Cancer Weekly articles from December 1999

Cancer Weekly archives from December 1999

DNA-PLGA Microparticles Studied as a Non-Viral Delivery Option.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- DNA-PLGA particles are a promising gene transfer delivery system for cancer gene therapy, suggested researchers from the United States. K. Ciftci and J. Su of Temple University, Pennsylvania, USA, evaluated...

Drug Side Effects May Include Damaged Intestinal Linings.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- A class of recently-developed painkiller drugs that also are being used to help prevent cancer may damage linings in the stomach and intestine in people with ulcers and other gastrointestinal damage, a team of...

Researchers Discover New Target Antigen.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- UroGenesys, Inc. reports the discovery of a novel gene that provides a promising route for developing new therapies to treat prostate cancer. The studies, published in the December 6, 1999, issue of...

Nitric Oxide Mediates C3L5 Tumor-Induced Angiogenesis.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Nitric oxide is a chief mediator of C3L5 tumor-induced angiogenesis, according to a recent report from Canada. Previously, L. Jadeski and colleagues discovered a positive correlation between the expression of...

Sulfated Dextrins Slow Progression of Kaposi's Sarcoma.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- by Cathy Clark, Senior Editor -- Sulfated dextrins inhibit the formation of new blood vessels, according to researchers from the United Kingdom. They also slow the clinical progression of Kaposi's sarcoma,...

bcl-2 Apoptosis Points to Long-Term Survival.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- bcl-2 apoptosis-related gene expression indicates a favorable outcome in breast cancer and suggests long-term survival. Apoptosis is an important physiological process controlled by multiple genes, including...

Continuation of Screening in Elderly Has Limited Benefit.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Continuing mammography screening for women over the age of 69 results in a small gain in life expectancy, according to an article in the December 8, 1999, issue of The Journal of the American Medical Association....

HLA-G Implicated in Tumor Escape from Immunosurveillance.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- HLA-G is a tolerance antigen which may be responsible for a tumor's ability to escape from host immunosurveillance, researchers from France suggest. "To define rational anti-tumor immunotherapy strategies, the...

Combination Therapy Backfires in Clinical Trial.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Combining granulocyte/macrophage-colony-stimulating factor (GM-CSF) and interleukin (IL)-2 with monoclonal antibody mAb17-1A hampered, not enhanced, the clinical effect of the antibody in patients with colorectal...

Pain Severity and Quality of Life Studied.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Cancer patients' quality of life is reduced with increasing pain severity. X. Wang, of the University of Texas, and associates investigated the relationship between 216 Chinese patients' pain severity and...

KAI1 Suppressor Gene Shows Reduced Expression.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- The metastasis suppressor gene KAI1 shows reduced expression in advanced metastatic colon cancer. The expression of the KAI1 gene and its gene product were studied by researcher C.A. Maurer and colleagues from...

Study Shows Need for Second Pathologist's Opinion.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- A study of more than 6,000 patients by Johns Hopkins University researchers found that one or two out of every 100 people who come to larger medical centers for treatment following a biopsy arrive with a diagnosis...

Three Ribosomal Protein Genes Are Elevated in Response to p53.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Researchers from the University of South Carolina, USA, have identified three ribosomal protein genes which have elevated expression in response to mutant p53. The wild-type p53 protein is a DNA-binding...

Aldosterone-Producing Adenomas are Examined.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- A study from Italy examines mutations in CYP11B1 gene. In the human adrenal cortex, cortisol and aldosterone are synthesized by the isozymes 11beta-hydroxylase and aldosterone synthase, respectively, encoded...

Key Phase of Human Immune Response Seen.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- The first detailed pictures of key immune system cells locked onto fragments of a foreign substance provide new clues about how the immune system identifies enemy threats and may even lead to a novel way of...

Mutation Strikes Women Smokers Three Times More Often than Men.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Scientists at the University of California San Francisco and Harvard University, Cambridge, Massachusetts, tracking lung cancer surgery patients have discovered that those who bear a common cancer-causing mutation...

Truncated HBV RNA Indicates Chronic Hepatitis.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Truncated hepatitis B virus RNA is a marker of chronic hepatitis infection but may or may not be a marker of liver cancer in older patients. RNA from tissue samples of 46 HBsAg seropositive hepatocellular...

RAGE-1 Pulsed Dendritic Cells Stimulate Anti-Cancer Response.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Autologous mature dendritic cells (DCs) pulsed with a RAGE-1 HLA-B7 peptide induced anti-cancer responses in patients with renal cell carcinoma (RCC). E. Ranieri and colleagues from institutions in the United...

Patient-Specific Dosimetry Is Worth the Effort.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Patient-specific dosimetry in anti CD-20 radioimmunotherapy for cancer treatment helps clinicians deliver a more accurate dose of radiolabelled antibodies than does standard doses based on patient weight or body...

Rapid Data Acquisition Allows for More Accurate Dosing.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Rapid data acquisition methods for I-131 anti-B1 radioimmunotherapy (RIT) treatment planning allows for more accurate and patient-specific dosing, reports researchers from the United States. "RIT with I-131...

PBSC Purging Offers Survival Advantage to Patients.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Purging peripheral blood stem cells (PBSC) from patients with chronic myeloid leukemia (CML) who have no other therapeutic option offers a survival advantage to these patients, reports researchers from Italy. ...

Molecular Markers May Help To Redefine Relapse in Patients.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Fred Hutchinson Cancer Research Center researchers are working to better understand the meanings of remission, relapse, and cure by using molecular markers to detect minimal residual disease (MRD) in patients who...

Stem Cells Have Advantage over BMT for Some Patients.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- In the largest study ever to compare outcomes of cancer patients transplanted with marrow versus stem cells, Fred Hutchinson Cancer Research Center researchers have found that for certain patients, stem cells offer...

Early Tests Show Promise for New Therapy.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- An experimental therapy has shown remarkable promise against one form of leukemia in early tests, helping every patient in whom the standard treatment had failed. The drug, STI-571, is intended to treat chronic...

Care Suggested When Combining Paclitaxel with Amifostine.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) Preliminary research indicates the potential for interaction between the chemotherapeutics amifostine and paclitaxel when used in lung cancer patients. Y.W. Zhu and colleagues from the University of Cincinnati and...

Cooled Tip Radiofrequency Beats Laser Photocoagulation.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Cooled tip radiofrequency (RF) therapy is almost twice as effective as interstitial laser photocoagulation (ILP) therapy for the treatment of liver tumors. W.R. Lees and A.R. Gillams of London, England,...

Extruded DOTAP:Cholesterol Liposome Used for Gene Delivery.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Nonviral vectors are being rapidly developed for the treatment of various diseases. Nancy Smyth Templeton from the Baylor College of Medicine, Texas, USA, recently presented data on the progress being made in...

Butter with Natural Fatty Acid Reduces Risk In Animals.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Butter made from milk containing increased levels of a natural fatty acid reduced the risk of breast cancer in laboratory animals, according to new research published in the November 25, 1999, issue of the Journal...

Company Develops New Optimized Antiestrogen Compounds.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- Nanodesign Inc., Guelph, Ontario, Canada, announces the achievement of an important milestone in its development of drug candidates for the treatment of breast cancer. Biological testing has demonstrated that...

Draft Guidelines for Stem Cell Research Published.(Brief Article)(Statistical Data Included)
December 27, 1999... 1999 DEC 27 - (NewsRx.com) -- The U.S. National Institutes of Health (NIH) has published in the Federal Register its draft guidelines for research involving human pluripotent stem cells. The draft guidelines recommend procedures to help...