Cancer Weekly articles from March 2000

Cancer Weekly archives from March 2000

Novel Chimeric p27/p16 Molecules Are More Effective.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Novel chimeric p27/p16 fusion molecules are more potent tumor killers than their parental molecules, researchers report. Salil D. Patel and colleagues developed replication-defective recombinant adenovirus...

Centrosome Abnormalities Observed.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Abnormalities of the centrosome increase as biliary malignancy advances into later stages, according to a new study. Two centrosomes are needed for accurate assembly of bipolar spindles and fidelity of the...

"Energy" Molecule May Help Cancer Patients.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Giving cancer patients a compound that provides energy in the body could help prevent the muscle loss and weakness that make life miserable and sometimes prove fatal, researchers reported. They said an...

Polysaccharide Exhibits Anti-Tumor Activity.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Researchers in the Peoples Republic of China have shown that the K1 capsular polysaccharide antigen (K1CPS) of Klebsiella displays anti-tumor activities. In this study, Y.M. Choy and colleagues at the...

Adjuvant Active Specific Immunotherapy for Stage II and III Colon Cancer.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Adjuvant active specific immunotherapy for stage II and III colon cancer with an autologous tumor cell vaccine was evaluated in a clinical trial, reported researchers from the United States. "A randomized,...

Fhit Protein Loss May Be Prognostic Factor.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Fhit protein loss may be a prognostic indicator in gastric carcinoma, researchers say. In many human tumors, including gastric carcinomas, the FHIT gene is inactivated by deletion. The Fhit protein has...

Hepatitis C Virus Genotypes 1a and 4 are Risk Factors.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- A study from Egypt suggests that expression of hepatitis C virus genotypes 1a and 4 are risk factors for liver cancer. The distribution of hepatitis C virus (HCV) genotypes among Egyptian patients positive...

Antisense Therapy Induces Growth Arrest and Apoptosis.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Growth arrest and apoptosis can be induced by antisense to SV40 early gene region in T-antigen-positive human pleural mesothelioma cells, researchers from the United States reported. "Although SV40...

Gene Transfer of NGF Gene Modulates Cell Proliferation.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Nerve growth factor (NGF) may be responsible for the modulation of neuroectodermal tumor cell proliferation and differentiation, suggested researchers from the United States. "The response of wild-type and...

Patients Show Significant Survival Rate.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- In the February 2000 issue of Chest, researchers reported a significant 41% five-year overall survival rate among 2,263 patients who had surgery for non-small cell lung cancer (NSCLC). Jules M.M. van den...

P11 Cells May Produce Pro-Inflammatory-Like Factor.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- An alteration of the microenvironment of the anterior pituitary may result in inducible nitric oxide synthase expression. This may change function of the hypothalamic-pituitary-adrenal axis. P11...

Chemosensitization and Delayed Androgen-Independent Recurrence Realized.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Chemosensitization and delayed androgen-independent recurrence of prostate cancer can be achieved with the use of antisense Bcl-2 oligodeoxynucleotides, researchers from Canada reported. "Increased...

Uncovering Structure of Cellular Switch Could Aid Design of New Cancer-Fighting Drugs.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Cornell University cancer researchers have revealed the molecular structure of a protein complex believed to influence the malignant transformation of cells, setting the stage for development of unique...

Combined Markers Detect Liver Cancer.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Researchers have determined that two markers, high-sensitivity des-gamma-carboxy prothrombin (H-DCP) and Lens culinaris agglutinin A-reactive alpha-fetoprotein (AFP-L3), are useful for detecting small...

Regulation of bcl-2 Family Members Leads to rAD-p5-Mediated Apoptosis.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- rAD-p53-mediated apoptosis can be induced by regulation of bcl-2 family and caspases, according to recent study findings. Isabella Atencio and G. William Demers examined the regulation of pro-apoptotic and...

Anti-Angiogenic Therapy Targeting VEGF is Efficacious.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Anti-angiogenesis therapy that targets vascular endothelial growth factor is effective against human bladder cancer, especially when accompanied by chemotherapeutic agents, according to researchers working in...

Template-Assembled Porating Peptides Aim for Telomerase.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Targeting telomerase may be possible by using template-assembled porating peptides (TAPP) to deliver peptide nucleic acids (PNA), according to a new study. "Selective targeting of oligonucleotides to a...

Body Surface Area is Not a Sensitive Index in Determining Doses.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- In a study from Canada, researchers determined body surface area was not a sensitive index of body size in relation to chemotherapy dose. According to Y. Madarnas and colleagues, there has been a recent...

Port Malfunction Caused by Initial Placement.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Scientists presented findings at the Society of Gynecologic Oncologists 31st Annual Meeting showing that initial placement of a subcutaneous implanted central venous port (SIP) catheter tip in the central...

Endometrial Tissue Culture Mimics in vivo Changes.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Scientists from the University of Oklahoma announced at the Society of Gynecologic Oncologists 31st Annual Meeting that they have been able to develop a cell culture technique that mimics endometrial growth...

Cytokine Therapy Produces Antitumoral Effects.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Cytokine therapy using electroporation produced an antitumoral effect in esophageal cancer, according to researchers. In previous research, Hisahiro Matsubara and colleagues used interleuken-2 (IL-2) or...

Node Biopsy Dramatically Reduces Pain Clinic Referrals.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Increased use of sentinel lymph node biopsy (SLNB) has resulted in a dramatic reduction in cases of Post-Mastectomy Pain Syndrome (PMPS), according to R. Miguel and colleagues from the University of South...

Vaccine Data from Largest-Ever Study Presented.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Corixa Corporation, Seattle, Washington, announced that data from a Phase III, randomized trial to evaluate Corixa's therapeutic vaccine for the treatment of melanoma, Melacine, were presented February 17,...

No Association Found Between Diet and Breast Cancer Prognostic Factors.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- In a recent study from Canada, researchers reported no association between diet and traditional prognostic factors was found. Y. Madarnas and associates also determined increasing fat intake did not...

Dietary Fat Levels Are Associated with Breast Cancer.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- In a recent study from the United States, researchers reported high levels of dietary fats could cooperate with putative hormonal carcinogens. This cooperation could then influence the promotion of mammary...

Center Launches Pain Relief Unit.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- The University of California, San Diego, Cancer Center has established a new clinical service unit dedicated to alleviating cancer pain and related symptoms that affect quality of life such as nausea, fatigue,...

Diet and Exercise Play Critical Role in Cancer Prevention.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Poor diet and lack of exercise are behind just as many cancer cases as smoking, says Dennis Savaiano, dean of Purdue's School of Consumer and Family Sciences and professor of foods and nutrition. ...

Drug Target for Cancer Identified.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Myriad Genetics, Inc., Salt Lake City, Utah, announced that it has discovered a drug target for the potential treatment of colon and rectal cancers. Moreover, several candidate therapeutic compounds, which...

Collaboration Aims To Develop Taxane-Based Tumor-Activated Prodrugs.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- ImmunoGen, Inc., Norwood, Massachusetts, announced that it has entered into a research collaboration with the State University of New York (SUNY) at Stony Brook to develop taxane compounds which can be used as...

NewsRx.com Daily Health, Medical, and Biotech News Site Opens at www.NewsRx.com with $30 Million Giveaway.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- After months of anticipation by current subscribers, NewsRx.com has launched its daily health and medical news site with tiered content for professionals and consumers at www.NewsRx.com. "NewsRx.com...

Cancer Patients Treated with New Laser and Light Technology.(Brief Article)(Statistical Data Included)
March 7, 2000... 2000 MAR 7 - (NewsRx.com) -- Physicians from Emory Hospitals, Atlanta, Georgia, are now treating cancer patients with photodynamic therapy (PDT). PDT is a type of treatment that uses lasers and lights. It uses drug and light...

Estrogen Receptor Activity Modulated by Genetic Manipulation.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Estrogen receptor (ER) activity may be modulated via genetic approaches, a recent study showed. "Successful endocrine therapy in breast cancer is frequently characterized by effective pharmacological...

Cannabinoids Tested Against Gliomas in Rats; Model Questioned by Some Researchers.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Marijuana-like drugs eradicated some brain cancers in rats and helped other animals live longer, according to a study published in the March 2000 issue of the journal Nature Medicine. The study dealt with...

Down-Regulation of GD3 Ganglioside Slows Melanoma Progression.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- The down-regulation of GD3 ganglioside and its O-acetylated derivative by stable transfection with antisense vector against GD3-synthase gene expression reduces progression of hamster melanoma cells,...

Retrovirally Transduced Mouse DCs Require CD4(+) T-Cell Help.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Retrovirally transduced mouse dendritic cells need CD4(+) T-cell help to elicit antitumor immunity, researchers from the United States reported. "Presentation of MHC class I-restricted peptides by...

Anti-Idiotype Antibody Vaccine Mimics Disialoganglioside GD2.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- TriGem used as a cancer vaccine has minimal toxicity and generates robust and specific IgG immune responses against the disialoganglioside GD2, reported researchers from the United States. "To determine...

Thrombopoietin and Its Receptor Not Involved In Disease Progression.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Neither thrombopoietin (TPO) nor its receptor, c-mpl, play a significant role in the progression of chronic myelogenous leukemia (CML), according to researchers. Because TPO and c-mpl support the...

Chromosome Deletions Non-Randomly Over-Represented.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Chromosome deletions were non-randomly over-represented after bone marrow transplantation for chronic myeloid leukemia. Chronic myeloid leukemia (CML) patients with persistent or relapsed disease...

Gene Inducing Pituitary Tumors Also Plays Early Role in Colon Cancer Development.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- A gene that incites the development and growth of pituitary tumors is also expressed in colorectal tumors, pre-cancerous colorectal polyps, and, most abundantly, in invasive colorectal cancer, researchers at...

Assay Detects Tumor-Associated Antigen.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- A novel assay monitors the circulating amount of tumor-associated antigen in cancer patients, according to recent research from the Peoples Republic of China "In 1994, a novel sensitive method termed...

Epstein-Barr Virus DNA Not Found in LMP-1-Negative Disease.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- In classical Hodgkin's disease (HD), LMP-1-negative cases do not harbor Epstein-Barr virus (EBV) DNA within Hodgkin-Reed-Sternberg (H-RS) cells, researchers say. In developing countries, EBV can be...

Metastatic Disease Results "Striking" But Preliminary.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- A vaccine-like treatment wiped out or shrank tumors in patients whose kidney cancer had spread elsewhere in their bodies, according to a new study. Experts called the results striking but cautioned that...

Mutations in APC Gene Found.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Patients with papillary thyroid carcinoma (PTC) frequently have APC mutations that cluster in codons 463-1387 in exon 15, according to researchers. One to two percent of patients with familial adenomatous...

Clinical Trial Evaluates MAb in Lymphoma Patients.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- A European Phase II study evaluated Rituximab (chimeric anti-CD20 monoclonal antibody) in patients with lymphoma. "Mantle-cell lymphoma (MCL), immunocytoma (IMC), and small B-cell lymphocytic lymphoma...

Scientists Create Mouse Model for Most Common Human Cancer.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- A new line of transgenic mice, created by researchers at the University of Michigan and the Hospital for Sick Children/University of Toronto, Canada, will help scientists understand genetic and biochemical...

Antisense-Transferrin Receptor Gene Inhibits Breast Cancer.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Down-regulation of transferrin receptors inhibits the growth of breast carcinoma cells, reported researchers from the United States. "The transferrin receptor, a cellular membrane protein, is critical for...

Successful Delivery of Cancer Drugs by Bispecific Fusion Proteins.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Immunomedics, Inc., Princeton, New Jersey, announced that results with its proprietary bispecific fusion protein method for selective targeting of cancer drugs were presented at the International Conference...

Different Recovery Mechanisms from RAIT in Different Tumors.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Tumors differentially regulate angiogenic factors and their receptors following radioimmunotherapy, indicated researchers from the United States. Tumor-recovery and regrowth after therapy may depend on...

Metalloproteinases Associated with Recurrent Malignancies.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Metalloproteinases (MMP-2,9) have been associated with a variety of tissue and body fluids of patients with cancer. Researchers at the University of Louisville report that MMPs can also be found in the urine...

Findings Say Goserelin/Tamoxifen Outcomes Good.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Study findings suggest that premenopausal women with breast cancer may want to investigate the combination goserelin/tamoxifen therapy. A study presented at the 22(nd) Annual San Antonio Breast Cancer...

Triapine Phase I Single Dose Study Announced.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Vion Pharmaceuticals, Inc., New Haven, Connecticut, announced it has completed a Phase I single dose study of Triapine, a potent ribonucleotide reductase inhibitor that blocks a critical step in the synthesis...

Lead Candidate Drug To Move Quickly into Phase I/II Trial for Myeloma.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Celgene Corp., Warren, New Jersey, announced the results of its initial Phase I clinical studies of the first two compounds from its proprietary class of Immunomodulatory Drugs (IMiDs). The IMiDs are a...

Genomics and Proteomics Technologies Combined.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- UroGenesys, Inc. and Protein Pathways, Inc. announced an alliance to apply Protein Pathways' proprietary bioinformatics technologies to UroGenesys' proprietary database of cancer-associated antigens. The...

U.S. National Institutes of Health Launches ClinicalTrials.gov Web Site.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- The U.S. National Institutes of Health announced the launch of the first phase of a consumer-friendly database, ClinicalTrials.gov, with information on more than 4,000 federal and private medical studies...

Health News Mega Site www.NewsRx.com Offer Jams Web Site; NewsRx.com Named Official Online News Sponsor of eHealthcareWorld.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- The $30 million health news giveaway announced by NewsRx.com at www.NewsRx.com resulted in an instantaneous onrush. "We announced the giveaway at 7:30 a.m. Traffic peaked immediately and by 8:00 a.m. the...

GVAX Cancer Vaccine Advanced to Multicenter Phase I/II Trial.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Cell Genesys, Inc., Foster City, California, announced that it has initiated a multicenter Phase I/II clinical trial of GVAX lung cancer vaccine. This clinical trial follows an initial pilot study which...

Researcher Discovers Cellular Action of Tolonium Chloride (Toluidine Blue).(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Zila Inc., Phoenix, Arizona, announced that research explains the mechanism of action of Zila Tolonium Chloride (also known as toluidine blue), the active ingredient in Zila's OraTest oral cancer detection...

Researchers Seek African American Families for Genetic Study.(Brief Article)(Statistical Data Included)
March 14, 2000... 2000 MAR 14 - (NewsRx.com) -- Scientists at Fred Hutchinson Cancer Research Center and the University of Washington are conducting a search, involving hundreds of families in the U.S., to find the genes responsible for inherited prostate...

Researchers Home in on Gene that Could Play a Major Role.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- Researchers who have spent 10 years studying brothers with prostate cancer are hot on the trail of a gene that may be significant for the cancer's development in many men. They have identified the genetic...

Interferon Treatment Beneficial in Stem Cell Transplantation.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- In some patients with acute lymphoblastic leukemia a treatment regimen that contains interferon might benefit autologous stem cell transplantation, according to researchers working in Italy. The treatment...

Docetaxel/Vinorelbine Combination May Lead to Life-Threatening Colitis in Cancer Patients.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- The use of docetaxel and vinorelbine for chemotherapy may be implicated in colitis in breast cancer patients. "Docetaxel and vinorelbine as combined treatment for metastatic breast cancer can have the...

Apoptosis Induced by Adenovirus-Delivered Anti-bcl-2 Ribozyme.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- Apoptosis was induced in oral cancer cells by the adenovirus-mediated delivery of an anti-bcl-2 ribozyme, researchers from the United States reported. "Human oral cancer cells may have any of several...

Transdermal Fentanyl Shows Promise.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- Transdermal delivery of analgesics, particularly fentanyl, are particularly well-suited for chronic cancer pain. "The transdermal therapeutic system (TTS) allows continuous systemic application of opioids...

Human Autoantibodies to CEA Induced By Vaccinia-CEA Vaccine.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- Human autoantibodies to carcinoembryonic antigen (CEA) can be induced by a vaccinia-CEA vaccine, researchers from the United States reported. "CEA is a well-characterized oncofetal glycoprotein whose...

Complete Lymphadenectomy Best for Node Involvement.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- Physicians should be more aggressive about performing complete lymphadenectomies, even when lymph node metastasis is detected, say researchers at Leiden University in Leiden, Netherlands. Such a policy...

Antitumor Immunity Induced by Indomethacin and Cancer Vaccine.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- Combination immunotherapy and indomethacin induced anticancer immunity in murine cancer models, researchers from Israel reported. "Irradiated tumor cells given, together with indomethacin, to syngeneic...

MAb A103 Can Be Used as a Marker for Steroid-Producing Cells.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- The monoclonal antibody (MAb) A103 can be used for detecting steroid-producing cells in fine-needle aspiration biopsies of the adrenal, researchers from the United States reported. "Fine-needle aspiration...

High Rate of Site-Specific Deletion Observed in Pancreatic Cancer.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- Many types of tumors, including pancreatic carcinoma, exhibit alterations of the candidate tumor suppressor gene FHIT. FHIT genomic inactivation follows an unusual mechanism, primarily occurring by...

Peptide Drug Has Dual Role in Immune Recognition of and Response to Cancer and Infection.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- SciClone Pharmaceuticals, San Mateo, California, announced that a study published in the March 2000 issue of the European Journal of Immunology, shows that Zadaxin (thymosin alpha 1) directly increases the...

Aggressive Stem Cell Transplantation Approach Confirmed.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- A multicenter study confirmed the suitability of an aggressive approach to de novo multiple myeloma patients, according to researchers from Italy. The outcome of patients with multiple myeloma (MM) has...

Human Chorionic Gonadotropin Associated with Breast Cancer Risk.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- Despite theories that human chorionic gonadotropin (hCG) has a protective effect against breast cancer, a recent study showed that instead, it has an adverse effect. Because pregnancy has been associated...

High-Dose Epirubicin Is Active in Treating Advanced Breast Cancer.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- A recent study found high-dose epirubicin to be "highly active" in treating patients with advanced breast cancer, despite the substantial hematologic toxicity associated with the compound. K.D. Miller and...

Cancer Chemotherapy Linked to Hepatitis B Mutation.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- Researchers in Hong Kong reported on an especially virulent hepatitis B virus mutation that appears to result from cytotoxic chemotherapy. Reactivation of the hepatitis B virus (HBV) is a rare, but well...

Mutations Not Sufficient for Tumor Line Immortalization.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- Mutation of the p53 gene confers survival advantages on tumors, but in itself this mutation is not sufficient for immortalizing a cell line, researchers. The tumor suppression traits of the p53 gene can...

Expression of p53 Target Gene Inhibits Tumor Growth.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- The expression of brain-specific angiogenesis inhibitor-1 (BAI1) gene inhibited tumor angiogenesis, thus inducing tumor dormancy in human pancreatic tumors, according to researchers working in Japan. It...

Combination Therapy Improves Breast Tumor Cell Kill Rate.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- Paclitaxel combined with adenoviral-mediated expression of E2F-1 increased rates of cell death in human breast cancer cell lines, reported researchers from the United States. "We have previously shown...

TRAIL Gene and Cisplatin Effective Against Breast Cancer.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- TRAIL gene therapy combined with a cisplatin-based chemotherapy regimen is effective against hormone and drug resistant breast carcinoma cells, reported researchers from the United States. "TRAIL (also...

Von Hippel-Lindau Tumor Suppressor Gene Has Therapeutic Potential.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- Adenovirus expressing Von Hippel-Lindau (VHL) and its target genes was examined for its anticancer potential by researchers from the United States. "Loss of VHL function has been shown to be associated...

Vector System May Have Potential for Tumor-Specific Therapy.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- A vector system using hypoxia responsive gene expression may have potential for tumor-specific gene therapy, according to researchers in the United States. Selective gene expression in response to the...

Genetic Test Developed for Skin Cancer.
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- A genetic test to help pathologists identify melanoma, the most common type of skin cancer, has been developed by researchers at University of California, San Francisco, and may be available to pathology labs...

Chemotherapy Compound Found To Have Antitumor Activity.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- SuperGen Inc., San Ramon, California, announced that data from a Phase I study using the company's anticancer compound decitabine were presented at the 10th International Congress on Anticancer Treatment. ...

Urokinase Contributes to Epithelial Cell Invasiveness in Breast Cancer.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- Urokinase (uPA) contributes to an osteopontin (OPN)-induced increase in human mammary epithelial cell (MEC) invasiveness, reported researchers from Canada. "We have recently shown that either exogenous...

Adenoviral Replication Model Interferes with Painful Metastasis.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- An adenovirus regulated by osteocalcin (OC) has significantly inhibited the growth of prostate cancer cell lines. A novel gene therapy protocol targeting the growth of both bone cancer and its surrounding...

Hormone Replacement Therapy OK for Cancer Patients, Researchers Say.(Brief Article)(Statistical Data Included)
March 21, 2000... 2000 MAR 21 - (NewsRx.com) -- Many studies have indicated that women who have been diagnosed with breast cancer should not take hormone replacement therapy (HRT) to treat menopausal symptoms. According to a study presented at the 22(nd)...