Cancer Weekly articles from February 1992

Cancer Weekly archives from February 1992

Scientists discover new hormone. (9-cis retinoic acid) (Ligand Pharmaceuticals and Salk Institute)
February 3, 1992... Ligand Pharmaceuticals and Salk Institute A team of San Diego, California, scientists has discovered a new human hormone that has a major role in regulating cell growth and differentiation and may prove to have significant medical benefit...

Study finds link between cervical cancer and B-vitamin. (folic acid may help prevent cervical cancer) (University of Alabama)
February 3, 1992... Alabama Researchers have found that eating spinach and broccoli can help prevent one of the most common forms of cancer in women. The study of cervical cancer and blood levels of the B-vitamin folate was done by researchers at the...

Hepatitis C virus and hepatocellular carcinoma. (studies done in Taiwan & Italy)
February 3, 1992... Taiwan/Italy Two studies published in January 1992 come to different conclusions about the role of hepatitis B and C viruses in the etiology of hepatocellular carcinoma (HCC), with a report from Taiwan finding that hepatitis B virus is a...

Medarex files IND for novel antibody treatment for leukemia. (Investigational New Drug application for MDX-11) (New Jersey)
February 3, 1992... New Jersey Medarex Inc. announced that it has filed an Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA) for a novel monoclonal antibody-based treatment for patients with Acute Myeloid Leukemia...

Research centers on development of Anticode therapies to treat cancer and AIDS. (Genta Inc.)
February 3, 1992... Genta Inc. Genta Inc., San Diego, California, with proceeds from a new December 1991 $25 million public offering, has as its principal research and development objective to discover and develop proprietary Anticode agents which will...

Camptothecin-derivative shows activity in clinical testing. (CPT-11) (Japan)
February 3, 1992... Japan A derivative of the plant alkaloid camptothecin has been shown to have significant activity with acceptable toxicity in the treatment of non-small cell lung cancer (NSCLC) patients. Camptothecin-11 (CPT-11) is one of two...

Smoking is major cause of cancers of renal pelvis and ureter. (U.S. National Cancer Institute)
February 3, 1992... U.S. NCI Cigarette smoking is the major cause of cancers of the renal pelvis and ureter, with seven of 10 cases among men attributable to the habit, according to the largest population-based case-control study of these cancers ever...

Older oncologist more likely to stress prevention. (survey of members of the American Society of Clinical Oncologists)
February 3, 1992... California A nationwide survey of 729 members of the American Society of Clinical Oncologists (ASCO) found a significantly more favorable attitude toward cancer prevention and control efforts among physicians with more than 20 years...

Publication bias originates with investigator, not editors. (Johns Hopkins Health Institutions, Maryland)
February 3, 1992... Maryland Contrary to popular opinion, publication bias in the reporting of medical research originates with investigators and not journal editors, according to publication review of Johns Hopkins Health Institution research data. ...

Registry for women with breast implants established. (International Breast Implant Registry) (Medic Alert Foundation)
February 3, 1992... Medic Alert Foundation Medic Alert Foundation (MAF) announced that it has established a worldwide registry for women with breast implants. Introduced as the International Breast Implant Registry, with a toll-free number,...

Dow Corning will release breast implant data. (U.S. Food and Drug Administration)
February 3, 1992... U.S. FDA Dow Corning Corporation will make public 90 studies and internal memoranda cited by the U.S. Food and Drug Administration (FDA) as part of the basis for a moratorium on silicone gel breast implants, company officials said. ...

Clinics offer alternative to silicone-gel breast implants. (woman's own stomach tissue used in what is called the upper-abdominal transverse rectus abdominis myocutaneous flap technique) (Wisconsin)
February 3, 1992... Wisconsin Plastic surgeons at a Marshfield, Wisconsin, clinic say they can use a woman's stomach tissue to reconstruct a breast instead of silicone-gel implants, which are being investigated by the U.S. Food and Drug Administration...

Height, weight linked to DES-associated vaginal cancer. (diethylstilbestrol) (University of Tennessee)
February 3, 1992... Tennessee DES (diethylstilbestrol)-exposed women who were taller and more obese at 14-15 years old have an increased risk of developing vaginal cancer compared with DES-exposed women who were shorter and thinner during adolescence,...

Companies sign letter of understanding to produce taxol. (Regal One Corporation and Xechem Inc.)
February 3, 1992... Regal One Corporation and Xechem Inc. Regal One Corporation, Los Angeles, California, and Xechem Inc. of New Brunswick, New Jersey, have entered into a Letter of Understanding, pursuant to which Xechem will become a wholly owned...

Biochemist awarded shark cartilage patent. (I. William Lane) (New Jersey)
February 3, 1992... New Jersey I. William Lane, a biochemist researching the use of shark cartilage to fight disease, has been awarded a U.S. patent for his method of using shark cartilage powder to inhibit, or block, blood vessel development, known as...

To market new product line for supportive care of HIV, AIDS and cancer patients. (Unimist for dry mouth) (Unimed Inc.)
February 3, 1992... Unimed Inc. Unimed Inc. announced that it has signed an agreement to market a new product line for supportive care of HIV, AIDS and cancer patients. Initial product introduction is scheduled for February. The product line, which...

Minority oncology leadership academic award. (National Cancer Institute research grant announcement) (Research Report)
February 3, 1992... AUTHORS: PA: PA-92-33. U.S. National Cancer Institute. "Application Receipt Dates: February 1, 1992, June 1, 1992, October 1,1992. Purpose: The Comprehensive Minority Biomedical Program, Division of Extramural Activities, U.S....

A case control study on the risk factors for endometrial cancer in premenopausal women. (Research Report)
February 3, 1992... Minority Oncology Leadership Academic Award AUTHORS: Tammy Neibauer, Joe Chu and Lynda Voigt. The University of Washington. According to the authors' abstract of a poster presentation to the 37th annual meeting of the Western...

Investigation of estrogen receptor status and responsiveness of a new endometrial adenocarcinoma cell line #684, at protein, mRNA, and gene level. (Research Report)
February 3, 1992... Investigation of Estrogen Receptor Status and AUTHORS: Gail B. Womack, George Moore and Kim Leslie. University of California at Sacramento. According to the authors' abstract of a poster presentation to the 37th annual meeting of...

Alteration of the p53 gene in human head and neck squamous cell carcinomas. (Research Report)
February 3, 1992... Alteration of the p53 Gene in Human Head and Neck AUTHORS: W. Weiser, G. Casey, J. Pitcock and F. Meyskens. Clinical Cancer Center, University of California at Irvine. According to the authors' abstract of a poster presentation to...

Androgen receptor analysis in prostate cancer. (Research Report)
February 3, 1992... AUTHORS: F.J. Meyers, R.W. deVere White and P.H. Gumerlock. University of California at Sacramento. According to the authors' abstract of a poster presentation to the 37th annual meeting of the Western Association of Physicians, to be...

Psychosocial adjustment in long-term survivors of childhood medulloblastoma and ependymoma treated with craniospinal irradiation. (Research Report)
February 3, 1992... Androgen Receptor Analysis in Prostate Cancer AUTHORS: E. Seaver, R. Geyer, S. Sulzbacher, M. Warner, L. Batzel, J. Milstein and M. Berger. University of Washington at Seattle. According to the authors' abstract of a poster...

Ventilatory support of pediatric bone marrow transplant patients. (Research Report)
February 3, 1992... AUTHORS: Karen Todd, Frances Wiley, Elliot Landaw, James Gajewski and Stephen Feig. University of California at Los Angeles. According to the authors' abstract of a poster presentation to the 37th annual meeting of the Western...

Hepatitis C virus infection as a risk factor for hepatocellular carcinoma in patients with cirrhosis. (Periodical Report)
February 3, 1992... SOURCE: Annals of Internal Medicine, January 15, 1992;116(2):97-102. An Italian report concludes that hepatitis C virus infection is a more important risk factor for hepatocellular carcinoma than hepatitis B virus infection. ...

A study of fadrozole, a new aromatase inhibitor, in postmenopausal women with advanced metastatic breast cancer. (Periodical Report)
February 3, 1992... SOURCE: Journal of Clinical Oncology, January, 1992;10(1):111-116. Fadrozole, a nonsteroidal imidazol derivative, was effective as a second-line treatment in postmenopausal women with metastatic breast cancer in a study conducted by...

A randomized trial of two dosage schedules of mitomycin C in advanced breast carcinoma. (Periodical Report)
February 3, 1992... SOURCE: Cancer, January 15, 1992;69(2):476-481. Metastatic breast cancer patients treated with low -dose mitomycin C had a similar treatment outcome with less toxicity than patients treated with a high-dose regimen in a M.D. Anderson...

Inhibition of colon and breast carcinoma cell growth by interleukin-4. (Periodical Report)
February 3, 1992... SOURCE: Cancer Research, January 15, 1992;52:275-279. A study from England's University of Oxford found that interleukin-4 (IL-4) showed "substantial inhibition" of breast and colon carcinoma cells in vitro. IL-4, a 20-kDa...

Chemotherapy for nonmetastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience. (Periodical Report)
February 3, 1992... SOURCE: Journal of Clinical Oncology, January, 1992;10(1):5-15. Intensive chemotherapy can improve disease-free survival in surgically treated patients with osteogenic sarcoma, but more reliable methods of identifying patients who would...

Comparison of outcome between clinically staged, unresected superior sulcus tumors and other stage III non-small cell lung carcinomas treated with radiation therapy alone. (Periodical Report)
February 3, 1992... SOURCE: Cancer, January 15, 1992;69(2):363-369. A Fox Chase Cancer Center report concludes that lung cancer patients with superior sulcus tumors do not have a more favorable prognosis than those with other stage III non-small cell lung...

Breast Cancer Coalition learning from AIDS movement. (Dr. Susan Love urges more government spending on breast cancer research) (Washington, D.C.)
February 10, 1992... Washington, D.C. Leaders of the Breast Cancer Coalition said February 5, 1992, that they are following the example of the AIDS community by taking political action to demand more government research into a killing disease. "Women...

Large genome comparison reveals details of genomic evolution. (California Institute of Technology)
February 10, 1992... California Institute of Technology The most extensive sequence comparison ever made between the genomes of different species has revealed that genetic evolution proceeds at distinctly different rates and by distinctly different...

Panel withholds recommendation to approve Ethyol. (amifostine, WR-2721) (U.S. Food and Drug Administration's Oncologic Drugs Advisory Committee)
February 10, 1992... U.S. FDA U.S. Bioscience Inc., a pharmaceutical company specializing in the development and commercialization of anticancer compounds, said that the U.S. Food and Drug Administration's (FDA) Oncologic Drugs Advisory Committee withheld a...

Co-expression of vimentin and keratins predict melanoma metastasis. (University of Arizona)
February 10, 1992... University of Arizona Co-expression of the protein marker vimentin and the keratins K8 and K18 appear to predict metastasis in patients with melanoma, according to a report from the University of Arizona College of Medicine, Tuson,...

Researchers look for genetic links to breast cancer. (University of California)
February 10, 1992... California University of California, Berkley, California researchers are using genetic mapping techniques to identify a gene they believe is responsible for certain hereditary breast cancers, in an effort to facilitate earlier detection...

Consensus development conference on skin cancer held. (U.S. National Institutes of Health)
February 10, 1992... U.S. NIH Dr. Frank Meyskens Jr., director of the University of California/Irvine (UCI) Clinical Cancer Center and a leading skin cancer authority, participated in panel discussions on early skin cancer with Dr. DuPont Guerry of the...

Scientists "see" molecules of heredity. (adenine & thymine) (Lawrence Livermore National Laboratory)
February 10, 1992... Lawrence Livermore National Laboratory Scientists are moving closer to the ability to visualize the individual molecules whose patterns determine human heredity. Using a special kind of microscope known as a scanning tunneling...

Hodgkin's disease study marks new approach to drug economics. (Duke University)
February 10, 1992... Duke University A new study of the benefits of an infection-fighting hormone in cancer patients represents the first example of a more rigorous approach to cost-benefit analysis of new drugs, say the scientists who conducted it. ...

Center to conduct Phase II study of liposome encapsulated doxorubicin in breast cancer. (Roswell Park Cancer Institute)
February 10, 1992... Roswell Park Cancer Institute Roswell Park Cancer Institute, Buffalo, New York, announced that patient accruals began in January 1992 for a Phase II clinical trial of liposome-encapsulated doxorubicin (TLC D-99, Liposome Company Inc.,...

Doctor invents device that helps detect breast cancer in women with breast implants. (Dr. Marion Jabczenski) (Breast Evaluation Center, Phoenix, Arizona)
February 10, 1992... Arizona Dr. Marion Jabczenski, of the Breast Evaluation Center in Phoenix, Arizona, recently announced the invention of a compression device that helps to detect breast cancer in women who have breast implants by improving the...

Companies to co-develop third generation bisphosphonate. (Rhone-Poulenc Rorer Inc., Boehringer Mannheim GmbH and Boehringer Mannheim Pharmaceuticals Corp.) (Germany)
February 10, 1992... Germany Rhone-Poulenc Rorer Inc. (RPR), Collegeville, Pennsylvania, Boehringer Mannheim GmbH and Boehringer Mannheim Pharmaceuticals Corporation, Mannheim, Germany, have announced that they will co-develop and co-market Boehringer...

New cancer trials will study impact of human stem cells. (purified bone marrow therapy) (Baxter International Inc.)
February 10, 1992... Baxter International Inc. Baxter announced that it will begin clinical trials of a promising new bone marrow therapy in the spring of 1992, at Johns Hopkins Oncology Center, Baltimore, Maryland. The therapy may allow for more aggressive...

Company announces collaborative arrangement to apply SCA technology to cancer treatment. (Single-Chain Antigen-Binding technology) (Enzon Inc.)
February 10, 1992... Enzon Inc. Enzon Inc., South Plainfield, New Jersey, announced that it has signed a letter of intent with Neoprobe Corporation for an exclusive licensing arrangement involving the use of Enzon's Single-Chain Antigen-Binding (SCA)...

Researchers hope to begin testing on new cancer compound. (GL331) (University of North Carolina)
February 10, 1992... University of North Carolina A California firm hopes to begin human testing in 1992 on a new compound that has impressed cancer researchers with its ability to fight the disease. Genelabs Technologies Inc., of Redwood City,...

Zofran offers cancer patients improved quality of life during chemotherapy. (ondansetron HCl) (Glaxo Inc.)
February 10, 1992... Glaxo Inc. Zofran (ondansetron HCl), a drug for preventing the nausea and vomiting associated with cancer chemotherapy, is improving many patients' ability to tolerate their treatment and get on with their lives, according to Judith...

Genetic "switch" may one day help turn off oncogene. (myc oncogene research by Jas Lang) (Ohio State University)
February 10, 1992... Ohio State University Understanding how the myc oncogene is turned on and off may someday provide a means of controlling deadly malignancies, said Jas Lang, a research scientist with Ohio State University's Arthur G. James Cancer...

Immunotoxin cytotoxicity, internalization, intracellular routing, and degradation in malignant T lymphocytes. (Research Report)
February 10, 1992... AUTHORS: W.J. Trautman and O.W. Press. University of Washington Medical Center at Seattle. According to the authors' abstract of a presentation to the 37th annual meeting of the Western Association of Physicians, held February 5-6,...

Germ-line and somatic p53 mutations in multifocal osteogenic sarcoma. (Research Report)
February 10, 1992... AUTHORS: A. Iavarone, K.K. Matthay, T.M. Steinkirchner and M.A. Israel. University of California at San Francisco. According to the authors' abstract of a presentation to the 37th annual meeting of the Western Association of Physicians,...

Hypermethylation of the human parathyroid hormone-related protein gene role in lymphocyte neoplasia. (Research Report)
February 10, 1992... AUTHORS: E. Ejima, S. Gebremedhim and D. Prager. UCLA School of Medicine, Los Angeles, California. According to the authors' abstract of a presentation to the 37th annual meeting of the Western Association of Physicians, held February...

Comparison of tumor uptake and nuclear medicine images of gallium-67, thallium-201, and (cobalt-57)-vitamin B-12 in sarcoma-bearing mice. (Research Report)
February 10, 1992... AUTHORS: Herbert H. Warnock, Douglas A. Collins and Kathryn A. Morton. University of Utah Medical School at Salt Lake City. According to the authors' abstract of a presentation to the 37th annual meeting of the Western Association of...

Detection of cytokine mRNA in retinoblastoma using in situ hybridization. (Research Report)
February 10, 1992... AUTHORS: Robert T. Lin, Shawny Kaleta-Michaels and Devron H. Char. University of California at San Francisco. According to the authors' abstract of a presentation to the 37th annual meeting of the Western Association of Physicians, held...

Collagenase expression in normal prostate, PIN, and invasive prostatic carcinoma. (Research Report)
February 10, 1992... AUTHORS: D. Friedman, J.D. Knox, M. Siadat-Pajouh, J. Kittelson and M. Navre. University of Arizona at Tucson. According to the authors' abstract of a presentation to the 37th annual meeting of the Western Association of Physicians,...

Pulse-chase studies of gastrin releasing peptide receptor. (Research Report)
February 10, 1992... AUTHORS: V.L. denBoer and M.A. Kane. Denver, Colorado. According to the authors' abstract of a presentation to the 37th annual meeting of the Western Association of Physicians, held February 5-6, 1992, in Carmel, California, "Gastrin...

Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer. (Periodical Report)
February 10, 1992... SOURCE: The Lancet, January 18, 1992;339:139-143. Researchers at a French laboratory suggest that loss of heterozygosity on chromosome 7q31 might identify patients with breast cancer who are at risk of relapse. Molecular analysis...

Nicotine and cotinine in the cervical mucus of smokers, passive smokers, and nonsmokers. (Periodical Report)
February 10, 1992... SOURCE: Cancer Epidemiology, Biomarkers and Prevention, January/February, 1992;1:125-129. Tobacco constituents, such as nicotine and cotinine, were found in the uterine cervix of more than 80 percent of smokers involved in a University...

Enhancement of alkylating agent activity by SR-4233 in fibrosarcoma. (3-amino-1,2,4-benzotriazine-1,4-dioxide) (Periodical Report)
February 10, 1992... SOURCE: Journal of the National Cancer Institute, February 5, 1992;84(3):187-193. The cytotoxic agent SR-4233 may improve the clinical efficacy of widely used antitumor alkylating agents, according to a Dana-Farber Cancer Institute...

ICRF-187 permits longer treatment with doxorubicin in women with breast cancer. (ADR-529, a bisdioxpiperazine compound) (Periodical Report)
February 10, 1992... SOURCE: Journal of Clinical Oncology, January, 1992;10(1):117-127. The bisdioxpiperazine compound ICRF-187, when given with doxorubicin, permits significantly greater doses of the antineoplastic agent with less cardiotoxicity, according...

Does endoscopic follow-up improve the outcome of patients with benign gastric ulcers and gastric cancer? (Periodical Report)
February 10, 1992... SOURCE: Cancer, January 1, 1992;69(2):301-305. Endoscopic surveillance may detect resectable cancer in selected patients with gastric ulcers, but it is unclear whether this follow-up strategy improves survival, according to a report from...

Leukoregulin and gamma-interferon inhibit human papillomavirus type 16 gene transcription in human papillomavirus-immortalized human cervical cells. (Periodical Report)
February 10, 1992... SOURCE: Cancer Research, January 15, 1992;52:456-463. Leukoregulin (LR) and recombinant gamma-interferon (r-IFN-gamma) appear to selectively inhibit transcription of human papillomavirus-transforming genes and suggest a molecular...

Illinois scientist says cancer establishment continues to mislead public. (Dr. Samuel Epstein of the University of Illinois School of Public Health) (includes Dr. Epstein's views, American College of Radiology views, and U.S. National Cancer Institute views)
February 17, 1992... U.S. NCI At a news conference a group of 60-plus scientists and physicians released a statement condemning the U.S. National Cancer Institute (NCI) for ignoring or trivializing evidence of how carcinogens in air, food, water and...

Low but chronic exposure to antineoplastic agents alters gene expression in nurse study. (Brazil)
February 17, 1992... Brazil Chronic exposure to even small amounts of antineoplastic agents altered genetic material in a group of Brazilian nurses, adding to the growing evidence that workers in the cancer field are at increased risk of cancer. The...

Colorectal cancer related to gallstones, not to cholecystectomy. (Denmark)
February 17, 1992... Denmark People with gallstones are more likely to develop colorectal cancer than the those with normal gallbladder, according to a report in the January 1992 issue of Diseases of the Colon and Rectum, a publication of the American...

Telephone follow-up improves adherence to colposcopy among lower income women. (Fox Chase Cancer Center)
February 17, 1992... Fox Chase Cancer Center Brief, structured telephone counseling appears to be a cost-effective way to promote diagnostic follow-up and treatment for a variety of cancer screening tests among lower income and minority women, according to a...

Certain types of benign breast disease increase women's cancer risk. (proliferative benign breast disease) (American Medical Association)
February 17, 1992... American Medical Association A certain type of benign breast disease has been found to increase breast cancer risk in premenopausal women, notes a study in the February 19, 1992, issue of the Journal of the American Medical Association....

Marked regional differences found in breast cancer treatment. (American Cancer Society)
February 17, 1992... American Cancer Society Women with breast cancer are treated differently depending on the part of the country they live in, according to a recent analysis of data from the National Cancer Data Base (NCDB) of 41,680 women with breast...

Mammogram machines used to test thousands failed state test. (Michigan)
February 17, 1992... Michigan Michigan health officials urged thousands of women who received mammograms on machines that failed a new state test to check with their doctors. The bulk of machines that did not meet state standards late, in 1991, for...

Hundreds of cancer patients got incorrect treatment. (radiotherapy undertreatment, due to computer error) (England)
February 17, 1992... England Doctors in Staffordshire in northern England said that they have written to hundreds of cancer patients telling them they were incorrectly treated. A computer mistake that went unnoticed for 10 years meant patients...

Industry is developing 263 medicines for use in women. (Pharmaceutical Manufacturers Association)
February 17, 1992... Pharmaceutical Manufacturers Association A new survey has found that 263 medicines are in human clinical trials or awaiting approval at the U.S. Food and Drug Administration (FDA) for diseases that exclusively or disproportionately affect...

Association between childhood rhabdomyosarcoma and maternal stillbirths reported. (Yale University)
February 17, 1992... Yale University The mothers of children with rhabdomyosarcoma (RMS) have a significantly higher number of stillbirths than the general population, but it is not known whether this association is genetic or involves in utero exposure to...

Prostate cancer patients have less pain with new agent. (rhenium 186 etidronate) (Vanderbilt University Medical Center)
February 17, 1992... Vanderbilt University Medical Center The first results of a clinic trial at Vanderbilt University Medical Center (VUMC) of an experimental radiotherapeutic agent have shown great promise for improved treatment of cancers which have...

Maryland tops nation in cancer deaths, says cancer society. (American Cancer Society)
February 17, 1992... American Cancer Society The American Cancer Society is predicting that Maryland will have the highest cancer death rate of any state in the nation in 1992. There will be 192 deaths from cancer per 100,000 population in Maryland,...

Smoker with cancer loses first European suit against tobacco firms. (Finland)
February 17, 1992... Finland A Helsinki, Finland, court has rejected the first European case against tobacco producers, who were sued by a man suffering from cancer after smoking for 45 years, news reports said. Court officials said that the man was...

Cigarette companies agree to put labels on all packs. (R.J. Reynolds/Philip Morris)
February 17, 1992... R.J. Reynolds / Philip Morris Tobacco giants Philip Morris and R.J. Reynolds Tobacco will start putting warning labels on all their cigarette packages, amid mounting criticism over sales of unlabeled smokes in some developing countries....

Judge: tobacco industry may be king of disinformation. (U.S. District Judge H. Lee Sarokin) (New Jersey)
February 17, 1992... New Jersey Confidential tobacco industry documents provide "damaging evidence" that cigarette makers intentionally have lied about the dangers of smoking for decades, a U.S. federal judge has ruled. U.S. District Judge H. Lee...

Cigarette vending machines banned in most public places. (New York)
February 17, 1992... New York A New York law aimed at keeping cigarettes out of the reach of children has gone into effect, resulting in a ban on cigarette vending machines in all public places except bars. "Here is a very concrete, real step to keep a...

Researcher: ceramic implant holds promise for drug delivery. (calcium-phosphorous capsules developed by Praphulla Bajpai) (Ohio)
February 17, 1992... Ohio Ceramic capsules implanted in the body soon could end daily pill-taking and offer hope for those who suffer side effects from medications, a university researcher said. Praphulla Bajpai, a University of Dayton (Ohio) professor...

Cancer drug, insecticide found in common tree. (paw paw) (Indiana)
February 17, 1992... Indiana A Purdue University researcher is reporting that a simple, inexpensive new test has led to the isolation of a powerful anticancer drug and a safe, natural pesticide from the paw paw tree, sometimes called the "Indiana banana."...

Filing of Investigational New Drug application announced. (for AMI-227, a magnetic resonance imaging contrast agent) (Advanced Magnetics )
February 17, 1992... Advanced Magnetics Advanced Magnetics Inc. announced that its licensee, Squibb Diagnostics, a division of Bristol-Myers Squibb, has filed an Investigational New Drug Application (IND) with the U.S. Food and Drug Administration (FDA). ...

Company receives license to chemoprotective drug. (drug reduces hematologic toxicity of chemotherapeutic agents) (Baker Cummins Phamraceuticals)
February 17, 1992... Baker Cummins Pharmaceuticals IVAX Corporation announced that its wholly owned subsidiary, Baker Cummins Pharmaceuticals Inc., received an exclusive worldwide license to a proprietary new drug for use in reducing toxicities associated...

Estrogen and growth factors regulation of c-myc and c-fos expression in human ovarian cancer. (Research Report)
February 17, 1992... AUTHORS: C. Chien and F. Chen. National Yang Ming Medical Center, Taipei, Taiwan. According to the authors' abstract of a poster presentation to the 8th International Congress of Human Genetics, held in Washington, D.C., "Two ovarian...

Suppression of tumorigenicity of the p53 gene in human hepatocellular carcinoma cells. (Research Report)
February 17, 1992... AUTHORS: Y.L. Hou, J.Y. Shew and C.W. Wu. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. According to the authors' abstract of a poster presentation to the 8th International Congress of Human Genetics, held in...

Mutant p53 from human tumors is transcriptionally inactive. (Research Report)
February 17, 1992... AUTHORS: G. Lozano, L. Raycroft and J. Hansen. University of Texas M.D. Anderson Cancer Center, Houston, Texas. According to the authors' abstract of a poster presentation to the 8th International Congress of Human Genetics, held in...

Characterization of Alu RNA transcripts in human embryonal carcinoma cell. (Research Report)
February 17, 1992... AUTHORS: D. Sinnett, C. Richter and D. Labuda. University of Montreal, Montreal, Quebec, Canada. According to the authors' abstract of a poster presentation to the 8th International Congress of Human Genetics, held in Washington, D.C.,...

Loss of heterozygosity on 17p and p53 overexpression in Barrett's adenocarcinoma. (Research Report)
February 17, 1992... AUTHORS: P. Bount, S. Ramei, W. Raskind, C. Sanchez, R. Haggitt, P. Dean, P. Rabinovitch and B. Reid. University of Washington at Seattle and Ersta Hospital, Stockholm, Sweden. According to the authors' abstract of a poster presentation...

Evidence for activation of erb-B2 directly causes malignancy in oncogenesis of primary ovarian cancer. (Research Report)
February 17, 1992... AUTHORS: S.I. Chang and D.K. Kim. Keimyung University School of Medicine, Taegu, Korea. According to the authors' abstract of a poster presentation to the 8th International Congress of Human Genetics, held in Washington, D.C.,...