Cancer Weekly articles from December 2002

Cancer Weekly archives from December 2002

Geographic region of residence more than race affects rates.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Racial and regional disparities in cancer screening rates are narrowing but persist. Findings in a study published in the journal Cancer indicate that racial and regional differences were less apparent...

New evidence disfavors tamoxifen for primary liver cancer.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Members of a research team headed by doctors at the National Cancer Center in Singapore have concluded tamoxifen is not useful for treating hepatocellular...

New technique lets doctors examine milk ducts for breast problems.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- A new technique enables doctors to directly examine the lining of milk ducts in the breast for early signs of cancer and other abnormalities, according to research at Washington University School of...

Team pioneers tests of new drug with 'red wine compound.'.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- The University of Leicester has been selected as one of the first centers in the world to trial a revolutionary new cancer prevention drug, based on a natural compound found in red wine. This will form...

Herpes amplicon vectors used to develop vaccines against metastatic liver cancer.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Vaccines consisting of irradiated colon cancer cells that released granulocyte-macrophage colony-stimulating factor (GM-CSF), or GM-CSF along with the...

Interesting lead found in treatment.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Research scientists at INSERM, CNRS and the Institut Curie, in collaboration with physicians, have used a mouse model to demonstrate the efficacy of an innovative therapeutic approach to Ewing sarcoma:...

Smoking encourages neovascularization of bronchial mucosa.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Scientists have learned that smoking increases cellular proliferation and neovascularization in the bronchial mucosa of the lungs. These changes may be...

Can cured cancer patients expect to live as long as the general population?
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- The outcome for some cancer patients can now be predicted much earlier by making the right choice of treatment based on a mathematical model rather than the current life-table method, which has been in...

Sulfonamide derivative counters angiogenesis with integrin blockade.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - A new sulfonamide derivative, E7820, can inhibit neovascular signaling by blocking endothelial adhesion molecules, scientists at Tsukuba Research Laboratories...

High rates concern California county.(Marin County has high rate of breast cancer)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Women living in wealthy Marin County, set in the wooded hills just north of San Francisco, suffer one of the nation's highest breast cancer rates, a cluster that has confounded health officials. On...

Suros Surgical Systems offers new petite needle.(Brief Article)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Suros Surgical Systems, Inc., has added a new 9-gauge petite needle to its ATEC advanced breast biopsy and excision system product line, making outpatient vacuum-assisted biopsies a reality for...

Tamoxifen boosts antiangiogenic therapy in murine model.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Synergistic activity of an antiestrogen drug combined with an angiogenesis inhibitor reduced tumor growth in a study of human breast cancer conducted in mice. The researchers who conducted the work...

Antisense treatment suppresses growth of human tumor xenografts in mice.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Study results suggest that colony-stimulating factor-1 blockade could be a new approach to treatment of solid tumors. According to a researchers in Austria, "Matrix metalloproteinases (MMPs) foster...

Experimental vaccine induces protection against some glioblastoma cells.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Wistar Institute researchers have shown that "[i]noculation of mice with a recombinant vaccinia virus expressing the full-length mouse wild-type p53 protein (Vp53-wt)...[induces] partial protection...

GenoMed initiates colon cancer gene discovery effort.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- GenoMed, Inc., (GMED), a St. Louis, Missouri-based medical genomics biotechnology company, is going after colon cancer. GenoMed will begin work immediately to identify genes associated with colon...

Company wins patent to protect lead compound, NC381.(NuChem Pharmaceuticals Inc.)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Lorus Therapeutics, Inc., announced that its subsidiary, NuChem Pharmaceuticals Inc., has received notice from the United States Patent and Trademark Office of the allowance of a patent that protects...

PRIMABioMed announces success of phase I trial for dendritic cell based therapy.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- PRIMABioMed, Ltd., the cancer and immunotherapy research and therapeutic development company, announced successful progress in the development of its Cancer Vac subsidiary's dendritic cell based therapy...

Study: Tumor regression occurs after injection of DNA complex.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- In a scientific article published this month, a group of research scientists with Genzyme Molecular Oncology (GZMO) report that immune-stimulating complexes made up of lipid and plasmid DNA produced...

Dendritic-cell based immunotherapy may have potential against brain tumors.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Neurologists in Japan report enhancement of antitumor immune responses in murine models of brain tumors by genetically modified dendritic cells producing Semliki Forest virus-mediated interleukin-12....

Angiopoietin 1 promotes tumor angiogenesis, tumor vessel plasticity in mice.(Brief Article)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Using a murine model of cervical cancer, researchers in Singapore have shown that increased expression of angiopoietin 1 boosts tumor angiogenesis and leads to tumor vessel plasticity. ...

New data confirm the impact of once-per-cycle pegfilgrastim for neutropenia.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Data presented for the first time in Europe, at the 27th European Society of Medical Oncology (ESMO) Congress confirm that Neulasta (pegfilgrastim) has the potential to improve the management of...

Medix Biochemica licenses CEA antibody technology.(carcinoembryonic antigen )(Brief Article)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Immunomedics, Inc., (IMMU) announced that Medix Biochemica of Kauniainen, Finland, entered into a nonexclusive license agreement under Immunomedics' portfolio of carcinoembryonic antigen (CEA) patents....

New method allows mass production of dendritic cells.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Large-scale production of dendritic cells is possible through the use of a cell selector followed by culture in a sterile-bag system, according to...

Incara closes sale of liver cell program.(Brief Article)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Incara Pharmaceuticals Corp. (INCR) announced that its wholly owned subsidiary, Incara Cell Technologies, Inc., has completed the sale of substantially all of the assets and certain related liabilities...

Antiangiogenic protein is tumor marker in hepatocellular carcinoma.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - A Japanese study of protein markers in cancer patients suggests serum endostatin can predict tumor vascularity in hepatocellular carcinoma (HCC), a primary form...

Pharmion completes $40 million private placement.(Brief Article)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Pharmion Corp. announced that it completed a $40 million private equity placement from a syndicate of new and existing investors. Investors in this round include New Enterprise Associates; General...

Interleukin-6 enhances human herpesvirus-8 activity.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - The cytokine interleukin (IL)-6 may play a key role in the development of several AIDS-related malignancies, researchers in Japan say. "Human herpesvirus-8...

Hospice may not be right for all patients.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- by Lynn Yoffee, senior medical writer - In an effort to improve quality of care for patients at the end of life, researchers have attempted to characterize and compare two different types of patients...

Two phase II trials to evaluate efficacy of HDAC inhibitor SAHA.(histone deacetylase)(Brief Article)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Aton Pharma, Inc., announced that it has initiated a single-agent phase II clinical study of its lead product candidate, SAHA, in cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma (PTCL)....

European Union's CPMP recommends approval of Caelyx.(Committee for Proprietary Medicinal Products)(Brief Article)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Schering-Plough Corp. (SGP) reported that the European Union's (E.U.) Committee for Proprietary Medicinal Products (CPMP) of the European Agency for the Evaluation of Medicinal Products (EMEA) has...

Paclitaxel-based chemotherapy increases survival by 31%.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- New data adds to existing evidence that Taxol offers women with metastatic breast cancer (MBC) a 31% improvement in overall survival compared with standard treatment. The data collected from 640...

Phase II trial of Navelbine plus Herceptin for HER2 looks promising.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- New research suggests that the combination of Navelbine (vinorelbine tartrate) Injection, a first-line chemotherapy treatment for advanced non-small cell lung cancer, and the monoclonal antibody therapy...

FDG PET reassures and reveals high risk.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Whole-body FDG PET scans were able to identify previously undetected disease and also confirm that precancerous conditions had not become active disease for 66 patients with multiple myeloma and related...

Modifying doxorubicin delivery extends its utility in cancer patients.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - A modified form of doxorubicin appears to increase its duration of efficacy in multiple myeloma patients, according to researchers at the Cleveland Clinic...

Stem cell transplants safe, effective as partially outpatient procedure.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Liberal hospitalization policies can safely lower the cost of hematopoietic stem cell transplants for myeloma patients, researchers in Italy argue. "A...

Gene therapy partially prevents cisplatin-induced condition.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Neurotrophin-3 may help prevent neuropathy frequently associated with cisplatin therapy. Now scientists have found they can use gene therapy - with or without viral vectors - to induce continuous...

Smoking cessation education for physicians needs an overhaul.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- by Lynn Yoffee, senior medical writer - Smoking cessation education for physicians in training needs to be revamped. A new study suggests that patient outcomes would improve if smoking cessation is...

Chemotherapy well tolerated after yttrium-90 ibritumomab tiuxetan treatment.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Mayo Clinic hematologists report that in patients with relapsed B-cell non-Hodgkin lymphoma, chemotherapy or autologous stem cell transplantation after yttrium-90 ibritumomab tiuxetan treatment is...

Overexpression of p27(Kip1) induces growth arrest, apoptosis in cell line.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Researchers in Japan report that up-regulation of a cyclin-dependent kinase inhibitor inhibits growth of an oral cancer cell line. "p27(Kip1) is a cyclin-dependent kinase inhibitor which regulates...

Antitumor effects induced by dendritic cell-based immunotherapy in animal model.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Researchers in Japan report positive results in their study of dendritic cell-based immunotherapy of pancreatic cancer in a hamster model. "Because the prognosis of patients with pancreatic cancer...

NCI awards grant to develop diagnostic test for pancreatic cancer.(to Panacea Pharmaceuticals, Inc.)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Panacea Pharmaceuticals, Inc., announced that it has been awarded a phase I Small Business Innovation Research (SBIR) grant from the National Cancer Institute (NCI) of the National Institutes of Health...

Finding points to new drug target.(prostate cancer)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Doctors have long known that the medications they use to treat prostate cancer effectively for 1-2 years inevitably fail, leaving patients with few treatment options as the disease progresses, killing...

Flaxseed-rich diet blocks disease growth in mice.(prostate cancer)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- A diet rich in flaxseed seems to reduce the size, aggressiveness and severity of tumors in mice that have been genetically engineered to develop prostate cancer, according to new research from Duke...

Protein patterns in blood may predict prostate cancer diagnosis.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Patterns of proteins found in patients' blood serum may help distinguish between prostate cancer and benign conditions, scientists from the National Cancer Institute (NCI) and the Food and Drug...

RITA addresses impact of temporary infusion pump supply issue.(RITA Medical Systems, Inc.)(Brief Article)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- RITA Medical Systems, Inc., (RITA) announced that it was experiencing a supply disruption with an accessory infusion pump used with its StarBurst XLi disposable devices. As a result, system sales...

Pharmacia teams with American Cancer Society to help smokers quit.(Brief Article)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Pharmacia Corp. and the American Cancer Society have announced a collaboration designed to focus on smoking cessation support strategies. Pharmacia Oncology and the American Cancer Society began...

Physicians should add national tobacco control guidelines to repertoire.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- by Lynn Yoffee, senior medical writer - The majority of patients (88%) questioned in a recent survey about smoking cessation reported that they had received no physician assistance in their quitting...

Stem cell grafts best choice for de novo erythroleukemia treatment.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Hematopoietic stem cell transplantation (HSCT) is the best treatment option for patients suffering from de novo erythroleukemia (EL), researchers in Europe say....

Company appeals delisting notification from NASDAQ.(Vion Pharmaceuticals, Inc.)(Brief Article)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Vion Pharmaceuticals, Inc., (VION) announced that it will appeal Nasdaq's determination to delist Vion's common stock from the NASDAQ National Market by requesting a hearing before a NASDAQ Listing...

NASDAQ approves Satraplatin developer's listing on Small-Cap Market.(Brief Article)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- NeoTherapeutics, Inc., (NEOT) announced that the company has met all requirements for listing on the NASDAQ Small-Cap Market and that NASDAQ has approved the company's Small-Cap Market application. ...

No general association to cancer risk found.(psychological stress)
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- Extreme psychological stressors, such as the death of a child, are not generally associated risk factors for the development of cancer. Findings in a study published in the journal Cancer indicate...

Combretastatin A-4-P shuts down life support in malignant tumors.
December 3, 2002... 2002 DEC 3 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - The antivascular properties of combretastatin A-4 3-O-phosphate (CA-4-P) make it particularly suited for tumor therapy, according to researchers in England. ...

Modified tetracycline may help prevent cancer recurrence.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- Building on previous research, University of Iowa scientists have discovered that a drug already being tested as an anticancer agent could potentially be used in conjunction with other cancer therapies...

Oral tyrosine kinase inhibitor PKI166 limits kidney cancer angiogenesis.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Researchers in Houston, Texas, say a new epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor can block angiogenesis in human renal cell carcinoma...

Mutated plasminogen precursor manufactures angiostatin.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Scientists in Spain have developed a method for generating angiostatin from furin-mutated plasminogen. Studies have shown angiostatin has significant...

Molecular tag pinpoints which tumors are most likely to spread.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- A new molecular tag discovered by scientists at the University of Texas M.D. Anderson Cancer Center may help doctors decide which breast cancer patients need more aggressive treatment and which can...

Tumor vaccine raises antigen-specific response in gastric cancer patients.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Medical collaborators in Japan and Sweden have completed a phase I trial of peptide-pulsed dendritic cells in gastric cancer patients. Scientists have...

Cyclophilin B peptide fails in phase 1 lung cancer trial.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Phase 1 clinical trial results revealed that a cyclophilin B peptide vaccine was safe when given to lung cancer patients, but did not elicit a...

American Cancer Society issues new early detection guidelines.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- The American Cancer Society has issued new guidelines addressing when and how often women should get early detection tests for cervical cancer and precancer. The new guidelines were developed by an...

UT Southwestern researcher wins AstraZeneca Excellence in Chemistry Award.(University of Texas, Dr. Patrick Harran)
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- Other researchers have called his discovery good detective work. Dr. Patrick Harran calls it good chemistry, and it's helped him win national acclaim. Harran, associate professor of biochemistry...

SpectRx completes milestone clinical study of new noninvasive cervical cancer device.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- SpectRx, Inc., (SPRX) announced that it has completed the multicenter, prepivotal clinical trial of its noninvasive cervical cancer detection device, and the company is making final preparations to...

New method could overcome drug resistance in cancer, infectious diseases.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- Immunomedics, Inc., (IMMU) announced the issuance of United States Patent No. 6,468,530, which covers a method of treatment that uses conjugated polyspecific antibodies, or antibodies that bind to more...

New way to stop cancer cell growth described.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- A new study from the University of Illinois at Chicago (UIC) College of Pharmacy may lead to the development of a drug to stop the growth of cancer cells. Dr. Lucio Miele, associate professor of...

Activation of tumor-reactive CTL by weak agonists could be new design approach.(cytotoxic T lymphocytes)
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- University of Texas, M.D. Anderson Cancer Center researchers have been working on a new angle in designing cancer vaccines. A. Castilleja and colleagues explained: "To design side chain variants...

DNA fusion vaccine components induce protective CTL against a single epitope.(cytotoxic T lymphocytes)
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- DNA fusion vaccine components were able to induce protective cytotoxic T cells against a single epitope of a tumor antigen, according to a recent study. "DNA vaccines can activate immunity against...

Leukapheresis products are potential sources of quantities of dendritic cells.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- Researchers in Australia have suggested what may be a practical way to obtain cells for studies of dendritic cell-based vaccines. F.J. Radcliff and colleagues, Royal Children's Hospital, described...

First results from novel antiangiogenic drug trial in patients.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- A new drug that targets tumor blood vessels has produced a surprisingly effective response in its first patient study - shrinking the tumors in a number of patients treated so far, according to...

Scientists describe new genetic option for thwarting cancer.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- From ultraviolet radiation to food carcinogens, our bodies are bombarded with stuff that can make a normal cell go haywire, multiplying out of control and turning cancerous. Thanks to a set of tumor...

Preclinical studies identify novel ways to enhance effect.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- Researchers have found that blocking the action of a growth factor on tumor stroma cells increases the uptake of cancer drugs by the tumor. The findings could be crucial for efforts to make standard...

Link to human cytomegalovirus seen.(Brief Article)
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- Preliminary research findings suggest that a common human virus may play a part in the cellular processes involved in the development of colorectal cancer. Colorectal cancer is the second most...

Who gets cancer treatment, and who completes it?(Brief Article)
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- Cancer treatment is now very effective in many cases, yet not all patients with cancer are referred and not all complete their treatment program. This has puzzled cancer specialists who have...

Gene transfer sensitizes liver cancer cells to chemotherapy.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Anti-multidrug resistance ribozymes driven by alpha-fetoprotein (AFP) promoters can steer chemosensitivity in hepatocellular carcinomas. It is not...

Encouraging results reported on Trisenox in myelodysplasia, CML.(chronic myeloid leukemia)
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- In a satellite symposium in conjunction with the Chinese Society of Hematology 2002 Conference, researchers presented data from clinical trials indicating that arsenic trioxide may be effective in...

Postsurgical hepatitis linked to shortened survival.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Postoperative hepatitis increases the risk for poor outcomes in patients who undergo surgery for hepatitis C virus (HCV)-related liver cancer. Patients...

Halfway mark reached in enrollment for pivotal phase III ETHECC trial.(Efficacy of Thymitaq in Hepatocellular Carcinoma)
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- Eximias Pharmaceutical Corporation announced that 223 patients have been enrolled into its ETHECC (Efficacy of Thymitaq in Hepatocellular Carcinoma) trial, achieving 50% recruitment. The ETHECC...

Cell fusion vaccine approach being tested.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- Genzyme Molecular Oncology (GZMO) launched a new clinical trial in kidney cancer that uses an innovative vaccine made from combining the patient's own cancer cells with powerful, immune-stimulating...

Bcl-2 and Bax protein expression in lymphocytic cells aren't interindependent.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- "Our previous work demonstrated that antisense oligonucleotides complementary to Bcl-2 mRNA sequences were able to reduce Bcl-2 protein expression in B-cell chronic lymphocytic leukemia (B-CLL) cells,"...

Study of Navelbine plus gemcitabine suggests similar efficacy to standard therapy.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- Results of a randomized clinical study suggest that the combination of Navelbine (vinorelbine tartrate) injection and gemcitabine offers a comparably effective and well tolerated treatment alternative...

Interleukin-12 an unexpected suppressor in dendritic cell vaccine.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Data from a dendritic cell vaccine study have yielded some unexpected results, scientists report. Interleukin (IL)-12 diminishes rather than enhances the...

T-cell clones shrink tumors.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- A preliminary clinical trial suggests that armies of T cells generated in the lab can be injected into patients to halt the spread of cancerous tumors. The study, conducted by Dr. Cassian Yee, a...

Therapeutic polyvalent vaccine prolongs overall survival.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- Canvaxin, a therapeutic polyvalent vaccine (PV), has been shown to significantly improve overall survival of patients with metastatic melanoma. The aim of D.L. Morton and colleagues, St. John's...

Loss of Dpc4 expression helps distinguish among carcinomas.
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- Johns Hopkins University Hospital pathologists report that loss of expression of a particular nuclear transcription factor is a useful marker for distinguishing metastatic pancreatic carcinoma from...

Interim data on Onco TCS evaluated.(Brief Article)
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- Inex Pharmaceuticals Corporation (INEX; IEX) announced that an abstract on the company's lead product, Onco TCS, was accepted for presentation at the American Society of Hematology (ASH) annual...

Norwegian study demonstrates targeted coxibs may prevent disease.(COX-2 inhibitors to prevent head and neck cancer)
December 10, 2002... 2002 DEC 10 - (NewsRx.com & NewsRx.net) -- Norwegian researchers are planning the world's first phase III randomized trial to prevent head and neck cancer. They will use COX-2 inhibitors (coxibs) - a particular type of nonsteroidal...