Cancer Weekly articles from June 1992

Cancer Weekly archives from June 1992

250 million to die worldwide from smoking. (American Cancer Society)
June 1, 1992... American Cancer Society Data from the American Cancer Society's Cancer Prevention Study II (CPS-II) show that, if current smoking rates continue, more than one-fifth of all people now living in developed countries will be killed by...

American smoking at lowest level in 37 years. (U.S. Centers for Disease Control)
June 1, 1992... U.S. CDC Americans are extinguishing their cigarettes in record numbers, leading U.S. health officials to predict the nation will meet its health objective on smoking by the year 2000. The U.S. Centers for Disease Control (CDC)...

Small numbers of pharmacists stop selling cigarettes. (New York)
June 1, 1992... New York Pharmacist Jim Bollinger had grappled for several years with the ethics of selling medicine at one counter and cigarettes at another. "We're supposed to be a healthcare provider," said the owner of McLane's Pharmacy in...

Anti-smoking campaign faces uphill battle. (China)
June 1, 1992... China China has an estimated 300 million smokers among its 1 billion people and produces 310 billion cigarettes a year. Both numbers are higher than for any other country in the world. Sixty percent of men smoke, as well as many women...

State declares breast cancer an epidemic. (Massachusetts)
June 1, 1992... Massachusetts Declaring breast cancer an epidemic - a term usually reserved for communicable diseases - the state of Massachusetts has launched a campaign to fight the affliction, which strikes one in nine women. "Clearly, with one...

State distributes videotape encouraging mammograms for older women. (Pennsylvania)
June 1, 1992... Pennsylvania Pennsylvania Secretary of Aging Linda M. Rhodes said that the state is distributing a videotape urging women age 60 and older to have regular mammograms. Rhodes said the videotape, "Woman to Woman - Straight Talk about...

Grants fund basic research into causes and treatment of disease. (grant recipients Dr. Emmett V. Schmidt, Dr. Richard H. Simon, Dr. Howard Fine) (Brain Tumor Society)
June 1, 1992... Brain Tumor Society The Brain Tumor Society has announced the presentation of three research grants totaling nearly $100,000. The grants, the first to be given by the Society, will go to funding three separate research projects, all...

Computers "see" brain tumors to improve treatment for cancer patients. (COVIRA - Computer Vision in Radiology) (United Kingdom)
June 1, 1992... United Kingdom An estimated 200,000 cancer patients previously thought to be unsuited for surgery or radiation treatment may benefit from an IBM RISC/6000 program called COVIRA -Computer Vision in Radiology. Especially useful for...

Researchers find common bacteria product kills colon cancer cells. (Clostridium difficile toxin) (Medical College of Wisconsin)
June 1, 1992... Medical College of Wisconsin Medical College of Wisconsin (MCW), Milwaukee, Wisconsin, researchers have found that a product secreted by a common bacteria has the ability to selectively target and kill colon cancer cells in vitro and...

Drug company criticized at meeting for price of cancer medicine. (Johnson and Johnson; levamisole) (American Society for Clinical Oncology meeting)
June 1, 1992... American Society for Clinical Oncology A drug company was criticized for charging 100 times more to treat humans than animals with the first effective medicine for colon cancer. Dr. Charles G. Moertel of the Mayo Clinic, Rochester,...

Study says emergency room workers face hepatitis and HIV risks. (hepatitis B and C) (Johns Hopkins Hospital)
June 1, 1992... Johns Hopkins Hospital Healthcare workers in inner-city emergency rooms appear to face a significant risk of exposure to two types of hepatitis that are not detected by routine screening, a study reported. Tests of 2,523 patients...

Hepatitis B prevention program launched. (National Foundation for Infectious Diseases)
June 1, 1992... National Foundation for Infectious Diseases According to a nationwide survey, 85 percent of young adults (18-24) feel that not enough is being done to educate the public about hepatitis B, a highly contagious, sexually-transmitted virus...

Suntan still perceived as sign of good health. (parents surveyed on attitudes & efforts to prevent sunburn in their children) (American Medical Association)
June 1, 1992... American Medical Association More than 80 percent of parents questioned believed that a suntan makes their children look healthy, even though one bad sunburn in childhood can lead to skin cancer in adulthood, according to a study...

Treatment of HIV-associated Hodgkin's disease (HIV-HD): is there a clue regarding the etiology of Hodgkin's disease? (Research Report)
June 1, 1992... AUTHORS: S. Newcom, M. Ward, V. Napoli and M. Kutner. Emory University School of Medicine, Atlanta, Georgia. According to the authors' abstract of a poster presentation to the 28th annual meeting of the American Society of Clinical...

Systemic hyperthermia in the treatment of HIV related malignancy: a Phase I study. (Research Report)
June 1, 1992... AUTHORS: K. Alonso, P. Pontiggia, E. DeBartolomei, G. Calvi, F. Cuppone Curto and C. Nardi. European Hospital, Rome, Italy. According to the authors' abstract of a poster presentation to the 28th annual meeting of the American Society of...

Lung cancer in patients with human immunodeficiency virus infection compared with historical controls. (Research Report)
June 1, 1992... AUTHORS: K.S. Sridhar, M.R. Flores, W. Raub and S.P. Richman. Sylvester Comprehensive Cancer Center, University of Miami School of Medicine and the V.A. Medical Center, Miami, Florida. According to the authors' abstract of a poster...

Breast conservation therapy: local tumor control in patients with pathologically clear margins who receive 5000 CGY breast irradiation without local boost. (Research Report)
June 1, 1992... AUTHORS: R.D. Pezner, L.D. Wagman, J. Ben-Ezra, T. Odom-Maryon and K.H. Luk. City of Hope National Medical Center, Duarte, California. According to the authors' abstract of a poster presentation to the 28th annual meeting of the...

Male breast cancer: risk factors and clinical features. (Research Report)
June 1, 1992... AUTHORS: S. Mani, Y.H. Ahmad and R.J. Papac. Yale University Medical School, New Haven, Connecticut. According to the authors' abstract of a poster presentation to the 28th annual meeting of the American Society of Clinical Oncology,...

A two-year adjuvant chemotherapy without radiation therapy for acute and extensive inflammatory breast carcinoma: long-term follow up. (Research Report)
June 1, 1992... AUTHORS: J.F. Morere, T. Bouillet, C. Boaziz, J.L. Breau and L. Israel. University of Paris, Paris, France. According to the authors' abstract of a poster presentation to the 28th annual meeting of the American Society of Clinical...

Risk of second primary cancers after Hodgkin's disease by type of treatment: analysis of 2,846 patients in the British National Lymphoma Investigation. (Periodical Report)
June 1, 1992... SOURCE: British Journal of Medicine, May, 1992;304:1137-1143. The risk of solid cancers is the major long term hazard of treatment for Hodgkin's disease, but this risk is small when compared with the great improvements in survival seen...

Human breast cancer: prognostic significance of the c-erbB-2 oncoprotein compared with epidermal growth factor receptor. (Periodical Report)
June 1, 1992... SOURCE: Journal of Clinical Oncology, May, 1992;10(5):686-695. Overexpression of the c-erbB-2 oncoprotein appears to be an important indicator of relapse in stage I-II breast cancer, according to a European report. The c-erbB-2 (or...

Segregation analysis of esophageal cancer in 221 high-risk Chinese families. (Periodical Report)
June 1, 1992... SOURCE: Journal of the National Cancer Institute, May 20, 1992;84(10):771-776. A recessive major gene appears to predispose certain families to esophageal cancer, according to a segregation analysis of a commune in North China where...

Medical risk factors and the development of brain tumors. (Periodical Report)
June 1, 1992... SOURCE: Cancer, May 15, 1992;69(10):2541-2547. A German Cancer Research Center study suggests that allergies, infections and diabetes may decrease the risk of brain cancers. There is very little known about the cause of brain...

Retinoic acid inhibition of serum-induced c-fos transcription in a fibrosarcoma cell line. (Periodical Report)
June 1, 1992... SOURCE: Cancer Research, May 1, 1992;52:2394-2401. Retinoic acid-mediated down-regulation of c-fos expression is a mechanism for growth inhibition in rat fibroblast cells, and this may be associated with the antitumor activity of...

Cytogenetic evidence of the multistep origin of head and neck squamous cell carcinomas. (Periodical Report)
June 1, 1992... SOURCE: Journal of the National Cancer Institute, May 20, 1992;84(10):793-797. Head and neck squamous cell carcinoma appears to result from the accumulation of genetic changes that involve the deletion of putative tumor suppressor genes...

Current trends: discomfort from environmental tobacco smoke among employees at worksites with minimal smoking restrictions - United States, 1988. (Periodical Report)
June 1, 1992... SOURCE: Morbidity and Mortality Weekly Report, May 20, 1992. "Exposure to environmental tobacco smoke (ETS) is a potential occupational carcinogen according to guidelines of the Occupational Safety and Health Administration (OSHA)...

PCBs and DDT could be causative agent in breast cancer. (University of Michigan)
June 8, 1992... University of Michigan A small study conducted by researchers at the University of Michigan suggests that environmental contaminants such as polychlorobiphenyls (PCBs) and pesticides such as DDT trapped in breast fat could be an...

DDT exposure clearly linked to pancreas cancer. (University of Michigan)
June 8, 1992... University of Michigan Researchers reported that they have the first clear evidence that heavy exposure to the insecticide DDT substantially increases the risk of pancreas cancer in humans. The study was conducted by the University...

Standards for breast conservation treatment issued by medical societies. (American College of Radiology, American College of Surgeons, College of American Pathologists, Society of Surgical Oncology) (American Cancer Society)
June 8, 1992... American Cancer Society For the first time, four leading professional organizations have reached a consensus about the specific and overall standards that physicians should follow in their care of women who have selected breast...

Panel approves gene therapy for brain tumors. (U.S. National Institutes of Health Recombinant DNA Advisory Committee)
June 8, 1992... U.S. NIH The first attempt to use gene therapy to combat brain tumors, one of the deadliest types of cancer, won approval from a U.S. National Institutes of Health (NIH) advisory panel. By a vote of 19-0 with one abstention, the...

Sickness and politics: the influence of disease advocates; cancer vs. AIDS. (Washington, D.C.)
June 8, 1992... Washington, D.C. The politics surrounding Washington, D.C. health research issues has taken on a new meaning as a result of the AIDS pandemic. Sheila Swanson of Saratoga, California, founded the Bay Area Cancer Network in 1990 with...

Interferon-beta increases impact of radiation therapy to lung cancer. (Medical College of Wisconsin)
June 8, 1992... Medical College of Wisconsin Doctors at the Medical College of Wisconsin (MCW), Milwaukee, Wisconsin, are breaking new ground in therapeutic strategies for lung cancer with a novel combination of treatments designed to enhance the...

Researchers perform first successful laryngeal transplant in dogs. (University of California, Los Angeles)
June 8, 1992... University of California, Los Angeles A team of researchers from the University of California, Los Angeles (UCLA), School of Medicine has performed the first successful laryngeal transplant in a canine model. The research team was...

One in 11 cancer patients seeks alternate therapy. (American Cancer Society poll)
June 8, 1992... American Cancer Society One in 11 cancer patients resorts to "questionable" treatments like hypnosis or vitamin supplements in their battle against the disease, a nationwide survey showed. The poll, commissioned by the American...

New technologies highlight symposium. (American Society of Colon and Rectal Surgeons)
June 8, 1992... American Society of Colon and Rectal Surgeons New technologies are turning the war on colon cancer into a high technology battlefield with the goal of making diagnosis more accurate, achieving better preoperative staging of surgery and...

Family history obtained at screening mammography: effective recruitment strategy for the Breast Cancer Prevention Trial (BCPT). (Research Report)
June 8, 1992... Family History Obtained at Screening Mammography: AUTHORS: V.G. Vogel, M.L. Bondy, S.S. Halabi and J.A. Lord. University of Texas M.D. Anderson Cancer Center, Houston, Texas. According to the authors' abstract of a poster...

Value of serum prostate specific antigen in prostate cancer screening in the community. (Research Report)
June 8, 1992... AUTHORS: R.O. Dillman, T. Williams and S.A. MacDonald. Hoag Cancer Center, Newport Beach, California. According to the authors' abstract of a poster presentation to the 28th Annual Meeting of the American Society of Clinical Oncology,...

Phase I study of difluoromethylornithine (DFMO) as a chemopreventive agent (CPA). (Research Report)
June 8, 1992... AUTHORS: P.J. Creaven, L. Pendyala, N. Petrelli, H. Douglass, L. Herrera, C. Porter and J. Solomon. Roswell Park Cancer Institute, Buffalo, New York. According to the authors' abstract of a poster presentation to the 28th Annual...

Tumorigenic capacity of a human rhabdomyosarcoma (RMS) cell line RD is suppressed by antibodies against insulin-like growth factor (IGF) I receptor. (Research Report)
June 8, 1992... AUTHORS: T. Kalebic, F. Kull, S. Jacobs and L. Helman. Pediatric Branch, U.S. National Cancer Institute, Bethesda, Maryland, and Wellcome Research Laboratories, Research Triangle Park, North Carolina. According to the authors' abstract...

Five-year progress report: the Collaborative Ocular Melanoma Study. (choroidal melanoma) (Research Report)
June 8, 1992... AUTHORS: J.M. Kirkwood, J.D. Earle, S.L. Fine, B.S. Hawkins, B.R. Straatsma and R.L. Mowery. University of Pittsburgh School of Medicine and Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, and Mayo Clinic, Rochester, Minnesota. ...

Morphometric and flow cytometric study of intraductal papilloma. (breast tumor) (Research Report)
June 8, 1992... AUTHORS: S. Mori, H. Miki, S. Kobayashi and M. Ohmori. Kagawa Medical School, Kagawa, Japan. According to the authors' abstract of a poster presentation to the 83rd annual meeting of the American Association for Cancer Research, held...

Community Clinical Oncology Program. (National Cancer Institute research grant announcement) (Research Report)
June 8, 1992... AUTHORS: RFA Available: CA-92-15. U.S. National Cancer Institute. "Letter of Intent Receipt Date: June 29, 1992. Application Receipt Date: August 24, 1992. Purpose: The Division of Cancer Prevention and Control (DCPC), U.S....

Relationship of human papillomavirus type to grade of cervical intraepithelial neoplasia. (Periodical Report)
June 8, 1992... SOURCE: Journal of the American Medical Association, May 13, 1992;267(18):2493-2496. Cervical intraepithelial neoplasia should be classified into two separate categories distinguishing low-grade and high-grade types, according to a...

Phase II trial of fludarabine phosphate in lymphoma: an effective new agent in low-grade lymphoma. (Periodical Report)
June 8, 1992... SOURCE: Journal of Clinical Oncology, May, 1992;19(5):790-794. Fludarabine phosphate (FAMP) has significant efficacy in the treatment of follicular lymphoma, but more investigation is needed to clarify its lack of efficacy in...

Bone-marrow transplantation of chronic myelogenous leukemia in chronic phase: evaluation of risks and benefits. (Periodical Report)
June 8, 1992... SOURCE: Journal of Clinical Oncology, May, 1992;10(5):779-789. Bone-marrow transplant (BMT) should be offered soon after diagnosis to chronic myelogenous leukemia (CML) patients in chronic phase who have compatible sibling donors,...

Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine and procarbazine chemotherapy in the treatment of glioma. (Periodical Report)
June 8, 1992... SOURCE: Cancer, May 15, 1992;69(10):2532-2570. Clinicians should closely monitor the use of procarbazine in the treatment of primary brain tumors due to the frequency of hypersensitivity reactions, and the drug should be stopped if rash...

The relationship of sex and treatment modality to neuropsychologic outcome in childhood acute lymphoblastic leukemia. (Periodical Report)
June 8, 1992... SOURCE: Journal of Clinical Oncology, May, 1992;10(5):810-817. A Dana-Farber Cancer Institute study suggests that girls are more likely than boys to develop neurotoxicity from cranial irradiation used in the treatment of acute...

Effect of liarozole, a new antitumoral compound, on retinoic acid-induced inhibition of cell growth and on retinoic acid metabolism in MCF-7 human breast cancer cells. (Periodical Report)
June 8, 1992... SOURCE: Cancer Research, May 15, 1992;52:2841-2846. The imidazole derivative liarozole (R 75 251) appears to have antitumor activity in conjunction with retinoic acid on MCF-7 human breast cancer cells, according to an in vitro study....

Interleukin-2 after high dose chemotherapy and autologous bone-marrow transplantation (AMBT) in metastatic melanoma. (Research Report)
June 8, 1992... AUTHORS: S. Negrier, P. Viens, J.Y. Ranchere, D. Blaise, I. Philip, A.M. Stoppa, P. Biron, C. Pourreau, P. Palmer, D. Maraninchi and T. Philip. Institute P. Calmettes, Marseille, France, and Eurocetus Amsterdam, Amsterdam, The Netherlands....

p53 gene prognostic indicator in breast/prostate cancers. (Massachusetts)
June 15, 1992... Massachusetts Two studies, published in the June 3, 1992 issue of the Journal of the National Cancer Institute, conclude that p53 nuclear protein expression is a significant prognostic indicator in both breast and prostate cancers. ...

Researchers identify new form of hereditary colon cancer. (Creighton University)
June 15, 1992... Creighton University Researchers at Creighton University's Hereditary Cancer Institute have identified another new hereditary colon cancer disorder described fully for the first time in the May 1992 issue of Diseases of the Colon and...

Rising colon cancer risk linked to increase in body iron stores. (American Society of Colon and Rectal Surgeons)
June 15, 1992... American Society of Colon and Rectal Surgeons A new study links increased risk of colon cancer to higher levels of iron in the body. In a presentation at the 91st Annual Meeting of the American Society of Colon and Rectal Surgeons...

Oriental population sees dramatic increase in colorectal cancer. (American Society of Colon and Rectal Surgeons)
June 15, 1992... American Society of Colon and Rectal Surgeons Dietary changes may play an important role in the dramatic increase of colorectal cancer among Orientals, according to a study reported at the 91st annual convention of the American Society of...

Killing the mRNA suppresses cancer cells. (effect of transretinoic acid on cytokine production) (University of California, Irvine)
June 15, 1992... California A drug that reduces the lifetime of messenger RNA (mRNA) for certain proteins in tumor cells also decreased the proliferation of human cancer cells by up to 75 percent, according to Helen Ross, assistant professor of...

Study for prevention of recurrence of malignant melanoma following surgery. (testing Melacine melanoma theraccine) (Southwest Oncology Group)
June 15, 1992... Southwest Oncology Group The Southwest Oncology Group (SWOG) will conduct a large-scale Phase III human clinical study to determine the ability of Melacine melanoma theraccine to prevent recurrence of disease following surgical removal...

Committee investigates ozone depletion link to skin cancer. (U.S. Senate Ad Hoc Subcommittee on Consumer and Environmental Affairs)
June 15, 1992... U.S. Senate An expert on sun protection told a Congressional hearing that mounting evidence that UV radiation causes long-term, clinically significant damage "points to the growing need for highly protective sunscreen products." ...

Scientists report garlic can contribute to cancer prevention and treatment. (aged garlic extract: SGP, or Kyolic) (Fourth International Conference on the Prevention of Human Cancer)
June 15, 1992... A team of scientists, headed by Dr. John Pinto of Memorial Sloan-Kettering Cancer Center, New York, New York, Dr. Robert I. Lin of Nutrition International, Irvine, California, and Dr. Fillmore Freeman of the University of California at Irvine,...

Diagnostic product approved for use. (Cellfree IL-2R Bead Assay Kit for adult T-cell leukemia) (Japan)
June 15, 1992... T Cell Sciences Inc., Cambridge, Massachusetts, announced that its Japanese partner, Yamanouchi Pharmaceutical Company Ltd., has received approval from Japanese regulatory authorities to market the Cellfree IL-2R Bead Assay Kit for monitoring...

Company provides update on Doxil clinical studies. (Liposome Technology Inc.'s formulation of doxorubicin) (Israel)
June 15, 1992... Liposome Technology Inc. (LTI), a Menlo Park, California-based pharmaceutical company, reported the initiation and preliminary results from an NDA-track clinical study designed to determine the "maximum tolerated dose" (MTD) of Doxil. ...

Cancer registries/tobacco regulation addressed. (U.S. Congress)
June 15, 1992... Women's health, cancer registries, regulation of tobacco products, medicare coverage and the drug approval process were among the cancer-related topics addressed by the 102nd Congress. The Cancer Registries Amendment Act, introduced in...

Should cost effectiveness be considered in breast cancer treatment? (autologous bone marrow transplants) (Virginia)
June 15, 1992... Women with breast cancer live an average of six months to 18 months longer if they receive a controversial bone-marrow transplant that costs an average of $116,000 for each year of life it buys, a study found. Doctors, patients and...

Prostate cancer imaging agent enters Phase III of human testing. (OncoScint) (Cytogen Corporation, Cytorad Inc.)
June 15, 1992... Cytogen Corp. and Cytorad Inc. reported that, based on the encouraging results of the Phase I and Phase II human clinical trials for OncoScint prostate, Phase III trials to evaluate pre-surgical patients have been initiated. The study...

Company to grant license for rhenium cancer therapy. (NeoRx Corporation)
June 15, 1992... NeoRx Corporation, Seattle, Washington, announced that it has signed a binding agreement with Sterling Winthrop Inc. and Eastman Kodak Company. Under this agreement, within 30 days, the parties expect to execute a definitive agreement...

Medical research laser introduced. (Coherent Inc.)
June 15, 1992... Coherent Inc., Palo Alto, California, announced the development of an advanced medical research tool which allows a choice of simultaneous use of up to three of seven different available wavelengths in one solid-state laser. Dr. Michael...

Contemporary approaches to ovarian cancer biology research. (National Cancer Institute research grant announcement) (Research Report)
June 15, 1992... AUTHORS: RFA Available: CA-92-18. U.S. National Cancer Institute. "Letter of Intent Receipt Date: July 17, 1992. Application Receipt Date: October 9, 1992. Purpose: The Cancer Biology Branch of the Division of Cancer Biology,...

Phase I study of taxol (T) and doxorubicin (D) with G-CSF in patients (pt) without prior chemotherapy (CT) for metastatic breast cancer (MBC). (granulocyte colony-stimulating factor) (Research Report)
June 15, 1992... AUTHORS: F.A. Holmes, D. Frye, V. Valero, R.S. Walters, R.L. Teriault, D. Booser, S. Vadan-Raj and G.N. Hortobagyi. M.D. Anderson Cancer Center, Houston, Texas. According to the authors' abstract of a poster presentation to the 28th...

An analysis of causes of study 'hold' for oncology drug INDs submitted to the FDA. (investigational new drugs) (Research Report)
June 15, 1992... AUTHORS: G. Sokol, A.J. Murgo, R. Scully, R. Justice and J. Johnson. Federal Drug Administration Center for Drug Evaluation (CDER), Rockville, Maryland and Uniformed Services University, Bethesda, Maryland. According to the authors'...

Phase I human trial of testicular circulatory isolation. (Research Report)
June 15, 1992... AUTHORS: J.J. Gibbons, R.O. Parra, G.P. Andriole and F.E. Johnson. St. Louis University and Washington University, St. Louis, Missouri. According to the authors' abstract of a poster presentation to the 28th Annual Meeting of the...

C-myc amplification in human colonic tumors: an Eastern Cooperative Oncology Group study. (Research Report)
June 15, 1992... AUTHORS: L. Augenlicht, G. Corner, B. Heerdt, B. Czerniak, L. Ryan, A. Benson and S. Wadler. Albert Einstein Cancer Center, Bronx, New York and Dana-Farber Cancer Institute, Boston, Massachusetts and Northwestern University, Chicago,...

Phase III trial of trilostane versus aminoglutethimide in metastatic postmenopausal breast cancer. (Research Report)
June 15, 1992... AUTHORS: P.P.B Hames and C.J. Williams. UK Trilostane Study Group, Southampton, United Kingdom. According to the authors' abstract of a poster presentation to the 28th Annual Meeting of the American Society of Clinical Oncology, held...

The UCLA experience of whole body positron emission tomography in human breast cancer. (Research Report)
June 15, 1992... AUTHORS: N. Tse, C. Hoh, R. Hawkins and J. Glaspy. University of California, Los Angeles, School of Medicine, Los Angeles, California. According to the authors' abstract of a poster presentation to the 28th Annual Meeting of the...

Morphometric and flow cytometric study of intraductal papilloma. (Research Report)
June 15, 1992... AUTHORS: S. Mori, H. Miki, S. Kobayashi and M. Ohmori. Kagawa Medical School, Kagawa, Japan. According to the authors' abstract of a poster presentation to the 83rd annual meeting of the American Association for Cancer Research, held...

Increased circulating nitrogen oxides after human tumor immunotherapy: correlation with toxic hemodynamic changes. (Periodical Report)
June 15, 1992... SOURCE: Journal of the U.S. National Cancer Institute, June 3, 1992;84(11):864-867. Increased production of nitric oxide in the plasma of patients receiving treatment with interleukin-2 (IL-2) could explain hemodynamic toxicity...

Intravenous interleukin-2 in patients over 65 with metastatic renal carcinoma. (Periodical Report)
June 15, 1992... SOURCE: British Journal of Cancer, May, 1992;65(5):723-726. Age does not appear to alter response in metastatic renal carcinoma patients treated with continuous infusion interleukin-2, but there is a particular cardiac toxicity in...

cdc2-like kinase is associated with the retinoblastoma protein. (Periodical Report)
June 15, 1992... SOURCE: Oncogene, June, 1992;7:1067-1074. cdc2-like kinase appears to be the main kinase for phosphorylation of retinoblastoma (RB) proteins in vivo, according to a report from Japan. Mutations of RB gene have been detected in...

Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails. (Periodical Report)
June 15, 1992... SOURCE: Proceedings of the National Academy of Sciences, May, 1992;89:4309-4313. In vivo evolution of epidermal growth factor receptor (EGFR) genes appears to reach oncogenic potential through gene amplification with subsequent and...

Effectiveness, costs and cost-effectiveness of recruitment strategies for a mammographic screening program to detect breast cancer. (Periodical Report)
June 15, 1992... SOURCE: Journal of the U.S. National Cancer Institute, June 3, 1992;84(11):877-882. Personal recruitment strategies appear to be more effective than public strategies in persuading women to have routine mammograms, according to an...

Gene puts lethal bomb into brain tumor cells, study says. (inserting herpes virus gene that is sensitive to ganciclovir) (U.S. National Institutes of Health)
June 22, 1992... U.S. NIH In laboratory research that soon will be tried on humans, scientists have shown that a brain cancer can be cured by injecting it with a gene that makes the tumor cells sensitive to an anti-herpes drug. The technique cured a...

Age plays important role in survival of brain tumor patients. (American College of Radiology)
June 22, 1992... American College of Radiology Brain tumor patients under the age of 50 live nearly twice as long as older patients, a Radiation Therapy Oncology Group (RTOG) study has found. More than 1,500 patients with glioblastoma multiforme or...

Researchers begin two gene therapy experiments. (for metastatic melanoma & familial hypercholesteremia) (University of Michigan)
June 22, 1992... Michigan Separate gene-therapy trials have begun at the University of Michigan, Ann Arbor, Michigan, in efforts to develop treatments for skin cancer and a hereditary disorder that causes extremely high cholesterol levels. The two...

Human trials on MDR1 technique could begin in 1993. (multidrug resistance 1 gene) (U.S. National Cancer Institute)
June 22, 1992... U.S. NCI The ability of cancer cells to resist drugs may be used to help patients withstand the rigors of chemotherapy, researchers said. Human trials on a technique that will shield human bone marrow using the so-called Multidrug...

Scientists define structure of Ah receptor involved in carcinogenesis. (dioxin receptor) (University of California, Los Angeles)
June 22, 1992... University of California, Los Angeles In a study published in the May 22, 1992, issue of the journal Science, University of California, Los Angeles, (UCLA) scientists reported their discoveries about the structure and function of the ARNT...

New approach to gene therapy announced. (immunostimulatory genes inserted into difficult-to-grow cancer cells) (San Diego Regional Cancer Center)
June 22, 1992... San Diego Regional Cancer Center A team of San Diego, California, scientists announced research findings that point to a new method of gene therapy against cancer using a patient's normal skin fibroblast cells to introduce therapeutic...

Gene linked with recurring childhood cancer. (p53 mutations) (Massachusetts)
June 22, 1992... Massachusetts A gene already linked with several kinds of cancer may sometimes be involved when youngsters with the disease develop a second unrelated malignancy, a study concludes. The study links the risk of these new bouts of...