FLI-1," researchers in Japan report. "Although TEL is essential for...

The oncogenic protein Id2 is upregulated by EWS/ets protein and c-myc.(Ewing sarcoma)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "The chromosomal translocation specifically linked to the Ewing sarcoma family results in the generation of fusion proteins comprising the amino terminal portion of EWS...

PKC pathway involved in survival response to ionizing radiation of cell line.(Protein Kinases C in erythroleukemia )
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "Friend erythroleukemia cells require high doses (15 Gy) of ionizing radiation to display a reduced rate of proliferation and an increased number of dead cells," researchers in Italy report. "Since...

Pathogenicity of Helicobacter pylori may not be determined by cag PAI genes.(gastric cancer)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "The cag pathogenicity island genes of Helicobacter pylori (i.e., cag1, cag5, cagT, cagE, and cagA) were detected by PCR in DNA extracted from endoscopically collected gastric juice, and the...

Herpes simplex virus protein VP22 a promising tool for gene delivery.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - A protein from herpes simplex virus type 1, known as VP22, represents a potent new way to deliver gene therapy to desired targets without the use of viral...

Genetic events a hallmark of angiogenesis in astrocytomas.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "Angiogenesis is required for the development and biologic progression of infiltrative astrocytomas and takes the form of 'microvascular hyperplasia' in glioblastoma multiforme, the most malignant...

Combination of antibody and nimustine deconstruct glioblastoma xenografts.
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Researchers in Japan "evaluated the effectiveness of vascular endothelial growth factor (VEGF) blockade alone and in combination with...

Resistance to syncytia is due to viral protein's truncation.(human T-cell leukemia virus)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "Human T-cell leukemia virus (HTLV) envelope (Env) glycoproteins induce fusion, leading to rampant syncytium formation in a broad range of cell lines. Here, we identified murine, hamster, canine, and...

Two methylase genes, hpyIIIM and hpyIM, are preceded by alternative genes.(Helicobacter pylori gene)(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "A recently identified Helicobacter pylori gene, hrgA, was previously reported to be present in 70 (33%) of 208 strains examined," researchers in Japan report. "Sequence analysis of nine such...

Apoptosis is induced by treatment with a new bisphosphonate, YM529.(hematopoietic tumors)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "In recent years, it has been reported that bisphosphonates inhibited the cell cycle of myeloma cells to inhibit cell proliferation directly, and it was also reported...

Method of mapping integration sites identifies new CISs.(common sites of retroviral integration in hematopoietic tumors)(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "Retroviral insertional mutagenesis in mouse hematopoietic tumors provides a powerful cancer gene discovery tool," researchers in the United States report. "Here, we describe a high-throughput,...

Activated stellate cells express TRAIL and can be eliminated differentially.(tumor necrosis factor-related apoptosis-inducing ligand in hepatic fibrosis)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Apoptosis has emerged as an important mechanism to reduce numbers of activated stellate cells during the resolution phase of hepatic fibrosis. These...

NOVP chemotherapy induces sperm aneuploidies.(Novantrone, Oncovin, Velban, and Prednisone)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- A chemotherapy regimen used to treat Hodgkin disease can damage sperm, researchers in California warn. S. Frias and colleagues at Lawrence Livermore National Laboratory conducted a study "to...

Cell lines characterized by frequent aberrations on chromosomes 2p, 9p.(Hodgkin's lymphoma)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a study from Germany, "Four Hodgkin's lymphoma cell lines (KM-H2, HDLM-2, L428, L1236) were analyzed for cytogenetic aberrations, applying multiplex fluorescence in situ hybridization,...

Condition may be presenting sign of acute graft-versus-host disease.(hypereosinophilia )
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to recent research from France, "The authors report two cases of hypereosinophilia as the major presenting sign of acute graft-versus-host disease (GVHD) after allogeneic bone marrow...

Combination of bacterial, host, environmental factors may lead to condition.(gastrointestinal cancer)(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to recent research from England, "Intestinal metaplasia (IM) of the stomach is a risk factor in developing intestinal-type gastric cancer and, hence, the question of reversibility is vital....

Fludara receives European marketing approval as first-line B-CLL treatment.(B-cell chronic lymphocytic leukemia )
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Schering AG (FSE: SCH, NYSE: SHR) announced that the European Union type II variation procedure for Fludara i.v. to extend the indication to first-line treatment of patients with B-cell chronic...

Imatinib mesylate therapy shows high incidence of early responses.(Philadelphia-positive myeloid leukemia)(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- "Fifty patients with Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in early chronic phase received imatinib mesylate, 400 mg orally daily," researchers in the United States...

New HuMax-CD20 and HuMax-EGFr preclinical data presented.(antibody)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Genmab A/S announced that its HuMax-CD20 human antibody appears to kill tumor cells that are resistant to rituximab, a marketed antibody directed to the same disease target. In preclinical testing,...

Researchers discover how virus spreads through the body.(human T-lymphotropic virus type 1)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Researchers from Imperial College London, University of Oxford, Kagoshima University (Japan), and University of the Ryukyus (Japan) have discovered the mechanism by which human T-lymphotropic virus type...

Sildenafil and vardenafil induce caspase-dependent apoptosis.(chronic lymphocytic leukemia)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a study from France, "Type 4 phosphodiesterase (PDE4) inhibitors reportedly induce apoptosis in chronic lymphocytic leukemia (CLL) cells. "Following clinical improvement of one...

Targeted immunotherapy eradicates cancer in mice.(leukemias, lymphomas)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- Researchers have developed a novel approach to genetically instruct human immune cells to recognize and kill cancer cells in a mouse model. The investigators plan to ultimately apply this strategy in a...

Pseudoepitheliomatous hyperplasia is sometimes associated.(squamous cell nests)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to recent research from Australia, "Small tentacles or separated nests of squamous cells in the dermis are not uncommonly seen in longstanding vulvar lichen sclerosus (LS) associated with...

Cell cycle-regulated gene HURP is overexpressed in hepatocellular carcinoma.(hepatoma upregulated protein)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- The newly identified gene for hepatoma upregulated protein (HURP), which regulates the cell cycle, is overexpressed in hepatocellular carcinoma, researchers in Taiwan report. "An analytic strategy...

Micropapillary pattern, even in early stage, is a marker for poor prognosis.(adenocarcinomas )
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "Adenocarcinomas with a micropapillary pattern (MPP), featuring small papillary tufts lacking a central fibrovascular core, are thought to have a poor prognosis. To...

Agreement covers analysis of NCI tumor databases for gene markers of disease.(National Cancer Institute and AnVil Inc., life sciences firm)(lung cancer)(Brief Article)
March 4, 2003... 2003 MAR 4 - (NewsRx.com & NewsRx.net) -- In the quest to discover better predictive models for cancer diagnostics and treatment, life sciences company AnVil, Inc., announced an agreement with the National Cancer Institute (NCI), a component of...