Cancer Weekly articles from June 2000

Cancer Weekly archives from June 2000

Aspirin-Like Drugs May be Useful for Cancer Treatment.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- An enzyme implicated in colon cancer may also play a role in other cancers by promoting development of blood vessels to feed tumors, a Vanderbilt-Ingram Cancer Center scientist and his colleagues reported in...

ErbB2 Potentiates Breast Tumor Proliferation.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- "Overexpression of the ErbB2 receptor, a major component of the ErbB receptor signaling network, contributes to the development of a number of human cancers, ErbB2 presents itself therefore, as a target for...

Antisense Enhances Immunogenicity of Tumor Cell Vaccine.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Cotransfection with genes encoding antisense insulin-like growth factor-1 and B7.1 molecules can enhance the immunogenicity of tumor cell vaccines. "Insulin-like growth factor-1 (IGF-1) is expressed in...

Vector Combines IL-4 and HSV-tk for Glioma Tumor Vaccine.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Researchers in the United States constructed a retroviral vector that combined interleukin-4 (IL-4) with the herpes simplex virus thymidine kinase (HSV-tk) gene into a glioma tumor cell vaccine. ...

Brachial Plexus Catheter Infiltration Can Provide Upper Extremity Pain Relief.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Using a catheter reservoir system to deliver anesthetic directly to the brachial plexus can provide pain relief to patients with cancer in the upper extremities, researchers report. M.Y. Wang and...

DNA-Based Vaccine Boosted by Nonviral Cytokine Gene Transfer.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Nonviral cytokine gene transfer has an adjuvant effect when added to a DNA-based anticancer vaccine. "Intramuscular (i.m.) injections of a plasmid encoding human carcinoembryonic antigen (CEA) elicited...

Tumor-Associated Glycoprotein 72 is Expressed in Salivary Gland Neoplasias.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Researchers in Greece conducted an immunohistochemical study using the monoclonal antibody (MAb) CC49 to determine tumor-associated glycoprotein 72 (TAG-72) expression in salivary gland neoplasias. "The...

Suicide Gene Therapy Evaluated in Rat Model.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Researchers in France have evaluated a herpes simplex virus-thymidine kinase (HSV-tk) suicide gene therapy approach in a rat model of hepatocellular carcinoma. "Transfer of the HSV-tk gene followed by the...

New Method of Removing Soft Tissue Tumors Has Positive Implications.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- A recent study has found that radio frequency interstitial tissue ablation was successful in treating localized renal tumors and did not have toxic effects. According to M.M. Walther and colleagues with...

Surgery Effective for Treating Liver Metastases from Breast Cancer.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Surgery is the best treatment option for breast cancer patients with liver metastases, according to researchers. Breast cancer patients with liver metastases typically survive less than six months if...

Novel Differentiating Factor Identified.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Researchers have discovered a novel myeloid-cell differentiating factor, myelopeptide-4 (MP-4). L.A. Strelkov and colleagues at the M.M. Shemyakin Bioorganic Chemistry Institute in Moscow, Russia, studied...

Low-Energy Radiochemicals Preferable for Treating Cancer-Related Bone Pain.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Radioactive chemicals that emit relatively low-energy particles are superior radiopharmaceuticals for treating bone pain in terminal cancer patients, according to researchers writing in the Journal of Nuclear...

Treatment of Malignant Gliomas Tested in Animal Model.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Improving microglia response might boost efficacy of herpes simplex virus thymidine kinase (HSV-tk) gene transfer and ganciclovir administration in treatment of gliomas, researchers suggest. A.M. Sandmair...

Significant Survival Improvement Announced in Patients.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Allos Therapeutics, Inc. (ALTH), Denver, Colorado, announced that significant survival improvement was achieved with RSR13, combined with cranial radiation therapy, in a Phase II clinical trial in patients with...

Diabetes Drug Shows Effects in Cancer.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- A diabetes drug recently pulled from the market because of toxic liver effects may help in some cases of cancer and deserves further study, researchers said on May 20, 2000. They said they had found...

Thalidomide Appears to be Effective Treatment in Variety of Cancers.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Teams of researchers investigating the use of Thalomid (thalidomide) announced study results in patients suffering from several types of hematological and solid tumor cancers. These findings were announced...

Clinical Trials of New Vaccine Slated for Fall 2000.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- National clinical trials for a colon cancer vaccine developed by two Cincinnati, Ohio, researchers are expected begin this fall, doctors announced May 20, 2000, at the American Society of Clinical Oncology...

Technology Used to Detect Hard-To-Find Cancer Cells.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Using the patented Origen technology developed by Igen International, Inc., researchers have identified colon cancer cells not normally detected by conventional diagnostic methods. Investigators from the...

Drug Shows Long-Term Prevention of Colon Polyps in Patients.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Clinical results from familial adenomatous polyposis (FAP) patients treated with Aptosyn (exisulind) for up to 18 months were presented on May 23, 2000, at the annual meeting of the American...

Investigators See Immune Response in Cancer Vaccine Trial.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Genzyme Molecular Oncology (GZMO), Framingham, Massachusetts, announced that investigators of its Phase I/II melanoma cancer vaccine trial have observed immune responses in several patients. Of nine...

Cancer Vaccine Extends Five-Year Overall Survival.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Avax Technologies, Inc., announced the presentation of data at the 36th Annual Meeting of the American Society of Clinical Oncology on May 23, 2000, in New Orleans, Louisiana, on the company's autologous cell...

Neoadjuvant Docetaxel Benefits Patients with Locally Advanced Cancer.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- The use of docetaxel (Taxotere) as neoadjuvant therapy prior to local treatment, surgery, or radiotherapy improves survival compared to local treatment alone in patients with locally advanced non-small-cell...

Vaccine Induces Positive Immunological and Clinical Outcomes.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Avax Technologies, Inc. announced the presentation of data at the 36th Annual Meeting of the American Society of Clinical Oncology (ASCO), May 22, 2000 in New Orleans, Louisiana, on the company's autologous...

Positive Results in Initial GVAX Vaccine Trial Reported.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Cell Genesys, Inc. (CEGE), Foster City, California, reported prolongation of disease-free survival in a Phase I trial of a pancreatic cancer vaccine in patients who received the vaccine following surgery and...

Molecular Markers Predict Relapse After Radiation Treatment.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Cancer researchers at Jefferson Medical College have found two potential molecular biomarkers that may predict the effectiveness of therapy for prostate cancer and the potential for relapse following radiation...

Prolactin Promotes Prostate Cell Growth.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Prolactin (PRL) promotes the growth of prostate cells, partly through the potassium channel, according to researchers. To clarify the role of PRL in the prostate, N. Prevarskaya and colleagues at the...

Positive Results for Abarelix Depot-M in Two Pivotal Phase III Clinical Trials.
June 6, 2000... 2000 JUN 6 - (NewsRx.com) -- Praecis Pharmaceuticals Inc., announced the results of two Phase III studies for its lead compound, abarelix depot-M, for the treatment of prostate cancer. Praecis is developing this product globally with...

Means to Prevent Cardiotoxicity Addressed.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Scientists recently concluded that close screening, attention to risk factors, and monitoring for symptoms can prevent cardiotoxicity in patients who have undergone chemotherapy. V.B. Pai and a colleague...

Optimized Electroporation Shows Potential for Treatment of Gliomas.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Optimized electroporation as a gene delivery mechanism shows promise for the treatment of glioma, suggests research from Japan. "Electroporation, a standard laboratory method of introducing exogenous...

Gene Therapy-Based Approach May be Useful.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Adenovirus (Ad)-mediated p14(ARF) gene transfer into mesothelioma cells resulted in G[1]-phase arrest and apoptosis, according to a recent study. "The p14(ARF) protein encoded by the INK4a/ARF locus...

Vinblastine and VEGF Receptor-2 Antibody Cause Tumor Regression.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- According to a study from Canada, a low dose combination therapy with vinblastine and vascular endothelial growth factor (VEGF) receptor-2 antibody induced tumor regression in an animal model. "Various...

Complete Reversal of Multidrug Resistance Phenotype Not Possible in Leukemia Cells.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Research from Germany indicates it is not feasible to achieve complete reversal of the multidrug resistance (MDR) phenotype in human leukemia cells with mdr1-targeted antisense oligonucleotides. "The...

Celecoxib Induces Cancer Cell Death by Kinase Inhibition.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- The selective cyclooxygenase-2 (COX-2) inhibitor celecoxib appears to induce apoptosis in prostate cancer cells by down-regulating the anti-apoptotic kinase Akt, rather than the proto-oncogene Bcl-2 as had...

Intravital Fluorescence Videomicroscopy Used to Study Tumor Angiogenesis and Microcirculation.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Researchers in Germany are using intravital microscopy for the analysis of tumor angiogenesis, microcirculation, and overall perfusion. "Its application to the study of tumor-induced neovascularization...

System Developed for Detecting Urine Angiostatin and Plasminogen.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Researchers from Sweden have developed an antibody-based analysis system for detecting angiostatin and plasminogen/plasmin (Pgn/plasmin) in urine. The system combines a lysine-ELISA assay and Western...

Dual-Monoclonal Sandwich Assay Detects Prostate-Specific Membrane Antigen.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- A dual-monoclonal sandwich assay accurately detects prostate-specific membrane antigen (PSMA) in tissues, seminal fluid, and urine. "PSMA is a 750-residue integral membrane glycoprotein and the target of...

Angiogenesis is a Prognostic Factor for Survival.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Microvessel density is a predictor of survival from gastric cancer, researchers report. "Gastric cancer (GC) continues to be a highly aggressive malignancy with poor prognosis and low survival rates. The...

Determining Factors of Tumor Invasion.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Vocal cord ability as well as mucosal distribution of the tumor accurately indicate degree of laryngeal tumor invasion, otolaryngologists in England report. "Previous pathologic studies of the spread of...

Endoscopic Surgery More Effective than Radiotherapy.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- The comparison of radiotherapy and endoscopic surgery or cricohyoidoepiglottopexy as treatments for stage I and stage II laryngeal cancer was the focus of a study conducted in Switzerland. L. Bron and...

Repeat Thoracic Irradiation Effective for Relief of Recurrent Symptoms.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Patients with recurrent lung cancer who have already undergone thoracic radiation therapy apparently can benefit from a reprise of such therapy. "Controversy exists regarding the retreatment because of...

Thymidine Phosphorylase Expression Correlates with Several Factors.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Researchers have correlated thymidine phosphorylase (TP) expression by ovarian cancer cells with microvessel density, apoptosis, and peak systolic velocity. Shimane Medical University researcher K. Hata...

Microcirculation Studied in Experimental Rat Cancer.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Researchers from Germany conducted a study of angiogenesis and microcirculation in 16 male Lewis rats. J. Schmidt and colleagues, University of Heidelberg, established their model by "induction of a...

Proteins in Extracellular Matrix May Inhibit Tumor Development.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Researchers have found that an increased presence of extracellular matrix (ECM) proteins in aging cells may play a role in inhibiting tumor development. The alterations in gene expression that cause...

Activator 2 Protein May Play Role in Tumor Proliferation.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Prostate tumors that are low in activator protein 2 (AP-2) tend to lack differentiation. AP-2, a transcription factor, stimulates p21 (waf1/cip1) expression, which inhibits cell growth by blocking the...

Effect of Linomide on Tumor Growth and Metastasis in an Animal Model.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Researchers in Germany recently studied the effect of linomide on tumor growth and metastasis in a human hormone-resistant prostate cancer cell line. "It has been demonstrated that...

FHIT Mutations Occur Early in Disease Development.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Researchers have found that changes in the fragile histidine triad (FHIT) gene take place early in the development of tumors. FHIT gene mutation has been observed in many forms of cancer, and correction...

Mitomycin C Not Effective for Relief of Symptoms.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Mitomycin C (MMC) is not an effective adjunct to orchiectomy for treatment of poor prognosis M1 prostate cancer, and can actually cause a decline in quality of life, according to researchers writing in...

PSA-Based Vaccine Generates Reactive Effector Cells.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- A prostate-specific antigen (PSA)-based vaccine generates PSA-reactive effector cells in prostate cancer patients. "JET 1001 is a vaccine used for therapy of prostate cancer (CA), which consists of...

Early Squamous Cell Carcinoma Effectively Treated with Surgery.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Otolaryngologists report that surgery effectively manages early stage tonsil cancer. "The management of tonsil carcinoma has gradually evolved such that the literature is replete with outcome summaries of...

Drugs Blocking Tumors' Blood Supply Show Promise, Hazards.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Drugs designed to stop tumors by cutting off their blood supply, one of the most closely watched new developments in cancer research, have raised concerns about possible dangerous side effects. ...

Treatment Could Alleviate Debilitating Side Effects.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Wasting response in humans as well as several forms of debilitating inflammation, among other side effects afflicting recipients of bone marrow transplantation may be significantly alleviated using a new...

Combination Therapy with Oral Rubitecan Effective in Variety of Solid Tumors.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- SuperGen Inc. (SUPG & SUPGZ), San Ramon, California, announced that in two separate Phase I clinical studies, combination therapy involving the company's oral anticancer compound rubitecan showed efficacy in...

Combretastatin A-4 Disodium Phosphate Effectively Targets Tumors.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Research results presented in San Francisco, California, at the American Association for Cancer Research 91(st) Annual Meeting, have shown that combretastatin A-4 Disodium phosphate (CA4DP) is an effective...

Biomodulation of Fusion Protein Increases in vitro Cytotoxicity in Cells.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Ligand Pharmaceuticals Inc. announced the presentation of preclinical study results on May 23, 2000, suggesting that the addition of biomodulatory strategies to the Ontak(R) (denileukin diftitox/DAB389IL-2)...

Gene Expression Profile Conducted.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Researchers have identified genes whose expression is altered in prostate cancer. Y.Q. Chen and colleagues at Wayne State University in Detroit, Michigan, used serial analysis of gene expression (SAGE) to...

Insulin-Like Growth Factor Receptor Re-Expression Induces Intracellular Signalling Differentiation.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Type 1 insulin-like growth factor receptor (IGF-1R) re-expression causes intracellular signals to differentiate in cells of the prostate epithelium, researchers say. Expression of IGF-1R is reduced when...

Phase II Trial Data Announced.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Xenova Group plc (XNVA; XEN), Slough, United Kingdom, announced trial data for a colorectal study, which is one of four open label Phase II efficacy studies currently being carried out in conjunction with the...

Discovery Announced for Increasing Cord Blood Stem Cells.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Aastrom Biosciences, Inc. (ASTM), Ann Arbor, Michigan, announced important new results for a large-scale procedure to grow human stem cells outside of the body (ex vivo) from cord blood. The procedure,...

Company Says Unplanned Analysis Didn't Allow Time for Vaccine to Realize Full Potential.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Progenics Pharmaceuticals, Inc. (PGNX), Tarrytown, New York, announced that the Eastern Cooperative Oncology Group (ECOG) will conclude its participation in the company's Phase III clinical trial for the GMK...

Phase III Advanced Cancer Treatment Study Enrollment Completed.(Statistical Data Included)(Brief Article)
June 13, 2000... 2000 JUN 13 - (NewsRx.com) -- Atrix Laboratories (ATRX), Fort Collins, Colorado, announced that it has completed the enrollment of patients in its Phase III human clinical trial for advanced prostate cancer. The therapy uses the...

Genetic Approach Targets Breast and Ovarian Cancers.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- University of Washington, Seattle, researchers in collaboration with the Seattle-based Corixa Corp., have determined that the HER-2/neu protein, which is overproduced, or expressed, by some breast and ovarian...

Hormone Analog is Promising New Treatment.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Reporting in the June 1, 2000, issue of Cancer Research, U.S. Department of Veterans Affairs (VA) scientists and colleagues have identified a promising new treatment for kidney cancer. Using a...

Weight-Loss Herb Damaged Kidneys.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- A Chinese herb in a weight-loss preparation damaged the kidneys of 105 patients at a Belgian clinic and apparently caused 18 cases of cancer among them, researchers report. "Our findings reinforce the...

New Gene Delivery Technique Thwarts Blood-Brain Barrier.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- University of California, Los Angeles (UCLA), researchers have developed the first non-invasive method for delivering therapeutic genes into the brain. This new approach could provide a treatment option...

Gene that Blocks Metastasis Identified.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Researchers at Pennsylvania State University's College of Medicine have discovered a gene that blocks metastasis in breast cancer. The gene is called breast cancer metastasis suppressor, or BRMS1, and is...

Hormone-Based Therapy Might Help Some Post-Menopausal Women Avoid Mastectomy.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Results from an exploratory study published in the June 7, 2000, issue of Clinical Cancer Research suggest that pre-treatment with Arimidex (anastrozole), a hormonal therapy manufactured by AstraZeneca, may...

Immunogene Therapy for Head and Neck Cancer Explored.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Alloantigen gene therapy shows promise for the adjunctive treatment of head and neck cancer. "New treatment methods are needed for head and neck cancer to improve survival without increasing morbidity,"...

Allogeneic Tumor Cell-Based Vaccine Produces Antitumor Response.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Potent antitumor responses were realized from a granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting allogeneic tumor cell-based vaccine, according to a recent study. GM-CSF-transduced...

Scientists Discover New Way the Body Distinguishes Self From Foreign.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Challenging an important dogma, immunologists have discovered a new way the body distinguishes its cells from foreign cells so it can destroy microbes without harming itself. The findings suggest a new...

Antibody May Play Diagnostic Role in Malignant Disease.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- The anti-MAGE antibody 57B may have diagnostic usefulness for determining the malignant potential of a melanocytic tumor. "The melanoma-associated antigen (MAGE) family consists of a number of antigens...

Investigators Report Complete Eradication of Human Lymphoma in Mouse Model.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Genta Inc., Lexington, Massachusetts, announced publication of results with Genasense, the company's lead antisense drug (formerly G3139), used alone and in combination with standard therapy for non-Hodgkin's...

Phase I Trial Evaluates Bcl-2 Antisense Therapy.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Results of a Phase I clinical trial suggest antisense oligonucleotide therapy could have antitumor activity in patients with non-Hodgkin's lymphoma. J.S. Waters and colleagues, Royal Marsden Hospital,...

Iron Overload Contributes to Liver Cancer Formation.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- More scientific findings have linked iron overload with the formation of hepatocellular carcinoma (HCC) in patients with hepatitis C associated liver cirrhosis. Stating that the role of iron deposits in...

Use in Cell Culturing Activates Oncogene.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Scientists report that using telomerase to extend the life-span of human tissue culture cells is associated with activation of the c-myc oncogene and thus may present some level of cancer risk if the cells are...

Vascular Growth Factor Negatively Impacts Chemotherapy Response.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Medical investigators recently reported that vascular endothelial growth factor (VEGF) overexpression negatively impacts the response to chemotherapy. At the International Meeting on Angiogenesis, held in...

Research Focuses on Minimally Invasive Techniques.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- New technologies presented at the "Era of Hope" U.S. Department of Defense Breast Cancer Research Program meeting, in Atlanta, Georgia, feature minimally invasive procedures and promising approaches that...

Anti-Angiogenesis Approach Targets Malignant Ascites.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Anti-angiogenesis gene therapy of malignant ascites in a murine model produced encouraging results, researchers in Japan and the United States reported. "Recent evidence suggests that tumor-mediated...

Anti-Angiogenic Drug Much More Effective When Immune System Primed Against Cancer.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- University of Pittsburgh, Pennsylvania, scientists have shown that triggering an anti-tumor immune response significantly potentiates the effects of the anti-angiogenic drug endostatin in animal models,...

High Alanine Aminotransferase Levels Seen with Cancer Recurrence.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Alanine aminotransferase (ALT) levels are used as markers for chronic liver disease. When these markers remain high or increase after a patient has been hepatectomized for hepatocellular carcinoma (HCC), the...

Role of Angiogenic Chemokines Explored.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Researchers in the United States examined the relationship of angiogenic chemokines in AIDS-associated Kaposi's sarcoma. "AIDS-associated Kaposi's sarcoma is an angioproliferative disease characterized by...

Further Evidence of Angiopoietin 2 Role Presented.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Further evidence that angiopoietins, especially angiopoietin-2 (ang-2), are associated with tumor angiogenesis, was presented at the International Meeting on Angiogenesis held in Amsterdam. Georg...

Licensing Agreement Extended for Cytochrome P450 Enzymes.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- A promising cancer therapy, developed by scientists at Boston University, Massachusetts General Hospital (MGH), and the Dana-Farber Cancer Institute, has begun clinical trials at Oxford BioMedica. A...

Researchers Developing Vaccines with the Aid of Tobacco.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Federal research funding is flowing to U.S. scientists trying to use genetically altered tobacco as a tool to fight cervical cancer. Researchers at North Carolina State University and Georgetown...

Anti-Cancer Drug Passes First Clinical Hurdle.
June 27, 2000... 2000 JUN 27 - (NewsRx.com) -- Australian pharmaceutical company, Novogen Limited (NVGN; NRT) announced the completion of the first stage of Phase I clinical evaluation of its anti-cancer drug, NV-06. These initial trials were...