Cancer Weekly articles from January 2004

Cancer Weekly archives from January 2004

Calcium and vitamin D collaborate to reduce cancer risk.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- The nutrients calcium and vitamin D work in tandem, not separately, to reduce the risk of colorectal cancer, according to a new Dartmouth study. The research builds on a multicenter study led by...

Cancer's love-hate relationship with proteins offers new treatment window.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Scientists at Washington University School of Medicine in St. Louis have found that the absence of two proteins cells use to cope with heat stress can make it easier for the cells to become cancerous,...

Bisphosphonate suppress growth and induces apoptosis in cancer cells in culture.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Bisphosphonate (BPs) suppress growth and induces apoptosis in cancer cells in culture and may influence survival of cancer cells in an osteoclast-independent manner, researchers report. "BPs...

Angiotensin II receptor blockers staunch prostate cancer growth.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Angiotensin II receptor blockers staunch prostate cancer growth. According to recent research from Japan, "angiotensin 11 (A-II) receptor (AT(1) receptor) blockers (ARB) are a class of...

Many factors affect how oncolytic adenoviruses transfect tumors.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Many factors affect how oncolytic adenoviruses transfect tumors. "Avoiding transduction of normal tissue after intravenous application of oncolytic adenoviruses (Ad) is an important strategy to...

Microbeams point to future of radiotherapy.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Zapping cancer cells with a futuristic microbeam - one of only two fully operational in the world - could pave the way for significant advances in radiotherapy, scientists from Cancer Research UK...

Genasense plus chemo demonstrates enhanced activity for older AML patients.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Genta, Inc., (GNTA) announced the presentation of results from several clinical studies that showed safety and potentially enhanced activity when chemotherapy was combined with Genasense (oblimersen...

Vectosomes improve the delivery of antisense oligonucleotides.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Vectosomes improve the delivery of antisense oligonucleotides. "VP22, a protein of the herpes simplex virus tegument, can form complexes with fluorescein-labeled oligonucleotides. These particles,...

Change in biological rhythms may cause early deaths from premature aging, cancer.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Disturbance of orderly biological rhythms may result in earlier deaths due to premature aging and cancers, researchers report. "This paper reviews abundant evidence suggesting that causes and...

Repifermin reduces the severity of graft-versus-host-disease.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Repifermin may separate the toxicity of graft-versus-host-disease (GVHD) from the beneficial graft-versus-leukemia (GVL) effects after allogeneic bone marrow transplantation (BAIT). According to...

Bone marrow-derived endothelial progenitor cells are marginal to gliomas.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Bone marrow-derived endothelial progenitor cells are marginal to gliomas. "Until recently, it was generally accepted that the vascularization of solid tumors occurred exclusively through the...

A delivery system for targeting anticancer drugs to the brain developed.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- In vivo studies show that compound 23 of the 1,4-dihydropyridine chemical delivery system (CDS) type was able to cross the blood-brain barrier (BBB) at detectable concentrations. According to...

Altered cyclin E protein linked to genetic instability, endocrine resistance.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Researchers at The University of Texas M.D. Anderson Cancer Center have found that a protein linked to poor outcome in breast cancer is often associated with genetic instability and increased resistance...

Battery-powered gamma detection probe available for lymph node mapping.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- SenoRx Inc. announced the U.S. product launch of its first battery-powered Gamma detection probe for intraoperative lymph node mapping. Gamma Finder is the first and only cordless hand-held probe to...

Chemotherapy advance reported for women with node-positive early breast cancer.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- A docetaxel (Taxotere)-based regimen reduced the relative risk of death in women with early stage breast cancer by 30% and lowered the relative risk of the cancer returning by 28% when compared to a...

Data from Theratope Vaccine trial presented.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Biomira, Inc., (BIOM, BRA) and Merck KGaA of Darmstadt, Germany, announced that data from the final analysis of their Theratope Vaccine phase III clinical trial in women with metastatic breast cancer...

Fewer than half of patients with early-stage disease get full chemotherapy dose.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- New study data point to an alarming pattern in breast cancer treatment: fewer than half of women with early-stage breast cancer whose records were evaluated received their full, recommended dose of...

Mammograms don't reach all communities equally.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Despite an overall rise in mammography use over the last two decades, women living in poor and rural communities of the U.S. lag when it comes to early breast cancer detection, but may be positively...

Oral drug shows promise for prevention of ER-negative disease in mouse model.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- The oral drug ZD1839, also known as gefitinib, prevented the development of estrogen receptor (ER)-negative breast cancer in a mouse model, which raises the possibility that the drug could be a...

Positive Abraxane phase III data released.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- American Pharmaceutical Partners, Inc., (APPX) (APP) and ABRAXIS Oncology, the proprietary drug division of APP, announced positive results of the randomized, controlled phase III clinical trial in...

Positive data reported on phase II breast tumor cell proliferation study.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Ascend Therapeutics, Inc., announced that it presented data from a phase II dose-escalating study comparing the antiproliferative effect of the company's percutaneous TamoGel (4-Hydroxytamoxifen gel) to...

Post-tamoxifen use of Femara reduces risk of breast cancer recurrence by 43%.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Extended adjuvant treatment with Femara (letrozole tablets) in a group of postmenopausal women with early breast cancer who had completed 5 years of therapy with tamoxifen cut the risk of recurrence of...

Randomized trial examines second-line endocrine therapy in advanced breast cancer.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- A study shows the greater aromatase-inhibiting activity of letrozole and indicates that advanced breast cancer (BC) is more responsive to letrozole than to anastrozole as second-line endocrine therapy....

Researchers develop a mathematical modeling of comedo DCIS of the breast.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Researchers show how the duct wall deforms as the tumor grows and how the progression of the tumor along the duct depends upon the stiffness of the wall. "The growth of a tumor in a cylindrical duct...

Residential magnetic field exposure does not increase risk of breast cancer.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Residential magnetic field exposure does not increase risk of breast cancer. "Some experimental and epidemiologic evidence suggests that residential exposure to power-frequency magnetic fields can...

SAFB1 and SAFB2 may be novel breast tumor suppressor genes.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Scaffold attachment factor B1 (SAFB1) and Scaffold attachment factor B2 (SAFB2) may be novel breast tumor suppressor genes, researchers say. "SAFB1 and SAFB2 are large, multifunctional proteins that...

Shc proteins are prognostic markers for primary breast cancer.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Shc proteins are strong, independent prognostic markers for both node-negative and node-positive primary breast cancer. "Activated Shc signaling proteins are implicated in many pathways associated...

Short-term postmenopausal hormone therapy does not measurably increase breast cancer risk.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- The majority of women prescribed short-term postmenopausal hormone therapy (HT) for treatment of vasomotor symptoms show no measurable increase in their risk for breast cancer, researchers say. ...

Some patients may benefit from endocrine therapy alone.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- The estrogen receptor status of breast cancer may help to predict which patients will benefit from chemotherapy treatment, say researchers at The University of Texas M.D. Anderson Cancer Center. ...

Study data indicate promise for investigational compound GW572016.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Data from an early phase, multicenter clinical trial suggest that GW572016, a reversible inhibitor of two growth factor receptors involved in the proliferation and survival of many solid tumors in a...

Study supports tailoring adjuvant therapy for early-stage disease.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Premenopausal women with lymph node-negative breast cancer should receive adjuvant therapy tailored according to the estrogen receptor status of the primary tumor, concludes a study by the International...

Study to provide more data on targeted 5-day radiotherapy for DCIS patients.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Proxima Therapeutics, Inc., announced the initiation of the largest partial breast irradiation study for patients with ductal carcinoma in situ (DCIS). The study will be conducted at six breast...

Tailored dosage of chemotherapy is effective treatment, study shows.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- By tailoring the dosage of chemotherapy to each individual patient, the treatment of breast cancer could be improved considerably, suggest study results from Sweden. The method has proven to yield...

Urokinase-type plasminogen activator receptor marks metastatic breast cancer.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Urokinase-type plasminogen activator receptor marks metastatic breast cancer. "The urokinase-type plasminogen activator receptor (uPAR, CD87) plays a central role in the plasminogen activation...

Nutrition counseling, drug therapy recommended for anorectic cancer patients.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Treatment of anorectic cancer patients should include nutritional counseling and drug therapy, researchers say. "Anorexia and reduced food intake are important issues in the management of patients...

Requirement discussed for Arf6 in cell adhesion, migration, cancer cell invasion.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Researchers discuss the possible roles of a small GTP-binding protein, Arf6, in epithelial cell adhesion and migration, and in cancer cell invasion. According to published research from Japan, "Cell...

Company receives CE Mark for Nipple Endoscope.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Jim Holmes, CEO of Lifeline BioTechnologies, Inc., (LBTT) announced that the company has received CE Mark Certification for its Nipple Endoscope (nipple microendoscope) in Europe. CE Mark...

EUROCARE-3 publishes new childhood cancer survival figures.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- The Nordic countries of Sweden, Norway, Finland and Iceland represent a gold standard for the treatment of children's cancer. They have survival rates to which all European countries that devote similar...

Non-small cell lung cancer drug market to exceed $4.1 billion in 2012.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Decision Resources, Inc., forecasts that the non-small cell lung cancer (NSCLC) drug market will exceed $4.1 billion in 2012. According to the new Pharmacor study entitled "Non-Small-Cell Lung...

Homocysteine thiolactone is a proangiogenic agent.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Homocysteine thiolactone is a proangiogenic agent. According to recent research published in the journal Biochemical and Biophysical Research Communications, "homocysteine thiolactone is a highly...

Company reports on phase II meeting with FDA on Oravescent Fentanyl.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Cima Labs, Inc., (CIMA) announced that it held its end of phase II meeting with the U.S. Food and Drug Administration (FDA) regarding the company's proprietary OraVescent Fentanyl transmucosal dosage...

Differential documentation of pain may be noted when hospice is involved.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- There may be differential documentation of pain when hospice is involved, possibly due to superior pain assessment by hospice, researchers say. "This study examined the observed differential...

The effect of donepezil in patients receiving opioids for cancer pain.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Donepezil significantly improves sedation and fatigue, anxiety, well-being, depression, anorexia, and problems with sleep in patients with cancer pain. "Opioid-induced sedation is a major...

Organosulfer compounds stop liver cancer invasion, migration, and angiogenesis.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Organosulfer compounds stop liver cancer invasion, migration, and angiogenesis. According to a study from South Korea, "numerous studies have revealed the chemopreventive and hepatoprotective...

Cyclooxygenase-2 is a prognostic indicator of oral squamous cell carcinoma.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "cyclooxygenase-2 (COX-2) is known as one of the critical prognostic factors in carcinomas of the various organs. However, the importance of COX-2 overexpression in oral...

Teratomas from stem cells provide a platform for studying cancer mechanisms.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Teratomas from stem cells provide a platform for studying cancer mechanisms. According to a study from Israel, "there is currently no available experimental system wherein human cancer cells can be...

Information interventions may help people make screening decisions.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Brochures and web-based information that individuals access independently may help them make appropriate decisions about cancer screening, says a report by the Task Force on Community Preventive...

Modified Rotterdam Symptom Checklist is reliable, valid for cancer patient use.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- The modified Rotterdam Symptom Checklist (RSCL-M) is a reliable and valid instrument for use with cancer patients in the United States, researchers say. "The Rotterdam Symptom Checklist (RSCL) is a...

New way to lock DNA-slicing enzyme onto chromosomes could lead to novel drugs.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- St. Jude scientists' discovery of new way to lock Topoisomerase 1 onto DNA suggests a new approach to designing drugs targeting solid tumors and leukemia Investigators at St. Jude Children's...

Data: LPAAT-beta has potential use in myeloid and lymphoid malignancies.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- In four presentations at the recent American Society of Hematology (ASH) meeting, scientists presented data on a novel cancer target from Cell Therapeutics, Inc., (CTI) (CTIC), LPAAT-beta. ...

INEX releases Onco TCS data from three clinical trials.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Inex Pharmaceuticals Corp. (IEX) announced that it released results from three separate clinical trials that indicate the company's lead anticancer product Onco TCS is able to reduce the size of tumors...

Inhibiting DNA replication-initiation protein induces apoptosis.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells. According to a study from China, "DNA replication-initiation proteins are expressed in...

Novacea licenses anticancer product candidate.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Novacea, Inc., and KuDOS Pharmaceuticals announced that Novacea has licensed from KuDOS the North American rights to develop and commercialize AQ4N, a hypoxic, cell-activated agent with broad potential...

P-glycoprotein and Mrp1 protect bone marrow from vincristine-induced toxicity.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- P-glycoprotein and Mrp1 protect bone marrow from vincristine-induced toxicity. "ABC transporter proteins may protect hematopoietic progenitor cells from chemotherapy-induced toxicity," scientists in...

Researchers analyze model of a virus that replicates selectively in tumor cells.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Researchers analyze a model in which viruses infect tumor cells, replicate inside them, and eventually cause their death. According to a study from the United States, "We consider a procedure for...

Study: Multiple mechanisms of action make INGN 241 a promising approach.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Introgen Therapeutics, Inc., (INGN) and its collaborators at the University of Texas M. D. Anderson Cancer Center presented preclinical data highlighting the broad and multifunctional potential of INGN...

VGA1155 inhibits vascular endothelial growth factor binding.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- VGA1155 inhibits vascular endothelial growth factor binding. According to a study from Japan, "vascular endothelial growth factor (VEGF) plays a pivotal role in the processes of angiogenesis, which...

Tumor growth inhibited by vaccination with Her-2/neu peptides.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Tumor cell growth was inhibited by antibodies induced after vaccination with peptides derived from the extracellular domain of Her-2/neu. According to a study from Austria, "The anti Her-2/neu...

Vaccines for leukemia therapy reviewed.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Researchers have reviewed progress in the development of leukemia vaccines in a recent issue of the journal Acta Haematologica. According to a study from Germany, "Evidence that immunological...

Multiple mechanisms contribute to the carcinogenicity of cadmium.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Multiple mechanisms contribute to the carcinogenicity of cadmium, researchers say. "Cadmium is a heavy metal, which is widely used in industry, affecting human health through occupational and...

Delayed complications of endovascular stenting for carotid blowout examined.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- The long-term effectiveness of carotid stents for controlling of acute carotid blowouts in the setting of head and neck malignancy and overlying infection is suspect, researchers say. "Endovascular...

Autophagy active in tumor suppression.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Normal cell growth requires well-coordinated balance between synthesis and breakdown. Autophagy is a regulated lysosomal pathway whereby long-lived cellular proteins and cytoplasmic organelles are...

Functions of p53 equally important in halting for cancer cell growth.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- The tumor suppressor protein called p53 has been described both as the caretaker of the genome, since it can stop cells damaged in their genetic material from proliferating until they carry out repairs,...

The immunomodulator FTY720 bars VEGF-induced vascular permeability.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- The immunomodulator FTY720 bars VEGF-induced vascular permeability. "FTY720, a potent immunosuppressive agent, is phosphorylated in vivo into FTY720-P, a high affinity agonist for sphingosine...

Nomadic outposts of transplanted stem cells tracked.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Doctors regularly inject stem cells into patients whose bone marrow has been destroyed by chemotherapy or radiation, but they haven't known where these cells go after being injected. Research at...

Educating women about disease link to smoking persuades more to quit.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Providing women with brief written information linking between smoking and cervical cancer increases their readiness to quit smoking, a new study shows. Since women who smoke have double the chance...

Eighty-one percent of surveyed women want noninvasive cervical cancer test over Pap test.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Eighty-one percent of women tested with SpectRx's (SPRX) non-invasive cervical cancer detection prototypes wanted the test to be used as a replacement for the invasive Pap test, according to a study...

Additional patent issued for Tocosol Paclitaxel cancer drug.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Sonus Pharmaceuticals, Inc., (SNUS) announced that an additional United States patent has been issued for Tocosol Paclitaxel, expanding claims directed to the composition of Tocosol Paclitaxel and also...

CT, MRI help in delineating location, extent of chest wall tumors.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Computed tomography (CT) and magnetic resonance (MR) imaging are helpful in further delineating the location and extent of the tumor and in identifying tumor tissues and types, researchers report. ...

Abnormal bone marrow angiogenesis persists after stem cell transplantation.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Abnormal bone marrow angiogenesis persists after stem cell transplantation. According to recent research from the United States, "increased bone marrow angiogenesis is a poor prognostic marker in...

Deal signed for solid-tumor cancer treatment development.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Avanir Pharmaceuticals (AVN) announced that a commercial license agreement with Peregrine Pharmaceuticals, Inc., (PPHM) has been executed for an antibody Avanir produced for a cancer target in...

A3 adenosine receptor agonist inhibits colon cancer growth.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- The A3 adenosine receptor agonist CF101 inhibits primary colon carcinoma growth and liver metastasis. According to recent research published in the British Journal of Cancer, "Adenosine is a purine...

Activation of PPAR gamma in colon tumor cell lines.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Oxidation products of linoleic acid are metabolically produced endogenous ligands for PPAR gamma and that PPAR gamma plays an important role in the differentiation of intestinal cells. According to...

Dendritic cell vaccine to be used in trial for new cancer treatment.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Aastrom Biosciences, Inc., (ASTM) announced the initiation of a phase I clinical trial in collaboration with investigators at Duke University Medical Center (Duke). The clinical trial will evaluate...

Total energy and macronutrients associated with colon cancer risk.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Study findings may provide an explanation for some of the racial differences in colon cancer incidence, "The higher incidence of colon cancer in African Americans compared with other U.S....

Risk factors determine need for colonoscopy.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- An index being developed by researchers at the Indiana University School of Medicine may help determine patients' risk levels for colorectal cancer and whether they require a colonoscopy for further...

15-Hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Treating colon cancer cells with 15S-HETE inhibits cell proliferation and induces apoptosis in a PPARgamma-dependent pathway, researchers report. "Peroxisome proliferator-activated receptor gamma...

Knudson's theory can explain diverse experimental situations.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Knudson's two-hit theory can explain diverse experimental situations and guide specific predictions, including some directly relevant to cancer prevention, researchers report. "The multistep model...

Phase II clinical trials of KOS-862 initiated.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Kosan Biosciences Incorporated (KOSN) announced the start of multicenter phase II clinical trials within the Kosan and Roche partnership to evaluate the efficacy of KOS-862 (Epothilone D) as a...

Study projects colorectal cancer drug sales to reach $2.1B in 2012.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Decision Resources, Inc., forecasts that the colorectal cancer (CRC) drug market will be driven by the introduction of Sanofi-Synthelabo's Eloxatin in the United States, and the use of Pfizer's...

Organotypic raft cultures typify spectral analysis of in vivo tissues.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Organotypic raft cultures typify spectral analysis of in vivo tissues. According to a study from the United States, "there is a growing body of evidence showing that optical spectroscopy has the...

Preclinical data on microbubble drug delivery reported.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- AVI BioPharma, Inc., (AVII) announced the presentation of preclinical data at two international conferences. The first presentation detailed a novel drug delivery mechanism, AVI's proprietary...

Circadian rhythms reveal when antiangiogenic therapy should be administered.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Circadian rhythms reveal when antiangiogenic therapy should be administered. "Because angiogenesis is essential for tumor growth and metastasis, inhibition of angiogenesis has emerged as a new...

NIH begins human Ebola vaccine trial using Biojector 2000.
January 6, 2004... 2004 JAN 6 - (NewsRx.com & NewsRx.net) -- Bioject Medical Technologies, Inc., (BJCT), a developer of needle-free drug delivery systems, announced that the Vaccine Research Center (VRC) at the National Institute of Allergy and Infectious...